Objective:To investigate the differential gene expression profiles in coronary heart disease(CHD) patients of blood-stasis syndrome(BSS) by oligonucleotide microarray technique,and the clinical significance of target ...Objective:To investigate the differential gene expression profiles in coronary heart disease(CHD) patients of blood-stasis syndrome(BSS) by oligonucleotide microarray technique,and the clinical significance of target gene.Methods:Subjects were assigned to CHD patients with BSS(n=8),CHD patients without BSS (n=8),and BSS patients without CHD(n=8) based on coronary angiography and the diagnostic criteria of BSS. The sex- and age-matched healthy volunteers(n=8) were enrolled as the control group.Venous blood s...展开更多
Parameter estimation for ordinary differential equations arises in many fields of science and engineering. To be the best of our knowledge, traditional methods are often either computationally intensive or inaccurate ...Parameter estimation for ordinary differential equations arises in many fields of science and engineering. To be the best of our knowledge, traditional methods are often either computationally intensive or inaccurate for statistical inference. Ramsay et al.(2007) proposed a generalized profiling procedure. It is easily implementable and has been demonstrated to have encouraging numerical performance. However, little is known about statistical properties of this procedure. In this paper, we provide a theoretical justification of the generalized profiling procedure. Under some regularity conditions, the procedure is shown to be consistent for a broad range of tuning parameters. When the tuning parameters are sufficiently large, the procedure can be further shown to be asymptotically normal and efficient.展开更多
基金Supported by the Major Research Plan of National Natural Science Foundation of China(No.90409021)
文摘Objective:To investigate the differential gene expression profiles in coronary heart disease(CHD) patients of blood-stasis syndrome(BSS) by oligonucleotide microarray technique,and the clinical significance of target gene.Methods:Subjects were assigned to CHD patients with BSS(n=8),CHD patients without BSS (n=8),and BSS patients without CHD(n=8) based on coronary angiography and the diagnostic criteria of BSS. The sex- and age-matched healthy volunteers(n=8) were enrolled as the control group.Venous blood s...
基金supported by National Science Foundation of USA (Grant Nos. DMS1209191 and DMS-1507511)
文摘Parameter estimation for ordinary differential equations arises in many fields of science and engineering. To be the best of our knowledge, traditional methods are often either computationally intensive or inaccurate for statistical inference. Ramsay et al.(2007) proposed a generalized profiling procedure. It is easily implementable and has been demonstrated to have encouraging numerical performance. However, little is known about statistical properties of this procedure. In this paper, we provide a theoretical justification of the generalized profiling procedure. Under some regularity conditions, the procedure is shown to be consistent for a broad range of tuning parameters. When the tuning parameters are sufficiently large, the procedure can be further shown to be asymptotically normal and efficient.
