Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify t...Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify this issue.Methods Twelve Holstein cows were randomly divided into two groups:conventional diet group(CON,n=6)and the HG diet group(n=6).On day 7 of week 4,rumen fluid was sampled to measure pH,milk was sampled to meas-ure components,and blood was sampled to measure biochemical parameters and fatty acid composition.After the experiment,cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.Results HG feeding decreased the ruminal pH,milk’s fat content and long-chain fatty acid proportion(P<0.05)and increased the proportion of short-and medium-chain fatty acids in the milk(P<0.05)as compared with CON diets.The concentrations of blood cholesterol,low-density lipoprotein,and polyunsaturated fatty acids in the HG cows were lower than those in CON cows(P<0.05).In muscle tissue,HG feeding tended to increase the triacylglycerol(TG)concentration(P<0.10).Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway,the regulation of lipolysis in the adipocytes pathway,and the PPAR signalling pathway.In adipose tissue,HG feeding increased the concentration of TG and decreased the concentration of C18:1 cis9(P<0.05).At the transcrip-tome level,the fatty acid biosynthesis pathway,linoleic acid metabolism pathway,and PPAR signalling pathway were activated.Conclusion HG feeding leads to subacute rumen acidosis and a decreased milk fat content.The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding.In muscle and adipose tissue,HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis,while down-regulated the expression of genes related to lipid transport.These results complement our knowledge of the fatty acid composi-tion of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.展开更多
Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the p...Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.展开更多
Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dacty...Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dactylifera L</span></i><span style="font-family:Verdana;">.) El-Hayani cultivar on serum glucose and lipids profile in induced diabetic male albino rats. Palm pollen chemically analyzed besides chemical constituents, mineral contents, polyphenols </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> flavonoids. Male Albino rats (36</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">rats </span><span style="font-family:Verdana;">weight 170</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">190</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">gm) were divided </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> 6 groups. 1</span><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">Normal control (</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">), 2</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> Alloxanized diabetes control (+) (150</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mg/Kg rat body weight). Diabetic groups 3 and 4 had 0.5%,</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">1.0% date palm pollen, respectively, also diabetic </span><span style="font-family:Verdana;">group</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 5 and 6 had 100 ppm, 200 ppm date palm pollen extract, respectively. At the end of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">experiment</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (4 weeks) rats were fasted overnight and anesthetized and blood samples were taken for analysis of serum glucose, lipids profile </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> renal-hepatic function parameters, relative organ weight data obtained are </span><span style="font-family:Verdana;">statistically</span><span style="font-family:Verdana;"> analysis. Results showed that the major polyphenolic components were that e-vanillic acid (16.33 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), pyrogallol (15.02 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), epicatechin (11.04 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), catechin (10.96 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g). </span><span style="font-family:Verdana;">While,</span><span style="font-family:Verdana;"> date palm pollen was rich in hesperidin (8.84 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), Kaempferol 3</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">2 p-coumaroyl glucose (6.92 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), </span><span style="font-family:Verdana;">hesperitin</span><span style="font-family:Verdana;"> (5.10 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), rutin (3.11mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g) as flavonoids components. Date palm pollen has </span><span style="font-family:Verdana;">high</span><span style="font-family:Verdana;"> content of protein, calcium </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> iron (30.87 g/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g, 510.82 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 236.50 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), respectively. Also, serum glucose decreased significantly in diabetic groups (3, 4, 5 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 6, respectively) (179.47, 137.80, 156.77, 145.47 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">mL, respectively). Lipids profile, renal and liver functions were improved </span><span style="font-family:Verdana;">significant</span></span><span style="font-family:Verdana;">ly</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (P < 0.05) in diabetic groups </span><span style="font-family:Verdana;">which had</span><span style="font-family:Verdana;"> date palm pollen or its extracts.</span></span><span> </span><span style="font-family:Verdana;">It is concluded that the dried date palm pollen 1% in the diet and 200 ppm extract are more effective compared with controlling diabetes mellitus, also improve renal and liver functions. Diabetics are advised to eat date palm pollen</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> are considered treatment foods for Diabetes Mellitus.</span>展开更多
Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and...Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and apolipoprotein by automatic biochemic analytical instrument; T cell subsets by flow cytometer; and MDA, SOD were evaluated by the thiobarbituric acid (TBA) test and the nitrite method modified by Oyanagui respectively using spectrophotometry. Results In men, the serum levels of follicle stimulating hormone ( FSH)、luteinizing hormone(LH) increased significantly with aging, but serum prolactin(PRL) and progesterone(P) levels remained unchanged in all life; Both testosterone (T) and free testosterone (FT) all decreased greatly with aging, but 17β - estradiol( 17β - E_2) was reverse ; E_2 was negatively correlated with T and E_2/T increased with aging. The level of serum total cholesterol (TC) increased with aging, but triglycerides (TG) remain unchanged; compared with young group, high - density lipoprotein cholesterol ( HDL - C) ; HDL - C/TC of other groups decreased significantly, but low - density lipoprotein cholesterol ( LDL - C ) changed inversely; HDL- C/LDL- C reduced slightly with aging and showed no difference between groups. Apolipoprotein A1 (apoA1) and apoB all enhanced greatly with aging; meanwhile the ratio of apoA1/apoB decreased. The concentration of serum glucose (GLU) was unchanged in all life. To compare with those in the young group, CD3 + , CD4 + in other groups reduced greatly, CD4 + remained unchanged. Meanwhile, CD8 + increased significantly with aging. Compared with the young group, serum malondialdehyde(MDA) value of the old ones increased obviously, but the activity of superoxide dismutase(SOD) was reverse. By partial correlation analysis (controlling BMI, FSH, LH and PRL), TC、 LDL-C、apoA1、apoB、CD8 + 、MDA of men all presented a positive correlation with E_2/T respectively, their correlation coefficients (γ) were 0. 262、0. 136、 0. 532、0. 379、0. 394、0. 234 (P < 0. 001 ) ; HDL - C、 HDL- C/TC、HDL- C/LDL- C、CD3 + 、CD4 +/CD8 + 、SOD showed a negatively correlation with E_2/T respectively, γequaled - 0.563、- 0.332、- 0.654、- 0.1530、-0.4140、-0.236(P<0.001). In women, the serum concentrations of FSH、LH increased significantly after menopause; PRL increased little with aging; compared with young group, E_2 and P in postmenopausal groups reduced obviously, E_2/P revealed significant reduce with aging. T enhanced significantly after menopause, but nor did FT. E_2, P and the ratio of E_2/P were negatively correlated with age respectively by bivariate correlation analysis, and a positive relation between T and age. After 70 years old, the level of TC increased obviously, and so did that of TG after menopause; HDL decreased with aging, but LDL increased after 70, with the result that the ratios of HDL- C/TC and HDL- C/LDL- C all reduced with aging; apoA1 decreased gently after 70, but apoB increased signifi- cantly after menopause; correspondingly, the ratio of apoA1/apoB declined obviously. The concentration of GLU increased with aging. CD3 + and CD4 + didn't change until 60, but reduced after 60. Compared with the young groups, CD8 + remained unchanged, CD4 +/CD8 + reduced greatly with aging, CD4 + and CD8 + presented a negatively correlation with age respectively. The value of MDA in serum of women increased notably after 70 years old, but SOD activity already decreased significantly from 60. By partial correlation analysis (controlling BMI, FSH, LH and PRL), HDL-C、CD4 +、CD4 +/CD8 + showed a certain correlation with E_2/P respectively; γ were 0. 245、 0.157、0. 154 ( P <0.05 ) ; TG、 LDL、 apoB、 apoA1/ apoB、SOD presented a negatively correlation with E_2/P respectively, γ were 0. 452、 0. 236、 0.321、 0. 135、 0.156、0.154、0.426 ( P < 0.05 ). Conclusions The Disequilibrium of SH had correlations with lipid profile, cellular immunological function and lipid peroxides and oxidation system; these suggested SH took an important role in the process of aging.展开更多
