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Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection
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作者 Ao-Han Li Su Bu +2 位作者 Ling Wang Ai-Min Liang Hui-Yu Luo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期79-89,共11页
BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitiv... BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances. 展开更多
关键词 propofol SEVOFLURANE Radical resection of gastric cancer Anesthetic effect Cognitive function Negative emotion
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Comparison of Propofol and Fentanyl for Preventing Emergence Agitation Following Sevoflurane Anesthesia in Pediatric Patients: A Single-Center Study in Bangladesh
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作者 Md. Saiful Islam Khan Md. Abir Tazim Chowdhury +8 位作者 Farzana Fardousi Munama Magdum Md. Ahaduzzaman Taneem Mohammad Shamima Akter Suriya Akter Md. Saiful Islam Azad Md. Mozaffer Hossain M. Abdur Rahman 《Pharmacology & Pharmacy》 2024年第6期223-235,共13页
Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare... Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare their associated complications or side effects. Methods: This prospective randomized observational comparative study was conducted at Dhaka Medical College Hospital from July 2013 to June 2014. The study aimed to evaluate the effects of propofol and fentanyl on EA in children aged 18 to 72 months undergoing circumcision, herniotomy, and polypectomy operations. Ninety children were included in the study, with 45 in each group. Patients with psychological or neurological disorders were excluded. Various parameters including age, sex, weight, American Society of Anesthesiologists (ASA) class, duration of anesthesia, Saturation of Peripheral Oxygen (SPO2), heart rate (HR), respiratory rate (RR), Pediatric Anesthesia Emergence Delirium (PAED) score, duration of post-anesthesia care unit (PACU) stay, incidence of laryngospasm, nausea, vomiting, and rescue drug requirement were compared between the two groups. Results: Age, sex, weight, ASA class, and duration of anesthesia were comparable between the two groups. Perioperative SpO2 and HR were similar in both groups. However, the PAED score was significantly higher in the fentanyl group during all follow-ups except at 30 minutes postoperatively. The mean duration of PACU stay was significantly longer in the fentanyl group. Although the incidence of laryngospasm was higher in the fentanyl group, it was not statistically significant. Conversely, nausea or vomiting was significantly higher in the fentanyl group. The requirement for rescue drugs was significantly higher in the fentanyl group compared to the propofol group. Conclusion: Both propofol and fentanyl were effective in preventing emergence agitation in pediatric patients undergoing various surgical procedures under sevoflurane anesthesia. However, propofol demonstrated a better safety profile with fewer incidences of nausea, vomiting, and rescue drug requirements compared to fentanyl. 展开更多
关键词 Emergence Agitation (EA) General Anesthesia propofol FENTANYL Pediatric Patients Pediatric Anesthesia Emergence Delirium (PAED) Score BANGLadESH
