期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Crystalline inclusion complexes formed between the drug diflunisal and block copolymers
1
作者 Zhi Zhong Xiaotong Yang +4 位作者 Xiao-Bin Fu Ye-Feng Yao Bao-Hua Guo Yanbin Huang Jun Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第6期1268-1275,共8页
The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certa... The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certain drugs have been found to form crystalline inclusion complexes(ICs) with multiple types of linear polymers,representing a new subcategory of pharmaceutical solids.In this study,we used diflunisal(DIF) as the model drug host and extended the guest of drug/polymer ICs from homopolymers to block copolymers of poly(ethylene glycol)(PEG) and poly(s-caprolactone)(PCL).The block length in the guest copolymers showed a significant influence on the formation,thermal stability and dissolution behavior of the DIF ICs.Though the PEG block could hardly be included alone,it could indeed be included in the DIF ICs when the PCL block was long enough.The increase of the PCL block length produced IC crystals with improved thermal stability.The dissolution profiles of DIF/block copolymer ICs exhibited gradually decreased aqueous solubility and dissolution rate with the increasing PCL block length.These results demonstrate the possibility of using drug/polymer ICs to modulate the desired pharmaceutical profiles of drugs in a predictable and controllable manner. 展开更多
关键词 Pharmaceutical solid forms Inclusion complexes Drugs block copolymers Thermal stability Aqueous solubility Dissolution profiles
原文传递
Drug-polymer inclusion complex as a new pharmaceutical solid form
2
作者 Xiaotong Yang Zhi Zhong +1 位作者 Jun Xu Yanbin Huang 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第11期2099-2104,共6页
The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharma... The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes (ICs), and summarizes their structural features, structure- property relationships, as well as potential pharmaceutical applications 展开更多
关键词 Pharmaceutical solid forms Crystalline inclusion complex Thermal stability Dissolution profiles Homopolymers block copolymers
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部