BACKGROUND The prevalence of osteoporosis and low bone mass is steadily rising each year.Low body weight is commonly linked to diminished bone mass and serves as a robust predictor of osteoporosis.Nonetheless,the conn...BACKGROUND The prevalence of osteoporosis and low bone mass is steadily rising each year.Low body weight is commonly linked to diminished bone mass and serves as a robust predictor of osteoporosis.Nonetheless,the connection between body mass index(BMI),bone mineral density,and lipid profiles among the elderly remains elusive.AIM To examine the association between BMI and bone mass,explore the correlation between lipid profiles and bone mass,and delve into the interplay between lipid metabolism and bone health.METHODS The study included 520 patients aged≥65 years(178 men and 342 women).Age,sex,weight,and height were recorded.Femoral neck bone mineral density and T scores were determined using a dual-energy X-ray absorptiometry scanner.Blood calcium(Ca),phosphorus(P),albumin(ALB),alkaline phosphatase(ALP),aspartate aminotransferase,alanine aminotransferase,triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL)and low-density lipoprotein(LDL)levels were measured.Patients were classified by sex(male and female),age(65-79 years and≥80 years),and T score(normal bone mineral density,osteopenia and osteoporosis).RESULTS Age,sex,BMI,and ALP and TG levels were independent risk factors for osteoporosis.For the 65-79-and≥80-yearold groups,females presented lower T scores than males.Ca,P,ALB,ALP,TC,HDL and LDL levels were significantly different between men and women in the 65-79-year-old group.In addition,BMI and TG levels were significantly decreased in osteoporotic patients compared with patients with normal bone mass.TC levels declined in 65-to 79-year-old male and female osteoporosis patients.In the group of women aged≥80 years,osteoporotic patients showed significantly increased ALP levels.Furthermore,we found positive correlations between BMI and TG levels in the male and female patient groups.However,we found no significant differences in ALB,Ca,P,HDL and LDL levels in osteoporotic patients compared to patients with normal bone mass.CONCLUSION Osteoporotic patients showed significantly decreased BMI and TG levels compared with those with normal bone mass.BMI showed positive correlations with TG levels in male and female patients.These results indicate correlations between BMI and bone mass and between lipid profiles and bone mass.展开更多
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia. DM-related dyslipidemia are associated with complications resulting from progressive damage of various organs. CD36 is...Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia. DM-related dyslipidemia are associated with complications resulting from progressive damage of various organs. CD36 is 88-kD, class B scavenger receptor, expressed on different types of cells. In diabetic patients, LDL particles are glycated with strong level;this increases CD36 expression, initiates foam cell formation and accelerates atherosclerosis. Objective: This study aimed to determine the correlation between serum CD36 level and lipid profile among patients with type 2 diabetes mellitus in Zeenam Specialized center, Khartoum State, Sudan, in a period between 2019 and 2022. Methodology: Hundred participants at different ages were included in this study;70 were type 2 diabetic patients (cases) and 30 apparently healthy individual (control). 3 ml of venous blood were collected from the participants by using a sterile needle and syringe into a labeled plain container. Each sample was stood until complete clot occurs. Clotted blood sample was then centrifuged to obtain the serum. Then they were used for measurement of total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride and soluble CD36 levels. Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were measured using Biosystem chemistry analyzer BTS-302. Serum CD36 was measured using Microplate Reader (URIT-660). Results: The results revealed that serum total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels were significantly higher in patients with type 2 diabetes mellitus compared with control (P = 0.03, P = 0.031, P = 0.000, P = 0.000) respectively, while there is no statistically significant differences in serum CD36 level between cases and control (P = 0.129). Also this study showed that there is no statistically significant correlation between serum CD36 level and total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, age and body mass index. Conclusion: This study concluded that there is no statistically significant difference in serum CD36 level between cases and control. And sCD36 level was not correlated with total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, body mass index, and age.展开更多
Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was p...Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and SciELO.Randomized controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were included.Independent reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) evaluations.Total body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for meta-analysis.Results:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were included.RT groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to CG.However,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to CG.Conclusion:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.展开更多
Macronutrients serve as a source of energy for both gut microbiota and its host. An increase or decrease in macronutrients can either increase or decrease the composition of gut microbiota, leading to gut dysbiosis wh...Macronutrients serve as a source of energy for both gut microbiota and its host. An increase or decrease in macronutrients can either increase or decrease the composition of gut microbiota, leading to gut dysbiosis which has been implicated in many diseases state including non-communicable diseases. To achieve this, seven diets were formulated by restricting 60% of each macronutrient. These diets were fed on 42 albino rats (Wistar), divided into 7 groups of 6 rats each. Group 1 was fed on a normal laboratory chow diet (ND), group 2 received a fat-restricted diet (FRD), group 3 received a protein-restricted diet, (PFD), group 4 received a carbohydrate-restricted diet (CRD), group 5 received a protein and fat-restricted diet (PFRD), group 6 re-ceived a carbohydrate and fat-restricted diet (CFRD) and group 7 received a carbohydrate and protein-restricted diet (CPRD). Feed and water intake were given ad libitum and daily weight and food intake were recorded. The experiment went on for 4 weeks after which animals were sacrificed and intestinal content and blood were collected for analysis (gut microbial composition, glucose, insulin levels, serum lipid, and enzyme). Compared to the control group results showed a decrease in Bacteroides (40.50 - 14.00 CFU), HDL (68.20 - 40.40 mg/dl), and AST (66.62 - 64.74 U/L) in FRD. An increase in AST (66.6 - 69.43 U/L), Bifidobacterial (59.50 - 92.00 CFU) and decreased Bacteroides (40.5 - 19.5 CFU) for PRD was also recorded. CRD reduced Lactobacillus (73 - 33.5 CFU), total bacterial count (129 - 48 CFU), HDL (68.2 - 30.8 mg/dl), and cholesterol (121.44 - 88.65 mg/dl) whereas intestinal composition of E. coli (30.5 - 51.5 CFU) increased. PFRD increased Lactobacillus (73.00 - 102.5 CFU), Bifidobacterial (59.5 - 100 CFU), HDL (68.2 - 74.7 mg/dl), and Triglyceride (111.67 - 146.67 mg/dl) concentration. Meanwhile, a reduction in Bifidobacterial (59.5 - 41.5 CFU), and an increasing of AST (66.62 - 70.30 U/l) were recorded for CFRD. However, Bacteroides (40.5 69.5 CFU), LDL (30.95 - 41.98 mg/dl) increased and Bifidobacterial (59.5 - 38.00 CFU) and HDL (68.2 - 53.5 mg/dl) decreased for CPRD. This work, therefore, concludes that macronutrient restriction causes significant changes in serum marker and enzyme profile, and gut microbial composition which can cause gut dysbiosis and later on could expose the host to inflammatory diseases in the long run.展开更多
