Health risk assessment of trace metal(loid)s in agricultural soils based on Monte Carlo simulation coupled with positive matrix factorization model in Chongqing, southwest China

This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed the source apportionment and assessed the health risk of TMs in agricultural soils by using positive matrix factorization(PMF) model and health risk assessment(HRA) model based on Monte Carlo simulation. Meanwhile, we combined PMF and HRA models to explore the health risks of TMs in agricultural soils by different pollution sources to determine the priority control factors. Results showed that the average contents of cadmium(Cd), arsenic (As), lead(Pb), chromium(Cr), copper(Cu), nickel(Ni), and zinc(Zn) in the soil were found to be 0.26, 5.93, 27.14, 61.32, 23.81, 32.45, and 78.65 mg/kg, respectively. Spatial analysis and source apportionment analysis revealed that urban and industrial sources, agricultural sources, and natural sources accounted for 33.0%, 27.7%, and 39.3% of TM accumulation in the soil, respectively. In the HRA model based on Monte Carlo simulation, noncarcinogenic risks were deemed negligible(hazard index <1), the carcinogenic risks were at acceptable level(10^(-6)<total carcinogenic risk ≤ 10^(-4)), with higher risks observed for children compared to adults. The relationship between TMs, their sources, and health risks indicated that urban and industrial sources were primarily associated with As, contributing to 75.1% of carcinogenic risks and 55.7% of non-carcinogenic risks, making them the primary control factors. Meanwhile, agricultural sources were primarily linked to Cd and Pb, contributing to 13.1% of carcinogenic risks and 21.8% of non-carcinogenic risks, designating them as secondary control factors.

Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease

BACKGROUND Psychological distress,especially depression,associated with perianal fistulizing Crohn’s disease(PFCD)is widespread and refractory.However,there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD.AIM To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD.METHODS The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical staff.Depressive symptoms,life quality,and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9,Inflammatory Bowel Disease Patient Quality of Life Questionnaire(IBDQ),and Inflammatory Bowel Disease(IBD)Fatigue Patient Self-assessment Scale.The basic demographic information,overall disease features,perianal clinical information,and laboratory inflammation indicators were also gathered.Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD.RESULTS A total of 123 patients with PFCD were involved,and 56.91%were suffering from depression.According to multivariate logistic regression analysis,Perianal Disease Activity Index(PDAI)score[odds ratio(OR)=0.69,95%confidence interval(CI):0.50 to 0.95],IBDQ score(OR=0.93,95%CI:0.88 to 0.97),modified Van Assche index(OR=1.24,95%CI:1.01 to 1.53),and IBD Fatigue score(OR=1.72,95%CI:1.23 to 2.42)were independent risk factors of depression-related prevalence among patients with PFCD(P<0.05).Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index(βvalue=0.166,95%CI:0.02 to 0.31)and decreasing IBDQ score(βvalue=-0.116,95%CI:-0.14 to-0.09)were independently associated with the severity of depression(P<0.05).CONCLUSION Depressive symptoms in PFCD patients have significantly high prevalence.PDAI score,modified Van Assche index,quality of life,and fatigue severity were the main independent risk factors.

Epidemiological Aspects of Obesity, Overweight and Cardiovascular Risk Factors at Associes in Semi-Urban Areas (Case of Sébikotane)

Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Patients and Methods: This was a cross-sectional, descriptive study conducted on November 28 and 29, 2023 in Sébikotane. It focused on volunteers for screening for chronic non-communicable diseases. Epidemiological and clinical data were evaluated. Results: One hundred and twenty-nine cases of obesity were recorded (28%). Two hundred and eighty-two cases were overweight or obese (61.3%). The mean age was 49.55 years, with a standard deviation of 12.41 years. The age group [40 - 49 years] was the most representative, with 85 cases (30.1%), and the majority were female, with 264 cases (93.6%). Primary education was the most common, with 75 cases (46.3%). Grade 1 obesity concerned ninety-seven cases (75.2%), and diabetes was present in thirty cases (23%). Hypertension was present in ninety-five cases (33.7%). Obesity was more marked in the age group [40 - 49 years] with 45 cases (36%). Conclusion: Obesity and overweight are a major cause of morbidity and mortality. The development and implementation of a prevention and management program is essential.

Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients

BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal valve.Despite undergoing radical surgery,a subset of patients experiences recurrent inflammation at the anasto-motic site,necessitating further medical attention.AIM To investigate the risk factors associated with anastomotic insufficiency following ileocecal resection in CD patients.METHODS This study enrolled 77 patients who underwent open ileocolic resection with pri-mary stapled anastomosis.Patients were stratified into two groups:Group I co-mprised individuals without anastomotic insufficiency,while Group II included patients exhibiting advanced anastomotic destruction observed endoscopically or those requiring additional surgery during the follow-up period.Surgical and non-surgical factors potentially influencing anastomotic failure were evaluated in both cohorts.RESULTS Anastomotic insufficiency was detected in 12 patients(15.6%),with a mean time interval of 30 months between the initial surgery and recurrence.The predomi-nant reasons for re-intervention included stenosis and excessive perianastomotic lesions.Factors associated with a heightened risk of anastomotic failure encompassed prolonged postoperative obstruction,anastomotic bleeding,and clinically confirmed micro-leakage.Additionally,patients in Group II exhibited preoperative malnutrition and early recurrence of symptoms related to CD.CONCLUSION Successful surgical outcomes hinge on the attainment of a fully functional anastomosis,optimal metabolic status,and clinical remission of the underlying disease.Vigilant endoscopic surveillance following primary resection facilitates the timely identification of anastomotic failure,thereby enabling noninvasive interventions.

Distribution, Mobility, and Health Risks Assessment of Trace Metals in River Sediments from Intense Agricultural Activity Areas in West Africa

The economy of West African countries is mainly based on agriculture. However, the trace metal(loid)s contamination status in rivers is relatively unknown in the region. In this work, 45 surface sediments collected from the Bandama, Comoé, and Bia Rivers in south and south eastern Côte d’Ivoire (West Africa), were analyzed for total metal concentrations and chemical speciation. The results showed that the river sediments were considerably contaminated by Cd and moderately contaminated by As, Cu, Pb, and Zn. Significant spatial variations were observed among the stations but not between the rivers. Metals Cd and Cu were likely to cause more ecological risks. The speciation analysis unravelled that the metal(loid)s partitioned mainly in the residual fraction, with the potential mobile fraction varying from 14% to 28%. The study calls for establishment of strict policies relative to the application of fertilizers and agrochemicals and mining activities to protect the environment and human health risks.

S-100β CysC和NF-κB对急性缺血性脑卒中患者静脉溶栓后出血转化的预测价值

目的 探讨急性缺血性脑卒中(AIS)外周血中S-100β、CysC和NF-κB水平对静脉溶栓后出血转化的影响及预测价值。方法 收集2019-03—2022-03接受溶栓治疗的AIS患者140例,根据溶栓后24 h是否发生出血转化(HT)将患者分为非HT组(n=112)和HT组(n=28)。比较2组一般临床资料,采用多因Logistic回归分析影响HT发生的危险因素,受试者工作特征(ROC)曲线评估S-100β、CysC和NF-κB预测HT发生的价值。结果 HT组与非HT组相比,患者年龄、发病至溶栓时间、房颤、TOAST分型、C反应蛋白、凝血酶原时间、S-100β、CysC、NF-κB、白质高信号和脑微出血等均有统计学差异(P<0.05)。Logistic多因素回归分析显示,房颤、S-100β、CysC和NF-κB为影响HT发生的危险因素。S-100β、CysC和NF-κB预测AIS患者静脉溶栓后出血转化的曲线下面积分别为0.915(0.902~0.923)、0.874(0.856~0.882)和0.789(0.771~0.796),均具有一定的预测价值。结论 S-100β、CysC和NF-κB为AIS患者静脉溶栓后HT发生的危险因素,对HT发生具有一定的预测价值。

Contamination and human health risk assessment of heavy metal(loid)s in topsoil and groundwater around mining and dressing factories in Chifeng,North China

Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk assessment of heavy metal(loid)s driven by the wide distribution of metal ore processing,mining,and smelting factories in Hexigten Banner and Bairin Left Banner.We conducted surveys to assess the levels of heavy metal(loid)s(Cr,As,Pb,Cd,and Hg)in the topsoil and groundwater of the areas.The results indicated that the concentrations of As,Cd,and Pb in partial soil samples exceeded the environmental quality standards of Grade II.Based on contamination assessments,such as geoaccumulation indices and pollution indices,we inferred that Cd,Pb,and As were primary pollutants in topsoil.Potential ecological risks when considered as part of the average risk indices(RI)are up to 1626.40 and 2818.76,respectively,in the two areas.Comparative analysis revealed that Cd posed a very high potential ecological risk,followed by As.Moreover,the evaluation showed that the three exposure pathways of carcinogenic and non-carcinogenic risk followed a descending order:inhalation>ingestion>dermal contact,except for Pb.Arsenic in topsoil posed a potential non-carcinogenic risk to human health,while there were no adverse efects of As in groundwater.In addition,the average total carcinogenic risk for As in the two areas,as well as the risk of Pb in the topsoil of Bairin Left Banner and all the fve heavy metal(loid)s in groundwater,exceeded human tolerance.Pb–Zn mines caused higher human health risks.In addition,the tandem contamination of heavy metal(loid)s in soil and groundwater was not obvious.This research study provides a basis for pollution remediation to control heavy industry-induced ecological and health risks of heavy metal(loid)s.

Multiple assessments, source determination, and health risk apportionment of heavy metal(loid)s in the groundwater of the Shule River Basin in northwestern China

Global ecosystems and public health have been greatly impacted by the accumulation of heavy metal(loid)s in water.Source-specific risk apportionment is needed to prevent and manage potential groundwater contamination with heavy metal(loid)s.The heavy metal(loid)s contamination status,water quality,ecological risk,and health risk apportionment of the Shule River Basin groundwater are poorly understood.Therefore,field sampling was performed to explore the water quality and risk of heavy metal(loid)s in the groundwater of the Shule River Basin in northwestern China.A total of 96 samples were collected from the study area to acquire data for water quality and heavy metal(loid)s risk.There was noticeable accumulation of ferrum in the groundwater of the Shule River Basin.The levels of pollution were considered to be moderately low,as evaluated by the degree of contamination,heavy metal evaluation index,heavy metal pollution index,and Nemerow pollution index.The ecological risks were also low.However,an assessment of the water quality index revealed that only 58.34%of the groundwater samples had good water quality.The absolute principal component scores-multiple linear regression model was more suited for this study area than the positive matrix factorization model.There were no obvious noncarcinogenic or carcinogenic concerns for all types of receptors according to the values of the total hazard index and total carcinogenic risk.The human activities and the initial geological environment factor(65.85%)was the major source of noncarcinogenic risk(residential children:87.56%;residential adults:87.52%;recreational children:86.77%;and recreational adults:85.42%),while the industrial activity factor(16.36%)was the major source of carcinogenic risk(residential receptors:87.96%;and recreational receptors:68.73%).These findings provide fundamental and crucial information for reducing the health issues caused by heavy metal(loid)s contamination of groundwater in arid areas.

黄土液化作用及其次生灾害风险评估方法初探——以积石山M_(S)6.2地震为例

2023年12月18日甘肃积石山6.2级地震引发的黄土液化泥石流地质灾害,造成了大量人员伤亡和财产损失。以此为背景,系统梳理了液化调查、风险评估和风险区划的工作思路:选定地区液化的内在和诱发因子,收集并分析资料,拟定调查工作底图,以调查问卷的形式开展液化影响因素摸底工作,开展针对性的外业调查或辅以物探和钻探工作,得到土壤液化发育潜势实际材料图;其后借用常规地质灾害的评估方法,开展调查区域的易发性、易损性评价和风险评价,得到调查区风险区划图。利用此方法对积石山地震诱发的泥石流灾害进行验证,分析其液化灾害的地质环境背景、形成机理和危害特征,并对其发生的风险进行评价。文章首次提出土的液化作用及其次生灾害区域调查因子的选择和风险评估的流程,可为开展土层液化作用及其次生灾害隐患区排查、国土空间规划,特别是高烈度山区集中居住点地质安全评估和选址建议提供参考。

滇西南1976年龙陵M_(S)7.3、M_(S)7.4双强震触发滑坡遥感解译及其构造意义

深入研究中国滇西南地区发育的龙陵-澜沧新生地震构造带对于合理划分活动地块边界及未来开展强震危险性评价工作具有重要意义。使用高分辨率卫星影像对已发生的双强震震例开展回溯研究是一种可行的技术手段。文中对震前、震后高分辨率Keyhole卫星影像进行遥感解译,结合野外验证和前人研究结果,获得了1976年M_(S)7.3、M_(S)7.4龙陵双强震触发滑坡较为完整的数据库。结果显示:1)共解译滑坡14448个,总面积为17.2km^(2),70.9%的滑坡分布在花岗岩质的岩体风化层中,单体滑坡面积集中在数百至1000m^(2)区间,多为表层风化层内的浅层滑坡,滑动距离较小;2)同震滑坡密集区与高烈度区不匹配,其空间分布显示破裂区规模约为30km,且均位于活动断裂的一侧,表明其发震构造并非为龙陵-瑞丽断裂或畹町断裂。滇西南地区共轭强震破裂可能局限了单次强震的空间规模,因此在确认未来强震危险区时应重点关注NE向与NW向构造的交会部位。