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ADS-B信号在对流层大气波导中的传播性能
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作者 田斌 张厶允 +2 位作者 陈子豪 闫孟宝 牟伟琦 《海军工程大学学报》 CAS 北大核心 2024年第1期8-14,共7页
对流层大气环境存在特殊大气结构“大气波导”,可形成电波超视距传播或产生雷达盲区等。目前,通过雷达、GNSS信号等可以对大气波导进行一定程度的反演探测,但均存在一定的不足。ADS-B信号具有应用范围广、信号密度大、实时性高等特点,... 对流层大气环境存在特殊大气结构“大气波导”,可形成电波超视距传播或产生雷达盲区等。目前,通过雷达、GNSS信号等可以对大气波导进行一定程度的反演探测,但均存在一定的不足。ADS-B信号具有应用范围广、信号密度大、实时性高等特点,为此提出利用ADS-B信号受到不同大气环境影响后能量损耗不同的特点对ADS-B信号与对流层大气环境关联性进行分析研究。以武汉地区ADS-B信号数据为例,基于抛物方程传播理论对路径损耗进行仿真分析,并进行了实验验证。结果表明:ADS-B接收信号与仿真结果存在线性相关性并给出线性表述,为后续利用ADS-B信号反演大气波导提供参考依据。 展开更多
关键词 对流层大气波导 抛物方程 adS-B信号 传播损耗
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基于ADE优化的IPMSM全速域无传感器控制
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作者 姚国仲 郝剑 +3 位作者 王贵勇 李涛 董文龙 詹益嘉 《传感器与微系统》 CSCD 北大核心 2024年第5期105-108,112,共5页
为了实现内置式永磁同步电机(IPMSM)全速域的无传感器控制和切换速域的平滑过渡,提出了一种基于自适应差分进化(ADE)算法优化的复合控制方法。分别在零低速域、中高速域采用旋转高频电压注入法和滑模观测器法来对电机转速和转子位置进... 为了实现内置式永磁同步电机(IPMSM)全速域的无传感器控制和切换速域的平滑过渡,提出了一种基于自适应差分进化(ADE)算法优化的复合控制方法。分别在零低速域、中高速域采用旋转高频电压注入法和滑模观测器法来对电机转速和转子位置进行估算,并在切换速域采用基于ADE算法的权重系数优化法来实现上述两种控制方法的平滑切换,从而实现IPMSM全速域无传感器控制。仿真结果表明:提出的复合控制方法能够实现电机全速域的无感控制和切换速域的平滑过渡,且具有良好的稳定性。 展开更多
关键词 内置式永磁同步电机 自适应差分进化算法 旋转高频电压注入法 滑模观测器
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Effect of remimazolam vs. propofol on hemodynamics during general anesthesia induction in elderly patients: Single-center, randomized controlled trial 被引量:1
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作者 Mingfeng He Chanjuan Gong +2 位作者 Yinan Chen Rongting Chen Yanning Qian 《The Journal of Biomedical Research》 CAS CSCD 2024年第1期66-75,共10页
The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in... The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study drug.We measured when patients entered the operating room(T_(0)),when the induction was successful(T_(1)),and when before(T_(2))and 5 min after successful endotracheal intubation(T_(3)).We found that mean arterial pressure(MAP)was lower at T_(1–3),compared with T_(0) in both groups,but higher at T_(2) in the group R,whileΔMAP_(T0–T2) andΔMAP_(max) were smaller in the group R(ΔMAP_(T0–T2):the difference between MAP at time point T_(0) and T_(2),ΔMAP_(max):the difference between MAP at time point T_(0) and the lowest value from T_(0) to T_(3)).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T_(1–3) in the group R.These findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels. 展开更多
关键词 remimazolam propofol elderly patients HYPOTENSION left ventricular systolic function systematic vascular resistance
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基于AD与TRIZ的加工中心主轴松拉刀机构优化设计
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作者 左斌 王仁忠 +1 位作者 陶宇 王敏 《机床与液压》 北大核心 2024年第4期119-125,131,共8页
数控加工中心在加工过程中常出现主轴松刀力不足或无法松刀的现象。针对此问题,通过TRIZ系统组件分析明确现有松拉刀机构各组件间作用关系,利用因果链分析得出影响松刀的根本原因,最终应用TRIZ理论中的物场模型分析方法和AD独立性原理... 数控加工中心在加工过程中常出现主轴松刀力不足或无法松刀的现象。针对此问题,通过TRIZ系统组件分析明确现有松拉刀机构各组件间作用关系,利用因果链分析得出影响松刀的根本原因,最终应用TRIZ理论中的物场模型分析方法和AD独立性原理提出优化设计方案。根据新方案计算出实际工况下的主轴松刀力和螺杆强度,并对松刀杆进行建模和仿真。结果表明:最大位移量为6.995μm,最大应力为45.24 MPa,符合结构设计要求。最后,经过现场实物测试,当液压力为5 MPa时,松刀行程、松刀力以及打刀量均符合生产要求,验证了优化设计方案的合理性。 展开更多
