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Prognostic significance of annexin VII expression in glioblastomas multiforme in humans 被引量:14
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作者 Hung KS Howng SL 《中国神经肿瘤杂志》 2003年第4期199-199,共1页
OBJECT:Glioblastoma multiforme(GBM)is the most common and lethal primary brain tumor in adults.It isnearly uniformly fatal,with a median survival time of approximately l year,despite modem treatment modalities.Neverth... OBJECT:Glioblastoma multiforme(GBM)is the most common and lethal primary brain tumor in adults.It isnearly uniformly fatal,with a median survival time of approximately l year,despite modem treatment modalities.Nevertheless,a range of survival times exists around this median.Efforts to understand why some patients livelonger or shorter than the average may provide insight into the biology of these neoplasms.The annexin VII(ANX7)gene is located on the human chromosome 10q21,a site long hypothesized to harbor tumor 展开更多
关键词 in of prognostic significance of annexin VII expression in glioblastomas multiforme in humans MIB
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Prognostic significance of carbonic anhydrase IX expression in clear cell renal cell carcinoma
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作者 叶烈夫 《外科研究与新技术》 2011年第4期242-242,共1页
Objective To evaluate the prognostic significance of carbonic anhydrase IX ( CA IX) expression in patients with clear cell renal cell carcinoma ( ccRCC) . Methods CA IX excression in a cohort of 120 patients with ccRC... Objective To evaluate the prognostic significance of carbonic anhydrase IX ( CA IX) expression in patients with clear cell renal cell carcinoma ( ccRCC) . Methods CA IX excression in a cohort of 120 patients with ccRCC was evaluated by P-V immunohistochemistry 展开更多
关键词 IX prognostic significance of carbonic anhydrase IX expression in clear cell renal cell carcinoma CELL
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Prognostic Significance of MiR-34a Expression in Patients with Gastric Cancer after Radical Gastrectomy 被引量:7
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作者 Wen.Tao Hui Xiao-Bin Ma +2 位作者 Ying Zan Xi-Jing Wang Lei Dong 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第19期2632-2637,共6页
Background: MiR-34a dysregulation has been implicated in tumorigenesis and progression of gastric cancer, but its role in prognosis of patients with gastric cancer remains unknown. The aim of this study was to invest... Background: MiR-34a dysregulation has been implicated in tumorigenesis and progression of gastric cancer, but its role in prognosis of patients with gastric cancer remains unknown. The aim of this study was to investigate the expression and prognostic significance of miR-34a in gastric cancer patients after radical gastrectomy. Methods: Quantitative real-time polymerase chain reaction was performed to detect the expression of miR-34a in human gastric cancer cell lines and tissues in 76 patients with gastric adenocarcinoma from China. Results are assessed for association with clinical features and overall survival (OS) using Kaplan-Meier analysis. Prognostic values of miR-34a expression and clinical outcomes were evaluated by Cox regression analysis. A molecular prognostic stratification scheme incorporating miR-34a expression was determined using receiver operating characteristic analysis. Results: The results show that the expression level of miR-34a was decreased in human gastric cancer cell lines and tissues, and down-regulated expression of miR-34a was associated with Lauren classification (P = 0.034). Decreased miR-34a expression in gastric cancer tissues was positively correlated with poor OS of gastric cancer patients (P = 0.0 l 3). Further multivariate Cox regression analysis suggested that miR-34a expression was an independent prognostic indicator for gastric cancer (P = 0.027). Applying the prognostic value of miR-34a expression to tumor node metastasis (TNM) stage system showed a better prognostic value in patients with gastric cancer than miR-34a expression (P = 0.0435) or TNM stage (P = 0.0249) alone. Conclusion: The results reinforce the critical role for the down-regulated miR-34a expression in gastric cancer and suggest that miR-34a could be a prognostic indicator for this disease. 展开更多
关键词 Gastric Cancer MIR-34A Overall Survival prognostic significance Radical Gastrectomy
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QUANTITATION OF P53 PROTEIN EXPRESSION IN GASTROINTESTINAL SMOOTH MUSCLE TUMORSCLINICOPATHOLOGICAL CORRELATION AND PROGNOSTIC SIGNIFICANCE 被引量:3
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作者 蔡建辉 蒋贻康 +4 位作者 张玉印 吕贵华 张祥宏 高清泽 左连富 《Chinese Medical Journal》 SCIE CAS CSCD 1995年第9期31-35,共5页
Quantitative analysis of P53 protein expression was performed on paraffin-embedded tissues from 55 smooth muscle tumors of the gastrointestinal tract, using immunofluo-rescence and flow cytometry. No positive expressi... Quantitative analysis of P53 protein expression was performed on paraffin-embedded tissues from 55 smooth muscle tumors of the gastrointestinal tract, using immunofluo-rescence and flow cytometry. No positive expression was found in normal smooth muscle tissues of the gastrointestinal tract. Over-expression of P53 gene was found in a significantly higher proportion in leiomyosarcomas (90%) and potentially malignant smooth muscle tumors (75%) as compared to leiomyomas (14%) (P< 0.005). The quantitation of P53 expression was found to be progressively enhanced in the sequence from leiomyoma through potentially malignant smooth muscle tumor to leiomyosarcoma (P< 0.005). It was markedly over-expressed when the mitotic counts ranged from one to more than one per 10 high power fields (P< 0.005) or the mild cytologic atypia was found (P< 0.005). The five-year survival rate was significantly higher in patients with low-expression of P53 than in those with over-expression of P53 (P< 0.005). It was suggested that P53 over-expression might be associated with the transformation of leiomyoma into leiomyosarcoma and could be used as an objective parameter in distinguishing the malignant from the benign and predicting the prognosis of patients with smooth muscle rumors of the gastrointestinal tract. 展开更多