Ibrutinib and atrial fibrillation:An in-depth review of clinical implications and management strategies

Ibrutinib,a targeted therapy for B-cell malignancies,has shown remarkable efficacy in treating various hematologic cancers.However,its clinical use has raised concerns regarding cardiovascular complications,notably atrial fibrillation(AF).This comprehensive review critically evaluates the association between ibrutinib and AF by examining incidence,risk factors,mechanistic links,and management strategies.Through an extensive analysis of original research articles,this review elucidates the complex interplay between ibrutinib’s therapeutic benefits and cardiovascular risks.Moreover,it highlights the need for personalized treatment approaches,vigilant monitoring,and interdisciplinary collaboration to optimize patient outcomes and safety in the context of ibrutinib therapy.The review provides a valuable resource for healthcare professionals aiming to navigate the intricacies of ibrutinib’s therapeutic landscape while prioritizing patient well-being.

Risk Assessment of Agricultural Products Supply-Chain Finance Based on D-S Theory

Agricultural products supply-chain finance, as one of the solutions to the issue of “capital problems” of agriculture, countryside and farmers, has proposed a kind of characteristics model to assess the risk of agricultural production, processing and marketing, which can improve the issue of farmers and enterprises lacking of funds. This model is proposed on the basis of uncertain information processing method of D-S theory and its data combination rules, combined with the “discount rate” correction model, and it includes a risk assessment index system of agricultural products supply-chain finance, fully considering the five aspects of production, processing, marketing, cooperation of supply chain and collateral. At last, a taro supply chain is taken for example. And the risk assessment of its supply-chain finance based on this model has been discussed in detail. And the result has proved that the model and its algorithm are practical and feasible.

碳钢在CO_(2)/H_(2)S共存体系下油田采出水中的腐蚀行为研究

CO_(2)、H_(2)S和高矿化度是油田采出水中3种常见的腐蚀因素,当3种腐蚀因素同时存在时,腐蚀行为远比CO_(2)、H_(2)S和高矿化度单独作用时复杂。利用反应釜模拟高矿化度采出水同时存在CO_(2)和H_(2)S的实际工况,研究了CO_(2)分压分别为0.15,0.75,1.5 MPa,H_(2)S分压为0.00015 MPa,温度为50,60,70℃条件下,20G、L245N和L360Q三种碳钢的腐蚀行为。结果表明,3种碳钢在CO_(2)/H_(2)S共存的油田高矿化度采出水体系中均腐蚀严重,在液相中比在气相中腐蚀更为严重,最大腐蚀速率达到3.4 mm/a,随着腐蚀时间的延长,腐蚀速率整体呈现波动性下降的趋势;随实验温度的提高其腐蚀速率呈总体增大趋势;在3种分压条件下,腐蚀速率随CO_(2)分压增加先增大后减小,在分压0.75 MPa时腐蚀速率最大;3种材质腐蚀速率大小顺序为L245N>L360Q>20G,则耐蚀顺序为20G>L360Q>L245N。

Fournier’s Gangrene: A Review of Fournier’s Gangrene Severity Index (FGSI) and Other Predictors of Mortality