关键词 主轴系统 松拉刀机构 ad独立性原理 TRIZ理论 优化设计
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基于改进型多斜Ⅲ技术的7位半AD转换器设计
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作者 张航 李留生 +1 位作者 罗期任 陈志雄 《环境技术》 2024年第5期200-204,共5页
高精度测试仪器在环境试验中扮演着重要角色,而积分型AD转换器被广泛的应用在高精度测试仪器中。针对传统型积分型AD转换器转换速率较低的问题,提出了一种提高转换速率的改进型多斜ⅢAD转换器,详细的介绍了其原理和设计思路。该转换器... 高精度测试仪器在环境试验中扮演着重要角色,而积分型AD转换器被广泛的应用在高精度测试仪器中。针对传统型积分型AD转换器转换速率较低的问题,提出了一种提高转换速率的改进型多斜ⅢAD转换器,详细的介绍了其原理和设计思路。该转换器以单片机与CPLD一同控制积分型ADC,在积分末尾利用单片机片内ADC测量积分器的残留电压,以达到提高转换速率的目的。经理论分析该AD转换器比传统型转换速率快836倍,分辨率可达到31位,在±10V直流电压测量中可实现7位半分辨率。 展开更多
关键词 多斜ⅢA/D 高精度 ad转换器 7位半分辨率
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基于FPGA与AD9786的调制解调电路的设计
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作者 丁少轩 刘文耀 +1 位作者 石云波 刘昊东 《舰船电子工程》 2024年第2期170-174,共5页
谐振式光学陀螺因其高理论精度、小型化以及高稳定性受到了国内外的强烈关注。针对于谐振式光学陀螺检测信号微弱的特点,需要对该信号进行调制解调,以实现陀螺的稳定输出,设计了一种基于FPGA和AD9786的高精度模拟信号源,该信号以FPGA作... 谐振式光学陀螺因其高理论精度、小型化以及高稳定性受到了国内外的强烈关注。针对于谐振式光学陀螺检测信号微弱的特点,需要对该信号进行调制解调,以实现陀螺的稳定输出,设计了一种基于FPGA和AD9786的高精度模拟信号源,该信号以FPGA作为核心控制单元,AD9786作为数模转换器,实现16位的高精度DA转换,通过上位机实现指令的通信过程,可实现不同频率的交流信号。该实验结果表明,该系统符合陀螺测试系统调制解调要求,通过上位机对不同输出信号进行测试,且测试结果无纹波时输出噪声Vrms269μV,交流信号精度达到0.01%,最高频率可达到2M,稳定性高。 展开更多
关键词 陀螺 FPGA ad9786 模拟信号
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基于AD7616的16通道数据采集系统设计
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作者 蔺红彦 尚禹 +2 位作者 韩建宁 邢晨茹 郝国栋 《测试技术学报》 2024年第2期147-153,共7页
针对传统数据采集系统因通道不足或数据量过大,无法满足多通道同步采集的问题,设计了一种基于AD7616的16通道数据采集系统。系统以Xilinx系列FPGA作为主控芯片,ADI公司的AD7616作为模数转换芯片,DDR3 SDRAM作为缓存单元。介绍了各个模... 针对传统数据采集系统因通道不足或数据量过大,无法满足多通道同步采集的问题,设计了一种基于AD7616的16通道数据采集系统。系统以Xilinx系列FPGA作为主控芯片,ADI公司的AD7616作为模数转换芯片,DDR3 SDRAM作为缓存单元。介绍了各个模块硬件的设计思路,重点介绍了FPGA控制AD7616模数转换模块、DDR3 SDRAM缓存模块的软件程序设计,并对系统的多通道采样功能、同步性能以及实际水下超声信号的采集能力进行了实验验证,结果表明,系统可以完成水下超声信号的多通道同步采集。 展开更多
关键词 多通道数据采集 数据缓存 ad7616 Artix-7 DDR3 SDRAM
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基于动态离散模型的机场ADS-B攻击威胁影响研究
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作者 白洁 王布宏 +3 位作者 田继伟 王振 曾乐雅 阳勇 《电光与控制》 CSCD 北大核心 2024年第7期27-35,52,共10页
随着航空业信息技术的发展,空中交通管制系统面临着多种网络攻击的威胁。广播式自动相关监视(ADS-B)系统因其明文广播的数据传输方式,存在着被网络攻击的安全问题。依据“等待降落-降落-停泊-排队起飞-起飞”的航班运行全流程,建立了WL... 随着航空业信息技术的发展,空中交通管制系统面临着多种网络攻击的威胁。广播式自动相关监视(ADS-B)系统因其明文广播的数据传输方式,存在着被网络攻击的安全问题。依据“等待降落-降落-停泊-排队起飞-起飞”的航班运行全流程,建立了WLPQD动态离散模型,研究机场流量和航班延误。模型引入了系统冗余能力、处理速率等参数,模拟了攻击场景;通过受影响飞机数量和延误时间等指标研究了机场航班延误的传播影响。模型展示了ADS-B消息注入攻击对降落、起飞航班造成的延误,提出了两种攻击缓解方法。结果表明,延误规模的大小与攻击强度呈现正相关,且攻击对起飞航班的延误影响更大;提升对“幽灵飞机”和合法飞机的处理速率都可提升机场系统的抗毁性,但前者对提升机场系统冗余能力的效果更加显著。所做研究为机场系统抵御网络攻击、增强抗毁性提供了决策分析的参考依据。 展开更多
关键词 adS-B 动态离散模型 网络安全 航班延误
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采用AD654芯片的直流电压传感器及其温度漂移补偿
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作者 孟通 李长胜 《激光杂志》 CAS 北大核心 2024年第1期43-48,共6页
提出一种基于电压-频率变换的光电式电压传感器及电压传感信号温度漂移的补偿方法。电压传感系统主要包括电阻分压器、电压-频率变换芯片、发光二极管、光纤、光电探测与信号处理单元等。利用两块AD654型芯片分别作为被测电压和温度传... 提出一种基于电压-频率变换的光电式电压传感器及电压传感信号温度漂移的补偿方法。电压传感系统主要包括电阻分压器、电压-频率变换芯片、发光二极管、光纤、光电探测与信号处理单元等。利用两块AD654型芯片分别作为被测电压和温度传感单元,通过对两路光传感信号进行非线性数据拟合等方式实现了对电压传感信号温度漂移的实时补偿。实验测量了0.6 kV~5.0 kV范围内的直流电压,并实现了电压传感信号的温度漂移补偿,在-40℃~+60℃的温度范围内,电压传感信号温度漂移的平均相对误差约为±0.7%。 展开更多
关键词 光电式电压传感器 电压-频率变换 ad654芯片 温度漂移补偿
