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User Profile System Based on Sentiment Analysis for Mobile Edge Computing 被引量:1
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作者 Sang-Min Park Young-Gab Kim 《Computers, Materials & Continua》 SCIE EI 2020年第2期569-590,共22页
Emotions of users do not converge in a single application but are scattered across diverse applications.Mobile devices are the closest media for handling user data and these devices have the advantage of integrating p... Emotions of users do not converge in a single application but are scattered across diverse applications.Mobile devices are the closest media for handling user data and these devices have the advantage of integrating private user information and emotions spread over different applications.In this paper,we first analyze user profile on a mobile device by describing the problem of the user sentiment profile system in terms of data granularity,media diversity,and server-side solution.Fine-grained data requires additional data and structural analysis in mobile devices.Media diversity requires standard parameters to integrate user data from various applications.A server-side solution presents a potential risk when handling individual privacy information.Therefore,in order to overcome these problems,we propose a general-purposed user profile system based on sentiment analysis that extracts individual emotional preferences by comparing the difference between public and individual data based on particular features.The proposed system is built based on a sentiment hierarchy,which is created by using unstructured data on mobile devices.It can compensate for the concentration of single media,and analyze individual private data without the invasion of privacy on mobile devices. 展开更多
关键词 User profile sentiment analysis mobile edge computing social network
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Pressure Profile Systems工业用触觉传感器
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《电子产品世界》 2004年第07B期37-37,共1页
Pressure Profile Systems公司推出其工业用触觉传感器(ITS),一种可以由用户定义的传感器,为工业和高温环境下的高压测量而设计。该触觉传感器可以单个传感器独立工作,也可以按严格的网状结构集成为一个阵列来工作,以得出详细的压... Pressure Profile Systems公司推出其工业用触觉传感器(ITS),一种可以由用户定义的传感器,为工业和高温环境下的高压测量而设计。该触觉传感器可以单个传感器独立工作,也可以按严格的网状结构集成为一个阵列来工作,以得出详细的压力分布。该ITS可以被集成到客户数据采集系统中,也可以作为一个完整的数据采集硬件,软件系统而工作,该ITS适用于脚印。 展开更多
关键词 PRESSURE profile systems公司 触觉传感器 ITS 高压测量
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Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties
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作者 Wenqing Tan Xinbo Guo +7 位作者 Zhangying Wang Rong Zhang Chaochen Tang Bingzhi Jiang Ruixue Jia Yuanyuan Deng Shaohai Yang Jingyi Chen 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期494-510,共17页
Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their qualities.In this... Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their qualities.In this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato varieties.Three varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were identified.In addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological characterization.Group comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with flavonoids.Also,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf types.The findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value. 展开更多
关键词 sweet potato leaf tips phenotypic traits metabolic profile differentially expressed metabolites POLYPHENOLS
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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials
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作者 Paulo Ricardo Prado Nunes Pamela Castro-e-Souza +4 位作者 Anselmo Alves de Oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第2期145-159,共15页
Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was p... Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and SciELO.Randomized controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were included.Independent reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) evaluations.Total body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for meta-analysis.Results:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were included.RT groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to CG.However,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to CG.Conclusion:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females. 展开更多
关键词 C-reactive protein Fat mass Lipid profile MENOPAUSE Strength training
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An efficient physics-guided Bayesian framework for predicting ground settlement profile during excavations in clay
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作者 Cong Tang Shuyu He Wanhuan Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1411-1424,共14页