关键词 In QUANTITATION OF P53 PROTEIN EXPRESSION IN GASTROINTESTINAL SMOOTH MUSCLE TUMORSCLINICOPATHOLOGICAL CORRELATION AND prognostic significance HPF OVER
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Relationship between microsatellite instability and hepatocyte growth factor expression and their prognostic significance in colorectal cancer
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作者 杨光 《China Medical Abstracts(Internal Medicine)》 2016年第3期164-165,共2页
Objective To investigate the expression of hepatocyte growth factor(HGF)and its relationship with microsatellite instability(MSI)and their influence on survival in patients with colorectal cancer.Methods Immunohistoch... Objective To investigate the expression of hepatocyte growth factor(HGF)and its relationship with microsatellite instability(MSI)and their influence on survival in patients with colorectal cancer.Methods Immunohistochemistry(IHC)was used to detect the expression of HGF and MSI in 98 specimens of colorectal cancer.Tumors lacking protein expression of any of the our mis- 展开更多
关键词 MSI Relationship between microsatellite instability and hepatocyte growth factor expression and their prognostic significance in colorectal cancer HGF
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Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa,the Democratic Republic of the Congo 被引量:1
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作者 Josée K.Tshituta Francois B.Lepira +12 位作者 Francois P.Kajingulu Jean Robert R.Makulo Ernest K.Sumaili Pierre Z.Akilimali Aliocha N.Nkodila Freddy M.Mbuyi Angele I.Masewu Stephane Mutombo Eric B.Amisi Jean Pierre M.Ilunga Wilfrid B.Mbombo Patrick M.Mukuna Adolphe M.Kilembe 《World Journal of Cardiovascular Diseases》 2019年第9期665-680,共16页
BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of th... BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of the present study was to assess the prognostic significance of admission hyperglycemia in the acute phase of stroke in Congolese patients. METHODS: In a multicenter prospective cohort study, consecutive patients with acute stroke were examined in 5 Emergency Rooms or Intensive Care Units of Kinshasa between July 15th, 2017 and March 15th, 2018. The severity of stroke was assessed at admission using the Glasgow Coma Scale. Stress hyperglycemia was defined as random blood glucose levels at admission > 140 mg/dL in patients without known type 2 diabetes mellitus (T2DM). The endpoint was 10-day all-cause in-hospital mortality. Survival (time-to-death) curves were built using the Kaplan Meier methods. Cox proportional analysis was used to identify predictors of 10-day all-cause in-hospital mortality. The predictive performance of blood glucose level to predict 10-day all-cause in-hospital mortality was assessed using ROC curve analysis. RESULTS: Out of 194 patients (mean age 58.7 ± 13.1 years;64% males, 74.7% light to moderate stroke severity;63.4% ischemic stroke) enrolled, 106 (54.6%) had admission hyperglycemia with 77 (72.6%) having stress hyperglycemia. Ninety four deaths (48.5%);mortality rate of 6 deaths per 100 person-days (95%CI 2.7 - 9.3) occurred during a median follow up time 6 (5 - 7) days equivalent to 1542 person-days. Independent predictors of 10-day all-cause in-hospital mortality were admission hyperglycemia regardless of diabetes status (aHR 3.77;95%CI 1.92 - 7.42;p < 0.001), GCS - 5.23;p = 0.001) and non-use of mechanical ventilation (aHR 1.97;95%CI 1.05 - 3.70;p = 0.034). Blood glucose concentrations (AUC 0.743;95%CI 0.672 - 0.814) had a better predictive performance for 10-day all-cause in-hospital mortality with an optimal value of 154 mg/dL (sensitivity 76.6% and specificity 70%). CONCLUSION: More than half of critically ill stroke patients exhibit admission hyperglycemia that impacts negatively on their survival in the acute phase highlighting thus the need for a better blood glucose control to improve outcomes. 展开更多
关键词 Admission Hyperglycemia STROKE prognostic significance Black Africans
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PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma 被引量:1
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作者 Shi-Yuan Liu Wei Chen +5 位作者 Ehtesham Annait Chughtai Zhe Qiao Jian-Tao Jiang Shao-Min Li Wei Zhang Jin Zhang 《World Journal of Gastroenterology》 SCIE CAS 2017年第14期2585-2591,共7页
AIM To evaluate PIK3 CA gene mutational status in Northwest Chinese esophageal squamous cell carcinoma(ESCC) patients, and examine the associations of PIK3 CA gene mutations with clinicopathological characteristics an... AIM To evaluate PIK3 CA gene mutational status in Northwest Chinese esophageal squamous cell carcinoma(ESCC) patients, and examine the associations of PIK3 CA gene mutations with clinicopathological characteristics and clinical outcome.METHODS A total of 210 patients with ESCC who underwent curative resection were enrolled in this study. Pyrosequencing was applied to investigate mutations in exons 9 and 20 of PIK3 CA gene in 210 Northwest Chinese ESCCs. The associations of PIK3 CA gene mutations with clinicopathological characteristics and clinical outcome were examined.RESULTS PIK3 CA gene mutations in exon 9 were detected in 48 cases(22.9%) of a non-biased database of 210 curatively resected Northwest Chinese ESCCs. PIK3 CA gene mutations were not associated with sex, tobacco use, alcohol use, tumor location, stage, or local recurrence. When compared with wild-type PIK3 CA gene cases, patients with PIK3 CA gene mutations in exons 9 experienced significantly better disease-free survival and overall survival rates.CONCLUSION The results of this study suggest that PIK3 CA gene mutations could act as a prognostic biomarker in Northwest Chinese ESCC patients. 展开更多
关键词 PIK3CA gene mutations Esophageal squamous cell carcinoma Northwest Chinese prognostic significance
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