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Development and Application of Procedures for the Management of Skin Toxicity Related to Immune Checkpoint Inhibitors in Patients with Lung Cancer
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作者 Qianru Xu Qiong Wen 《Journal of Biosciences and Medicines》 2024年第7期289-300,共12页
Objective: To establish the procedures for the management of skin toxicity related to immune checkpoint inhibitors in patients with lung cancer and explore the effect of application. Methods: A total of 24 evidence-ba... Objective: To establish the procedures for the management of skin toxicity related to immune checkpoint inhibitors in patients with lung cancer and explore the effect of application. Methods: A total of 24 evidence-based evidences were collected from 7 aspects, including risk factors, baseline screening, ICIs monitoring, daily skin care, multidisciplinary management, symptom management and health education. A total of 157 lung cancer patients and 94 nurses from 8 wards of the Oncology department of our hospital from November 2022 to May 2023 were selected by convenience sampling. A total of 77 patients and 46 nurses from ward 1 - 4 were divided into the baseline group. There were 80 patients and 48 nurses in Ward 5 - 8 as the evidence-based practice group. In the baseline group, patients were treated with routine methods such as assessing skin symptoms, taking medication according to symptoms, guiding to keep skin clean and moist, eating a light diet, and avoiding scratching. The evidence-based practice group adopts an evidence-based continuous improvement model for nursing. The differences in the severity of symptoms of skin toxicity in the second cycle of medication and the knowledge and practice of self-care of skin toxicity were compared between the two groups before and after the use of the syndrome, as well as the differences in the implementation rate of review indicators, evidence-based ability and knowledge and practice of skin toxicity care before and after the use of the syndrome. Results: The incidence and severity of cutaneous toxicity were significantly lower after treatment than before treatment (P P < 0.05). Conclusion: The implementation of immune checkpoint inhibitor-related skin toxicity management procedures can effectively reduce the incidence and severity of skin toxicity symptoms, optimize the clinical pathway, and improve the quality of care. 展开更多
关键词 Lung Cancer Immune Checkpoint Inhibitors Skin toxicity Process Management NURSE
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Building a Productive Domain-Specific Cloud for Big Data Processing and Analytics Service
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作者 Yuzhong Yan Mahsa Hanifi +1 位作者 Liqi Yi Lei Huang 《Journal of Computer and Communications》 2015年第5期107-117,共11页
Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open sour... Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open source frameworks in Cloud Computing for storing and processing big data in the scalable fashion. Spark is the latest parallel computing engine working together with Hadoop that exceeds MapReduce performance via its in-memory computing and high level programming features. In this paper, we present our design and implementation of a productive, domain-specific big data analytics cloud platform on top of Hadoop and Spark. To increase user’s productivity, we created a variety of data processing templates to simplify the programming efforts. We have conducted experiments for its productivity and performance with a few basic but representative data processing algorithms in the petroleum industry. Geophysicists can use the platform to productively design and implement scalable seismic data processing algorithms without handling the details of data management and the complexity of parallelism. The Cloud platform generates a complete data processing application based on user’s kernel program and simple configurations, allocates resources and executes it in parallel on top of Spark and Hadoop. 展开更多
关键词 BUILDING a Productive Domain-specific CLOUD for BIG Data processing and ANALYTICS SERVICE
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Toxicity Reduction of Municipal Wastewater by Anaerobic-anoxic-oxic Process 被引量:5
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作者 MAN-HONG HUANG YONG-MEI LI GuO-WEi GU 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第6期481-486,共6页
Objective This study was conducted to optimize the operational parameters of anaerobic-anoxic-oxic (A^2/O) processes to reduce the toxicity of municipal wastewater and evaluate its ability to reduce toxicity. Method... Objective This study was conducted to optimize the operational parameters of anaerobic-anoxic-oxic (A^2/O) processes to reduce the toxicity of municipal wastewater and evaluate its ability to reduce toxicity. Methods A luminescent bacterium toxicity bioassay was employed to assess the toxicity of influent and effluent of each reactor in the A2/O system. Results The optimum operational parameters for toxicity reduction were as follows: anaerobic hydraulic retention time (HRT) = 2.8 h, anoxic HRT = 2.8 h, aerobic HRT = 6.9 h, sludge retention time (SRT) = 15 days and internal recycle ratio (IRR) = 100%. An important toxicity reduction (%) was observed in the optimized A2/O process, even when the toluene concentration of the influent was 120.7 mg·L^-1. Conclusions The toxicity of municipal wastewater was reduced significantly during the A^2/O process. A^2/O process can be used for toxicity reduction of municipal wastewater under toxic-shock loading. 展开更多
关键词 A^2/O process Municipal wastewater toxicity reduction Process optimization Toxic-shock loading
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Inhibitory effect of ammonia nitrogen on specific methanogenic activity of anaerobic granular sludge 被引量:6
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作者 周洪波 邱冠周 《Journal of Central South University of Technology》 EI 2006年第1期63-67,共5页
A series of batch experiments were conducted in 125 mL serum bottles to assess the toxicity of different concentrations of ammonia nitrogen to the specific methanogenic activity of anaerobic granular sludge from upflo... A series of batch experiments were conducted in 125 mL serum bottles to assess the toxicity of different concentrations of ammonia nitrogen to the specific methanogenic activity of anaerobic granular sludge from upflow anaerobic sludge bed(UASB) and expanded granular sludge bed(EGSB) reactors. The effects