Current Status of Key Competencies among Medical Students: A Latent Profile Analysis

The purpose of this study was to understand the overall level of key competencies of medical students and explore the potential profile of key competencies, promoting quality education, and improving the quality talent cultivation in medical colleges. A stratified random sampling method selected 734 medical students from four medical colleges in Chongqing Province of China. A general information questionnaire and a key competencies survey questionnaire were used to conduct the survey. The overall score and scores of each dimension of key competencies were analyzed. Latent profile analysis was conducted to classify the key competencies of medical students and compare the distribution differences of demographic variables among different categories. The results showed that 26% of medical students have never heard of the concept of key competencies, and 59% of them are not familiar with the content related to key competencies. The score of key competencies is 3.66 ± 0.60, with the highest score in the dimension of responsibility and the lowest score in the dimension of humanistic accomplishment. The latent profile analysis classified them into three categories: “low key competencies group (14.71%)”, “medium key competencies group (36.79%)”, and “high key competencies group (48.50%)”. The R3STEP regression analysis results showed statistically significant differences in educational level and whether they served as student cadres among different key competencies categories of medical students. This paper discusses three different potential key competencies categories among medical students, and the overall level of key competencies is relatively good. However, medical students lack a comprehensive and systematic understanding of key competencies. Humanistic accomplishment, healthy living, and practical innovation are the three dimensions with lower scores and should be given more attention. Medical colleges should integrate the concept of key competencies into teaching and implement it in medical practice to cultivate more high-quality medical talents for society.

Early Cretaceous Thrust and Nappe Tectonics in North Qilian Shan,Northern Tibetan Plateau:Evidence from Field Mapping,Geochronology,and Deep Structural Analysis

The North Qilian Shan fold and thrust belt,located at the northern Tibetan Plateau and southern margin of the Hexi Corridor,is a key tectonic unit to decode the formation and expansion of the plateau.Previous studies emphasize the Cenozoic deformation due to the far-field response to the Indo-Asian collision,but the Mesozoic deformations are poorly constrained in this area.We conducted detailed field mapping,structural analysis,geochronology,and structural interpretation of deep seismic reflectional profiling and magnetotelluric(MT)sounding,to address the superposed results of the Mesozoic and Cenozoic deformation.The results recognized the North Qilian thrust and nappe system(NQTS),the root and the frontal belt are the North Qilian thrust(NQT),and the Yumu Shan klippe(YK),respectively.The middle belt is located between the NQT and the YK.Monzonitic granite zircon U-Pb dating from the middle belt yields an age of ca.415 Ma,which is similar to south NQT.The thrusting displacement is estimated at ca.48 km by structural interpretation of deep profiles.The timing is constrained in the early stage of the Early Cretaceous by the formation of simultaneous growth strata.We suggest that the NQTS has resulted from the far-field effect of the Lhasa-Qiangtang collision,and the Yumu Shan is uplifted by the superposed Cenozoic deformation.

Isolation, Identification and Tissue Expression Profile Analysis of One Novel Differentially Expressed Sequence Tag in the Longissimus dorsi Muscle from Meishan, Meishan × Large White Hybrid and Large White Pigs

In order to detect the molecular mechanism of heterosis in pigs, the mRNA differential display technique was performed to investigate the differences of gene expression in the Longissimus dorsi tissue from Meishan, Meishan × Large White hybrid and Large White pigs with nine 3'-end anchored primers in combination with ten 5'-end arbitrary primers and nearly 3000 reproducible bands were examined. One novel expressed sequence tag (EST4, GenBank accession number: AY553914) that was differentially expressed in Meishan, Meishan× Large White hybrid and Large White pigs was isolated from the Longissimus dorsi muscle tissue and identified through semi-quantitative RT-PCR. BLAST analysis revealed that the 350 bp long EST (EST4) was not homologous to any of the known porcine genes. Tissue expression profile analyses showed that the EST4 was expressed in most of tissues.LIU Yong-gang, Ph D candidate

Analysis of Capacity Decay, Impedance, and Heat Generation of Lithium-ionBatteries Experiencing Multiple Simultaneous Abuse Conditions

