Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

A hybrid method integrating Green's function Monte Carlo and projected entangled pair states

This paper introduces a hybrid approach combining Green’s function Monte Carlo(GFMC)method with projected entangled pair state(PEPS)ansatz.This hybrid method regards PEPS as a trial state and a guiding wave function in GFMC.By leveraging PEPS’s proficiency in capturing quantum state entanglement and GFMC’s efficient parallel architecture,the hybrid method is well-suited for the accurate and efficient treatment of frustrated quantum spin systems.As a benchmark,we applied this approach to study the frustrated J_(1)–J_(2) Heisenberg model on a square lattice with periodic boundary conditions(PBCs).Compared with other numerical methods,our approach integrating PEPS and GFMC shows competitive accuracy in the performance of ground-state energy.This paper provides systematic and comprehensive discussion of the approach of our previous work[Phys.Rev.B 109235133(2024)].

Integrated Project Library Exploration in Landscape Design Teaching for Environmental Design Majors

To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.

“One Core,Two Sources”:The Endogenous Logic of China’s Path to Develop Human Rights from the Perspective of“Two Integrations”

The development of China’s human rights path is driven by both external and internal factors,influenced by general principles of human rights worldwide while also following China’s own endogenous logic.The concept of the“Two Integrations”reflects the continuous theoretical innovation of the Chinese Communist Party based on China’s national conditions,significantly illustrating the endogenous logic of China’s human rights path.Among these,the“basic principles of Marxism”occupy a“core”position within the endogenous logic of China’s human rights path,and to some extent,embody an understanding of the inherent laws of human rights.Meanwhile,“China’s specific realities”and“fine traditional Chinese culture”serve as the“living water sources”for the ongoing advancement of China’s human rights.The“Two Integrations”represent an intrinsic requirement of historical materialism and practical materialism.The logical structure of“One Core,Two Sources”explains the endogenous nature of China’s human rights path,offering both an interpretation of the driving forces behind China’s human rights path and a defense of its rationality.

LIE GROUP INTEGRATION FOR CONSTRAINED GENERALIZED HAMILTONIAN SYSTEM WITH DISSIPATION BY PROJECTION METHOD

For the constrained generalized Hamiltonian system with dissipation, by introducing Lagrange multiplier and using projection technique, the Lie group integration method was presented, which can preserve the inherent structure of dynamic system and the constraint-invariant. Firstly, the constrained generalized Hamiltonian system with dissipative was converted to the non-constraint generalized Hamiltonian system, then Lie group integration algorithm for the non-constraint generalized Hamiltonian system was discussed, finally the projection method for generalized Hamiltonian system with constraint was given. It is found that the constraint invariant is ensured by projection technique, and after introducing Lagrange multiplier the Lie group character of the dynamic system can't be destroyed while projecting to the constraint manifold. The discussion is restricted to the case of holonomic constraint. A presented numerical example shows the effectiveness of the method.

Creativity Assessment From Integration Between Chemistry and Physics Disciplines Using a Project

The aim of this study is to assess creativity of the students from a project of first year undergrad students of King Mongkut’s University of Technology Thonburi,a residential college(KMUTT-RC).A project is a part of academic contents from Physics and Chemistry subjects.There were instructors from Chemistry,Physics,Engineering,and Social Sciences Department for consulting and engineering students for building a prototype.Formative assessment activity is explored from question,answer,and presentation.The characters,assessed on creativity,associated with an analysis on the rubric of prototype design,knowledge,and selective materials.Most students understood the perspective on creativity correlating with the observation from instructors.The instructor’s view represented that most of creative scores gained from motivate design and materials selection while their knowledge was not adequate.The accuracy of prototypes from the students did not relate to creativity in terms of design but error of measurement could occur from confusing with refractive index scale and from preparing a standard solution in chemical laboratory.

Application of Harmony and Integrity Culture in Tourism Project Planning—A Case Study of Lumingling Scenic Area

Significance of tourism project planning in the transformation of tourism resources to tourist products was analyzed,it was proposed that culture is the soul of tourism project planning,harmony and integrity culture is the essence of Chinese cultures.Connotations and types of harmony and integrity culture were elaborated,such as harmony and integrity of human and nature,harmony and integrity of the society,harmony and integrity of the ego.On this basis,relationship between harmony and integrity and tourism projects was expounded,harmony and integrity culture was stressed as the source of tourism projects,and tourism projects as optimal carriers of demonstrating and inheriting harmony and integrity culture.Lumingling Scenic Area in south Jingxing County,Shijiazhuang City of Hebei Province was taken for an example to analyze the application of harmony and integrity culture in concrete planning of tourist projects from the perspectives of functional orientation,theme orientation and functional division.

