Purpose: Prolotherapy is a therapeutic method that involves injecting an irritant substance into injured areas of tendons, ligaments, and articular spaces. It has a wide application in orthopedic fields, including art...Purpose: Prolotherapy is a therapeutic method that involves injecting an irritant substance into injured areas of tendons, ligaments, and articular spaces. It has a wide application in orthopedic fields, including arthritis, tendinopathies, and back pain. Protocol of injection varies extensively based on the pathological condition. This review aims to discuss orthopedic applications of prolotherapy and its related outcomes, intending to introduce more specific injection protocols in each field. Methods: In a narrative review of literature, various musculoskeletal indications and contraindications of prolotherapy, as well as the method and location of injection, solution type, procedure intervals and frequencies, outcomes and side effects are investigated to reveal all aspects of the current knowledge about this new approach. Results: Chronic back pain, osteoarthritis, and tendinopathies are considered the most common indications for prolotherapy. Protocol of injection varies from one condition to another. The actual concentration of administered dextrose ranges from 12.5% to 25%. Results of the different studies indicate that prolotherapy could have a pleasing effect on improving patient’s pain and functional outcomes. No severe complication has been mentioned in previous investigations. Conclusion: Prolotherapy is a new therapeutic option that can be suggested as an effective method in recalcitrant musculoskeletal conditions.展开更多
This case report detailed the history and treatment of a female postpartum patient with diastasis recti. Treatment for this patient included the use of prolotherapy, an injection-based therapy using dextrose as the ac...This case report detailed the history and treatment of a female postpartum patient with diastasis recti. Treatment for this patient included the use of prolotherapy, an injection-based therapy using dextrose as the active compound. The solution used during the course of therapy was composed of 6 mL of 50% dextrose, 3 mL of 1% lidocaine, and 1 mL of methylcobalamin (1000 mcg/mL). Injections were administered every 2 weeks for a total of 7 prolotherapy sessions. Following the series of prolotherapy injections, there was a marked closure observed in the diastasis, decreasing from 2.7 cm to 0.5 cm. The patient did not report any side effects, and no complications were observed or recorded. This appears to be the first case report documenting an improvement in abdominal diastasis recti following a course of prolotherapy. Within the limitations of the study design, further research is recommended to evaluate prolotherapy for diastasis recti in postpartum patients.展开更多
Osteoarthritis （OA） reflects a slowly evolving joint disease with toss and erosion of articular cartilage, osteophytes formation and weakness or laxity of the soft tissues in the synovial joints, particularly the la...Osteoarthritis （OA） reflects a slowly evolving joint disease with toss and erosion of articular cartilage, osteophytes formation and weakness or laxity of the soft tissues in the synovial joints, particularly the large weight-bearing joints. The prevalence of the OA increases with age, and its radiological changes can be observed in over 50% of the retired people. Symptoms can vary from minimal to severe pain, stiffness, locking, decreased function and sometimes joint effusion. Inevitably, a wide range of potential therapies have been advocated, and not necessarily with strong supportive evidence. The Standard-of-care for treatment of pain is multidisciplinary; however, a recent systematic review reported no clear benefit of any one therapy. The Agency for Healthcare Research and Quality has called for the development of new therapies for pain management. In Interventional Regenerative Orthopedic Medicine （IROM）, Dextrose is used as a tissue proliferant for treatment of OA. It has different ways of action aiming to do tissue regeneration. Platelet Rich plasma is also used in IROM and is very promising because of delivering ＂growth-factors＂ which stimulate the local tissue progenitor cells （mesenchymal stem cells） enhancing the regeneration of the tissues. Adult Mesenchymal stem cells is the hot topic nowadays in the non-surgical joint reconstruction. The results revealed that patients treated for sports injuries and joint OA using IROM （dextrose, PRP and stem cells） showed a greater improvement regarding their sports performance as well as joint pain and function compared to those treated with traditional methods （different modalities of physiotherapy, steroids injections etc）. Moreover, athletes with sports injuries treated with steroid injections showed a deterioration in their sports performance, muscle strain, joint pain and function.展开更多
