Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC–MS method was developed and validated for the study of degradat...Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC–MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different pH（1.5, 3.0, 5.0, 6.5, 7.4, 9.0, 10 and 11.0） and temperature（0, 25, 37 and 45 °C）. The linear range was 0.5–25 μg/mL, the intra-and inter-day precisions were less than 7.0%, and accuracy ranged from 97.4–104.5% for each analyte. The observed rate obtained by measuring the remaining intact larotaxel was shown to follow first-order kinetics. The activation energies for degradation were 126.7 and 87.01 k J/mol at pH 1.5 and 11, respectively. Although larotaxel was stable in pH 5, 6.5 and 7.4 buffers at 37 °C for 24 h during our study, increasing or decreasing the pH of the solutions would decrease its stabilities. Moreover, three main degradation products in alkaline condition were separated by HPLC and identified by Q–TOF–MS. The three degradation products were confirmed as 10-deacetyl larotaxel, 7, 8-cyclopropyl baccatin Ⅲ and 10-deacetyl-7, 8-cyclopropyl baccatin Ⅲ.展开更多
Through the comparison of calcination conditions between cement preclinkering technology and cement precalcining technology,we studied the characteristics of temperature field distribution of cement preclinkering tech...Through the comparison of calcination conditions between cement preclinkering technology and cement precalcining technology,we studied the characteristics of temperature field distribution of cement preclinkering technology systems including cyclone preheater,preclinkering furnace,and rotary kiln.We used numericalsimulation method to obtain data of temperature field distribution.Some results are found by system study.The ratio of tailcoalof cement preclinkering technology is about 70%,and raw mealtemperature can reach 1070 ℃.Shorter L/D kiln type of preclinkering technology can obtain more stable calcining zone temperature.The highest solid temperature of cement preclinkering technology is higher than 80 ℃,and high temperature region（〉1450 ℃）length is 2 times,which is beneficialfor calcining clinker and higher clinker quality.So cement preclinkering technology can obtain more performance temperature filed,which improves both the solid-phase reaction and liquid-phase reaction.展开更多
Subject Code:B03 With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Ma Ding(马丁)from Peking University,Prof.Zhou Wu(周武)from the University ...Subject Code:B03 With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Ma Ding(马丁)from Peking University,Prof.Zhou Wu(周武)from the University of Chinese Academy of Sciences,Prof.Wen Xiaodong(温晓东)from the Institute of展开更多
Using the meteorological data set for 1951—1990 over 160 stations,a series of 10-year running mean curves of temperature and precipitation averaged for the country and its 7 climate regions,as well as for each season...Using the meteorological data set for 1951—1990 over 160 stations,a series of 10-year running mean curves of temperature and precipitation averaged for the country and its 7 climate regions,as well as for each season,are obtained and analyzed.The six aspects of main results can be summarized about the climate change in China and its influence on agriculture production in the last 40 years.展开更多
文摘Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC–MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different pH（1.5, 3.0, 5.0, 6.5, 7.4, 9.0, 10 and 11.0） and temperature（0, 25, 37 and 45 °C）. The linear range was 0.5–25 μg/mL, the intra-and inter-day precisions were less than 7.0%, and accuracy ranged from 97.4–104.5% for each analyte. The observed rate obtained by measuring the remaining intact larotaxel was shown to follow first-order kinetics. The activation energies for degradation were 126.7 and 87.01 k J/mol at pH 1.5 and 11, respectively. Although larotaxel was stable in pH 5, 6.5 and 7.4 buffers at 37 °C for 24 h during our study, increasing or decreasing the pH of the solutions would decrease its stabilities. Moreover, three main degradation products in alkaline condition were separated by HPLC and identified by Q–TOF–MS. The three degradation products were confirmed as 10-deacetyl larotaxel, 7, 8-cyclopropyl baccatin Ⅲ and 10-deacetyl-7, 8-cyclopropyl baccatin Ⅲ.
基金Funded by the Major State Basic Research Perelopment Program of China(973 Program)(No.2009CB623102)the Key Fund Project of Sichuan Provincial Department of Education(No.14ZA0086)the Key Fund Project of Professional Scientific Research Innovation Team of Southwest University of Science and Technology(No.14tdfk01)
文摘Through the comparison of calcination conditions between cement preclinkering technology and cement precalcining technology,we studied the characteristics of temperature field distribution of cement preclinkering technology systems including cyclone preheater,preclinkering furnace,and rotary kiln.We used numericalsimulation method to obtain data of temperature field distribution.Some results are found by system study.The ratio of tailcoalof cement preclinkering technology is about 70%,and raw mealtemperature can reach 1070 ℃.Shorter L/D kiln type of preclinkering technology can obtain more stable calcining zone temperature.The highest solid temperature of cement preclinkering technology is higher than 80 ℃,and high temperature region（〉1450 ℃）length is 2 times,which is beneficialfor calcining clinker and higher clinker quality.So cement preclinkering technology can obtain more performance temperature filed,which improves both the solid-phase reaction and liquid-phase reaction.
文摘Subject Code:B03 With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Ma Ding(马丁)from Peking University,Prof.Zhou Wu(周武)from the University of Chinese Academy of Sciences,Prof.Wen Xiaodong(温晓东)from the Institute of
文摘Using the meteorological data set for 1951—1990 over 160 stations,a series of 10-year running mean curves of temperature and precipitation averaged for the country and its 7 climate regions,as well as for each season,are obtained and analyzed.The six aspects of main results can be summarized about the climate change in China and its influence on agriculture production in the last 40 years.