Study on Characteristics of 3-D Translating-Pulsating Source Green Function of Deep-Water Havelock Form and Its Fast Integration Method

The singularities, oscillatory performances and the contributing factors to the 3-＇D translating-pulsating source Green function of deep-water Havelock form which consists of a local disturbance part and a far-field wave-like part, are analyzed systematically. Relative numerical integral methods about the two parts are presented in this paper. An improved method based on LOBATTO rule is used to eliminate singularities caused respectively by infinite discontinuity and jump discontinuous node from the local disturbance part function, which makes the improvement of calculation efficiency and accuracy possible. And variable substitution is applied to remove the singularity existing at the end of the integral interval of the far-field wave-like part function. Two auxiliary techniques such as valid interval calculation and local refinement of integral steps technique in narrow zones near false singularities are applied so as to avoid unnecessary integration of invalid interval and improve integral accordance. Numerical test results have proved the efficiency and accuracy in these integral methods that thus can be applied to calculate hydrodynamic performance of floating structures moving in waves.

Practice of Project Management Methodology for Commercial Aero engines Based on Integrative Project Architectures

To collect and share information of projects or products and make it consistent and correct so that the quality and costs of projects can be effectively controlled,an integrative project architecture integrating different types of breakdown structures is necessary.In this paper,the international research status on work breakdown structure(WBS)was analyzed,and an integrative project architecture for commercial aero-engines was designed,where product breakdown structure(PBS),WBS,organization breakdown structure(OBS)and cost breakdown structure(CBS)were integrated and built.And the architecture was applied in information systems.A transfer from technological views of complex products through their lifecycles to management views has been realized with this standardized architecture,thus development tasks and costs can be controlled.

Reflection on the Integrated Development of Marine Fisheries and Tourism Based on the Transformation of Fishery Facilities: A Case Study of Ningde City of Fujian Province, China

Based on the analysis on the current situation of marine fishery resources and development in Ningde City,this paper plans a spatial pattern for the integration of marine fishery and tourism of the“one belt,three zones,and multiple points”,designs key projects,analyzes the existing problems in the integrated development of fishery and tourism,and proposes relevant countermeasures and suggestions.

Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease

Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.

Solving Large Scale Nonlinear Equations by a New ODE Numerical Integration Method

In this paper a new ODE numerical integration method was successfully applied to solving nonlinear equations. The method is of same simplicity as fixed point iteration, but the efficiency has been significantly improved, so it is especially suitable for large scale systems. For Brown’s equations, an existing article reported that when the dimension of the equation N = 40, the subroutines they used could not give a solution, as compared with our method, we can easily solve this equation even when N = 100. Other two large equations have the dimension of N = 1000, all the existing available methods have great difficulties to handle them, however, our method proposed in this paper can deal with those tough equations without any difficulties. The sigularity and choosing initial values problems were also mentioned in this paper.

Unifying the theory of integration within normal-,Weyl- and antinormal-ordering of operators and the s-ordered operator expansion formula of density operators

By introducing the s-parameterized generalized Wigner operator into phase-space quantum mechanics we invent the technique of integration within s-ordered product of operators （which considers normally ordered, antinormally ordered and Weyl ordered product of operators as its special cases）. The s-ordered operator expansion （denoted by s…s ） formula of density operators is derived, which isρ=2/1-s∫d^2β/π〈-β｜ρ｜β〉sexp{2/s-1（s｜β｜^2-β＊α＋βa-αα）}s The s-parameterized quantization scheme is thus completely established.

Whole-Process Project Cost Management Based on Building Information Modeling (BIM)

The whole-process project cost management based on building information modeling(BIM)is a new management method,aiming to realize the comprehensive optimization and improvement of project cost management through the application of BIM technology.This paper summarizes and analyzes the whole-process project cost management based on BIM,aiming to explore its application and development prospects in the construction industry.Firstly,this paper introduces the role and advantages of BIM technology in engineering cost management,including information integration,data sharing,and collaborative work.Secondly,the paper analyzes the key technologies and methods of the whole-process project cost management based on BIM,including model construction,data management,and cost control.In addition,the paper also discusses the challenges and limitations of the whole-process BIM project cost management,such as the inconsistency of technical standards,personnel training,and consciousness change.Finally,the paper summarizes the advantages and development prospects of the whole-process project cost management based on BIM and puts forward the direction and suggestions for future research.Through the research of this paper,it can provide a reference for construction cost management and promote innovation and development in the construction industry.