of pH value and temperature on toxicity of ammonia nitrogen to anaerobes were investigated. The results show that the specific methanogenic activity of anaerobic granular sludge suffers inhibition from ammonia nitrogen, the concentrations of ammonia nitrogen that produce 50 % inhibition of specific methanogenic activity for sludge from UASB and EGSB reactor are 2.35 and 2.75 g/L, respectively. Hydrogen utilizing methanogens suffers less inhibition from ammonia mtrogen than that of acetate utilizing methanogens. Hydrogen-producing acetogens that utilize propionate and butyrate as substrates suffer serious inhibition from ammonia nitrogen. The toxicity of ammonia nitrogen to anaerobic granular sludge enhances when pH value and temperature increase. Anaerobic granular sludge can bear higher concentrations of ammonia nitrogen after being acclimated by ammonia nitrogen for 7 d. 展开更多
关键词 ammonia nitrogen toxicity anaerobic granular sludge specific methanogenic activity
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Prediction Model for Net Cutting Specific Energy in CNC Turning 被引量:3
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作者 ZHAO Guoyong LI Chunxiao +2 位作者 TIAN Yingzhou ZHANG Junfeng ZHAO Guangxi 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2020年第3期385-392,共8页
A prediction model for net cutting specific energy in computer numerical control(CNC)turning based on turning parameters and tool wear is developed.The model can predict the net cutting energy consumption before turni... A prediction model for net cutting specific energy in computer numerical control(CNC)turning based on turning parameters and tool wear is developed.The model can predict the net cutting energy consumption before turning.The prediction accuracy of the model is verified in AISI 1045 steel turning.The comparative experimental results show that the prediction accuracy of the model is significantly improved because the influence of tool wear is taken into account.Finally,the influences of turning parameters and tool wear on net cutting specific energy are studied.With the increase of cutting depth,the net cutting specific energy decreases.With the increase of spindle speed,the additional load loss power of spindle drive system increases,so the net cutting specific energy increases.The net cutting specific energy increases approximately linearly with tool wear.The results are helpful to formulate efficient and energy-saving CNC turning schemes and realize low‑carbon manufacturing. 展开更多
关键词 net cutting specific energy turning parameters tool wear processing scheme low‑carbon manufacturing
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The riddles of number nine in Chinese medicine processing method 被引量:1
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作者 Xiang-Long Meng Xiao-Yan Zhang +2 位作者 Cong Hu Xiao-Juan Su Shuo-Sheng Zhang 《Traditional Medicine Research》 2021年第2期70-85,共16页
