Heritage Communities in Consumer Contexts Spatial Production of Tourism Research-Take Qixian Zhao Yu Historical City as an Example

Taking Zhaoyu Historical City in Qixian County as an example,this paper explores the production process of tourism space in Zhaoyu Historical City in the context of consumption,based on Lefebvre's triadic dialectic theory.The study reveals that,driven by the development of tourism,subjects such as the government and planners possess absolute dominance over spatial representations,while residents demonstrate receptive and adaptive action strategies and social relations are reproduced,presenting a harmonious state.Further exploring the tourism community in the environmental performance of the subject of action,social relations,consumption demand,daily life practice,cultural capital,etc.,the daily life practice of the tourism community has transcended the original logic of tourism spatial production and has a certain extension.The mechanism analysis in this paper can help guide the healthy development of tourism space in the neighboring historical cities or communities and achieve the dual purpose of promoting the economic development of the community and heritage protection.

Does innovative city pilot policy promote urban green growth in China?An analysis of green total factor productivity,2005-2020

The innovative city pilot policy(ICPP)is an essential manifestation of China’s construction of an innovative and green-driven development country.We incorporated urban green total factor productivity(GTFP)growth into the evaluation of ICPP.Based on the panel data of 223 cities in China from 2005 to 2020,we used the difference-in-differences model to empirically assess the influence and mechanism of the ICPP on urban GTFP growth.The main results show that(i)The ICPP has maintained an effectively fluctuating promotion on urban GTFP growth,mainly manifested in the urban green technological progress improvement.(ii)The ICPP has urban heterogeneity in promoting GTFP growth in pilot cities,mainly affecting key cities such as provincial capitals.(iii)The interaction between the agglomeration of producer services and the ICPP inhibits GTFP growth in pilot cities.

Production of Railwayscape in urban environment:Analysing railway heritage tourism potential in Siliguri City,India

For a long time,it has been argued that the theories and practices devoted to urban planning and management should conform to the fundamental role of planning policies in the production of urban space,but not merely the spatial distribution of the produced services.Towards this wider connotation,this study introduces the notion of Railwayscape,grounded on the theory of‘The Production of Space’,to examine the role of railway station districts as catalysts of urban development through the social production of urban space.The present research sets out to establish the notion of Railwayscape and apply it in a railway heritage,i.e.,the Darjeeling Himalayan Railway(DHR)and its point of inception,Siliguri City,India.Accordingly,a criteria-based evaluation of four railway station districts(New Jalpaiguri,Siliguri Town,Siliguri Junction,and Sukna)in Siliguri and its surroundings was performed.The information regarding the selected four railway station districts is obtained through field observation and key informant consultation,supplemented by published literature and remote sensing data.This evaluation is succeeded by the strengths,weaknesses,opportunities and threats(SWOT)analysis accentuating the potential strengths,weaknesses,opportunities and threats associated with the selected four railway station districts and their prospects to become the potential Railwayscape.The results of this research show that there is no railway station district in Siliguri that can fully meet the demands of the locals and tourists,therefore,relfecting a lack of awareness of the historical values of these districts.The results also indicate that there are significant differences in the relative potentials of railway station districts to become the Railwayscape in urban environment.The outcomes of this research,therefore,are expected to encourage policy-making insitutions and practitioners to realise the‘place value’of some railway station districts and their potentials to yield better economic,social and structural virtue for a wide range of actors.

Promoting the Empowerment of Science and Technology to Ensure Food Safety Production:A Case Study of Huizhou City

The current situation of grain production in Huizhou City was analyzed firstly,and then the existing problems and challenges of grain safety production were pointed out,such as increases in the pressure to ensure grain safety production and the difficulty of stable development of grain production.Finally,several countermeasures and suggestions for the stable development of grain production were put forward.

Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications

The Advanced Glycation End Products(AGE)binding with its receptor can increase reactive oxygen species(ROS)generation through specific signaling mediators.The effect of superoxide(O2-)and O2-mediated ROS and reactive nitrogen species depends on their concentration and location of formation.Nitric oxide(NO)has anti-inflammatory and anticoagulant properties and a vasodilation effect,but NO can be deactivated by reacting with O_(2)^(-).This reaction between NO and O2-produces the potent oxidant ONOO−.Therefore,ONOO-'s regulatory role in AGEs in diabetic cardiovascular complications must considered as a regulator of cardiovascular complications in diabetes.