Abuse of Lithium-ion batteries,both physical and electrochemical,can lead to significantly reduced operational capabilities.In some instances,abuse can cause catastrophic failure,including thermal runaway,combustion,and explosion.Many different test standards that include abuse conditions have been developed,but these generally consider only one condition at a time and only provide go/no-go criteria.In this work,different types of cell abuse are implemented concurrently to determine the extent to which simultaneous abuse conditions aggravate cell degradation and failure.Vibrational loading is chosen to be the consistent type of physical abuse,and the first group of cells is cycled at different vibrational frequencies.The next group of cells is cycled at the same frequencies,with multiple charge pulses occurring during each discharge.The final group of cells is cycled at the same frequencies,with a partial nail puncture occurring near the beginning of cycling.The results show that abusing cells with vibrational loading or vibrational loading with current pulses does not cause a significant decrease in operational capabilities while abusing cells with vibrational loading and a nail puncture drastically reduces operational capabilities.The cells with vibration only experience an increase in internal resistance by a factor of 1.09–1.26,the cells with vibration and current pulses experience an increase in internal resistance by a factor of 1.16–1.23,and all cells from each group reach their rated lifetime of 500 cycles without reaching their end-of-life capacity.However,the cells with vibration and nail puncture experience an increase in internal resistance by a factor of 6.83–22.1,and each cell reaches its end-of-life capacity within 50 cycles.Overall,the results show that testing multiple abuse conditions simultaneously provides a better representation of the extreme limitations of cell operation and should be considered for inclusion in reference test standards.

Comprehensive genomic analysis and expression profiling of cysteine-rich polycomb-like transcription factor gene family in tea tree

Cysteine-rich polycomb-like(CPP)is a small gene family in plants,which plays key role in plant development and stress response.Although CPP transcription factors have been characterized in several other plant species,a genome-wide characterization of the CPP gene family has been absent in Camellia sinensis.In this study,we totally identified 7,8,and 8 non-redundant CsCPP genes in three published genomes,including Camellia sinensis var.assamica cv.Yunkang-10(CSA-YK10),Camellia sinensis var.sinensis cv.Biyun(CSS-BY)and Camellia sinensis var.sinensis cv.Shuchazao(CSS-SCZ).CPP proteins from tea tree and other plant species were classified into three groups,which were further divided into four subgroups based on phylogenetic relationships.Most CPP genes in the same subgroup had similar gene structures and conserved motifs.The cis-acting elements analysis indicated that CPP genes might be involved in plant growth,development and stress responses.Analysis of gene expression using qRT-PCR experiments validated that CPP genes exhibited different expression patterns across the examined tissues.All the genes were expressed differentially in a range of tissues,indicating that CPPs were involved in a range of developmental and physiological processes.This study has obtained new insights into the evolution and function of the CPP gene family in the growth and development of tea plants,and also provide candidate genes for further functional characterization in tea tree.

User Profile System Based on Sentiment Analysis for Mobile Edge Computing

Emotions of users do not converge in a single application but are scattered across diverse applications.Mobile devices are the closest media for handling user data and these devices have the advantage of integrating private user information and emotions spread over different applications.In this paper,we first analyze user profile on a mobile device by describing the problem of the user sentiment profile system in terms of data granularity,media diversity,and server-side solution.Fine-grained data requires additional data and structural analysis in mobile devices.Media diversity requires standard parameters to integrate user data from various applications.A server-side solution presents a potential risk when handling individual privacy information.Therefore,in order to overcome these problems,we propose a general-purposed user profile system based on sentiment analysis that extracts individual emotional preferences by comparing the difference between public and individual data based on particular features.The proposed system is built based on a sentiment hierarchy,which is created by using unstructured data on mobile devices.It can compensate for the concentration of single media,and analyze individual private data without the invasion of privacy on mobile devices.