This study is to assess the potential factors that could affect the serum prostate-specific antigen (PSA) level in healthy younger men. We evaluated the associations of age, body mass index (BMI) and serum lipid p...This study is to assess the potential factors that could affect the serum prostate-specific antigen (PSA) level in healthy younger men. We evaluated the associations of age, body mass index (BMI) and serum lipid profile with serum PSA level in 6774 Chinese men (aged 20-49 years) who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight (〈18.5), normal (18.5-22.9), overweight (23.0-24.9), obese (25.0-29,9) and very obese (〉30) according to the redefined World Health Organization (WHO) criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age (P〈0.0001). Negative correlations existed between PSA and BMI (P〈0.0001) and triglyceride level (P=0.01). No relationship could be found between PSA and serum cholesterol (P=0.711) or high-density lipoprotein (HDL; P =0.665). In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.展开更多
Objective To investigate the effects of physical activity (PA) on dyslipidemia and elevated resting heart rate (RHR) in a large-scale cross-sectional study in China. Methods We recruited community-based individual...Objective To investigate the effects of physical activity (PA) on dyslipidemia and elevated resting heart rate (RHR) in a large-scale cross-sectional study in China. Methods We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants were classified as low, moderate, or high, using the International Physical Activity Questionnaire. Dyslipidemia was defined as the detection of abnormalities in lipid indicators, and 4 lipid parameters were evaluated using fasting blood samples. Multivariate logistic regression analyses were used to evaluate the associations of PA with dyslipidemia and RHR. Results A total of 10,321 participants (38.88% men) were included in this study. The percentages of individuals with high, moderate, and low PA levels were 46.5%, 43.9%, and 9.6%, respectively. In both men and women, high PA provided odds ratios of 0.88 [95% confidence interval (CI): 0.83, 0.94] for dyslipidemia and 0.82 (95% CI: 0.73, 0.92) for elevated RHR, compared to participants with low PA. Conclusion Our data suggested that substantial health benefits (related to dyslipidemia and elevated RHR) occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men.展开更多
Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) wa...Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.展开更多
Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the ...Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the performance, egg yolk and blood serum lipid profile of Isa Brown laying hens were investigated. A total of 96 layers were assigned into 4 groups to receive either 1 of 4 different diets contained 0.0%, 1.5%, 3.0% and 4.5% sesame oil, respectively. Sample of 12 eggs obtained from each groups were assessed for egg quality. The egg yolk fatty acid profile was determined with gas chromatography. Results revealed that the higher levels of sesame oil in the diet decreased egg production, egg weight, and egg yolk color except feed conversion ratio. In addition, supplementation of sesame oil increased the flow index of the eggs and the Haugh unite. The egg yolk lipid profile was not significantly different in the sesame oil fed groups, whereas, compare to control, it decreased the level of cholesterol. The blood serum lipid profile decreased in the sesame oil groups compare to control group. Meanwhile, monoacildigliserol also decreased in the sesame addition groups. In parallel with increasing levels of sesame oil, monounsaturated fatty acid (oleic acid) in the egg yolks significantly increased compared to the control (37.00%, 42.89%, 42.20% and 43.48%, respectively). It can be implied that sesame oil supplementation into the laying hens diet is necessary to produce monounsaturated fatty acid (MUFA) enriched eggs.展开更多
Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure...Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.展开更多
<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></s...<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></span><span><span><span style="font-family:;" "="">mortality and morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease. There have been numerous studies confirming the association of hyperlipidemias with coronary heart disease in most of the Western as well as Asian countries of the <span>world. But we have very little data on the relation between CHD and lipid</span> profile.</span></span></span><span><span><span style="font-family:;" "=""> <b>Aim of the Study:</b> The aim of this study was to assess abnormal lipid levels and their association with coronary heart disease.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Methods:</span></b></span></span><span><span><span style="font-family:;" "=""> This comparative observational study was conducted at the </span></span></span><span><span><span style="font-family:;" "="">Department of Cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh</span></span></span><span><span><span style="font-family:;" "=""> from January 2019 to December 2019. Properly written consent was taken from all the participants before starting the main part of the investigation. Obeying inclusion and exclusion criteria of the study, a total of 131 participants were finalized as the study population. Among them, the Case Group was formed with 90 pa<span>tients who had CHD, and with 41 healthy people, the Control Group was</span> <span>formed. All necessary data were collected, analyzed, and disseminated by</span> several programs of MS-Office and SPSS version 23. <b>Result:</b> The study was conducted with 90 case group participants and 41 control group participants. Among the case group, 78% were male and 22% were female. Among the male case group participants, 44.29% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 35.71% were from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age and the rest 20% were above 60 years of age. On the other hand, among the female participants of Case Group, 45% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 30% from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age, and 25% were over 60 years of age. Regression analysis between the male and the female showed the P-value of 0.242.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Serum cholesterol concentration and HDL concentration were significant between the Case and Control groups in all age groups and the P-value was <0.0001 in every age group. Triglyceride concentration was significant between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years age groups with a P-value of <0.0001. But in the >60 years age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-value was 0.478. LDL concentration between the groups showed significant correlations between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60-years’ age groups <span>where the P values were found, <0.0001 and 0.0002 respectively. But in </span>the >60 years’ age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">value was 0.515. <b>Conclusion:</b> In this study, it was found that the total choles<span>terol, triglycerides, HDL cholesterol, and LDL cholesterol concentrations </span>were significantly higher in coronary heart disease (CHD) patients.</span></span></span>展开更多
Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endo...Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprotein by the respective enzymatic colorimetric methods. In addition, low density lipoprotein and very low density lipoprotein were determined by Friedewald's formula. Results: The mean waist circumference (WC), hip circumference (HC), BMI, total cholesterol, low density lipoprotein, and LBP of the metabolic endotoxemia group were significantly higher (P<0.05) than those of the control group. WHR, TG, high density lipoprotein and very low density lipoprotein of the metabolic endotoxemia group were not significantly different (P>0.05) from those of the control group. The mean WC, HC, WHR, and BMI of the obese group with metabolic endotoxemia were significantly higher (P<0.05) than those of the overweight group and the normal weight group with metabolic endotoxemia. Significant positive correlations were obtained between BMI and LBP (r=0.610, P=0.001), total cholesterol and LBP (r=0.385, P=0.007), TG and LBP (r=0.356, P=0.014) in patients with metabolic endotoxemia. Conclusions: Metabolic endotoxemia arising from increased circulating level of bacterial derive particles consequent to perturbation in the gut microbial community and the elevated ;serum level of LBP may precede the development of obesity, characterized by dyslipidemia, dysregulation of gut energy harvest, and metabolic energy imbalance.展开更多
