Acetylcholinesterase inhibitor modifications: a promising strategy to delay the progression of Alzheimer's disease

Alzheimer＇s disease （AD）, a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care （World Alzheimer Report, 2013）.

Progress and Development Strategy of Biomass Energy Utilization Technologies in China

I. Preface Biomass includes the residues of agriculture, forest and stock breeding, as well as straw, algae and energy crops. In its broad meaning, biomass is a kind of organic matter produced by the photosynthesis of plants, which is not only renewable, but also contains plentiful energy.

Safety risk management of underground engineering in China：Progress, challenges and strategies

Underground construction in China is featured by large scale, high speed, long construction period,complex operation and frustrating situations regarding project safety. Various accidents have been reported from time to time, resulting in serious social impact and huge economic loss. This paper presents the main progress in the safety risk management of underground engineering in China over the last decade, i.e.（1） establishment of laws and regulations for safety risk management of underground engineering,（2） implementation of the safety risk management plan,（3） establishment of decision support system for risk management and early-warning based on information technology, and（4） strengthening the study on safety risk management, prediction and prevention. Based on the analysis of the typical accidents in China in the last decade, the new challenges in the safety risk management for underground engineering are identified as follows：（1） control of unsafe human behaviors;（2） technological innovation in safety risk management; and（3） design of safety risk management regulations. Finally, the strategies for safety risk management of underground engineering in China are proposed in six aspects, i.e. the safety risk management system and policy, law, administration, economy, education and technology.

Toward Robust and Efficient Low-Light Image Enhancement:Progressive Attentive Retinex Architecture Search

In recent years,learning-based low-light image enhancement methods have shown excellent performance,but the heuristic design adopted by most methods requires high engineering skills for developers,causing expensive inference costs that are unfriendly to the hardware platform.To handle this issue,we propose to automatically discover an efficient architecture,called progressive attentive Retinex network(PAR-Net).We define a new attentive Retinex framework by introducing the attention mechanism to strengthen structural representation.A multi-level search space containing micro-level on the operation and macro-level on the cell is established to realize meticulous construction.To endow the searched architecture with the hardware-aware property,we develop a latency-constrained progressive search strategy that successfully improves the model capability by explicitly expressing the intrinsic relationship between different models defined in the attentive Retinex framework.Extensive quantitative and qualitative experimental results fully justify the superiority of our proposed approach against other state-of-the-art methods.A series of analytical evaluations is performed to illustrate the validity of our proposed algorithm.