Kinetic equilibrium reconstruction with internal safety factor profile constraints on EAST tokamak

Reconstruction of plasma equilibrium plays an important role in the analysis and simulation of plasma experiments. The kinetic equilibrium reconstruction with pressure and edge current constraints has been employed on EAST tokamak. However, the internal safety factor(q) profile is not accurate. This paper proposes a new way of incorporating q profile constraints into kinetic equilibrium reconstruction. The q profile is yielded from the Polarimeter Interferometer(POINT)reconstruction. Virtual probes containing information on q profile constraints are added to inputs of the kinetic equilibrium reconstruction program to obtain the final equilibrium. The new equilibrium produces a more accurate internal q profile. This improved method would help analyze EAST experiments.

APPLICATION OF THE CENTRAL MOMENT METHODS TO ANALYSIS OF X－RAY DIFFRAC－TION LINE PROFILE

Pure X-ray diffraction profiles have been analysed for polyamide (PA) 1010 and added BMI system by means of multipeak fitting resolution of X-ray diffraction. The methods of variance and fourth moment have been applied to determine the particle size and strain values for paracrystalline materials, and the values thus obtained have been compared. The results indicated that both variance and fourth moment of X-ray diffraction line profile' yielded approximately the 'same values of the particle size and the strain. The particle sizes of (100) reflection have been found tO decrease with increasing BMI content.On the contrary, the strain values were on the increase.

Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles

We analyzed profiles of IgG autoantibodies to 16 cardiac specific proteins and their main immunogenic region B-epitopes, in the groups of already verified cardiac pathology: acute and chronic lymphocytic myocarditis, ST elevation myocardial infarction, postinfarction remodeling of myocardium, dilated cardiomyopathy and in healthy controls along with patients, suffered from gastritis (to evaluate immune response against cross-reactive B-epitopes). AAB specific patterns allowed us to distinguish cases among themselves by means of multiparametrical canonical discriminant analysis in approximately 95% of cases. Positive predictive value in the group of MYO reached 95%, in the STEMI—89%, in the PIR—99%, in the DCM—99%, in the group of gastritis—88%. Principal component analysis of mentioned cardiac pathologies extended current clinical knowledge of their immunopathogenesis. Obtained data markedly proved a usability of serum AAB profiling for non invasive screening, differential diagnostics and working hypothesis composition.

A search for evidence of small-scale inhomogeneities in dense cores from line profile analysis

In order to search for intensity fluctuations on the HCN（1-0） and HCO＋（1-0） line pro- files, which could arise due to possible small-scale inhomogeneous structure, long-term observations of high-mass star-forming cores S140 and S199 were carried out. The data were processed by the Fourier filtering method. Line temperature fluctuations that exceed the noise level were detected. Assuming the cores consist of a large number of randomly moving small thermal fragments, the total number of frag- ments is - 4 × 106 for the region with linear size - 0.1 pc in S140 and - 106 for the region with linear size - 0.3 pc in S 199. Physical parameters of fragments in S 140 were obtained from detailed modeling of the HCN emission in the framework of the clumpy cloud model.

Transcriptome Profiling and Analysis during Cotton Fiber Cell Development

In this project,we aim to elucidate the molecular mechanism controlling initiation and elongation of tetraploid Gossypium hirsutum fiber cells by setting up a high throughput custom-designed

An Integrated Analysis Method for miRNA, lncRNA and mRNA Profiles Based on Their Functional and Positional Relationships