Recently,the application of Bayesian updating to predict excavation-induced deformation has proven successful and improved prediction accuracy significantly.However,updating the ground settlement profile,which is cruc... Recently,the application of Bayesian updating to predict excavation-induced deformation has proven successful and improved prediction accuracy significantly.However,updating the ground settlement profile,which is crucial for determining potential damage to nearby infrastructures,has received limited attention.To address this,this paper proposes a physics-guided simplified model combined with a Bayesian updating framework to accurately predict the ground settlement profile.The advantage of this model is that it eliminates the need for complex finite element modeling and makes the updating framework user-friendly.Furthermore,the model is physically interpretable,which can provide valuable references for construction adjustments.The effectiveness of the proposed method is demonstrated through two field case studies,showing that it can yield satisfactory predictions for the settlement profile. 展开更多
关键词 Bayesian updating EXCAVATIONS Ground settlement profile Simplified model UNCERTAINTY
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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons
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作者 LI Yang LIN Dan +7 位作者 ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第5期479-493,共15页
Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal m... Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal microbiota.Methods Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old children.Subsequently,37 children were categorized into low-and high-exposure groups based on the sum of the ten OH-PAHs.Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine samples.Furthermore,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina MiSeq.Results The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide metabolism.Additionally,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in neurodevelopment.Conclusion Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived metabolites.Further investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes. 展开更多
关键词 Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile
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TP-PROFILE: Monitoring the Thermodynamic Structure of the Troposphere over the Third Pole
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作者 Xuelong CHEN Yajing LIU +6 位作者 Yaoming MA Weiqiang MA Xiangde XU Xinghong CHENG Luhan LI Xin XU Binbin WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1264-1277,共14页
Ground-based microwave radiometers(MWRs)operating in the K-and V-bands(20–60 GHz)can help us obtain temperature and humidity profiles in the troposphere.Aside from some soundings from local meteorological observatori... Ground-based microwave radiometers(MWRs)operating in the K-and V-bands(20–60 GHz)can help us obtain temperature and humidity profiles in the troposphere.Aside from some soundings from local meteorological observatories,the tropospheric atmosphere over the Tibetan Plateau(TP)has never been continuously observed.As part of the Chinese Second Tibetan Plateau Scientific Expedition and Research Program(STEP),the Tibetan Plateau Atmospheric Profile(TPPROFILE)project aims to construct a comprehensive MWR troposphere observation network to study the synoptic processes and environmental changes on the TP.This initiative has collected three years of data from the MWR network.This paper introduces the data information,the data quality,and data downloading.Some applications of the data obtained from these MWRs were also demonstrated.Our comparisons of MWR against the nearest radiosonde observation demonstrate that the TP-PROFILE MWR system is adequate for monitoring the thermal and moisture variability of the troposphere over the TP.The continuous temperature and moisture profiles derived from the MWR data provide a unique perspective on the evolution of the thermodynamic structure associated with the heating of the TP.The TP-PROFILE project reveals that the low-temporal resolution instruments are prone to large uncertainties in their vapor estimation in the mountain valleys on the TP. 展开更多
关键词 microwave radiometer thermodynamic structure vertical profile Tibetan Plateau
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Experimental study of core MHD behavior and a novel algorithm for rational surface detection based on profile reflectometry in EAST
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作者 叶凯萱 周振 +20 位作者 张涛 马九阳 王嵎民 李恭顺 耿康宁 吴茗甫 文斐 黄佳 张洋 邵林明 杨书琪 钟富彬 高善露 喻琳 周子强 向皓明 韩翔 张寿彪 李国强 高翔 the EAST Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第3期66-75,共10页
