Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these syste...Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these systems. The FRPS on HL-2A is developed, which is composed of transmission bar, digital grating displacement system, electromagnetic valves, stepping motor and so on. The high-pressure gas from the electromagnetic valves controlled by trigger signals provides the power to drive the transmission bar forward or backward. Reciprocating distance is 8 cm with the maximum speed of 1.5 m·s^-1.展开更多
Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolit...Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulationof the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditionalbiochemical methods are insufficient to systematically investigate the bio-molecular reactions for a high-throughput discovery. Here, we have reviewed an update on the recently developed chemical proteomicscalled activity-based protein profiling （ABPP）. ABPP is able to identify proteins interacted eithercovalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characteriza-tion of specific metabolite regulating; proteins in human disease progression.展开更多
文摘Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these systems. The FRPS on HL-2A is developed, which is composed of transmission bar, digital grating displacement system, electromagnetic valves, stepping motor and so on. The high-pressure gas from the electromagnetic valves controlled by trigger signals provides the power to drive the transmission bar forward or backward. Reciprocating distance is 8 cm with the maximum speed of 1.5 m·s^-1.
基金supported by the National Natural Science Foundation of China(No.81672440)Innovation Program of Science and Research from the DICP,CAS(No.DICP TMSR201601)the 100 Talents Program of Chinese Academy of Sciences
文摘Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulationof the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditionalbiochemical methods are insufficient to systematically investigate the bio-molecular reactions for a high-throughput discovery. Here, we have reviewed an update on the recently developed chemical proteomicscalled activity-based protein profiling （ABPP）. ABPP is able to identify proteins interacted eithercovalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characteriza-tion of specific metabolite regulating; proteins in human disease progression.