<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=&q...<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=""> </span><span "="">The most important modifiable risk factors of CVDs are unhealthy diet, physical inactivity and tobacco use. The effects of unhealthy diet and physical inactivity include abnormal blood lipid, obesity and hypertension. We tried to evaluate and correlate the pattern of lipid profile in obese and non-obese hypertensive patients. <b>Objectives:</b> This study was conducted at medicine department of Cumilla Medical College Hospital. The principal aim was to evaluate the lipid profile in obese and non-obese adult hypertensive patients. <b>Methodology:</b> During this cross sectional analytical study, </span>a total of<span "=""> </span>100 adult hypertensive patients were taken by purposive sampling. Among them 50<span "=""> </span>(group 1) patients were taken those were obese and 50<span "=""> </span>(group 2) patients taken those were non-obese according to BMI measurement on operational definition. Diagnosis of hypertension would be established with the help of ambulatory BP measurements two occasions few minutes apart. The staging of hypertension was done according to JNC7 Criteria. Morning blood samples were taken after 8<span "=""> </span>-<span "=""> </span>12 hours of fasting and lipid profiles were done on authentic laboratories. The laboratory values were interpreted according to the operational definition of dyslipidaemia. The ethical research and review committee approved the study protocol and signed informed consent was obtained from the participants. The statistics was analyzed using the IBM SPSS software of version 19.0.<span "=""> </span><span "="">Statistical significance was set at p < 0.05. <b>Results:</b> Among the two groups, there were 56 (56%) male</span>s and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was compared to that of group 2 (45.5 ± 10.6). Lipid profile abnormalities were significantly higher in the stage 2 hypertension<span "=""> </span>(59.62%) and stage 3 hypertension<span "=""> </span>(66.66%), higher in class 2 obese<span "=""> </span>(100%) and class 3 obese subjects<span "=""> </span>(100%),<span "=""> </span>female hypertensive patients had significantly higher BMI than their male counterparts<span "=""> </span>(27.24 ± 3.63<span "=""> </span><span "="">kg/m<sup>2</sup> versus 29.29 ± 3.99</span><span "=""> </span><span "="">kg/m<sup>2</sup>),</span><span "=""> </span>lipid profiles were higher in the female than male hypertensive patients (63.33% vs 55.35%) but only TC was statistically significant (4.45 ± 1.19<span "=""> </span>mmol/l versus 4.86 ± 1.29<span "=""> </span>mmol/l, p < 0.05). Those who were obese had significant high TG (p < 0.001), high TC (p < 0.001) and high LDL-C (p < 0.001). 38<span "=""> </span>(76%) of the obese hypertensive patients had dyslipidaemia whereas 21<span "=""> </span>(42%) of non-obese hypertensive patients had dyslipidaemia. In multivariate regression, TG was significantly and directly associated with BMI of subjects. Dyslipidaemia was more prevalent in the age group 30<span "=""> </span>-<span "=""> </span>59 of adult hypertensive patients. It showed that obese hypertensive patients had significantly higher SBP<span "=""> </span>(p < 0.001), DBP<span "=""> </span>(p < 0.001) than non-obese subjects. The mean TC (4.83 ± 0.95<span "=""> </span>mmol/l versus 4.15 ± 0.57<span "=""> </span>mmol/l, t = -9.70, p < 0.001), TG (2.64 ± 0.67<span "=""> </span>mmol/l versus 2.10 ± 0.45<span "=""> </span>mmol/l, t = -5.37, p < 0.001) and LDL-C (3.00 ± 0.82<span "=""> </span>mmol/l versus 2.44 ± 0.53<span "=""> </span>mmol/l, t = -9.11, p < 0.001) were also significantly higher among the hypertensive obese subjects. The mean HDL-C was however comparable in the two groups (1.25 ± 0.27<span "=""> </span>mmol/l versus 1.24 ± 0.57<span "=""> </span>mmol/l, t = -0.25, p = 0.08)... </div>展开更多
The International Symposium on Lipid Science and Health(ISLSH),which was organized annually by Oil Crops Research Institute of Chinese Academy of Agricultural Sciences(OCRI-CAAS)since 2016,has gained a strong reputati...The International Symposium on Lipid Science and Health(ISLSH),which was organized annually by Oil Crops Research Institute of Chinese Academy of Agricultural Sciences(OCRI-CAAS)since 2016,has gained a strong reputation and attracted hundreds of delegates from around the world for discussion of lipid research trends and advances every year,to promote research and academic exchanges in the fields of lipid science and health.The 5th International Symposium on lipid Science and Health was successfully held in Wuhan,China,from October 23rd to 25th,2020,to celebrate the 60th anniversary of OCRI-CAAS.The two-day symposium gathered wellknown experts specialized in lipid science to share the current state of lipid research with emphasis on aspects covering:(1)lipid profiling and characterization,(2)lipid preparation and modification,(3)lipid improvement and regulation,and(4)lipid nutrition and health.The symposium was conducted by a combination of on-site and network meeting.More than 250 distinguished delegates from academia and industry participated in the on-site multidisciplinary meeting,and thousands of scholars attended the virtual event.This paper is as a record of the symposium proceedings and a brief summary of the advances and trends in 4 aspects of lipid science and health.展开更多
Cigarette smoking is one of the major modifiable and environmental risk factors which can alter the lipid profile that leads to the progression of atherosclerosis and cardiovascular diseases. The aim of the current st...Cigarette smoking is one of the major modifiable and environmental risk factors which can alter the lipid profile that leads to the progression of atherosclerosis and cardiovascular diseases. The aim of the current study is to explore the association of cigarette smoking with Hyperlipidemia in male individuals. A cross-sectional study was carried out from March 2017 to Au-gust 2018 in Xuzhou, Jiangsu, China. A total of 1561 male individuals were enrolled in the study with a mean age (years) of 55.33 ± 14.41. We collected data on demographic, anthropometric and lifestyle indices. Total cholesterol (TC), triglyceride (TGL), and high-density lipoprotein cholesterol (HDL-C) were determined by the enzymatic colorimetric method. The mean level of serum TC, TG, and HDL-C were 4.85 ± 0.91, 1.69 ± 1.45 and 1.27 ± 0.32 mmol/L respectively. We found that age, body mass index, pack-years, marital status, annual household income, alcohol consumption, smoking status, education level, and occupational status have significant association with Hyperlipidemia. Adjusted multiple logistic regressions showed that in old age, smoking behavior can significantly increase the risk of Hyperlipidemia. With an increase in pack-years, a significant increase is found only in TC while decreasing trend noticed in HDL-C level. Current smokers showed a significant increase in the risk of Hyperlipidemia compared to those who never smoked while smoking cessation decreases the risk of Hyperlipidemia. This study concluded that cigarette smoking along with increased age and pack-years can significantly increase the risk of Hyperlipidemia that further leads to heart diseases.展开更多
<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.&...<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.展开更多
Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is produced by fungus of the genus Fusarium (Fusarium verticiloides and F. proliferatum), and occurs predominantly in maize. The consumption of feed con...Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is produced by fungus of the genus Fusarium (Fusarium verticiloides and F. proliferatum), and occurs predominantly in maize. The consumption of feed contaminated with FB<sub>1</sub> has been reported to cause deleterious effects in some fish species. This study was designed to determine the effects of dietary FB<sub>1</sub> on growth and lipids profile of Clarias gariepinus. 450 juvenile catfish were stocked into 5 groups of tanks consisting of 3 tanks per group and fed one of five diets amended with FB<sub>1</sub> (0.0 mg;10.0 mg;20.0 mg;40.0 mg and 80.0 mg FB<sub>1</sub>/kg) for 56 days. At time point’s day 7, 14, 28 and 56, five fish were sampled from each tank weighted, length measured and bled for of lipids profile determinations. Results show that there was a significant reduction (P < 0.05), in the mean body length of the fish fed diets amended with various amounts of FB<sub>1</sub> compared with those fed control diet;also, there was a significant reduction (P < 0.05) in the weight gain of fishes fed diets amended with FB<sub>1</sub> compared with the control. The specific growth rate and the feed conversion ratio at 56 days shows fish fed 0.0 mg FB<sub>1</sub>/kg had the highest specific growth rate (0.39 ± 0.14%/day) and the lowest feed conversion ratio (0.59 ± 0.01) whereas, fish fed 80.0 mg FB<sub>1</sub>/kg had the least specific growth rate (0.07% ± 0.01%/day) and the highest feed conversion ratio (1.95 ± 0.11). Dietary FB<sub>1</sub> caused significant increases (P < 0.05) in serum cholesterol, HDL-C;LDL-C;triglycerides and the sphinganine-sphingosine ratio. Dietary FB<sub>1</sub> at an inclusion rate ≥ 20 mg FB<sub>1</sub>/kg of diet produced significant reduction in weight gain and hyperlipidemia marked by hypercholesterolemia, increased blood high-density lipid cholesterol, increased blood low-density lipid cholesterol, elevated blood triglycerides and elevated sphinganine-sphingosine ratio.展开更多
基金funded by the National Key R&D Program of China(2022YFD1301001)the Natural Science Foundation of China(32072755).