Microwave reflectometry is a powerful diagnostic that can measure the density profile and localized turbulence with high spatial and temporal resolution and will be used in ITER,so understanding the influence of plasm... Microwave reflectometry is a powerful diagnostic that can measure the density profile and localized turbulence with high spatial and temporal resolution and will be used in ITER,so understanding the influence of plasma perturbations on the reflect signal is important.The characteristics of the reflect signal from profile reflectometry,the time-of-flight(TOF)signal associated with the MHD instabilities,are investigated in EAST.Using a 1D full-wave simulation code by the Finite-DifferenceTime-Domain(FDTD)method,it is well validated that the local density flattening could induce the discontinuity of the simulated TOF signal and an obvious change of reflect amplitude.Experimental TOF signals under different types of MHD instabilities(sawtooth,sawtooth precursors and tearing mode)are studied in detail and show agreement with the simulation.Two new improved algorithms for detecting and localizing the radial positions of the low-order rational surface,the cross-correlation and gradient threshold(CGT)method and the 2D convolutional neural network approach(CNN)are presented for the first time.It is concluded that TOF signal analysis from profile reflectometry can provide a straightforward and localized measurement of the plasma perturbation from the edge to the core simultaneously and may be a complement or correction to the q-profile control,which will be beneficial for the advanced tokamak operation. 展开更多
关键词 MHD instabilities profile reflectometry rational surface detection convolutional neural network(CNN) EAST tokamak
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An improved algorithm based on equivalent sound velocity profile method at large incident angle
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作者 Qianqian Li Qian Tong +3 位作者 Fanlin Yang Qi Li Zhihao Juan Yu Luo 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第2期161-167,共7页
With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical ... With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical equivalent sound speed profile(ESSP)method replaces the measured sound velocity profile(SVP)with a simple constant gradient SVP,reducing the computational workload of beam positioning.However,in deep-sea environment,the depth measurement error of this method rapidly increases from the central beam to the edge beam.By analyzing the positioning error of the ESSP method at edge beam,it is discovered that the positioning error increases monotonically with the incident angle,and the relationship between them could be expressed by polynomial function.Therefore,an error correction algorithm based on polynomial fitting is obtained.The simulation experiment conducted on an inclined seafloor shows that the proposed algorithm exhibits comparable efficiency to the original ESSP method,while significantly improving bathymetry accuracy by nearly eight times in the edge beam. 展开更多
关键词 equivalent sound speed profile ray tracing method large incident angle edge beam deep sea error correction multibeam echo-sounder system
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Three-Channel Interference Interpretation of Fano Profile
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作者 李波 李天钧 +3 位作者 马子茹 王希源 黄新朝 朱林繁 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第5期30-34,共5页
Fano resonance is a ubiquitous phenomenon, and it is commonly interpreted as a two-channel interference of the discrete and continuous channels. The present work investigates the Fano profile from a perspective of the... Fano resonance is a ubiquitous phenomenon, and it is commonly interpreted as a two-channel interference of the discrete and continuous channels. The present work investigates the Fano profile from a perspective of the temporal evolution of the wave function. By exciting the atom with a δ pulse and calculating the evolution of the wave function, the Fano formula is deduced. The results clearly show that the Fano resonance is of a three-channel interference, which is different from the traditional understanding. The three channels are revealed as the groundcontinuum, ground-discrete-continuum, and a previously unmentioned third channel, i.e., ground-continuumdiscrete-continuum. The present three-channel interpretation can be easily generalized to other physical systems,contributing to a deeper understanding of the Fano profile. 展开更多
关键词 function. profile. CONTINUUM
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On the calibration of a shear stress criterion for rock joints to represent the full stress-strain profile
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作者 Akram Deiminiat Jonathan D.Aubertin Yannic Ethier 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第2期379-392,共14页