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Propofol with Varied Functions: A Potential Therapeutic Opportunity for Postoperative Nausea, Vomiting and Pruritus—A Narrative Review
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作者 Thomas W. Anabah Fidelis Bayor +3 位作者 David Z. Kolbila Terence Kunfire Dakurah Sylvanus Kampo Juventus B. Ziem 《Open Journal of Anesthesiology》 2024年第2期13-24,共12页
Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms t... Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms that cause dissatisfaction among patients after anesthesia and surgery. A sub-hypnotic dose of propofol has been shown to reduce morphine-induced postoperative nausea, vomiting, and pruritus. This review article will provide sufficient knowledge on the role of propofol in minimizing opioid-induced postoperative nausea, vomiting, and pruritus by providing detailed information on propofol antiemetic and antipruritic effects, as well as discussions based on empirically available data. Method: We conducted a narrative review of the literature published between 1990 and 2023 from a range of databases;PubMed, BioMed Central, Biosis Previews, Nature, International Pharmaceutical Abstracts, Springer-Link, and Elsevier. Discussion and Conclusion: The literatures reviewed in this study have demonstrated that propofol may have diverse therapeutic effects including antiemetic and antipruritic. The antiemetic effect of propofol may be an effective therapeutic approach for the prevention of postoperative nausea and vomiting. The literature also demonstrated that the use of propofol for sedation during surgery may as well ameliorates opioids induced postoperative pruritus, which may be beneficial to surgical patients. Also, it was demonstrated that prophylactic use of propofol may be an effective way of preventing nausea and vomiting and pruritus during opioid use. 展开更多
关键词 propofol NAUSEA VOMITING ANTIEMETIC ANTIPRURITIC Surgery
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A Study to Observe Pulse Pressure Variation after Induction with Propofol for General Anesthesia
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作者 Kunal Tewari Vibhu Raghuvanshi +3 位作者 Deepak Mishra Nitin Pahuja Maj Jyotsna Om Bahadur Thapa 《World Journal of Cardiovascular Diseases》 CAS 2024年第5期343-350,共8页
Background and Aims: Pulse pressure variation (PPV) is a reliable and predictive dynamic parameter presently being utilized for fluid responsiveness. In the operating room, fluid administration based on PPV monitoring... Background and Aims: Pulse pressure variation (PPV) is a reliable and predictive dynamic parameter presently being utilized for fluid responsiveness. In the operating room, fluid administration based on PPV monitoring helps the physician in deciding whether to volume resuscitate or use interventions in patients undergoing surgery. Propofol is an intravenous induction agent which lowers blood pressure. There are multiple causes such as depression in cardiac output, and peripheral vasodilatation for hypotension. We undertook this study to observe the utility of PPV as a guide to fluid therapy after propofol induction. Primary outcome of our study was to monitor PPV as a marker of fluid responsiveness for the hypotension caused by propofol