ncRNAs have been identified as potential regulatory molecules and have multiple biological roles. Aberrant expression of specific ncRNAs contributes to multiple biological processes and many human diseases. Herein, we simultaneously profiled miRNA, lncRNA and mRNA in human HepG2 and L02 cells applying high-throughput sequencing and micro-array technologies. Abnormal miRNA, lncRNA and mRNA profiles were assessed through fold change filtering. A cross-platform integrated analysis method was developed to analyze differentially expressed miRNA, lncRNA and mRNA profiles. miRNA-mRNA interaction was analyzed according to their functional relationships. Target mRNAs of aberrantly expressed miRNAs were obtained from experimentally validated datasets or predicted using some programs. Generally, multiple target mRNAs were involved, and they have versatile roles by functional enrichment analysis. Ac-cording to actual expression datasets in the study, compared to deregulated miRNAs, these theoretical target mRNAs showed various expression patterns. The consistent or inconsistent expression was mainly derived from complex, mul-tiple, flexible and alternative regulatory relationships between miRNA and mRNA. Further, miRNA/mRNA and lncRNA were completely surveyed based on their location distributions on human chromosomes. Many miRNA-lncRNA and mRNA-lncRNA pairs always were located on the same strand or different strands in the specific genomic region. Due to the location distributions, they might have partly or completely overlapped regions or they could be reverse complementarily binding. These miRNA/mRNA-lncRNA pairs showed consistent or inconsistent expression pat-terns, although they might have functional relationships through reverse complementarily binding events. Moreover, we also detected and analyzed various isomiRs from a given miRNA locus, including those isomiRs with 3’ additional non-template nucleotides. These isomiRs, especially for those 5’ isomiRs with the new “seed sequences” through “seed shifting” events, maybe have potential biological roles as well as isomiR repertoire and their expression patterns. The integrative analysis provides potential functional relationships between miRNA, lncRNA and mRNA across different datasets. The complex and various expression patterns suggest a robust regulatory network across different regulatory molecules and their targets.

Construction of Vertical Wind Profile from Satellite-Derived Winds for Objective Analysis of Wind Field

During summer Monex-79, a variety of observing systems viz. research ships, research aircrafts, constant pressure balloons and geostationary satellite etc. were deployed, besides the regular conventional observations. The purpose of these additional systems was to make the best possible data for the studies on various aspects of monsoon circulation. The present study is aimed at the construction of vertical wind profile using cloud motion vectors obtained from GOES (I-O) satellite and to examine whether the constructed wind profiles improves the representation of the monsoon system, flow pattern etc. in the objective analysis. For this purpose, climatological normals of the wind field are considered as the initial guess and the objective analyses of the wind field are made with, first using only data from conventional observations over land areas, subsequently including the constructed winds from cloud motion vectors. These analyses are then compared with the standard analyses of wind field obtained from Quick Look Atlas by T. N. Krishnamurti et al. (1979).It is inferred that satellite estimated mean wind profiles show good agreement with the mean wind profiles of the research ships with RMS errors less than 5 mps below 500 hPa and less than 8 mps above 500 hPa. It is further inferred that the inclusion of constructed winds shows a positive impact on the objective analysis and improvement is seen to be more marked in the data-sparse region of the Arabian sea. Analyses which include the constructed winds show better agreement with the standard analysis, than the analyses obtained using only conventional winds. Thus, results of our study suggest that the wind profiles constructed using cloud motion vectors are of potential use in objective analysis to depict the major circulation features over the Indian region.

Expression Profile Analysis of Genes Involved in Brassinosteroid Biosynthesis Pathway in Cotton Fiber Development

Cotton(Gossypium hirsutum L.) is the leading fiber crop and one of the mainstays of the economy in the world.Cotton fibers,as the main product of cotton plants,are unicellular,linear

EQUILIBRIUM COASTAL PROFILES:Ⅱ. EVIDENCE FROM EOF ANALYSIS

The validity of the concept of coastal equilibritun depends upon a pnd of the ekistence of equilibrium. In addition, the methods of calculating the actual equilibrium profile and the response time are rempred. This study evaluates equilibriuzn conditions using evidence from EOF (empirical orthogonal function) analysis of the coased profile data (bed slopes and associated elevations) obtained from Poole and Christchurch Bays, southem England. The preliminary results show tha the larges eigenvalue is much greater than the other eigenvalues and the temporally-related eigenfunction is staionary;thes observation implies the existence of wilibrium. Further, the spatially-related eigenfunction associated with the largest eigenvalue is used to calculate the actual beach profile at equilibrium. Although the temporal eigenfopction may nuctuate, it recovers rapidly, indicating tha the response time is short. However, further studies are required to determine the response hme accurately.

Genre Analysis of Online Company Profiles from Sporting Goods Brands

With the development of globalization and information technology,online company profile has been an effective commu-nication channel between companies and their target customers or clients.Online company profile,as a specific genre,has the dis-tinct features and functions in commercial activities.This study aims to do linguistic study of the constitution and the role of thesecompany profiles about sporting goods for communication on the Internet.To realize it,six company profiles have been selectedfrom the official websites of each sports company.The genre analysis of these samples is conducted from the perspective ofHasan’s Contextual Configuration(CC)and Generic Structure Potential(GSP).This thesis attempts to give the suggestions on howto compose a company profile for readers and sporting companies and the reference for the related researches in the future.