The“nine cycles of steaming and shining”,“nine making”,“nine turns”and“nine cycles of calcining and quenching”methods that are recorded and used since ancient times are merely one aspect of the unique processi... The“nine cycles of steaming and shining”,“nine making”,“nine turns”and“nine cycles of calcining and quenching”methods that are recorded and used since ancient times are merely one aspect of the unique processing methods of traditional Chinese medicine.Inducing the Chinese medicine processing method“nine cycles of steaming and shining”from historical review and summarizing the practical wisdom based on the canonical aspects of traditional Chinese medicine and the experiences of ancient Chinese medicine sages to promote the new development of traditional Chinese medicine.After the long-term and multiple“nine”processing,the materials of traditional Chinese medicine exhibit significant beneficial changes in terms of taste,efficacy,and chemical composition contents,thus emphasizing that Chinese medicine processing plays a significant role in their efficacy enhancement and toxicity reduction.Heshouwu(Polygoni Multiflori Radix),Dihuang(Rehmanniae Radix),Huangjing(Rhizoma Polygonati),Dahuang(Radix et Rhizoma Rhei),and Xixiancao(Herba Siegesbeckiae)are representatives of Chinese medicinal materials prepared using the“nine-system”processing method.This review discovers the aim and the molecular mechanism of“nine”processing of the abovementioned herbs from the viewpoints of modern pharmacochemistry and pharmacology to provide a theoretical support for the“nine”processing method of traditional Chinese medicine and to promote the international market of traditional Chinese medicine. 展开更多
关键词 Nine cycles of steaming and shining Chinese medicine processing Historical review Efficacy enhancement toxicity reduction
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Toxicity of Magnetic Albumin Microspheres Bearing Adriamycin
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作者 马建华 陈道达 +1 位作者 田源 陶凯雄 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2000年第3期261-262,共2页
Magnetic albumin microspheres bearing adriamycin (ADM MAM) is a novel chemotherapeutic compound with site specific drug delivery characteristics. The acute and subacute toxic tests of the compound, local irritating ... Magnetic albumin microspheres bearing adriamycin (ADM MAM) is a novel chemotherapeutic compound with site specific drug delivery characteristics. The acute and subacute toxic tests of the compound, local irritating test and anaphylactic test were performed on mice and guinea pigs. The results showed there was no macroscopically and microscopically direct cytotoxic injuries of the compound to the animal organs or to the cells. The LD 50 value of the compound was higher than that of the single used adriamycin, indicating that the compound was less toxic than the single adriamycin and quite safe in its therapeutic dosage. Furthermore, there was also no side effects or toxic reactions to be observed on clinical patients with advanced carcinoma or gastric cancer. 展开更多
关键词 magnetic albumin microspheres ADRIAMYCIN CHEMOTHERAPY site specific targeting toxicity
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Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment:An experimental mouse model 被引量:2
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作者 Ok-Hee Kim Ha-Eun Hong +6 位作者 Haeyeon Seo Bong Jun Kwak Ho Joong Choi Kee-Hwan Kim Joseph Ahn Sang Chul Lee Say-June Kim 《World Journal of Stem Cells》 SCIE 2020年第1期70-86,共17页
BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,named as the secretome,have been evaluated for overcoming the limitations of cell-based therapy while maintaining its advantages.A... BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,named as the secretome,have been evaluated for overcoming the limitations of cell-based therapy while maintaining its advantages.AIM To improve cell-free therapy by adding disease-specificity through stimulation of MSCs using disease-causing materials.METHODS We collected the secretory materials(named as inducers)released from AML12 hepatocytes that had been pretreated with thioacetamide(TAA)and generated the TAA-induced secretome(TAA-isecretome)after stimulating adipose-derived stem cells with the inducers.The TAA-isecretome was intravenously administered to mice with TAA-induced hepatic failure and those with partial hepatectomy.RESULTS TAA-isecretome infusion showed higher therapeutic potential in terms of(1)restoring disorganized hepatic tissue to normal tissue;(2)inhibiting proinflammatory cytokines(interleukin-6 and tumor necrosis factor-α);and(3)reducing abnormally elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase)compared to the naïve secretome infusion in mice with TAA-induced hepatic failure.However,the TAA-isecretome showed inferior therapeutic potential for restoring hepatic function in partially hepatectomized mice.Proteomic analysis of TAA-isecretome identified that antioxidant processes were the most predominant enriched biological networks of the proteins exclusively identified in the TAA-isecretome.In addition,peroxiredoxin-1,a potent antioxidant protein,was found to be one of representative components of TAA-isecretome and played a central role in the protection of TAA-induced hepatic injury.CONCLUSION Appropriate stimulation of adipose-derived stem cells with TAA led to the production of a secretome enriched with proteins,especially peroxiredoxin-1,with higher antioxidant activity.Our results suggest that appropriate stimulation of MSCs with pathogenic agents can lead to the production of a secretome specialized for protecting against the pathogen.This approach is expected to open a new way of developing various specific therapeutics based on the high plasticity and responsiveness of MSCs. 展开更多
关键词 Adipose-derived stem cells Disease-specificity Mesenchymal stem cells SECRETOME Peroxiredoxin-1 THIOACETAMIDE Toxic hepatic failure
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An Approach to Generation of Process-Oriented Requirements Specification
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作者 Jingbai Tian Keqing He +1 位作者 Chong Wang Huafeng Chen 《Journal of Software Engineering and Applications》 2009年第1期13-19,共7页
In service-oriented computing, process model may serve as a link to connect users’ requirements with Web Services. In this paper, we propose an approach and related key techniques to generate process-oriented require... In service-oriented computing, process model may serve as a link to connect users’ requirements with Web Services. In this paper, we propose an approach and related key techniques to generate process-oriented requirements specification from user’s goal. For this purpose, a requirements description language named SORL will be provided to capture users’ requirements. Then, a unified requirements meta-modeling frame RPGS will be used to construct reusable domain assets, which is the basis of generating requirements specifications. Finally, a set of rules are defined to extract process control structures from users’ requirements described with SORL, so that we can convert requirements description into process-oriented requirements specification smoothly. 展开更多