Conventional numerical solutions developed to describe the geomechanical behavior of rock interfaces subjected to differential load emphasize peak and residual shear strengths.The detailed analysis of preand post-peak... Conventional numerical solutions developed to describe the geomechanical behavior of rock interfaces subjected to differential load emphasize peak and residual shear strengths.The detailed analysis of preand post-peak shear stress-displacement behavior is central to various time-dependent and dynamic rock mechanic problems such as rockbursts and structural instabilities in highly stressed conditions.The complete stress-displacement surface(CSDS)model was developed to describe analytically the pre-and post-peak behavior of rock interfaces under differential loads.Original formulations of the CSDS model required extensive curve-fitting iterations which limited its practical applicability and transparent integration into engineering tools.The present work proposes modifications to the CSDS model aimed at developing a comprehensive and modern calibration protocol to describe the complete shear stressdisplacement behavior of rock interfaces under differential loads.The proposed update to the CSDS model incorporates the concept of mobilized shear strength to enhance the post-peak formulations.Barton’s concepts of joint roughness coefficient(JRC)and joint compressive strength(JCS)are incorporated to facilitate empirical estimations for peak shear stress and normal closure relations.Triaxial/uniaxial compression test and direct shear test results are used to validate the updated model and exemplify the proposed calibration method.The results illustrate that the revised model successfully predicts the post-peak and complete axial stressestrain and shear stressedisplacement curves for rock joints. 展开更多
关键词 Full shear profile Post-peak shear behavior Rock joint Joint roughness coefficient(JRC) Axial stress-strain curve
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Profiles of the Headspace Volatile Organic and Essential Oil Compounds from the Tunisian Cardaria draba (L.) Desv. and Its Leaf and Stem Epidermal Micromorphology
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作者 Wissal Saadellaoui Samiha Kahlaoui +6 位作者 Kheiria Hcini Abir Haddada Noomene Sleimi Roberta Ascrizzi Guido Flamini Fethia Harzallah-Skhiri Sondes Stambouli-Essassi 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第4期725-744,共20页
In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardariadraba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total... In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardariadraba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total of 37 volatileorganic compounds (96.7%–98.9%) were identified;4 esters, 4 alcohols, 7 hydrocarbons, 12 aldehydes, 5 ketones,1 lactone, 1 organosulfur compound, 2 organonitrogen compounds, and 1 acid. The hydrocarbons form the maingroup, representing 49.5%–84.6% of the total detected volatiles. The main constituent was 2,2,4,6,6-pentamethylheptane(44.5%–76.2%) reaching the highest relative percentages. Forty-two compounds were determined in thetwo fractions of EOs, representing 98.8% and 97.2% of the total oil composition, respectively. The principal componentswere hexadecanoic acid (34.6%), 6-methyl-5-hepten-2-one (18.3%), decanal (15.0%), 6,10,14-trimethyl-2-pentadecanone (13.2%), and n-pentacosane (13%). Micromorphological details of the leaf and stem epidermisusing light microscopy revealed polygonal cells with sinuous walls in the adaxial and abaxial leaf surfaces andnearly rectangular and long ones with linear and thick walls for the stem epidermis. The stomata complexes wereanisocytic in the leaf epidermis and mainly anisocytic and rarely paracytic in the stem epidermis. Non-glandulartrichomes were unbranched and long with an acute apex or short with a convex apex. The glandular ones wereidentified for the first time in this species. They were short-stalked with a large secretory head. The highest stomatalindex (17.02%) was recorded in the abaxial leaf surface. The identification of headspace volatiles and essentialoil compounds can be used to characterize this species, and the various epidermis micromorphologicalfeatures are very useful for biosystematics taxonomic studies within Brassicaceae. 展开更多
关键词 Cardaria draba aroma profile essential oils EPIDERMIS TRICHOMES
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三维薛定谔方程组的线性Profile分解
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作者 韩依洋 廖梦兰 《湘潭大学学报(自然科学版)》 CAS 2024年第2期44-49,共6页
为了研究线性薛定谔方程组解Strichartz估计的紧性缺失问题,针对H•^(1)(R^(3))×H•^(1)(R^(3))中的三维线性薛定谔方程组的有界解向量序列,使用解序列的Profile分解方法,构造为解向量子列的(1/√h_(n))U(t-t_(n))/h_(n)^(2),(x-x_(n... 为了研究线性薛定谔方程组解Strichartz估计的紧性缺失问题,针对H•^(1)(R^(3))×H•^(1)(R^(3))中的三维线性薛定谔方程组的有界解向量序列,使用解序列的Profile分解方法,构造为解向量子列的(1/√h_(n))U(t-t_(n))/h_(n)^(2),(x-x_(n))/h_(n)类型的Profile分解和.其中,U是线性薛定谔方程组的解向量,在Strichartz范数估计下具有一个很小的余项.首先确定伸缩变换参数序列族,利用傅里叶变换和迭代的思想确定Profile分解族.其次验证了Profile分解和的收敛性,说明了Strichartz范数下余项的收敛性.最后证明了当线性薛定谔方程组的解序列有界时,都可以分解为解向量子列和的形式. 展开更多