文摘Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify this issue.Methods Twelve Holstein cows were randomly divided into two groups:conventional diet group(CON,n=6)and the HG diet group(n=6).On day 7 of week 4,rumen fluid was sampled to measure pH,milk was sampled to meas-ure components,and blood was sampled to measure biochemical parameters and fatty acid composition.After the experiment,cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.Results HG feeding decreased the ruminal pH,milk’s fat content and long-chain fatty acid proportion(P<0.05)and increased the proportion of short-and medium-chain fatty acids in the milk(P<0.05)as compared with CON diets.The concentrations of blood cholesterol,low-density lipoprotein,and polyunsaturated fatty acids in the HG cows were lower than those in CON cows(P<0.05).In muscle tissue,HG feeding tended to increase the triacylglycerol(TG)concentration(P<0.10).Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway,the regulation of lipolysis in the adipocytes pathway,and the PPAR signalling pathway.In adipose tissue,HG feeding increased the concentration of TG and decreased the concentration of C18:1 cis9(P<0.05).At the transcrip-tome level,the fatty acid biosynthesis pathway,linoleic acid metabolism pathway,and PPAR signalling pathway were activated.Conclusion HG feeding leads to subacute rumen acidosis and a decreased milk fat content.The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding.In muscle and adipose tissue,HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis,while down-regulated the expression of genes related to lipid transport.These results complement our knowledge of the fatty acid composi-tion of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.
文摘Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.
文摘Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dactylifera L</span></i><span style="font-family:Verdana;">.) El-Hayani cultivar on serum glucose and lipids profile in induced diabetic male albino rats. Palm pollen chemically analyzed besides chemical constituents, mineral contents, polyphenols </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> flavonoids. Male Albino rats (36</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">rats </span><span style="font-family:Verdana;">weight 170</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">190</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">gm) were divided </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> 6 groups. 1</span><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">Normal control (</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">), 2</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> Alloxanized diabetes control (+) (150</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mg/Kg rat body weight). Diabetic groups 3 and 4 had 0.5%,</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">1.0% date palm pollen, respectively, also diabetic </span><span style="font-family:Verdana;">group</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 5 and 6 had 100 ppm, 200 ppm date palm pollen extract, respectively. At the end of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">experiment</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (4 weeks) rats were fasted overnight and anesthetized and blood samples were taken for analysis of serum glucose, lipids profile </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> renal-hepatic function parameters, relative organ weight data obtained are </span><span style="font-family:Verdana;">statistically</span><span style="font-family:Verdana;"> analysis. Results showed that the major polyphenolic components were that e-vanillic acid (16.33 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), pyrogallol (15.02 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), epicatechin (11.04 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), catechin (10.96 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g). </span><span style="font-family:Verdana;">While,</span><span style="font-family:Verdana;"> date palm pollen was rich in hesperidin (8.84 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), Kaempferol 3</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">2 p-coumaroyl glucose (6.92 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), </span><span style="font-family:Verdana;">hesperitin</span><span style="font-family:Verdana;"> (5.10 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), rutin (3.11mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g) as flavonoids components. Date palm pollen has </span><span style="font-family:Verdana;">high</span><span style="font-family:Verdana;"> content of protein, calcium </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> iron (30.87 g/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g, 510.82 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 236.50 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), respectively. Also, serum glucose decreased significantly in diabetic groups (3, 4, 5 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 6, respectively) (179.47, 137.80, 156.77, 145.47 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">mL, respectively). Lipids profile, renal and liver functions were improved </span><span style="font-family:Verdana;">significant</span></span><span style="font-family:Verdana;">ly</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (P < 0.05) in diabetic groups </span><span style="font-family:Verdana;">which had</span><span style="font-family:Verdana;"> date palm pollen or its extracts.</span></span><span> </span><span style="font-family:Verdana;">It is concluded that the dried date palm pollen 1% in the diet and 200 ppm extract are more effective compared with controlling diabetes mellitus, also improve renal and liver functions. Diabetics are advised to eat date palm pollen</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> are considered treatment foods for Diabetes Mellitus.</span>
文摘Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and apolipoprotein by automatic biochemic analytical instrument; T cell subsets by flow cytometer; and MDA, SOD were evaluated by the thiobarbituric acid (TBA) test and the nitrite method modified by Oyanagui respectively using spectrophotometry. Results In men, the serum levels of follicle stimulating hormone ( FSH)、luteinizing hormone(LH) increased significantly with aging, but serum prolactin(PRL) and progesterone(P) levels remained unchanged in all life; Both testosterone (T) and free testosterone (FT) all decreased greatly with aging, but 17β - estradiol( 17β - E_2) was reverse ; E_2 was negatively correlated with T and E_2/T increased with aging. The level of serum total cholesterol (TC) increased with aging, but triglycerides (TG) remain unchanged; compared with young group, high - density lipoprotein cholesterol ( HDL - C) ; HDL - C/TC of other groups decreased significantly, but low - density lipoprotein cholesterol ( LDL - C ) changed inversely; HDL- C/LDL- C reduced slightly with aging and showed no difference between groups. Apolipoprotein A1 (apoA1) and apoB all enhanced greatly with aging; meanwhile the ratio of apoA1/apoB decreased. The concentration of serum glucose (GLU) was unchanged in all life. To compare with those in the young group, CD3 + , CD4 + in other groups reduced greatly, CD4 + remained unchanged. Meanwhile, CD8 + increased significantly with aging. Compared with the young group, serum malondialdehyde(MDA) value of the old ones increased obviously, but the activity of superoxide dismutase(SOD) was reverse. By partial correlation analysis (controlling BMI, FSH, LH and PRL), TC、 LDL-C、apoA1、apoB、CD8 + 、MDA of men all presented a positive correlation with E_2/T respectively, their correlation coefficients (γ) were 0. 262、0. 136、 0. 532、0. 379、0. 394、0. 234 (P < 0. 001 ) ; HDL - C、 HDL- C/TC、HDL- C/LDL- C、CD3 + 、CD4 +/CD8 + 、SOD showed a negatively correlation with E_2/T respectively, γequaled - 0.563、- 0.332、- 0.654、- 0.1530、-0.4140、-0.236(P<0.001). In women, the serum concentrations of FSH、LH increased significantly after menopause; PRL increased little with aging; compared with young group, E_2 and P in postmenopausal groups reduced obviously, E_2/P revealed significant reduce with aging. T enhanced significantly after menopause, but nor did FT. E_2, P and the ratio of E_2/P were negatively correlated with age respectively by bivariate correlation analysis, and a positive relation between T and age. After 70 years old, the level of TC increased obviously, and so did that of TG after menopause; HDL decreased with aging, but LDL increased after 70, with the result that the ratios of HDL- C/TC and HDL- C/LDL- C all reduced with aging; apoA1 decreased gently after 70, but apoB increased signifi- cantly after menopause; correspondingly, the ratio of apoA1/apoB declined obviously. The concentration of GLU increased with aging. CD3 + and CD4 + didn't change until 60, but reduced after 60. Compared with the young groups, CD8 + remained unchanged, CD4 +/CD8 + reduced greatly with aging, CD4 + and CD8 + presented a negatively correlation with age respectively. The value of MDA in serum of women increased notably after 70 years old, but SOD activity already decreased significantly from 60. By partial correlation analysis (controlling BMI, FSH, LH and PRL), HDL-C、CD4 +、CD4 +/CD8 + showed a certain correlation with E_2/P respectively; γ were 0. 245、 0.157、0. 154 ( P <0.05 ) ; TG、 LDL、 apoB、 apoA1/ apoB、SOD presented a negatively correlation with E_2/P respectively, γ were 0. 452、 0. 236、 0.321、 0. 135、 0.156、0.154、0.426 ( P < 0.05 ). Conclusions The Disequilibrium of SH had correlations with lipid profile, cellular immunological function and lipid peroxides and oxidation system; these suggested SH took an important role in the process of aging.
