The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia

Tumor-induced osteomalacia （TIO） is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23 （FGF23） by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-la （HIF-la） in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-la mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-la and FGF23 were co-localized in spindle- shaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-la protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-la expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-la inhibitors decreased HIF-la and FGF23 protein accumulation and inhibited HIF-la-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-la consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-la inhibitor. These results show for the first time that HIF-la is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-la activity in TIO contributes to the aberrant FGF23 production in these patients.

Does innovative city pilot policy promote urban green growth in China?An analysis of green total factor productivity,2005-2020

The innovative city pilot policy(ICPP)is an essential manifestation of China’s construction of an innovative and green-driven development country.We incorporated urban green total factor productivity(GTFP)growth into the evaluation of ICPP.Based on the panel data of 223 cities in China from 2005 to 2020,we used the difference-in-differences model to empirically assess the influence and mechanism of the ICPP on urban GTFP growth.The main results show that(i)The ICPP has maintained an effectively fluctuating promotion on urban GTFP growth,mainly manifested in the urban green technological progress improvement.(ii)The ICPP has urban heterogeneity in promoting GTFP growth in pilot cities,mainly affecting key cities such as provincial capitals.(iii)The interaction between the agglomeration of producer services and the ICPP inhibits GTFP growth in pilot cities.

Agricultural productivity growth and technology progress in developing country agriculture: case study in China

The goal of this investigation was to analyze the impact of some production variables (input) on agricultural pro- ductivity growth (output) in China from 1989～2002. We selected through random sampling Zhejiang Province for our disaggre- gate analysis with the use of Cobb-Douglas function. The estimation results showed that all key parameters are significant and are of the expected sign. Labor and that capital and land have positive impact on agricultural productivity growth.

Productivity Growth in China's Agriculture During 1985-2010

This paper made an empirical analysis of China＇s agricultural growth path and influential factors using the province-level panel data of agricultural inputs and outputs during 1985-2010.The findings indicate that the increase in agricultural inputs and TFP contributed 40.6 and 55.2% to the agricultural output growth,respectively;China＇s agriculture had jumped out of the pattern which output growth was mainly driven by increasing input.Of the total inputs,chemical fertilizer had the most important contribution to the output growth,followed by mechanical inputs.The contribution of land and labor was negative.China＇s agricultural output growth belonged to the type of induced technology innovation.China＇s agricultural TFP growth had characteristics of fluctuations over time and unbalanced between regions,but the gap between the eastern,the middle,and the western regions has been narrowed.

Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects

We previously showed that the repair of bone defects is regulated by neural and vascular signals. In the present study, we examined the effect of topically applied β-nerve growth factor（β-NGF） on neurogenesis and angiogenesis in critical-sized bone defects filled with collagen bone substitute. We created two symmetrical defects, 2.5 mm in diameter, on either side of the parietal bone of the skull, and filled them with bone substitute. Subcutaneously implanted osmotic pumps were used to infuse 10 μgβ-NGF in PBS（β-NGF ＋ PBS） into the right-hand side defect, and PBS into the left（control） defect, over the 7 days following surgery. Immunohistochemical staining and hematoxylin-eosin staining were carried out at 3, 7, 14, 21 and 28 days postoperatively. On day 7, expression of β III-tubulin was lower on the β-NGF ＋ PBS side than on the control side, and that of neurofilament 160 was greater. On day 14, β III-tubulin and protein gene product 9.5 were greater on the β-NGF ＋ PBS side than on the control side. Vascular endothelial growth factor expression was greater on the experimental side than the control side at 7 days, and vascular endothelial growth factor receptor 2 expression was elevated on days 14 and 21, but lower than control levels on day 28. However, no difference in the number of blood vessels was observed between sides. Our results indicate that topical application of β-NGF promoted neurogenesis, and may modulate angiogenesis by promoting nerve regeneration in collagen bone substitute-filled defects.

Effects of Selenium on Fusarium Growth and Associated Fermentation Products and the Relationship with Chondrocyte Viability

This study determined the effects of selenium on the growth of Fusorium strains and the effects of products extracted from the fungal cultures on relevant indicators of chondrocytes injury.

Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products

Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons（Schwab and Strittmatter,2014）.

ZTE Achieves Strong Growth of Bearer Network Products

ZTE Corporation continues to register remarkable growthrate for its bearer network products according to theannouncement the

Online Fashion Retailer Bonobos Selects Gerber Technology's YuniquePLM^(TM) Industry-Tailored Software to Support Rapid Growth and Fast-Paced Product Innovation

Tolland,Connecticut,USA-Gerber Technology,a business unit of Gerber Scientific, Inc.(NYSE:GRB) and a world leader in automated CAD/CAM and PLM solutions for the apparel and flexible materials industry,announces that fast-growing internet retailer Bonobos,Inc. has selected the YuniquePLM product

A Panel Granger Causality Test of Investment in ICT Capital and Economic Growth： Evidence From Developed and Developing Countries

This paper applies the Pairwise Panel Granger Causality test to examine the relationship between ICT （information and communication technology） expenditure and the rate of growth of GDP （gross domestic product） per capita. This is accomplished by using cross-country time-series data for a total of 70 developed and developing countries for the period from 2003 to 2008. The study reveals that the existence of causality and its direction differ across different income-group of countries and over the number of lags included. ICT investment expenditure as a percentage of GDP appears to cause the rate of growth of GDP per capita for the high income group and all income groups combined with lags higher than one year. However, for the upper- and lower-middle income groups, the study detects causality in neither direction. Also, when only one lag is included, the study suggests no causality in either direction for any of the income-groups of countries.