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

Esophageal cancer(ESC)is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract.Although the exact pathogenesis of ESC has not been fully elucidated,excessive oxidative stress is an important characteristic that leads to the development of many cancers.Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs,which alters the growth and proliferation of ESCs and promotes their metastasis.Natural compounds,including alkaloids,terpenes,polyphenols,and xanthine compounds,can inhibit reactive oxygen species production in ESCs.These compounds reduce oxidative stress levels and subsequently inhibit the oc-currence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10,superoxide dismutase,the NF-+ACY-kappa+ADs-B/MAPK pathway,and the mammalian Nrf2/ARE target pathway.Thus,targeting tumor oxidative stress has become a key focus in anti-ESC therapy.This review discusses the potential of Natural products(NPs)for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment.The findings of this review provide a reference for drug development targeting ESCs.Nonetheless,further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.

Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

Reactive oxygen species are closely related to tumor development.In recent years,reactive oxygen species has become a hot spot in tumor therapy,and many natural substances in nature contain compound components with anti-tumor effects.However,there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen species.The terms“natural products”,“reactive oxygen species”,“anti-tumor”,and“chemotherapy”were used to identify the synergistic effects of natural products.We conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent years.We systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years.A total of 77 relevant literatures were included.Among them,45 literatures containing various natural products such as terpenoids,flavonoids,alkaloids,etc.exert anti-tumor effects by regulating reactive oxygen species levels,and 32 literatures regarding adjunctive role of natural products in anti-tumor therapy.In this study,we found that natural products exert anti-tumor effects by elevating reactive oxygen species levels.It provides strong theoretical support for future clinical studies.

Investigation and Analysis of Main Diseases of Landscape Plants in the Main Urban Area of Lu'an City

To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit attached green space and main road in the area under administration.The survey results showed that there were 29 species of urban landscape plant diseases,mainly powdery mildew and spot diseases.According to the characteristics of the diseases,the causes and problems of the diseases were analyzed,and the corresponding prevention and control measures were put forward.

Autophagy plays a protective role in advanced glycation end products-induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α,nuclear factor-κ B and reactive oxygen species

Objective: To study the adverse effects of advanced glycation end products(AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery. AGEs were administered during chondrocytes culture. The rapamycin was used to induce autophagy. The cell viability was determined by 3-[4,5-dimethylthiazol2-yl]-2,5-diphenyl tetrazolium bromide(MTT) assay.The expression of tumor necrosis factor-α(TNF-α) and nuclear factor-κ B(NF-κ B) was detected by quantitative real-time polymerase chain reaction. The reactive oxygen species(ROS) production and apoptosis of the chondrocytes were determined by fluorescent probe and flow cytometer, respectively. Results: The chondrocytes viability was significantly reduced after 12 h incubation with AGEs(P<0.01)). In contrast, rapamycin pretreatment increased the chondrocytes viability through autophagy. AGEs increased TNF-α and NF-κ B mRNA expression of chondrocytes and autophagy receded or proceeded the change. AGEs increased intracellular ROS accumulation and autophagy reversed the change. AGEs accelerated chondrocytes apoptosis and autophagy suspended apoptosis. Conclusions: Accumulation of AGEs may have an adverse role for chondrocytes by increasing TNF-α and NF-κB expression, ROS accumulation and apoptosis; meanwhile, autophagy ameliorates the AGEsinduced adverse effects.

Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols

Tea as the most consumed beverage in the world has received enormous attention for its promoting health benefits.The deleterious effect ofα-dicarbonyls and AGEs formed in Maillard reaction is also a longterm challenge.The connection between the two topics was the main aim of this review,to address and update the antiglycation effect and mechanism of tea and tea polyphenols.By analyzing recent publications,we have covered across chemistry models,cell lines and animal studies.Tea polyphenols,particularly catechins,showed outstanding antiglycation effect by trappingα-dicarbonyl compounds and impeding AGEs formation.Reduction of carbonyl stress brought alleviation to aging,diabetes,and collagen related diseases or complications through regulation of RAGE expression and subsequent MAPK and TGF-βpathway.Therefore,tea polyphenols can serve as promising natural candidates in the treatment and/or prevention of nephropathy,retinopathy,hepatopathy,hyperglycemia and obesity among others,by their potent antiglycation effect.Further studies need to address on aspects like exact mechanisms,solution of detection obstacles,balance of practical usage and harmful effects such as potential flavor damage and toxicity in food,to gain a comprehensive understanding of antiglycation activities of tea polyphenols and its actual application.