基金Supported by Jiangsu Elderly Health Research Project,No.LD2021010Jiangsu Elderly Health Research Project,Key Project of Elderly Health Research Project,No.LKZ2022010Open Project of National Key Professional Base for Standardized Training of Resident Physicians in Zhongda Hospital Affiliated to Southeast University,No.ZDZYJD-QK-2022-7.
文摘BACKGROUND The prevalence of osteoporosis and low bone mass is steadily rising each year.Low body weight is commonly linked to diminished bone mass and serves as a robust predictor of osteoporosis.Nonetheless,the connection between body mass index(BMI),bone mineral density,and lipid profiles among the elderly remains elusive.AIM To examine the association between BMI and bone mass,explore the correlation between lipid profiles and bone mass,and delve into the interplay between lipid metabolism and bone health.METHODS The study included 520 patients aged≥65 years(178 men and 342 women).Age,sex,weight,and height were recorded.Femoral neck bone mineral density and T scores were determined using a dual-energy X-ray absorptiometry scanner.Blood calcium(Ca),phosphorus(P),albumin(ALB),alkaline phosphatase(ALP),aspartate aminotransferase,alanine aminotransferase,triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL)and low-density lipoprotein(LDL)levels were measured.Patients were classified by sex(male and female),age(65-79 years and≥80 years),and T score(normal bone mineral density,osteopenia and osteoporosis).RESULTS Age,sex,BMI,and ALP and TG levels were independent risk factors for osteoporosis.For the 65-79-and≥80-yearold groups,females presented lower T scores than males.Ca,P,ALB,ALP,TC,HDL and LDL levels were significantly different between men and women in the 65-79-year-old group.In addition,BMI and TG levels were significantly decreased in osteoporotic patients compared with patients with normal bone mass.TC levels declined in 65-to 79-year-old male and female osteoporosis patients.In the group of women aged≥80 years,osteoporotic patients showed significantly increased ALP levels.Furthermore,we found positive correlations between BMI and TG levels in the male and female patient groups.However,we found no significant differences in ALB,Ca,P,HDL and LDL levels in osteoporotic patients compared to patients with normal bone mass.CONCLUSION Osteoporotic patients showed significantly decreased BMI and TG levels compared with those with normal bone mass.BMI showed positive correlations with TG levels in male and female patients.These results indicate correlations between BMI and bone mass and between lipid profiles and bone mass.
文摘Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia. DM-related dyslipidemia are associated with complications resulting from progressive damage of various organs. CD36 is 88-kD, class B scavenger receptor, expressed on different types of cells. In diabetic patients, LDL particles are glycated with strong level;this increases CD36 expression, initiates foam cell formation and accelerates atherosclerosis. Objective: This study aimed to determine the correlation between serum CD36 level and lipid profile among patients with type 2 diabetes mellitus in Zeenam Specialized center, Khartoum State, Sudan, in a period between 2019 and 2022. Methodology: Hundred participants at different ages were included in this study;70 were type 2 diabetic patients (cases) and 30 apparently healthy individual (control). 3 ml of venous blood were collected from the participants by using a sterile needle and syringe into a labeled plain container. Each sample was stood until complete clot occurs. Clotted blood sample was then centrifuged to obtain the serum. Then they were used for measurement of total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride and soluble CD36 levels. Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were measured using Biosystem chemistry analyzer BTS-302. Serum CD36 was measured using Microplate Reader (URIT-660). Results: The results revealed that serum total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels were significantly higher in patients with type 2 diabetes mellitus compared with control (P = 0.03, P = 0.031, P = 0.000, P = 0.000) respectively, while there is no statistically significant differences in serum CD36 level between cases and control (P = 0.129). Also this study showed that there is no statistically significant correlation between serum CD36 level and total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, age and body mass index. Conclusion: This study concluded that there is no statistically significant difference in serum CD36 level between cases and control. And sCD36 level was not correlated with total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, body mass index, and age.
基金supported by the Minas Gerais State University (UEMG/Brazil)a Research Productivity Scholarship Program (UEMG-PQ08/2021)+1 种基金a doctorate scholarship from the National Council of Technological and Scientific Development (CNPq/Brazil-Process140473/2020-3)a doctorate scholarship fromthe Coordination of Improvement of Higher Education Personnel (CAPES/Brazil-Code 001)。
文摘Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and SciELO.Randomized controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were included.Independent reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) evaluations.Total body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for meta-analysis.Results:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were included.RT groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to CG.However,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to CG.Conclusion:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.
文摘Macronutrients serve as a source of energy for both gut microbiota and its host. An increase or decrease in macronutrients can either increase or decrease the composition of gut microbiota, leading to gut dysbiosis which has been implicated in many diseases state including non-communicable diseases. To achieve this, seven diets were formulated by restricting 60% of each macronutrient. These diets were fed on 42 albino rats (Wistar), divided into 7 groups of 6 rats each. Group 1 was fed on a normal laboratory chow diet (ND), group 2 received a fat-restricted diet (FRD), group 3 received a protein-restricted diet, (PFD), group 4 received a carbohydrate-restricted diet (CRD), group 5 received a protein and fat-restricted diet (PFRD), group 6 re-ceived a carbohydrate and fat-restricted diet (CFRD) and group 7 received a carbohydrate and protein-restricted diet (CPRD). Feed and water intake were given ad libitum and daily weight and food intake were recorded. The experiment went on for 4 weeks after which animals were sacrificed and intestinal content and blood were collected for analysis (gut microbial composition, glucose, insulin levels, serum lipid, and enzyme). Compared to the control group results showed a decrease in Bacteroides (40.50 - 14.00 CFU), HDL (68.20 - 40.40 mg/dl), and AST (66.62 - 64.74 U/L) in FRD. An increase in AST (66.6 - 69.43 U/L), Bifidobacterial (59.50 - 92.00 CFU) and decreased Bacteroides (40.5 - 19.5 CFU) for PRD was also recorded. CRD reduced Lactobacillus (73 - 33.5 CFU), total bacterial count (129 - 48 CFU), HDL (68.2 - 30.8 mg/dl), and cholesterol (121.44 - 88.65 mg/dl) whereas intestinal composition of E. coli (30.5 - 51.5 CFU) increased. PFRD increased Lactobacillus (73.00 - 102.5 CFU), Bifidobacterial (59.5 - 100 CFU), HDL (68.2 - 74.7 mg/dl), and Triglyceride (111.67 - 146.67 mg/dl) concentration. Meanwhile, a reduction in Bifidobacterial (59.5 - 41.5 CFU), and an increasing of AST (66.62 - 70.30 U/l) were recorded for CFRD. However, Bacteroides (40.5 69.5 CFU), LDL (30.95 - 41.98 mg/dl) increased and Bifidobacterial (59.5 - 38.00 CFU) and HDL (68.2 - 53.5 mg/dl) decreased for CPRD. This work, therefore, concludes that macronutrient restriction causes significant changes in serum marker and enzyme profile, and gut microbial composition which can cause gut dysbiosis and later on could expose the host to inflammatory diseases in the long run.