关键词 Requirements specificATION PROCESS MODELING PROCESS Control Stucture NETWORKED SOFTWARE
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Study on Selection of Wheat Varieties for Noodle Production in Hebei Province and Factors Affecting the Processing Quality
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作者 Guocong ZHANG Zhanliang SHI 《Asian Agricultural Research》 2021年第2期50-54,57,共6页
[Objectives]To screen out the specific wheat varieties for noodle production in Hebei Province and analyze the factors affecting the processing quality of noodle.[Methods]The quality characteristics of grains,flour an... [Objectives]To screen out the specific wheat varieties for noodle production in Hebei Province and analyze the factors affecting the processing quality of noodle.[Methods]The quality characteristics of grains,flour and noodle of major medium gluten wheat varieties in Hebei Province were detected and analyzed.[Results]The sensory score of noodle is significantly positively correlated with wet gluten content of medium gluten wheat flour,and extensile length,cohesiveness,resilience,elasticity,gumminess,chewiness and extensile distance of TPA of noodle,and is significantly negatively correlated with softening degree.TPA of noodle can indirectly reflect sensory quality of noodle.[Conclusions]Han 7086,Xingmai 4,Liangxing 66,Shiyou 17,Heng 5229 and Liangxing 99 are suitable for producing high-quality noodle,and they can be used as noodle-specific varieties for promoting in Hebei Province. 展开更多
关键词 Hebei NOODLE specific wheat variety SCREENING processing quality Affecting factor
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陕产附子炮制前后急性毒性及强心作用研究 被引量:2
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作者 李凡 张景霞 +4 位作者 赵林涛 王卫锋 陈曦 韩昕 李芳 《中医药学报》 CAS 2024年第4期23-28,共6页
目的:考察陕产附子炮制前后的急性毒性和强心作用。方法:通过对生附子LD_(50)的测定和自制黑顺片最大耐受量实验比较生附子和自制黑顺片的急性毒性;通过复制慢性心衰大鼠模型,检测大鼠体质量、心脏指数、血流动力学指标,检测血清BNP及c... 目的:考察陕产附子炮制前后的急性毒性和强心作用。方法:通过对生附子LD_(50)的测定和自制黑顺片最大耐受量实验比较生附子和自制黑顺片的急性毒性;通过复制慢性心衰大鼠模型,检测大鼠体质量、心脏指数、血流动力学指标,检测血清BNP及cTnI含量以及组织病理学检查比较其强心作用。结果:生附子的半数致死量(LD_(50))为9.45 g/kg,黑顺片的最大耐受量为27.39 g/kg,经炮制后毒性降低。与模型组相比,自制黑顺片组大鼠症状及体征均有改善,能够降低心脏指数、左心室指数降低和左心室舒张压(LVEDP),升高左心室收缩压(LVSP)、收缩期左心室内压上升最大变化速率(+dp/dt_(max))和舒张期左心室内压下降最大变化速率(-dp/dt_(max))(P<0.05,P<0.01);降低血清中脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)含量(P<0.05);心肌纤维排列相对紧密,胞核清晰可见,但有一定断裂,其中有少量空泡存在,未发现炎性细胞浸润,各指标有明显差异。生附子组各指标有一定程度的改善,但差异无统计学意义(P>0.05)。结论:生附子经炮制后,毒性降低,起到减毒的作用;自制黑顺片较生附子强心作用有显著增强。 展开更多
关键词 附子 炮制 急性毒性 强心作用
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Visual Information Processing Based on Qualitative Mapping
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作者 LI Hua LIU Yongchang LI Chao 《现代电子技术》 2007年第3期153-155,共3页