Effects of iron electrovalence and species on growth and astaxanthin production of Haematococcus pluvialis

To increase the cell concentration and the accumulation of astaxanthin in the cultivation of Haematococcus pluvialis, effects of different iron electrovalencies (Fe2+-EDTA and Fe3+-EDTA) and species (Fe-EDTA, Fe(OH) 3x2xand FeC6H5O7) addition on cell growth and accumulation of astaxanthin were studied. Results show that different iron electrovalencies have various effects on cell growth and astaxanthin accumulation of H. pluvialis. Compared with Fe3+-EDTA, Fe2+-EDTA stimulate more effectively the formation of astaxanthin. The maximum astaxanthin content (30.70 mg/g biomass cell) was obtained under conditions of 18 μmol/L Fe2+-EDTA, despite the lower cell density (2.3×105 cell/ml) in such condition. Fe3+-EDTA is more effective than Fe2+-EDTA in improving the cell growth. Especially, the maximal steady-state cell density, 2.9×105 cell/ml was obtained at 18 μmol/L Fe3+-EDTA addition. On the other hand, all the various species of iron (EDTA-Fe, Fe(OH) 3x2x, FeC6H5O7) are capable to improve the growth of the algae and astaxanthin production. Among the three iron species, FeC6H5O7 performed the best. Under the condition of a higher concentration (36 μmol/L) of FeC6H5O7, the cell density and astaxanthin production is 2 and 7 times higher than those of iron-limited group, respectively. The present study demonstrates that the effects of the stimulation with different iron species increased in the order of FeC6H5O7, Fe(OH) 3x2x and EDTA-Fe.

Advanced glycation end products:Key mediator and therapeutic target of cardiovascular complications in diabetes

The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns.Cardiovascular complications associated with diabetes are the leading cause of morbidity and mortality.The cardiovascular diseases that accompany diabetes include angina,myocardial infarction,stroke,peripheral artery disease,and congestive heart failure.Among the various risk factors generated secondary to hyperglycemic situations,advanced glycation end products(AGEs)are one of the important targets for future diagnosis and prevention of diabetes.In the last decade,AGEs have drawn a lot of attention due to their involvement in diabetic pathophysiology.AGEs can be derived exogenously and endogenously through various pathways.These are a nonhomogeneous,chemically diverse group of compounds formed nonenzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein,lipids,and nucleic acid.AGEs mediate their pathological effects at the cellular and extracellular levels by multiple pathways.At the cellular level,they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation,inflammation,cellular proliferation,and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in diabetics.AGEs also cause covalent modifications and cross-linking of serum and extracellular matrix proteins;altering their structure,stability,and functions.Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities.In the present review,we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated complications.Furthermore,this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes.

Application of Rhododendron Species (Ericaceae) in Green System of Kunming City in Yunnan, China

Species, application frequencies, habitat features and combination modes of Rhododendron species in Kunming City were studied through random sampling in different subareas of Kunming City. The results show that Rhododendron species were widely applied in parks, residential areas and street-side green spaces. Diversified application patterns presented excellent landscape effects, but only a few species were used, for example, Rhododendron pulchrum Sweet., R. hybridum, R. simsii var. simsii, while R. delavayi Franch. and R. simsii var. mesembrinum Rehd. were occasionally found. Landscaping features of Kunming were characterized by domination of Rhododendron species, advantages and problems of Rhododendron species in landscaping of Kunming City were analyzed. It was proposed that introduction and domestication of wild Rhododendron species should be enhanced, rich germplasm resources of Rhododendron species should be fully used, and more indigenous Rhododendron species applied.

Assessing the impacts of ecological-living-productive land changes on eco-environmental quality in Xining City on Qinghai-Tibet Plateau, China

The Ecological-living-productive land(ELPL)classification system was proposed in an effort to steer China's land pattern to an ecological-centered path,with the development model shifting from a single function into more integrated multifunction land use.The focus is coordinating the man-land contradictions and developing an intensive,efficient and sustainable land use policy in an increasingly tense relationship between humans and nature.Driven by socioeconomic change and rapid population growth,many cities are undergoing urban sprawl,which involves the consumption of cropland and ecological land and threatens the ecological balance.This paper aims to quantitatively analyze the critical effects of ELPL changes on eco-environmental quality according to land use classification based on leading function of ecology,living and production from 1990 to 2015 with a case study of Xining City.Also,four future land use scenarios were simulated for 2030 using the Future Land Use Simulation(FLUS)model that couples human and natural effects.Our results show a decrease in productive land(PL)and an increase in ecological land(EL)and living land(LL)in Xining City.Forestry ecological land(FEL)covered the top largest proportion;agriculture productive land(APL)showed the greatest reduction and urban and rural living land(U-RLL)presented a dramatic increase.The eco-environmental quality improved in 1990-2010,mainly affected by the conversion of APL to FEL and GEL.However,the encroachment of U-RLL into APL,other ecological land(OEL)and FEL was the main contributor to the decline in eco-environmental quality in 2010-2015 as well as the primary reason for the increase area of lower-quality.The Harmonious Development(HD)-Scenario,characterized by a rational allocation of LL and PL and a better eco-environment,would have implications for planning and monitoring future management of ELPL,and may represent a valuable reference for local policy-makers.