Research on Financial Risk Management in the S Water Conservancy Project and Its Implications for Similar Projects

As a vital infrastructure initiative with significant impacts on national development and public welfare,water conservancy projects play an essential role in advancing agricultural development and mitigating losses caused by flooding.However,these projects often require substantial investments and extended construction periods,leading to the inevitable emergence of various financial risks during implementation.This paper aims to explore the current challenges in financial risk management of the S water conservancy project,offering practical management strategies and solutions to address these financial difficulties.Through a detailed assessment and analysis of the S water conservancy project,the study seeks to provide valuable references and insights for similar projects to better manage financial risks,ensuring their smooth progression and successful completion.The proposed control measures are designed not only to effectively mitigate the financial risks specific to the S water conservancy project but also to offer actionable lessons for other similar projects.By promoting and applying these measures,the overall financial management capabilities of the industry can be enhanced,providing robust support for the sustainable development of water conservancy projects.

Independent integration and innovation of the first domestically-integrated 60000 m^3/h air separation unit

Baosteel＇s 60000 m……3/h air separation unit （ASU）, the first domestically-integrated unit of its class, is a milestone in the Chinese air separation industry. In this paper,the process characteristics of the unit and the application of the original techniques are expatiated. Some difficulties in the process design, the risk control, the quality control, the control system integration and the system commissioning are analyzed and appraised. The mode of the project integration and innovation, the cooperation among industries and the user-orientated project management mode are introduced. Finally,the successful experiences in innovation are summarized with the focus on the integration of the project.

Inevitability and Emergent Problems of Science &Technology Innovation Access to Integration

The causes and the problems of integration of scientific ＆ technical innovation （ISTI） and inevitability are proposed. The status of domestic scientific ＆ technical innovation is analysed. A series of emergent managerial problems caused by the system ISTI （SISTI） are pointed out. Because of Hall three dimensions structure＇s enlightenment, a three dimensional logical net diagram in which the system integration of innovation based on problem in real world but not on disciplinary logic is drawn. The intelligent group＇ s need span is greater under the conditions of relatively low material level than common groups who have lower degree of education. The SISTI is composed by multi-rule and intelligent multi-agent behavior. It is concluded that the logical relationships of integrated technology which based on the author＇s experience and observation must be considerded for a valid management of SISTI.

Integrable System and Motion of Curves in Projective and Similarity Geometries

Based on the natural frame in the projective geometry, motions of curves in projective geometry are studied. It is shown that several integrable equations including Sawada-Kotera and KK equations arise from motion of plane curves in projective geometries. Motion of space curves described by acceleratlon field and governed by endowing an extra space variable in similarity geometry P^3 is also studied.

Reduction of signal reflection along through silicon via channel in high-speed three-dimensional integration circuit

The through silicon via （TSV） technology has proven to be the critical enabler to realize a three-dimensional （3D） gigscale system with higher performance but shorter interconnect length. However, the received digital signal after trans- mission through a TSV channel, composed of redistribution layers （RDLs）, TSVs, and bumps, is degraded at a high data-rate due to the non-idealities of the channel. We propose the Chebyshev multisection transformers to reduce the signal reflec- tion of TSV channel when operating frequency goes up to 20 GHz, by which signal reflection coefficient （$11） and signal transmission coefficient （$21） are improved remarkably by 150% and 73.3%, respectively. Both the time delay and power dissipation are also reduced by 4% and 13.3%, respectively. The resistance-inductance-conductance-capacitance （RLGC） elements of the TSV channel are iterated from scattering （S）-parameters, and the proposed method of weakening the signal reflection is verified using high frequency simulator structure （HFSS） simulation software by Ansoft.

The Generalization on Inequalities of Hermite-Hadamard's Integration

Some new inequalities of Hermite-Hadamard's integration are established. As for as inequalities about the righthand side of the classical Hermite-Hadamard's integral inequality refined by S Qaisar in [3], a new upper bound is given. Under special conditions,the bound is smaller than that in [3].