Background: Fournier gangrene is an acute and rapidly progressive necrotizing fasciitis of the scrotum, perianal and perineal region of the body. It is a polymicrobial infection having an interplay of both anaerobic and aerobic orgasms in a soup of microbial disaster. Fournier’s gangrene was also initially thought to be an idiopathic condition but a lot of risk factors have been associated now with this condition, both systemic risk factors and local. Systemic risk factors include diabetes mellitus, HIV/AIDS, cancers, chronic liver disease, chronic steroid use etc. The local risk factors include perineal injuries, watering can perineum, perianal abscess, chronic perineal itching etc. Purpose: The swiftly flourishing bacteria orgasms cause a similar disruptive event in the body of the patients both clinically and biochemically and these can be used to create a predictive score or index for patients in order to assess the disease severity and guide in the management and prognostication of this condition. Materials and Method: Urology ward record books, clinic record books and operating theater records were used to identify patients managed for Fournier gangrene in ATBUTH Bauchi. A retrospective study of the medical files of all the patients managed from January 2011 to January 2024 was done. Folders were retrieved and the medical records were reviewed. Results: Of the 50 patients reviewed, Male to female ratio is 24:1. The mean age is 56 years (2 weeks to 97 years). Mortality rate was 34%. There is a significant difference between delayed presentation/initial use of unorthodox treatment with mortality (p = 0.002). Of the 17 patients that died, 15 had FGSI > 9 and of the 33 patients that survived 29 had FGSI 9 is 88.2% while the mortality rate for those with FGSI Conclusion: knowledge of the predictors of its mortality is necessary in other to help stratify patients and ensure the best response by the caregivers. FGSI, delayed presentation/initial patronage of unorthodox care, and polymicrobial infection are important predictors of mortality in this condition.

Xinjiang to Become China's Largest Natural Gas Producer

With the opening of the Kela No. 2 gas field in the Tarim basin in China’s northwest Xinjiang Uygur Autonomous Region on Dec. 1, Xinjiang will produce 10 billion cubic meters of natural gas next year, becoming the country’s largest gas producer, according to an official with the China National Petroleum Corporation.

Production Well Microbial Mitigation and H2S Risk Management

One Field has been eternally acknowledged as a sweet arena without the presence of any souring phenomena.On the other hand,the Sulfate Reducing Bacteria(SRB)growth which has been lately observed in the field Water Injection System played a major role in increasing the H2S concentrations in particular A fields.The objective of this study is to mitigate the SRB growth in the A Water Injection System and manage the risk of the Hydrogen Sulfide(H2S).In order to reduce the H2S concentrations and the return the Fields back to their original states.Thereafter,Biocide Treatment usage;based on the thorough evaluation performed in both the Lab and Fields by collecting more than 100 samples from designated wellheads and identified sampling points in the field Water Injection System network.Biocide field trial for one year was conducted with a persistent monitoring program.It appealed that the Biocide Treatment is influential,efficient and functional,carving deeper in the SRB mitigation and H2S risk management,the averaged H2S concentrations and trends in the Fields are being controlled and minimized in both the oil and gas phases.

China Ranking Among the World's Largest Piano Producers

Music from a piano embodies widetechniques of expression, so thepiano is reputed as the king of musicalinstruments. China’s piano production datesback four decades. At present, there are 20piano production enterprises in the county,including such backbone enterprises as theGuangzhou Pearl River Piano IndustrialCorporation, the Beijing Xinghai MusicalInstruments Corporation Ltd., the ShanghaiPiano Corporation, the Yingkou NortheastPiano(Group) Corporation and the

某院血流感染患者产ESBLs大肠埃希菌检出情况、耐药特征及相关因素分析

目的:分析某院血流感染(BSI)患者产超广谱β内酰胺酶(ESBLs)大肠埃希菌检出情况、耐药特征及相关因素。方法:选取2021年1月—2023年12月韶关市第一人民医院收治的667例BSI患者作为研究对象,回顾性分析血培养分离病原菌和药敏试验结果等。结果:667例检测样本中,大肠埃希菌阳性最多,占比40.48%,其中产ESBLs大肠埃希菌占15.59%;菌株科室分布主要为重症医学科,占29.69%,呼吸重症医学科占22.04%,消化内科占14.39%。产ESBLs大肠埃希菌对氨苄西林、头孢曲松、头孢呋辛、头孢他啶的耐药率较高,均在90%以上,对亚胺培南、美罗培南药物较为敏感;非产ESBLs大肠埃希菌对氨苄西林耐药率较高为91.57%,对亚胺培南、美罗培南、阿米卡星等较为敏感;相较于非产ESBLs大肠埃希菌,产ESBLs大肠埃希菌对常用抗菌药的耐药性更高。多因素分析结果显示,产ESBLs大肠埃希菌血流感染的危险因素为年龄、住院时间、近3个月使用三代头孢菌素。结论:某院BSI患者中,产ESBLs大肠埃希菌较为常见,其对常用抗菌药的耐药性高,产ESBLs大肠埃希菌的血流感染的发生与患者的年龄、住院天数、近3个月使用三代头孢菌素有关。

China Becomes the World's Largest Producer and Exporter of Down Products

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