Musculoskeletal pain is a distressing, unpleasant feeling and an emotional experience associated with actual or potential tissue damage. Prolotherapy is an injection therapy designed to stimulate tissue healing. Lyfto...Musculoskeletal pain is a distressing, unpleasant feeling and an emotional experience associated with actual or potential tissue damage. Prolotherapy is an injection therapy designed to stimulate tissue healing. Lyftogt PIT （perineural injection therapy） treats the neurogenic inflammation. Therefore it stops the pain and promotes the release of NGFs （nerve growth factors） which are important for tissue regeneration. Vitamin D3 receptors are ubiquitous in tissue distribution, which opens the possibility for unforeseen biological functions of vitamin D endocrine system. Dextrose is the most commonly used tissue proliferant in prolotherapy. It has different ways of action aiming to stimulate the tissue regeneration. Platelet Rich Plasma is also used in the IROM （interventional regenerative orthopedic medicine）, and it is very powerful because it delivers ＂growth-factors＂ which stimulate the local tissue progenitor cells （adult mesenchymal stem cells） enhancing the regeneration of the tissues. Adult Mesenchymal stem cell is the hot topic nowadays in the non-surgical field of pain management. In this paper, 250 patients suffering from chronic pain and dysfunction of different body joints （knee, hip and elbow）, were treated with one or two injection therapy techniques, to evaluate the patient improvement regarding the pain and function. The effect of adding an intra-articular injection of vitamin D to the above techniques was also evaluated regarding the joint pain and function improvement. Some of the patients were treated with Platelet Rich Plasma and others were treated with Bone Marrow Stem cells. The results of the 250 patients were compared with those obtained from 30 matching control patients, having same conditions and were treated with physiotherapy, Conclusions show that the therapeutic benefit from combining the two techniques, Lyflogt Perineural Injection Therapy and Prolotherapy, is better than using only one of them regarding the pain and function for the different body joints. Adding an intra-articular injection of vitamin D to the treatment of some patients gave a better result than those treated with dextrose only. However, using the Platelet Rich Plasma and the Stem cells instead of dextrose gave the best results ever regarding the pain and function of the musculoskeletal system.展开更多
文摘Purpose: Prolotherapy is a therapeutic method that involves injecting an irritant substance into injured areas of tendons, ligaments, and articular spaces. It has a wide application in orthopedic fields, including arthritis, tendinopathies, and back pain. Protocol of injection varies extensively based on the pathological condition. This review aims to discuss orthopedic applications of prolotherapy and its related outcomes, intending to introduce more specific injection protocols in each field. Methods: In a narrative review of literature, various musculoskeletal indications and contraindications of prolotherapy, as well as the method and location of injection, solution type, procedure intervals and frequencies, outcomes and side effects are investigated to reveal all aspects of the current knowledge about this new approach. Results: Chronic back pain, osteoarthritis, and tendinopathies are considered the most common indications for prolotherapy. Protocol of injection varies from one condition to another. The actual concentration of administered dextrose ranges from 12.5% to 25%. Results of the different studies indicate that prolotherapy could have a pleasing effect on improving patient’s pain and functional outcomes. No severe complication has been mentioned in previous investigations. Conclusion: Prolotherapy is a new therapeutic option that can be suggested as an effective method in recalcitrant musculoskeletal conditions.
文摘This case report detailed the history and treatment of a female postpartum patient with diastasis recti. Treatment for this patient included the use of prolotherapy, an injection-based therapy using dextrose as the active compound. The solution used during the course of therapy was composed of 6 mL of 50% dextrose, 3 mL of 1% lidocaine, and 1 mL of methylcobalamin (1000 mcg/mL). Injections were administered every 2 weeks for a total of 7 prolotherapy sessions. Following the series of prolotherapy injections, there was a marked closure observed in the diastasis, decreasing from 2.7 cm to 0.5 cm. The patient did not report any side effects, and no complications were observed or recorded. This appears to be the first case report documenting an improvement in abdominal diastasis recti following a course of prolotherapy. Within the limitations of the study design, further research is recommended to evaluate prolotherapy for diastasis recti in postpartum patients.