关键词 薛定谔方程组 profile分解 STRICHARTZ估计 Sobolev嵌入 傅里叶变换
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Multi-circular formation control with reinforced transient profiles for nonholonomic vehicles:A path-following framework
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作者 Jintao Zhang Xingling Shao +1 位作者 Wendong Zhang Zongyu Zuo 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期278-287,共10页
This article investigates a multi-circular path-following formation control with reinforced transient profiles for nonholonomic vehicles connected by a digraph.A multi-circular formation controller endowed with the fe... This article investigates a multi-circular path-following formation control with reinforced transient profiles for nonholonomic vehicles connected by a digraph.A multi-circular formation controller endowed with the feature of spatial-temporal decoupling is devised for a group of vehicles guided by a virtual leader evolving along an implicit path,which allows for a circumnavigation on multiple circles with an anticipant angular spacing.In addition,notice that it typically imposes a stringent time constraint on time-sensitive enclosing scenarios,hence an improved prescribed performance control(IPPC)using novel tighter behavior boundaries is presented to enhance transient capabilities with an ensured appointed-time convergence free from any overshoots.The significant merits are that coordinated circumnavigation along different circles can be realized via executing geometric and dynamic assignments independently with modified transient profiles.Furthermore,all variables existing in the entire system are analyzed to be convergent.Simulation and experimental results are provided to validate the utility of suggested solution. 展开更多
关键词 Multi-circular formation Reinforced transient profiles Nonholonomic vehicles Path following
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Effect of dates on blood glucose and lipid profile among patients with type 2 diabetes
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作者 Hyder Osman Mirghani 《World Journal of Diabetes》 SCIE 2024年第6期1079-1085,共7页
Poor fruit and vegetable consumption is one of the 10 major risk factors for mortality.There is a misconception regarding the consumption of dates among patients with diabetes.This manuscript assessed the effects of d... Poor fruit and vegetable consumption is one of the 10 major risk factors for mortality.There is a misconception regarding the consumption of dates among patients with diabetes.This manuscript assessed the effects of date consumption on fasting and postprandial blood glucose,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoproteins,high-density lipoproteins,and microbial markers.Four literature databases were searched for relevant articles.Of the 595 studies retrieved,24 assessed the effects of dates on glycemic control and lipids.Overall,the evidence suggests that dates have a lowering effect on blood glucose.Dates reduce total cholesterol and triglyceride levels and increase high-density lipoprotein levels.Dates also promote the abundance of beneficial gut microbiota.Therefore,patients with diabetes and dyslipidemia can consume dates to reduce their blood glucose,cholesterol,and triglycerides. 展开更多
关键词 DATES Lipid profile Blood glucose Diabetes mellitus Microbial contamination
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Detection and analysis of serum bile acid profile in patients with colonic polyps
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作者 Xin Ji Hong Chen 《World Journal of Clinical Cases》 SCIE 2024年第13期2160-2172,共13页
BACKGROUND Analyzing the variations in serum bile acid(BA)profile can provide a certain biological basis for early warning and prevention of various diseases.There is currently no comprehensive study on the relationsh... BACKGROUND Analyzing the variations in serum bile acid(BA)profile can provide a certain biological basis for early warning and prevention of various diseases.There is currently no comprehensive study on the relationship between the serum BA profile and colonic polyps.AIM To study the serum BA profile detection results of patients with colonic polyps,and analyze the correlation between BA and colonic polyps.METHODS From January 1,2022,to June 1,2023,204 patients with colonic polyps who were diagnosed and treated at Zhongda Hospital Southeast University were chosen as the study subjects,and 135 non-polyp people who underwent physical examination were chosen as the control group.Gathering all patients'clinical information,typical biochemical indicators,and BA profile.RESULTS Compared with the control