induction. Secondary outcome included the correlation of PPV with other hemodynamic parameters like heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP);after induction with propofol at regular interval of time. Methods: A total number of 90 patients were recruited. Either of the radial artery was then cannulated under local anaesthesia with 20G VygonLeadercath arterial cannula and invasive monitoring transduced. A baseline recording of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and PPV was then recorded. Patients were then induced with predetermined doses of propofol (2 mg/kg) and recordings of HR, SBP, DBP, and PPV were taken at 5, 10 and 15 minutes. Results: Intraoperatively, PPV was significantly higher at 5 minutes and significantly lower at 15 minutes after induction. It was observed that there were no statistically significant correlations between PPV and SBP or DBP. PPV was strongly and directly associated with HR. Conclusion: We were able to establish that PPV predicts fluid responsiveness in hypotension caused by propofol induction;and can be used to administer fluid therapy in managing such hypotension. However, PPV was not directly correlated with hypotension subsequent to propofol administration. 展开更多
关键词 Pulse Pressure Variation (PPV) propofol Fluid Responsiveness
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面向Ad-Hoc协作的局部观测重建方法
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作者 陈皓 杨立昆 +1 位作者 尹奇跃 黄凯奇 《中国科学院大学学报(中英文)》 CSCD 北大核心 2024年第1期117-126,共10页
在多智能体强化学习的研究中,如何进行Ad-Hoc协作,也就是说如何适应种类和数量变化的队友,是一个关键问题。现有方法或者有很强的先验知识假设,或者使用硬编码的规则进行合作,缺乏通用性,无法泛化到更一般的Ad-Hoc协作场景。为解决该问... 在多智能体强化学习的研究中,如何进行Ad-Hoc协作,也就是说如何适应种类和数量变化的队友,是一个关键问题。现有方法或者有很强的先验知识假设,或者使用硬编码的规则进行合作,缺乏通用性,无法泛化到更一般的Ad-Hoc协作场景。为解决该问题,提出一种面向Ad-Hoc协作的局部观测重建算法,利用注意力机制和采样网络对局部观测进行重建,使得算法认识到并充分利用不同局面中的高维状态表征,实现了在Ad-Hoc协作场景下的零样本泛化。在星际争霸微操环境和Ad-Hoc协作场景上与代表性算法的性能进行对比与分析,验证了算法的有效性。 展开更多
关键词 多智能体 深度强化学习 信用分配 ad-Hoc协作
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Safety and efficacy comparison of remimazolam and propofol for intravenous anesthesia during gastroenteroscopic surgery of older patients:A meta-analysis
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作者 Fang-Zhuo Li Cheng Zhao +1 位作者 Yi-Xun Tang Ji-Tong Liu 《World Journal of Clinical Cases》 SCIE 2024年第7期1272-1283,共12页
BACKGROUND Remimazolam is characterized by rapid action and inactive metabolites.It is used as the general anesthetic for many clinical surgeries.In this study,we performed a meta-analysis to evaluate whether remimazo... BACKGROUND Remimazolam is characterized by rapid action and inactive metabolites.It is used as the general anesthetic for many clinical surgeries.In this study,we performed a meta-analysis to evaluate whether remimazolam is superior to propofol for gastroenteroscopy in older patients.AIM To compare the adverse events and efficacy of remimazolam and propofol during gastroenteroscopy in older adults.METHODS The PubMed,Web of Science,the Cochrane Library databases were queried for the relevant key words"remimazolam,""and propofol,""and gastrointestinal endoscopy or gastroscopy."The search scope was"Title and Abstract,"and the search was limited to human studies