文摘This study is to assess the potential factors that could affect the serum prostate-specific antigen (PSA) level in healthy younger men. We evaluated the associations of age, body mass index (BMI) and serum lipid profile with serum PSA level in 6774 Chinese men (aged 20-49 years) who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight (〈18.5), normal (18.5-22.9), overweight (23.0-24.9), obese (25.0-29,9) and very obese (〉30) according to the redefined World Health Organization (WHO) criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age (P〈0.0001). Negative correlations existed between PSA and BMI (P〈0.0001) and triglyceride level (P=0.01). No relationship could be found between PSA and serum cholesterol (P=0.711) or high-density lipoprotein (HDL; P =0.665). In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.
文摘Objective To investigate the effects of physical activity (PA) on dyslipidemia and elevated resting heart rate (RHR) in a large-scale cross-sectional study in China. Methods We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants were classified as low, moderate, or high, using the International Physical Activity Questionnaire. Dyslipidemia was defined as the detection of abnormalities in lipid indicators, and 4 lipid parameters were evaluated using fasting blood samples. Multivariate logistic regression analyses were used to evaluate the associations of PA with dyslipidemia and RHR. Results A total of 10,321 participants (38.88% men) were included in this study. The percentages of individuals with high, moderate, and low PA levels were 46.5%, 43.9%, and 9.6%, respectively. In both men and women, high PA provided odds ratios of 0.88 [95% confidence interval (CI): 0.83, 0.94] for dyslipidemia and 0.82 (95% CI: 0.73, 0.92) for elevated RHR, compared to participants with low PA. Conclusion Our data suggested that substantial health benefits (related to dyslipidemia and elevated RHR) occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men.
基金supported by the Tokushima prefectural government
文摘Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.
文摘Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the performance, egg yolk and blood serum lipid profile of Isa Brown laying hens were investigated. A total of 96 layers were assigned into 4 groups to receive either 1 of 4 different diets contained 0.0%, 1.5%, 3.0% and 4.5% sesame oil, respectively. Sample of 12 eggs obtained from each groups were assessed for egg quality. The egg yolk fatty acid profile was determined with gas chromatography. Results revealed that the higher levels of sesame oil in the diet decreased egg production, egg weight, and egg yolk color except feed conversion ratio. In addition, supplementation of sesame oil increased the flow index of the eggs and the Haugh unite. The egg yolk lipid profile was not significantly different in the sesame oil fed groups, whereas, compare to control, it decreased the level of cholesterol. The blood serum lipid profile decreased in the sesame oil groups compare to control group. Meanwhile, monoacildigliserol also decreased in the sesame addition groups. In parallel with increasing levels of sesame oil, monounsaturated fatty acid (oleic acid) in the egg yolks significantly increased compared to the control (37.00%, 42.89%, 42.20% and 43.48%, respectively). It can be implied that sesame oil supplementation into the laying hens diet is necessary to produce monounsaturated fatty acid (MUFA) enriched eggs.
文摘Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.
文摘<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></span><span><span><span style="font-family:;" "="">mortality and morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease. There have been numerous studies confirming the association of hyperlipidemias with coronary heart disease in most of the Western as well as Asian countries of the <span>world. But we have very little data on the relation between CHD and lipid</span> profile.</span></span></span><span><span><span style="font-family:;" "=""> <b>Aim of the Study:</b> The aim of this study was to assess abnormal lipid levels and their association with coronary heart disease.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Methods:</span></b></span></span><span><span><span style="font-family:;" "=""> This comparative observational study was conducted at the </span></span></span><span><span><span style="font-family:;" "="">Department of Cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh</span></span></span><span><span><span style="font-family:;" "=""> from January 2019 to December 2019. Properly written consent was taken from all the participants before starting the main part of the investigation. Obeying inclusion and exclusion criteria of the study, a total of 131 participants were finalized as the study population. Among them, the Case Group was formed with 90 pa<span>tients who had CHD, and with 41 healthy people, the Control Group was</span> <span>formed. All necessary data were collected, analyzed, and disseminated by</span> several programs of MS-Office and SPSS version 23. <b>Result:</b> The study was conducted with 90 case group participants and 41 control group participants. Among the case group, 78% were male and 22% were female. Among the male case group participants, 44.29% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 35.71% were from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age and the rest 20% were above 60 years of age. On the other hand, among the female participants of Case Group, 45% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 30% from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age, and 25% were over 60 years of age. Regression analysis between the male and the female showed the P-value of 0.242.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Serum cholesterol concentration and HDL concentration were significant between the Case and Control groups in all age groups and the P-value was <0.0001 in every age group. Triglyceride concentration was significant between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years age groups with a P-value of <0.0001. But in the >60 years age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-value was 0.478. LDL concentration between the groups showed significant correlations between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60-years’ age groups <span>where the P values were found, <0.0001 and 0.0002 respectively. But in </span>the >60 years’ age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">value was 0.515. <b>Conclusion:</b> In this study, it was found that the total choles<span>terol, triglycerides, HDL cholesterol, and LDL cholesterol concentrations </span>were significantly higher in coronary heart disease (CHD) patients.</span></span></span>
文摘Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprotein by the respective enzymatic colorimetric methods. In addition, low density lipoprotein and very low density lipoprotein were determined by Friedewald's formula. Results: The mean waist circumference (WC), hip circumference (HC), BMI, total cholesterol, low density lipoprotein, and LBP of the metabolic endotoxemia group were significantly higher (P<0.05) than those of the control group. WHR, TG, high density lipoprotein and very low density lipoprotein of the metabolic endotoxemia group were not significantly different (P>0.05) from those of the control group. The mean WC, HC, WHR, and BMI of the obese group with metabolic endotoxemia were significantly higher (P<0.05) than those of the overweight group and the normal weight group with metabolic endotoxemia. Significant positive correlations were obtained between BMI and LBP (r=0.610, P=0.001), total cholesterol and LBP (r=0.385, P=0.007), TG and LBP (r=0.356, P=0.014) in patients with metabolic endotoxemia. Conclusions: Metabolic endotoxemia arising from increased circulating level of bacterial derive particles consequent to perturbation in the gut microbial community and the elevated ;serum level of LBP may precede the development of obesity, characterized by dyslipidemia, dysregulation of gut energy harvest, and metabolic energy imbalance.