group,the serum levels of taurocholic acid,glycocholic acid,glycochenodeoxycholic acid,and taurochenodeoxycholic acid in the colonic polyp group were significantly higher than those in the control group,while the content of deoxycholic acid(DCA)was lower than that in the control group(P<0.05).When colonic polyps were analyzed as subgroups,it was shown that there was a strong correlation between changes in the BA profile and polyp diameter,location,morphology,pathological kind,etc.CONCLUSION The serum BA profile showed significant changes in patients with colonic polyps,with a significant increase in primary conjugated BA content and a decrease in secondary free bile acid DCA content.There is a certain correlation between primary free BA and pathological parameters of polyps. 展开更多
关键词 SERUM Bile acid profile Colonic polyps Bile acid metabolism
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Effect of Chuanzhifang component (ZGC) on macrophage inflammatory injury based on whole gene expression profile
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作者 JIANG Jie AN Wan-li +2 位作者 YANG Zhi-qian CHENG Wen-hui YANG Hong 《Journal of Hainan Medical University》 CAS 2024年第3期15-22,共8页
Objective: The effect of Chuanzhi Fang (ZGC) on the whole genome expression profile of RAW264.7 cells activated by lipopolysaccharide (LPS) was analyzed, and to explore the possible mechanism of action and core target... Objective: The effect of Chuanzhi Fang (ZGC) on the whole genome expression profile of RAW264.7 cells activated by lipopolysaccharide (LPS) was analyzed, and to explore the possible mechanism of action and core target of this formula on macrophage inflammatory injury at the overall level. Methods: A model of LPS-induced inflammation in RAW264.7 cells was constructed, and the effect of ZGC intervention on the genome-wide expression of inflammatory macrophages 3was examined by gene microarray technology, GO/KEGG enrichment analysis was performed for significantly differentially expressed genes among each group. Results: The results of genome-wide expression profiling microarray analysis showed that the ZGC intervention group upregulated the expression of 5 genes including C4bp and inhibited the expression of 22 genes including Mgat3, Psma6, and Siglecg relative to the LPS model group. KEGG signaling pathway analysis results showed that ZGC mainly acted through cytokine receptor interaction and the C-type lectin receptor signaling pathway. Conclusion: ZGC can interfere with the abnormal expression of 27 genes in inflammatory macrophages, and the related genes may exert corresponding anti-inflammatory effects by affecting cytokine receptor interactions, C-type lectin receptor signaling pathway, and TLR4/ NF-κB signaling pathway. 展开更多
关键词 Chinese herbal medicine component Chuanzhifang(ZGC) RAW264.7 cell CYTOKINE Gene expression profiling
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Profile of Full-Term Births in Maternity Wards of Public Hospitals in Douala Cameroon
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作者 Henri Essome Merlin Boten Bounyom +14 位作者 Astrid Ndolo Kondo Ingrid Doriane Ofakem Ilick Fulbert Mangala Nkwele Irène Cyrielle Edjoa Mboe Michel Roger Ekono Alphonse Ngalame Nyong Robert Tchounzou Moustapha Bilkissou Junie Ngaha Yaneu Marga Vanina Ngono Akam Gervais Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Nana Njamen Valère Mve Koh Pascal Foumane 《Open Journal of Obstetrics and Gynecology》 2024年第5期705-720,共16页
Introduction: Pregnancy as much as childbirth constitutes a risky situation, potentially fraught with sometimes dramatic complications: maternal death. Objective: We conducted this study with the aim of establishing t... Introduction: Pregnancy as much as childbirth constitutes a risky situation, potentially fraught with sometimes dramatic complications: maternal death. Objective: We conducted this study with the aim of establishing the profile of those giving birth in our context with the aim to anticipate operationally in the future on morbidity but more on maternal deaths. Methodology: We conducted, using a structured questionnaire, a prospective descriptive study in representative maternity wards in the city of Douala;the study variables were socio-economic, anthropometric, obstetrical and clinical. Statistical analyses were carried out with CS Pro 7.3 and SPSS version 25.0 software. The Student, Chi-square and Fischer tests were used to compare the means of the variables and the percentages. Results: We recruited 305 births for our study. The average age of our births was 28.7 years ± 6.1 with an average height of 161.6 cm ± 5.06;an average body mass index at the start of pregnancy of 28.0 kilograms/square meter and 31.3 kilograms/square meter at delivery;the average weight gain was 8.4 g ± 5.37;an average gestation of 2.84±1.90;an average parity of 2.2 ± 2.1 with an average birth interval of 27.7 months ± 23.7. The average gestational age was 39.2 weeks ± 1.21 with pregnancy pathology dominated by malaria;85.9% began their prenatal follow-up before the 14th week of amenorrhea. Conclusion: The profile of childbirth in urban Cameroon does not seem potentially dystocic compared to that of the same regional and racial area. 展开更多