Carbon Productivity Analysis to Address Global Climate Change

Developing low-carbon economy and enhancing carbon productivity are basic approaches to coordinating economic development and protecting global environment, which are also the major ways to address climate change under the framework of sustainable development. In this paper, the authors analyze the annual rate of carbon productivity growth, the differences of carbon productivity of different countries, and the factors for enhancing carbon productivity. Consequently, the authors clarify their viewpoint that the annual rate of carbon productivity growth can be used to weigh the efforts that a country takes to address climate change, and propose policies and suggestions on promoting carbon production.

PRODUCTION OF TRANSFORMING GROWTH FACTOR-β BY CULTURED RAT MESANGIAL CELLS

The purpose of this study was to examine whether transforming growth factor-β (TGFβ acts as an autocrine cytokine in cultured mesangial cells. Measangial cell conditioned media (CM) were prepared and tested for their effect on mesangial cell proliferation. CM showed a concentration dependent inhibition on mesangial cell proliferation and the activity was enhanced by treating conditioned media with acid. Gel filtration analysis showed peak inhibitory activity to reside in fractions with an estimated molecular weight range of 16-30 KD. The activity was partially blocked by anti-TGFβ antibody, but not nonimmune control IgG. The presence of TGFβ was confirmed using the mink lung epithelial cell assay. Furthermore, the addition of anti-TGFβ antibody directly into culture media significantly enhanced mesangial cell proliferation. These results demonstrate that measangial cell produce both active and latent forms of TGFβ, which functions as an autocrine growth inhibitor for mesangial cells.

Elasticity Ratio of Resource Consumption and the Resource Consumption

Today the resources are becoming scarcer, which should not be regarded as unexhausted any more. Correspondingly, the production would be constrained by the scarcity of resources clearly. Then the economic researchers would pay much more attention to reducing the consumption of natural resources in the future. Therefore this paper brings foreword the conception of elasticity ratio of resource consumption based on the concept of elasticity and analyzes the relationship between the parameters. For the certain relationships between the elasticity ratio of resource consumption and resource consumption, this paper will try to reveal, to keep economy growing while resource consumption reducing, what conditions should be met as to the relationships among resource productivity, its growth rate, energy saving efficiency, economic growth rate and elasticity ratio of resource consumption. This paper proves the relationship between the China＇s energy consumption and economy growth using statistic data from 1978 to 2003.

Oil Crisis, Market Reforms, and Human Welfare： An Econometric Analysis of the Australian Economy

As an active trader in international crude oil and petroleum product markets, Australia＇s human welfare is affected by oil crisis and contagion from the perspectives of economic growth, income inequality, and environmental sustainability. This paper investigates the impacts of oil price shocks upon Australia＇s gross domestic product （GDP） growth, Gini coefficients, and carbon dioxide emissions per capita from 1970 to 2012 with yearly frequency. Hypotheses concerning whether Australia＇s economic immunity against oil crisis is affected after the deregulation of oil market and whether endogenous oil price shocks account for more variations in human welfare than exogenous oil price shocks are tested. The methodologies include a theoretic model and a series of econometric tests. For the short-run dynamics, oil price is integrated into the model both linearly and non-linearly. Oil price shocks are categorized into exogenous and endogenous shocks. The conclusions are that inflated oil prices exert mainly non-linear negative impacts upon human welfare indicators and exogenous shocks induce endogenous shocks through labor price, Consumer Price Index （CPI）, interest rate, and exchange rate. For the long-run equilibrium, non-linear shocks＇ effects decay more slowly than linear shocks and the impacts of endogenous shocks last longer than that of exogenous shocks. Finally, oil market policies are evaluated and proposed.

Textile Industry to See Slow Growth Analysis of industrial production activities in the first four months

Textile industry, a major driver of the Chinese economy, has fallen victim to the global credit crisis and weaker demand. In the first two months, the output, sale, investment and export of textile industry grew at a slower pace than last year. But things began to pick up after that as the economy slowly begins to recover since March. Signif icant gains at that time will be hard to come by, and won’t be nearly enough to prevent other sizeable slippage in overall textile and apparel activity.

Textile industry to see slow growth Analysis of industrial production activities in the first eight months

The textile sector,a major driver of the Chinese economy,has fallen victim to the global credit crisis and weaker demand.In the first eight months

Industrial Structural Change and Economic Growth in China, 1987-2008

The present paper studies the sources of economic growth and the nature of structural change in the Chinese economy from 1987 to 2008. Using a methodology that evaluates the contribution o fan industry to economic growth, the present paper shows that the post-2000 subperiod marked an increased reliance on the services sector as a source of growth in the Chinese economy. Much of the acceleration in real GDP or aggregate labor productivity growth in China in the post-2000 subperiod compared to the pre-2000 period can be traced to an increased contribution from service-producing and high-technology exporting manufacturing industries. The evidence indicates that the Chinese economy has been rebalancing toward domestic consumption and shifting its export sector toward high- technology manufacturing industries.

Firm-Level TFP Growth in the Chinese Automobile Industry

China has been the world’s largest automobile producer since 2009,but it still lags behind other countries in terms of productivity. Based on theNational Bureau of Statistics of China (NBSC) firm-level data and the improvedapproach proposed by Ackerberg et al. (2015), this paper investigates thecontribution of total factor productivity (TFP) growth to the Chinese automobileindustry and evaluates the impact of firm entry and exit on TFP growth. Theempirical results show that the TFP of the Chinese automobile industry grows at10.7% per year. Joint venture and foreign-owned firms have a significantly higherTFP growth rate than others. Large-scale firms have a higher TFP growth rate thando small-scale firms, but the latter have caught up after 2004. Moreover, the entryof new firms and exit of old firms significantly improve the aggregate TFP growthrate.

The Output of Major Farm Products and Growth Rate in 1995

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