Research on temperature profiles of honeycomb regenerator with asymptotic analysis

An asymptotic semi-analytical method for heat transfer in counter-flow honeycomb regenerator is proposed. By introducing a combined heat-transfer coefficient between the gas and solid phase, a heat transfer model is built based on the thin-walled assumption. The dimensionless thermal equation is deduced by considering solid heat conduction along the passage length. The asymptotic analysis is used for the small parameter of heat conduction term in equation. The first order asymptotic solution to temperature distribution under weak solid heat conduction is achieved after Laplace transformation through the multiple scales method and the symbolic manipulation function in MATLAB. Semi-analytical solutions agree with tests and finite-difference numerical results. It is proved possible for the asymptotic analysis to improve the effectiveness, economics and precision of thermal research on regenerator.

Profiling the Change of Key Chemical Ingredients in Combination of Aconitum carmichaeli Debx. and Bletilla striata (Thunb.) Reichb.f. by UPLC-QTOF/MS with Multivariate Statistical Analysis

In the present study, an ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-QTOF/MS) based chemical profiling approach to rapidly evaluate chemical diversity after codecocting of the combination of Aconitum carmichaeli Debx.(wu-tou in Chinese, WT) and Bletilla striata(Thunb.) Reichb.f.(bai-ji in Chinese, BJ) incompatible pair. Two different kinds of decoctions, namely WT-BJ mixed decoction: mixed water extract of each individual herbs, and WT-BJ co-decoction: water extract of mixed two constituent herbs, were prepared. Batches of these two kinds of decoction samples were subjected to UPLC-QTOF/MS analysis, the datasets of tR-m/z pairs, ion intensities and sample codes were processed with supervised orthogonal partial least squared discriminant analysis(OPLS-DA) to holistically compare the difference between these two kinds of decoction samples. Once a clear classification trend was found in score plot, extended statistical analysis was performed to generate S-plot, in which the variables(tR-m/z pair) contributing most to the difference were clearly depicted as points at the two ends of "S", and the components that correlate to these ions were regarded as the most changed components during co-decocting of the incompatible pair. The identities of the changed components can be identified by comparing the retention times and mass spectra with those of reference compounds and/or tentatively assigned by matching empirical molecular formulae with those of the known compounds published in the literatures. Using the proposed approach, global chemical difference was found between mixed decoction and co-decoction, and hypaconitine, mesaconitine, deoxyaconitine, aconitine, 10-OH-mesaconitine, 10-OH-aconitine and deoxyhypaconitine were identified as the most changed toxic components of the combination of WT-BJ incompatible pair during co-decocting. It is suggested that this newly established approach could be used to practically reveal the possible toxic components changed/increased of the herbal combination taboos, e.g. the Eighteen Incompatible Medications(Shi Ba Fan), in traditional Chinese medicines.

Profiles of depressive disorders and influencing factors among the elderly in China: protocol for a secondary data analysis

Background:Depressive disorders have become a major risk factor that influences people’s health worldwide,but few studies have focused on the prevalence of depressive disorders among the Chinese elderly and their characteristics of depressive disorders.The current study is a secondary data analysis designed to explore the profiles of depressive disorders in the Chinese elderly by latent profile analysis.Methods:The China Health and Retirement Longitudinal Study(CHARLS 2018)database will be used for analysis.Latent profile analysis will be employed to identify the profiles of depressive disorders using data from the subsection“CESD Depression”in the section“Cognition and Depression”.Stepwise multinomial logistic regression will be used to explore the influencing factors of different profiles of depressive disorders among the Chinese elderly.Discussion:The prevalence of depressive disorders among the Chinese elderly and their profiles of depressive disorders will be reported.Possible influencing factors may include some demographic characteristics and associated psychological elements,which will provide a reference for further research and precise intervention.