文摘Osteoarthritis （OA） reflects a slowly evolving joint disease with toss and erosion of articular cartilage, osteophytes formation and weakness or laxity of the soft tissues in the synovial joints, particularly the large weight-bearing joints. The prevalence of the OA increases with age, and its radiological changes can be observed in over 50% of the retired people. Symptoms can vary from minimal to severe pain, stiffness, locking, decreased function and sometimes joint effusion. Inevitably, a wide range of potential therapies have been advocated, and not necessarily with strong supportive evidence. The Standard-of-care for treatment of pain is multidisciplinary; however, a recent systematic review reported no clear benefit of any one therapy. The Agency for Healthcare Research and Quality has called for the development of new therapies for pain management. In Interventional Regenerative Orthopedic Medicine （IROM）, Dextrose is used as a tissue proliferant for treatment of OA. It has different ways of action aiming to do tissue regeneration. Platelet Rich plasma is also used in IROM and is very promising because of delivering ＂growth-factors＂ which stimulate the local tissue progenitor cells （mesenchymal stem cells） enhancing the regeneration of the tissues. Adult Mesenchymal stem cells is the hot topic nowadays in the non-surgical joint reconstruction. The results revealed that patients treated for sports injuries and joint OA using IROM （dextrose, PRP and stem cells） showed a greater improvement regarding their sports performance as well as joint pain and function compared to those treated with traditional methods （different modalities of physiotherapy, steroids injections etc）. Moreover, athletes with sports injuries treated with steroid injections showed a deterioration in their sports performance, muscle strain, joint pain and function.
文摘Musculoskeletal pain is a distressing, unpleasant feeling and an emotional experience associated with actual or potential tissue damage. Prolotherapy is an injection therapy designed to stimulate tissue healing. Lyftogt PIT （perineural injection therapy） treats the neurogenic inflammation. Therefore it stops the pain and promotes the release of NGFs （nerve growth factors） which are important for tissue regeneration. Vitamin D3 receptors are ubiquitous in tissue distribution, which opens the possibility for unforeseen biological functions of vitamin D endocrine system. Dextrose is the most commonly used tissue proliferant in prolotherapy. It has different ways of action aiming to stimulate the tissue regeneration. Platelet Rich Plasma is also used in the IROM （interventional regenerative orthopedic medicine）, and it is very powerful because it delivers ＂growth-factors＂ which stimulate the local tissue progenitor cells （adult mesenchymal stem cells） enhancing the regeneration of the tissues. Adult Mesenchymal stem cell is the hot topic nowadays in the non-surgical field of pain management. In this paper, 250 patients suffering from chronic pain and dysfunction of different body joints （knee, hip and elbow）, were treated with one or two injection therapy techniques, to evaluate the patient improvement regarding the pain and function. The effect of adding an intra-articular injection of vitamin D to the above techniques was also evaluated regarding the joint pain and function improvement. Some of the patients were treated with Platelet Rich Plasma and others were treated with Bone Marrow Stem cells. The results of the 250 patients were compared with those obtained from 30 matching control patients, having same conditions and were treated with physiotherapy, Conclusions show that the therapeutic benefit from combining the two techniques, Lyflogt Perineural Injection Therapy and Prolotherapy, is better than using only one of them regarding the pain and function for the different body joints. Adding an intra-articular injection of vitamin D to the treatment of some patients gave a better result than those treated with dextrose only. However, using the Platelet Rich Plasma and the Stem cells instead of dextrose gave the best results ever regarding the pain and function of the musculoskeletal system.