文摘<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=""> </span><span "="">The most important modifiable risk factors of CVDs are unhealthy diet, physical inactivity and tobacco use. The effects of unhealthy diet and physical inactivity include abnormal blood lipid, obesity and hypertension. We tried to evaluate and correlate the pattern of lipid profile in obese and non-obese hypertensive patients. <b>Objectives:</b> This study was conducted at medicine department of Cumilla Medical College Hospital. The principal aim was to evaluate the lipid profile in obese and non-obese adult hypertensive patients. <b>Methodology:</b> During this cross sectional analytical study, </span>a total of<span "=""> </span>100 adult hypertensive patients were taken by purposive sampling. Among them 50<span "=""> </span>(group 1) patients were taken those were obese and 50<span "=""> </span>(group 2) patients taken those were non-obese according to BMI measurement on operational definition. Diagnosis of hypertension would be established with the help of ambulatory BP measurements two occasions few minutes apart. The staging of hypertension was done according to JNC7 Criteria. Morning blood samples were taken after 8<span "=""> </span>-<span "=""> </span>12 hours of fasting and lipid profiles were done on authentic laboratories. The laboratory values were interpreted according to the operational definition of dyslipidaemia. The ethical research and review committee approved the study protocol and signed informed consent was obtained from the participants. The statistics was analyzed using the IBM SPSS software of version 19.0.<span "=""> </span><span "="">Statistical significance was set at p < 0.05. <b>Results:</b> Among the two groups, there were 56 (56%) male</span>s and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was compared to that of group 2 (45.5 ± 10.6). Lipid profile abnormalities were significantly higher in the stage 2 hypertension<span "=""> </span>(59.62%) and stage 3 hypertension<span "=""> </span>(66.66%), higher in class 2 obese<span "=""> </span>(100%) and class 3 obese subjects<span "=""> </span>(100%),<span "=""> </span>female hypertensive patients had significantly higher BMI than their male counterparts<span "=""> </span>(27.24 ± 3.63<span "=""> </span><span "="">kg/m<sup>2</sup> versus 29.29 ± 3.99</span><span "=""> </span><span "="">kg/m<sup>2</sup>),</span><span "=""> </span>lipid profiles were higher in the female than male hypertensive patients (63.33% vs 55.35%) but only TC was statistically significant (4.45 ± 1.19<span "=""> </span>mmol/l versus 4.86 ± 1.29<span "=""> </span>mmol/l, p < 0.05). Those who were obese had significant high TG (p < 0.001), high TC (p < 0.001) and high LDL-C (p < 0.001). 38<span "=""> </span>(76%) of the obese hypertensive patients had dyslipidaemia whereas 21<span "=""> </span>(42%) of non-obese hypertensive patients had dyslipidaemia. In multivariate regression, TG was significantly and directly associated with BMI of subjects. Dyslipidaemia was more prevalent in the age group 30<span "=""> </span>-<span "=""> </span>59 of adult hypertensive patients. It showed that obese hypertensive patients had significantly higher SBP<span "=""> </span>(p < 0.001), DBP<span "=""> </span>(p < 0.001) than non-obese subjects. The mean TC (4.83 ± 0.95<span "=""> </span>mmol/l versus 4.15 ± 0.57<span "=""> </span>mmol/l, t = -9.70, p < 0.001), TG (2.64 ± 0.67<span "=""> </span>mmol/l versus 2.10 ± 0.45<span "=""> </span>mmol/l, t = -5.37, p < 0.001) and LDL-C (3.00 ± 0.82<span "=""> </span>mmol/l versus 2.44 ± 0.53<span "=""> </span>mmol/l, t = -9.11, p < 0.001) were also significantly higher among the hypertensive obese subjects. The mean HDL-C was however comparable in the two groups (1.25 ± 0.27<span "=""> </span>mmol/l versus 1.24 ± 0.57<span "=""> </span>mmol/l, t = -0.25, p = 0.08)... </div>
基金supported by the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAASASTIP-2016-OCRI).
文摘The International Symposium on Lipid Science and Health(ISLSH),which was organized annually by Oil Crops Research Institute of Chinese Academy of Agricultural Sciences(OCRI-CAAS)since 2016,has gained a strong reputation and attracted hundreds of delegates from around the world for discussion of lipid research trends and advances every year,to promote research and academic exchanges in the fields of lipid science and health.The 5th International Symposium on lipid Science and Health was successfully held in Wuhan,China,from October 23rd to 25th,2020,to celebrate the 60th anniversary of OCRI-CAAS.The two-day symposium gathered wellknown experts specialized in lipid science to share the current state of lipid research with emphasis on aspects covering:(1)lipid profiling and characterization,(2)lipid preparation and modification,(3)lipid improvement and regulation,and(4)lipid nutrition and health.The symposium was conducted by a combination of on-site and network meeting.More than 250 distinguished delegates from academia and industry participated in the on-site multidisciplinary meeting,and thousands of scholars attended the virtual event.This paper is as a record of the symposium proceedings and a brief summary of the advances and trends in 4 aspects of lipid science and health.
文摘Cigarette smoking is one of the major modifiable and environmental risk factors which can alter the lipid profile that leads to the progression of atherosclerosis and cardiovascular diseases. The aim of the current study is to explore the association of cigarette smoking with Hyperlipidemia in male individuals. A cross-sectional study was carried out from March 2017 to Au-gust 2018 in Xuzhou, Jiangsu, China. A total of 1561 male individuals were enrolled in the study with a mean age (years) of 55.33 ± 14.41. We collected data on demographic, anthropometric and lifestyle indices. Total cholesterol (TC), triglyceride (TGL), and high-density lipoprotein cholesterol (HDL-C) were determined by the enzymatic colorimetric method. The mean level of serum TC, TG, and HDL-C were 4.85 ± 0.91, 1.69 ± 1.45 and 1.27 ± 0.32 mmol/L respectively. We found that age, body mass index, pack-years, marital status, annual household income, alcohol consumption, smoking status, education level, and occupational status have significant association with Hyperlipidemia. Adjusted multiple logistic regressions showed that in old age, smoking behavior can significantly increase the risk of Hyperlipidemia. With an increase in pack-years, a significant increase is found only in TC while decreasing trend noticed in HDL-C level. Current smokers showed a significant increase in the risk of Hyperlipidemia compared to those who never smoked while smoking cessation decreases the risk of Hyperlipidemia. This study concluded that cigarette smoking along with increased age and pack-years can significantly increase the risk of Hyperlipidemia that further leads to heart diseases.
文摘<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.
文摘Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is produced by fungus of the genus Fusarium (Fusarium verticiloides and F. proliferatum), and occurs predominantly in maize. The consumption of feed contaminated with FB<sub>1</sub> has been reported to cause deleterious effects in some fish species. This study was designed to determine the effects of dietary FB<sub>1</sub> on growth and lipids profile of Clarias gariepinus. 450 juvenile catfish were stocked into 5 groups of tanks consisting of 3 tanks per group and fed one of five diets amended with FB<sub>1</sub> (0.0 mg;10.0 mg;20.0 mg;40.0 mg and 80.0 mg FB<sub>1</sub>/kg) for 56 days. At time point’s day 7, 14, 28 and 56, five fish were sampled from each tank weighted, length measured and bled for of lipids profile determinations. Results show that there was a significant reduction (P < 0.05), in the mean body length of the fish fed diets amended with various amounts of FB<sub>1</sub> compared with those fed control diet;also, there was a significant reduction (P < 0.05) in the weight gain of fishes fed diets amended with FB<sub>1</sub> compared with the control. The specific growth rate and the feed conversion ratio at 56 days shows fish fed 0.0 mg FB<sub>1</sub>/kg had the highest specific growth rate (0.39 ± 0.14%/day) and the lowest feed conversion ratio (0.59 ± 0.01) whereas, fish fed 80.0 mg FB<sub>1</sub>/kg had the least specific growth rate (0.07% ± 0.01%/day) and the highest feed conversion ratio (1.95 ± 0.11). Dietary FB<sub>1</sub> caused significant increases (P < 0.05) in serum cholesterol, HDL-C;LDL-C;triglycerides and the sphinganine-sphingosine ratio. Dietary FB<sub>1</sub> at an inclusion rate ≥ 20 mg FB<sub>1</sub>/kg of diet produced significant reduction in weight gain and hyperlipidemia marked by hypercholesterolemia, increased blood high-density lipid cholesterol, increased blood low-density lipid cholesterol, elevated blood triglycerides and elevated sphinganine-sphingosine ratio.