and publications in English.Seven studies wherein remimazolam and propofol were compared were included for the metaanalysis.RESULTS We selected seven randomized controlled trials involving 1445 cases for the analysis.Remimazolam reduced the hypotension(relative risk,RR=0.44,95%CI:0.29-0.66,P=0.000),respiratory depression(RR=0.46,95%CI:0.30-0.70,P=0.000),injection pain(RR=0.12,95%CI:0.05-0.25,P=0.000),bradycardia(RR=0.37,95%CI:0.24-0.58,P=0.000),and time to discharge[weighted mean difference(WMD)=-0.58,95%CI:-0.97 to-0.18,P=0.005],compared to those after propofol administration.No obvious differences were observed for postoperative nausea and vomiting(RR=1.09,95%CI:0.97-1.24,P=0.151),dizziness(RR=0.77,95%CI:0.43-1.36,P=0.361),successful sedation rate(RR=0.96,95%CI:0.93-1.00,P=0.083),or the time to become fully alert(WMD=0.00,95%CI:-1.08-1.08,P=0.998).CONCLUSION Remimazolam appears to be safer than propofol for gastroenteroscopy in older adults.However,further studies are required to confirm these findings. 展开更多
关键词 Remimazolam propofol Gastroenteroscopy ANESTHESIA Older adults SEDATION adverse events
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Propofol sedation in routine endoscopy:A case series comparing target controlled infusion vs manually controlled bolus concept
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作者 Riad Sarraj Lorenz Theiler +2 位作者 Nima Vakilzadeh Niklas Krupka Reiner Wiest 《World Journal of Gastrointestinal Endoscopy》 2024年第1期11-17,共7页
BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedatio... BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend. 展开更多
关键词 SEDATION ENDOSCOPY propofol Target controlled infusion Non-anaesthesiologist propofol sedation adverse event
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情境目标和Ad hoc关联影响言语产生的语义效应
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作者 方燕红 尹观海 张积家 《华南师范大学学报(社会科学版)》 北大核心 2024年第3期94-105,206,207,共14页
干扰词与目标词之间的语义关联性是影响言语产生中语义效应性质的关键因素。相比其他语义关联类型,Ad hoc关联是一种较为特殊的概念联系类型。考察情境目标和Ad hoc关联对语义效应的影响,结果表明:与其他语义关联性相比,Ad hoc关联对语... 干扰词与目标词之间的语义关联性是影响言语产生中语义效应性质的关键因素。相比其他语义关联类型,Ad hoc关联是一种较为特殊的概念联系类型。考察情境目标和Ad hoc关联对语义效应的影响,结果表明:与其他语义关联性相比,Ad hoc关联对语义效应的影响既有共性,又有差异。共性表现在:Ad hoc关联抑制图片命名,产生语义干扰效应,这种效应发生在图片命名早期(SOA从-200ms至0ms)。差异表现在:Ad hoc关联的语义干扰效应的产生要以情境目标提示为前提,有情境目标提示时,Ad hoc关联效应非常显著;无情境目标提示时,Ad hoc关联效应消失。不同语义关联类型产生不同语义效应的根源在于类别概念结点是否得到激活。 展开更多
关键词 情境目标 ad hoc关联 图-词干扰范式 语义效应
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Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients
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作者 Hong-Xun Yuan Li-Na Zhang +1 位作者 Gang Li Li Qiao 《World Journal of Psychiatry》 SCIE 2024年第3期370-379,共10页
BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term sedation.It remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical venti... BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term sedation.It remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical ventilation.AIM To compare the neuroprotective effects of dexmedetomidine and propofol for sedation during prolonged mechanical ventilation in patients without brain injury.METHODS Patients who underwent mechanical ventilation for>72 h were randomly