A carboxylative coupling reaction of various primary amine and 3-phenyl-2-propynyl or 2-nonynyl chloride in the presence of 8-diazabicyclo[5.4.0]undec-7-ene(DBU)using carbon dioxide as carboxylative reagent was presen...A carboxylative coupling reaction of various primary amine and 3-phenyl-2-propynyl or 2-nonynyl chloride in the presence of 8-diazabicyclo[5.4.0]undec-7-ene(DBU)using carbon dioxide as carboxylative reagent was presented.This transition-metal free reaction system shows broad substrate scope and gives a series of propargylcarbamates in moderate to good yield.The obtained N-alkyl substituted carbamate product can undergo base-catalyzed intramolecular cyclization reaction to afford functionalized 4-methylene-2-oxazolidinone in good yield.展开更多
基金National Natural Science Foundation of China(No.21172026)Scientific Research Fund of Liaoning Provincial Education Department(No.L2012024)X.-B.L.gratefully acknowledges the Chang Jiang Scholars Program(No.T2011056)from Ministry of Education of the People's Republic of China.
文摘A carboxylative coupling reaction of various primary amine and 3-phenyl-2-propynyl or 2-nonynyl chloride in the presence of 8-diazabicyclo[5.4.0]undec-7-ene(DBU)using carbon dioxide as carboxylative reagent was presented.This transition-metal free reaction system shows broad substrate scope and gives a series of propargylcarbamates in moderate to good yield.The obtained N-alkyl substituted carbamate product can undergo base-catalyzed intramolecular cyclization reaction to afford functionalized 4-methylene-2-oxazolidinone in good yield.