Ideas for Accelerating Development of Deep Processing Industry of Agricultural Products--A Case Study of Nanchong City

In order to provide certain references for further deepening the development of processing industry of agricultural products,this paper analyzed and elaborated the basic principles,construction priorities and safeguard measures of the development of deep processing industry of agricultural products in Nanchong City of Sichuan Province. Besides,it made a scientific planning for accelerating the deep processing of agricultural products in Nanchong City in 2018-2020,to ensure the full implementation of fine and deep processing of agricultural products.

Production Structure of Agriculture in Huai'an City

According to the data in 1990-2009 Huai'an Statistical Yearbook and Jiangsu Statistical Yearbook,production structure of agriculture in Huai'an City is analyzed.Result shows that economic efficiency of planting industry is significantly lower than that of other industry types of agriculture;and the production structure of agriculture in Huai'an City is unbalanced and needs further optimization.The reasons for the imbalance in industrial structure are various,such as the relatively low quality of agricultural employees,the backward marketing of planting,and the lack of standardization management.Finally,corresponding suggestions are put forward,including developing education,conducting vocational training,improving the human capital stock of Huai'an City,cultivating the leading enterprises for agricultural product processing,and realizing the scale agglomeration effect of agricultural production in planting industry.

Analysis of Vegetable Production Trends and Dominant Varieties in Zhangjiakou City of Hebei Province

Based on the production data during 2008 and 2017 of 16 main vegetables in Zhangjiakou City of Hebei Province,the comparative advantage model was used to analyze the superior varieties in the main producing areas. The results indicate that there are seven main vegetable producing areas in Zhangjiakou City,and the development of main producing areas tends to become balanced: white radish,celery,leaf lettuce,and carrot of Shangyi,sweet pepper and tomato of Chongli,lettuce and Chinese cabbage of Kangbao,spinach,broccoli,carrots,and cauliflower of Guyuan,spinach and eggplant of Xuanhua,Chinese cabbage and lettuce of Zhangbei. These vegetables have a strong competitiveness.

Colored-leaf Species Resources and Their Landscaping Application in Guang'an City

By investigating species, characteristics and landscaping application of colored-leaf species in Guang'an City, this paper proposed suggestions for the application of colored-leaf species in the local area.

Improvement of Native Pasture Productivity through Introduction of Various Types of Palatable Species on Dry Lands in Timor

This research was aimed to evaluate the productivity of native pasture in Timor Island by introducing various palatable species.The study was carried out on native pasture in Tuatuka,Timor Island for seven months.The study was performed by using randomized block design(RBD)with eight treatments(S0:no introduction,S1:Cynodon dactilon,S2:Dicanthium aristatum,S3:C.plectotachyus,S4:Brachiaria decumbens,S5:Desmanthus virgatus,S6:Macroptilium atropurpureum,S7:Clitoria ternatea)with four replications.Procedures on this study include trial plots preparation,tillers preparation for each species,introduction of species in trial plots,maintenance and observation of the productivity.Variables observed were forage production(fresh and dry matter(DM)in ton/ha),nutrient content(%)and stock capacity(animal unit(AU)/ha).Data were analyzed for variance based on RBD and followed by Duncan’s test.Analysis of variance showed that introduction of species had a very significant effect(p<0.01)on all observed variables.The introduction of M.atropurpureum produced the highest fresh forage(2.1 t/ha)and DM production(0.69 t/ha).M.atropurpureum also had the highest DM content(43.61%),nitrogen free extract(52.52%)and stock capacity(1.06 AU/ha).The highest crude protein and crude fiber content were found in D.virgatus(4.31%and 36.62%).The highest extract ether was observed in D.aristatum(1.48%).No introduction had the lowest productivity,but demonstrated the highest ash content.The introduction of palatable species increased the productivity of native pasture in Timor and M.atropupureum was the best introduced species.

IMPLEMENTATION OF CLEANER PRODUCTION STRATEGIES TOWARDS A SUSTAINABLE CITY

Rapid urbanization and growing size of cities will have an increasing impact on the global environment in the 21st century. As an engine of urban development to drive economic growth and technological innovations, industry has moved its focus from controlling environmental hazards to stimulating sustainable industrial development throughout the entire product lifecycle. These process- and technology-driven innovations for industrial production are prerequisites for enhancement of urban environment and sustainable development of cities. In this review, problems of environment and resources scarcity associated with rapid urbanization are demonstrated. And, on the basis of expatiations on the concepts and policies of the cleaner production(CP) and other similar initiatives with the goal of preventing pollution at the source and of managing the raw material more efficiently, two different ways to link the practice of cleaner production in industrial sector with performance of urban environment are discussed in detail. Then, the introduction, practice and legislation of CP strategies in China are outlined, and possibility for China to develop CPC (Cleaner Practices for Cities) approaches in the demonstration cities is discussed. Finally, some suggestions on implementation of CPC strategies are put forward.