Visual information processing is not only an important research direction in fields of psychology,neuroscience and artificial intelligence etc,but also the research base on biological recognition theory and technology... Visual information processing is not only an important research direction in fields of psychology,neuroscience and artificial intelligence etc,but also the research base on biological recognition theory and technology realization.Visual information processing in existence,e.g.visual information processing facing to nerve calculation,visual information processing using substance shape distilling and wavelet under high yawp,ANN visual information processing and etc,are very complex in comparison.Using qualitative Mapping,this text describes the specific attributes in the course of visual information processing and the results are more brief and straightforward.So the software program of vision recognition is probably easier to realize. 展开更多
关键词 可视信息处理 生物识别 图像处理 细节特征
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基于深度置信网络的多模态过程故障评估方法及应用 被引量:1
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作者 张凯 杨朋澄 +1 位作者 彭开香 陈志文 《自动化学报》 EI CAS CSCD 北大核心 2024年第1期89-102,共14页
传统的多模态过程故障等级评估方法对模态之间的共性特征考虑较少,导致当被评估模态故障信息不充分时,评估的准确性较低.针对此问题,首先,提出一种共性–个性深度置信网络(Common and specific deep belief network,CS-DBN),该网络充分... 传统的多模态过程故障等级评估方法对模态之间的共性特征考虑较少,导致当被评估模态故障信息不充分时,评估的准确性较低.针对此问题,首先,提出一种共性–个性深度置信网络(Common and specific deep belief network,CS-DBN),该网络充分利用深度置信网络(Deep belief network,DBN)的深度分层特征提取能力,通过度量多模态数据间分布的相似性和差异性,进一步得到能够反映多模态过程共有信息的共性特征以及反映每个模态独有信息的个性特征;其次,基于CS-DBN,利用多模态过程的已知故障等级数据生成多模态共性–个性特征集,通过加权逻辑回归构建故障等级评估模型;最后,将所提方法应用于带钢热连轧生产过程的故障等级评估中.应用结果表明,随着多模态故障等级数据的增加,所提方法的评估准确率逐渐增加,当故障信息充足时,评估准确率可达98.75%;故障信息不足时,与传统方法相比,评估准确率提升近10%. 展开更多
关键词 多模态过程 故障等级评估 共性–个性特征 深度置信网络 带钢热连轧
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黄芪下脚料粗多糖提取工艺优化及对鲤鱼非特异性免疫指标的影响 被引量:1
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作者 乔卿梅 程茂高 +2 位作者 刘文慧 霍嘉欣 张超伦 《黑龙江畜牧兽医》 CAS 北大核心 2024年第9期99-103,108,120,121,共8页
为了提高黄芪下脚料中粗多糖的提取率并明确黄芪下脚料中粗多糖对鲤鱼非特异性免疫指标的影响,试验采用单因素试验及响应面法优化黄芪下脚料中粗多糖的提取工艺;将100尾健康且体重接近的鲤鱼随机均分为空白对照组、中药对照组、低剂量... 为了提高黄芪下脚料中粗多糖的提取率并明确黄芪下脚料中粗多糖对鲤鱼非特异性免疫指标的影响,试验采用单因素试验及响应面法优化黄芪下脚料中粗多糖的提取工艺;将100尾健康且体重接近的鲤鱼随机均分为空白对照组、中药对照组、低剂量组、中剂量组和高剂量组,空白对照组饲喂基础饲料,中药对照组饲喂添加0.1%黄芪粗多糖的基础饲料,低、中、高剂量组分别饲喂添加0.1%、0.2%、0.4%黄芪下脚料粗多糖的基础饲料,连续饲喂42 d,取鲤鱼尾静脉血液,测定溶菌酶(LZM)、碱性磷酸酶(AKP)和超氧化物歧化酶(SOD)活性。结果表明:在提取温度为93℃、提取时间为2.8 h、料液比为1∶30条件下黄芪下脚料粗多糖最大提取率为7.67%。中剂量组LZM、SOD活性都显著高于空白对照组(P<0.05);低剂量组AKP活性显著高于空白对照组和中药对照组(P<0.05);高剂量组LZM活性显著低于中剂量组(P<0.05),SOD活性显著低于低剂量组和中剂量组(P<0.05),AKP活性低于低剂量组和中剂量组,但差异不显著(P>0.05)。说明通过响应面法优化黄芪下脚料粗多糖提取工艺后,可以从黄芪下脚料中提取到较高含量的粗多糖,且在基础饲料中添加0.1%~0.2%黄芪下脚料粗多糖可以明显提高鲤鱼的免疫力。 展开更多
关键词 黄芪下脚料 粗多糖 响应面法 工艺优化 非特异性免疫
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白术炮制规格及其化学成分与药理作用研究进展 被引量:3
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作者 杨田义 孙乐 《中国实用医药》 2024年第13期174-177,共4页
白术是菊科多年生草本植物,药典收载白术和麸炒白术两种饮片规格,主要有效成分为挥发油、内酯、多糖、黄酮和苷类等。主要作用于胃肠道、免疫与神经系统,发挥调节胃肠道、抗肿瘤、抗炎护肝和保护神经等多种药理作用。本文对白术的古今... 白术是菊科多年生草本植物,药典收载白术和麸炒白术两种饮片规格,主要有效成分为挥发油、内酯、多糖、黄酮和苷类等。主要作用于胃肠道、免疫与神经系统,发挥调节胃肠道、抗肿瘤、抗炎护肝和保护神经等多种药理作用。本文对白术的古今炮制规格及其化学成分和药理作用进行综述,以期为白术的临床应用提供参考。 展开更多
关键词 白术 炮制规格 化学成分 药理作用
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基于炎症大鼠代谢组学的马钱子炮制减毒存效机制研究
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作者 秦伟瀚 魏江平 +1 位作者 张小梅 阳勇 《天然产物研究与开发》 CAS CSCD 北大核心 2024年第5期825-837,共13页
