The physical datum method that uses the laser beam as the physical datum is proposed.A high accuracy of the straight movement on the line above 0.01 μm/100 mm is achieved through applying the method of the closed lo...The physical datum method that uses the laser beam as the physical datum is proposed.A high accuracy of the straight movement on the line above 0.01 μm/100 mm is achieved through applying the method of the closed loop feedback control that uses the laser beam as the datum.The measuring accuracy above 0.05 μm is obtained by applying the self making electric eddy displacement sensor to detect the geometric accuracy of the optical flat.It proves that the laser beam datum method can achieve the high accurcy of the straight movement and has the huge advantage.展开更多
Circulating cell-free tumor DNA（ctDNA） in the blood is DNA released from apoptotic, circulating, and living tumor cells. ctDNA is about 140 nt in length and has a half-life of about 1.5 h. ctDNA analysis provides a ...Circulating cell-free tumor DNA（ctDNA） in the blood is DNA released from apoptotic, circulating, and living tumor cells. ctDNA is about 140 nt in length and has a half-life of about 1.5 h. ctDNA analysis provides a noninvasive means to assess the genetic profile of cancer in real time. With the advent of molecular technologies, including digital PCR and massively parallel sequencing（MPS）, ctDNA analysis has shown promise as a highly sensitive and specific alternative to conventional tissue biopsy in cancer detection, longitudinal monitoring, and precision therapy. This review provides an overview of the latest development in our understanding of the biologic characteristics, detection methodologies, and potential clinical implications of ctDNA, as well as the challenges in translating ctDNA analysis from the research arena to patient care.展开更多
文摘The physical datum method that uses the laser beam as the physical datum is proposed.A high accuracy of the straight movement on the line above 0.01 μm/100 mm is achieved through applying the method of the closed loop feedback control that uses the laser beam as the datum.The measuring accuracy above 0.05 μm is obtained by applying the self making electric eddy displacement sensor to detect the geometric accuracy of the optical flat.It proves that the laser beam datum method can achieve the high accurcy of the straight movement and has the huge advantage.
文摘Circulating cell-free tumor DNA（ctDNA） in the blood is DNA released from apoptotic, circulating, and living tumor cells. ctDNA is about 140 nt in length and has a half-life of about 1.5 h. ctDNA analysis provides a noninvasive means to assess the genetic profile of cancer in real time. With the advent of molecular technologies, including digital PCR and massively parallel sequencing（MPS）, ctDNA analysis has shown promise as a highly sensitive and specific alternative to conventional tissue biopsy in cancer detection, longitudinal monitoring, and precision therapy. This review provides an overview of the latest development in our understanding of the biologic characteristics, detection methodologies, and potential clinical implications of ctDNA, as well as the challenges in translating ctDNA analysis from the research arena to patient care.