关键词 profile Delivery TERM MALARIA Douala
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Immunovirological Profile of HIV1 Infection in Children and Adolescents Followed at the Bangui Pediatric University Hospital
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作者 Simplice Cyriaque Kango Synthia Ningatoloum Nazita +3 位作者 Marie Colette Nganda-Bangue Michaël Dan-Houron Alexandre Manirakiza Jean Chrysostome Gody 《Open Journal of Pediatrics》 2024年第3期585-597,共13页
History: Pediatric management of HIV infection in children in the Central African Republic began in 2004 with the use of fractionated adult antiretrovirals and Cotrimoxazole. It has evolved over the years with the use... History: Pediatric management of HIV infection in children in the Central African Republic began in 2004 with the use of fractionated adult antiretrovirals and Cotrimoxazole. It has evolved over the years with the use of pediatric forms, oral suspensions and dispersible tablets. The transition to Dolutegravir took place in 2020. The active file of our patients will grow from 78 to over 1900 today. Follow-up examinations are carried out to assess adherence to treatment. Objective: To determine the immunovirological profile and factors associated with treatment failure during follow-up of children on ART at the Bangui pediatric university hospital. Patients and Method: This was a cross-sectional, analytical study from May 30 to December 02, 2022. The study sample was drawn from a cohort of HIV-1-infected children followed up at the Bangui pediatric university hospital and on ART for three semesters who met the selection criteria. Results: The prevalence of treatment failure varied from one semester to the next. Thus, the prevalence of therapeutic failure was 20% in the first semester, 10% in the second semester and 7% in the third semester. The prevalence of virological failure was 10.28% in the first half of the year, 6.91% in the second half and 4.98% in the third. Secondly, immunological failure was 0.48% in the first half of the year, 0.32% in the second 0.64% in the third half. Finally, clinical failure was 8.82% in the first half, 4.82% in the second half, 1.92% in the third half. Socio-demographic and clinical factors associated with treatment failure were male gender (p 1000 copies/ml (p Conclusion: The occurrence of treatment failures in children is a major problem, especially in our resource-limited countries, given the challenges facing antiretroviral therapy. It is therefore necessary to carry out a study on resistance genotyping in order to propose correct management protocols, as the future of treatment programs depends on it. 展开更多
关键词 profile Immunovirological HIV/AIDS CHILDREN Bangui
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Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic Republic of Congo
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作者 Candide About Kabamba Berry Ikolango Bongenya +10 位作者 Jocelyn Ewuti Nonga Lambert Omombo Losenga Noëlla Maketi Dikati Thérèse Kasaka Ntumba Grace Ipaya Booto Rosalie Djamba Dembo Stéphanie Mauwa Selenge Benoit Obel Kabengele Guy Makila Mabe Bumoko Marie-Thérèse Ayane Safi Sombo Erick Ntambwe Kamangu 《Neuroscience & Medicine》 2024年第1期1-22,共22页
Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to pr... Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) initiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: This is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. The International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. Results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. The average age was 40.1 ± 12.1 years. The secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as opportunistic infections. They were alcoholics in (30.2%). Their history was heart disease (15.6%), high blood pressure (18.8%);drug abuse (10.4%). The IHDS score was light in 55.2% of cases. The correlation between IHDS/IADL watches asymptomatic neurocognitive impairments (ANI) in 77.1%, almost all of subjects are found with normal overall functioning (94.8%) and a disturbed neurological examination in 53.1% of cases with a predominance of motor impairments in 79.1%. Conclusion: In view of these results, early and systematic screening of NCD and associated factors remains necessary in our context. . 展开更多
关键词 IHDS Dolutegravir Initiation KINSHASA Neurological profile PLHIV
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