运用动物模型、血浆药物化学及代谢组学方法,探讨马钱子炮制前后干预炎症大鼠作用机制。按不同剂量灌胃小鼠,以死亡率初步考察炮制前后毒性;建立大鼠蛋清性足跖肿胀模型,通过肿胀率和炎性因子水平评价炮制前后抗炎效果;采用高分辨质谱... 运用动物模型、血浆药物化学及代谢组学方法,探讨马钱子炮制前后干预炎症大鼠作用机制。按不同剂量灌胃小鼠,以死亡率初步考察炮制前后毒性;建立大鼠蛋清性足跖肿胀模型,通过肿胀率和炎性因子水平评价炮制前后抗炎效果;采用高分辨质谱结合多元统计学,鉴定入血后的移行成分及相应的代谢产物;比较分析各实验组代谢轮廓及差异生物标志物,并构建其代谢通路。结果显示,高剂量下马钱子砂烫品的毒性要明显低于生品。生品和砂烫品均能显著降低大鼠足肿胀率和肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)的水平,炮制前后在抗炎效果上差异无统计学意义(P>0.05)。通过血浆药物分析,鉴定出了12个移行成分,以及相应60个代谢产物,S-plot鉴定出10个差异性化合物。代谢组学实验共发现10个内源性代谢物含量发生显著变化(P<0.05),生物标志物主要涉及苯丙氨酸代谢、甘油磷脂代谢、谷氨酸及谷氨酰胺循环、精氨酸和脯氨酸代谢等途径。通过本研究确证马钱子生品和砂烫品均有较好抗炎治疗作用,高温炮制可以降低马钱子毒性;入血后有效成分应多为生物碱,经过I相反应就容易被体内清除;马钱子炮制抗炎、镇痛、减毒机制主要与氨基酸和脂质代谢相关。该实验结果进一步阐明了起效物质基础及体内作用机制,为后续炮制工艺改进和新药研发等提供科学支撑。 展开更多
关键词 马钱子 炮制 抗炎作用 代谢组学 减毒存效
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马钱子减毒增效途径及机制研究进展 被引量:1
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作者 李艳 高粉粉 +3 位作者 谈利红 朱照静 曾令高 毛景欣 《中国医药科学》 2024年第6期39-42,共4页
本文综述马钱子减毒增效的主要途径及其减毒增效的机制研究进展。马钱子减毒增效的主要途径包括炮制、配伍、新剂型与制剂新技术等;减毒增效的机制主要包括生物碱成分含量发生变化、生物碱药代动力学行为改变、影响CYP450酶的mRNA表达... 本文综述马钱子减毒增效的主要途径及其减毒增效的机制研究进展。马钱子减毒增效的主要途径包括炮制、配伍、新剂型与制剂新技术等;减毒增效的机制主要包括生物碱成分含量发生变化、生物碱药代动力学行为改变、影响CYP450酶的mRNA表达和酶活性、诱导血脑屏障上P-糖蛋白外向转运加速生物碱外排、缓释及靶向控制药物浓度梯度等。关于马钱子减毒增效的途径研究较多,但对其减毒增效的机制和原理研究较少且不甚深入,建议后续研究从毒性物质基础、体内暴露和体内过程、分子机制、量-时-毒-效关联性及转化规律等方面对马钱子减毒增效的机制进行深入研究。 展开更多
关键词 马钱子 减毒增效 机制 炮制
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飞龙掌血茎和根不同炮制品对小鼠的急性毒性试验
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作者 陈龙 陈小燕 +4 位作者 张淼 罗静 邓玲玉 朱华 许立拔 《湖北农业科学》 2024年第1期90-95,共6页
旨在了解飞龙掌血[Toddalia asiatica(Linn)Lam.]茎和根不同炮制对小鼠急性毒性作用。130只KM小鼠适应性喂养3 d后,随机分为13组,包括溶媒组和12个药物试验剂量组(1个药材茎生品组和5个茎炮制组,1个根生品组和5个根炮制组,其中5种药材... 旨在了解飞龙掌血[Toddalia asiatica(Linn)Lam.]茎和根不同炮制对小鼠急性毒性作用。130只KM小鼠适应性喂养3 d后,随机分为13组,包括溶媒组和12个药物试验剂量组(1个药材茎生品组和5个茎炮制组,1个根生品组和5个根炮制组,其中5种药材炮制品包括水煮制品、水洗制品、水蒸制品、酒蒸制品和酒炙制品)。溶媒组小鼠按40 mL/kg给予纯净水灌胃,给药3次,间隔4~5 h;茎各炮制品试验组小鼠按40 mL/kg灌胃,给药3次,间隔4~5 h;根各炮制品试验组小鼠按30 mL/kg灌胃,给药2次,间隔4~5 h,记录给药后各组小鼠14 d的主要临床症状、体重变化,并统计死亡率。结果表明,飞龙掌血及各炮制品可对小鼠产生急性毒性作用,临床中毒症状有自主活动减少、安静怠动、俯卧和翻正反射消失。炮制品组与溶媒组比较,在14 d内茎和根各炮制品均可致小鼠体重明显降低,且死亡率显著高于溶媒组(P<0.05或P<0.01);而与生品组比较,茎和根的5种炮制品在14 d内对小鼠体重的影响不显著,可有效降低小鼠的死亡率,其中以水煮法效果最佳。水煮、水洗、水蒸、酒蒸、酒炙炮制方法可以减小飞龙掌血茎和根(生品)对小鼠的毒性作用,但对小鼠体脂影响不显著。 展开更多
关键词 飞龙掌血[Toddalia asiatica(Linn)Lam.] 根和茎 炮制品 小鼠急性毒性 中药炮制减毒
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《中药饮片临方炮制规范》解读
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作者 马彦江 桂新景 +5 位作者 董峰宇 鲁静 姚静 刘瑞新 陈天朝 李学林 《医药导报》 CAS 北大核心 2024年第7期1046-1049,共4页
为推进中药饮片临方炮制规范发展,由中华中医药学会医院药学分会组织,河南中医药大学第一附属医院和江苏省中医院牵头,会同全国28家医疗机构共同起草了《中药饮片临方炮制规范》。2021年6月,中华中医药学会批准发布该团体标准(T/CACM 13... 为推进中药饮片临方炮制规范发展,由中华中医药学会医院药学分会组织,河南中医药大学第一附属医院和江苏省中医院牵头,会同全国28家医疗机构共同起草了《中药饮片临方炮制规范》。2021年6月,中华中医药学会批准发布该团体标准(T/CACM 1367-2021)。该文对该规范进行详细解读,以期促进《中药饮片临方炮制规范》的落地实施,推动传统中药炮制的传承创新。 展开更多
关键词 中药饮片 临方炮制 团体标准 规范解读
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中英规范关于疏浚工程施工精度的对比分析
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作者 郑金海 费子豪 +1 位作者 周春艳 张继生 《水利水电技术(中英文)》 北大核心 2024年第S01期92-96,共5页
随着国际疏浚业的不断发展,对疏浚工程施工精度的要求日趋提高,对比分析中英疏浚工程规范的差异,能够提升我国水运企业在海外疏浚行业的竞争力。全面总结了中英疏浚工程规范体系的设计理念和特点,对比分析了中英规范在水下验收测线间距... 随着国际疏浚业的不断发展,对疏浚工程施工精度的要求日趋提高,对比分析中英疏浚工程规范的差异,能够提升我国水运企业在海外疏浚行业的竞争力。全面总结了中英疏浚工程规范体系的设计理念和特点,对比分析了中英规范在水下验收测线间距、水深测量精度、疏浚精度方面的差异,以及对设备选型、施工效率和浚后验收测量的影响。以东帝汶Tibar Bay港口项目疏浚工程为例,展示了在实际疏浚工程中,通过对比中英疏浚规范,合理选择疏浚参数,优化施工工艺,进而减少高标准对施工效率和成本的负面影响,保障工程顺利履约,为准确运用国内外标准提供了有益的指导。 展开更多
关键词 疏浚工程 施工精度 规范对比 工艺优化
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