Based on the remote sensing images of algae, the present work analyzes the horizontal distribution characteristics of algal blooms in Chaohu Lake, China, which also reveals the frequency of algal blooms under differen...Based on the remote sensing images of algae, the present work analyzes the horizontal distribution characteristics of algal blooms in Chaohu Lake, China, which also reveals the frequency of algal blooms under different wind directions. Further, an unstructured-grid, three-dimensional finite-volume coastal ocean model （FVCOM） is applied to investigate the wind-induced currents and the transport pro- cess to explain the reason why algal blooms occur at the detected places. We first deduce the primary distribution of biomass from overlaid satellite images, and explain the formation mechanism by analyzing the pollution sources, and simulating the flow field and transportation process under prevailing wind over Chaohu Lake. And then, we consider the adjustment action of the wind on the corresponding day and develop a two-time scale approach to describe the whole formation process of algae horizontal distribution in Chaohu Lake. That is, on the longer time scale, i.e., during bloom season, prevailing wind determines the primary distribution of biomass by inducing the characteristic flow field; on the shorter time scale, i.e., on the day when bloom occurs, the wind force adjusts the primary distribution of biomass to form the final distribution of algal bloom.展开更多
Alarm flood is one of the main problems in the alarm systems of industrial process. Alarm root-cause analysis and alarm prioritization are good for alarm flood reduction. This paper proposes a systematic rationalizati...Alarm flood is one of the main problems in the alarm systems of industrial process. Alarm root-cause analysis and alarm prioritization are good for alarm flood reduction. This paper proposes a systematic rationalization method for multivariate correlated alarms to realize the root cause analysis and alarm prioritization. An information fusion based interpretive structural model is constructed according to the data-driven partial correlation coefficient calculation and process knowledge modification. This hierarchical multi-layer model is helpful in abnormality propagation path identification and root-cause analysis. Revised Likert scale method is adopted to determine the alarm priority and reduce the blindness of alarm handling. As a case study, the Tennessee Eastman process is utilized to show the effectiveness and validity of proposed approach. Alarm system performance comparison shows that our rationalization methodology can reduce the alarm flood to some extent and improve the performance.展开更多
The recent GMP （good medical practice） rules actualisation and its requirements introduction widened the GMP guidelines for every life cycle of medicinal products, including the stage of processes scaling and techno...The recent GMP （good medical practice） rules actualisation and its requirements introduction widened the GMP guidelines for every life cycle of medicinal products, including the stage of processes scaling and technology transfer. This requires the technology transfer process to be regulated as the part of pharmaceutical quality system and the following development of corresponding written procedures. The following publication is dedicated to the development of TTP （technology transfer process） and its accessible graphic formalisation alongside the definition of main stages and possible procedures limited by the offered model. According to the actualized GMP rules, the technology transfer is an essential part of pharmaceutical quality system at a modem pharmaceutical company.展开更多
基金supported by the Hundred Talents Program of Chinese Academy of Sciencesthe National Natural Science Fundation of China for Distinguished Young Scholar(10825211)
文摘Based on the remote sensing images of algae, the present work analyzes the horizontal distribution characteristics of algal blooms in Chaohu Lake, China, which also reveals the frequency of algal blooms under different wind directions. Further, an unstructured-grid, three-dimensional finite-volume coastal ocean model （FVCOM） is applied to investigate the wind-induced currents and the transport pro- cess to explain the reason why algal blooms occur at the detected places. We first deduce the primary distribution of biomass from overlaid satellite images, and explain the formation mechanism by analyzing the pollution sources, and simulating the flow field and transportation process under prevailing wind over Chaohu Lake. And then, we consider the adjustment action of the wind on the corresponding day and develop a two-time scale approach to describe the whole formation process of algae horizontal distribution in Chaohu Lake. That is, on the longer time scale, i.e., during bloom season, prevailing wind determines the primary distribution of biomass by inducing the characteristic flow field; on the shorter time scale, i.e., on the day when bloom occurs, the wind force adjusts the primary distribution of biomass to form the final distribution of algal bloom.
基金Supported by the National Natural Science Foundation of China(61473026,61104131)the Fundamental Research Funds for the Central Universities(JD1413)
文摘Alarm flood is one of the main problems in the alarm systems of industrial process. Alarm root-cause analysis and alarm prioritization are good for alarm flood reduction. This paper proposes a systematic rationalization method for multivariate correlated alarms to realize the root cause analysis and alarm prioritization. An information fusion based interpretive structural model is constructed according to the data-driven partial correlation coefficient calculation and process knowledge modification. This hierarchical multi-layer model is helpful in abnormality propagation path identification and root-cause analysis. Revised Likert scale method is adopted to determine the alarm priority and reduce the blindness of alarm handling. As a case study, the Tennessee Eastman process is utilized to show the effectiveness and validity of proposed approach. Alarm system performance comparison shows that our rationalization methodology can reduce the alarm flood to some extent and improve the performance.
文摘The recent GMP （good medical practice） rules actualisation and its requirements introduction widened the GMP guidelines for every life cycle of medicinal products, including the stage of processes scaling and technology transfer. This requires the technology transfer process to be regulated as the part of pharmaceutical quality system and the following development of corresponding written procedures. The following publication is dedicated to the development of TTP （technology transfer process） and its accessible graphic formalisation alongside the definition of main stages and possible procedures limited by the offered model. According to the actualized GMP rules, the technology transfer is an essential part of pharmaceutical quality system at a modem pharmaceutical company.