assigned to receive sedation with dexmedetomidine or propofol.The Richmond Agitation and Sedation Scale(RASS)was used to evaluate sedation effects,with a target range of-3 to 0.The primary outcomes were serum levels of S100-βand neuron-specific enolase(NSE)every 24 h.The secondary outcomes were remifentanil dosage,the proportion of patients requiring rescue sedation,and the time and frequency of RASS scores within the target range.RESULTS A total of 52 and 63 patients were allocated to the dexmedetomidine group and propofol group,respectively.Baseline data were comparable between groups.No significant differences were identified between groups within the median duration of study drug infusion[52.0(IQR:36.0-73.5)h vs 53.0(IQR:37.0-72.0)h,P=0.958],the median dose of remifentanil[4.5(IQR:4.0-5.0)μg/kg/h vs 4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the median percentage of time in the target RASS range without rescue sedation[85.6%(IQR:65.8%-96.6%)vs 86.7%(IQR:72.3%-95.3),P=0.592],and the median frequency within the target RASS range without rescue sedation[72.2%(60.8%-91.7%)vs 73.3%(60.0%-100.0%),P=0.880].The proportion of patients in the dexmedetomidine group who required rescue sedation was higher than in the propofol group with statistical significance(69.2%vs 50.8%,P=0.045).Serum S100-βand NSE levels in the propofol group were higher than in the dexmedetomidine group with statistical significance during the first six and five days of mechanical ventilation,respectively(all P<0.05).CONCLUSION Dexmedetomidine demonstrated stronger protective effects on the brain compared to propofol for long-term mechanical ventilation in patients without brain injury. 展开更多
关键词 DEXMEDETOMIDINE propofol SEDATION Prolonged mechanical ventilation Brain protective
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ADS-B系统导频同步算法研究及改进
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作者 王忠跃 梁源 向新 《电光与控制》 CSCD 北大核心 2024年第3期58-60,69,共4页
针对ADS-B接收模块中,低功率信号匹配滤波器输出信号检测峰值低,且报文接收误包率较高的问题,研究和改进了导频同步算法。通过理论分析其原理,合理设计了匹配滤波器参数以实现接收性能改善,验证了基于互相关检测的前导脉冲序列检测方法... 针对ADS-B接收模块中,低功率信号匹配滤波器输出信号检测峰值低,且报文接收误包率较高的问题,研究和改进了导频同步算法。通过理论分析其原理,合理设计了匹配滤波器参数以实现接收性能改善,验证了基于互相关检测的前导脉冲序列检测方法,优化了匹配滤波器互相关检测延时模型,使得抽样时刻为最大值。仿真结果表明,与初始的模块匹配滤波器相比,所设计的匹配滤波器有效提高了低功率下的峰值,且能够有效降低误包率。 展开更多
关键词 adS-B 前导脉冲 匹配滤波 互相关
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维生素AD联合锌剂治疗呼吸道合胞病毒肺炎的效果
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作者 廖丽娟 王会丰 陈志玮 《中外医学研究》 2024年第19期1-4,共4页
目的:研究维生素AD联合锌剂治疗呼吸道合胞病毒肺炎(RSVP)的效果。方法:选取2022年7月—2023年10月深圳市龙华区妇幼保健院收治的200例RSVP患儿作为研究对象,随机分为A组、B组、C组、D组,各50例。A组给予常规治疗;B组在常规治疗基础上... 目的:研究维生素AD联合锌剂治疗呼吸道合胞病毒肺炎(RSVP)的效果。方法:选取2022年7月—2023年10月深圳市龙华区妇幼保健院收治的200例RSVP患儿作为研究对象,随机分为A组、B组、C组、D组,各50例。A组给予常规治疗;B组在常规治疗基础上单独给予维生素AD治疗;C组在常规治疗基础上单独给予锌剂治疗;D组在常规治疗用药基础上,予以维生素AD及锌剂的联合治疗。比较四组临床疗效、症状改善时间、免疫功能指标及不良反应发生情况。结果:D组总有效率高于A组、B组及C组,差异有统计学意义(P<0.05)。D组退热、喘息改善时间均早于A组,咳嗽、气促及肺部哮鸣音改善时间均早于A组、B组、C组,且C组咳嗽改善时间早于A组、B组,B组、C组气促及肺部哮鸣音改善时间均早于A组,差异有统计学意义(P<0.05)。治疗后,四组免疫球蛋白E(IgE)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)均高于治疗前,且D组均高于A组、B组、C组,B组、C组均高于A组,差异有统计学意义(P<0.05)。四组药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:维生素AD联合锌剂治疗RSVP患儿的效果较好,能够有效改善其临床症状及机体的免疫功能,且安全性较高。 展开更多
关键词 维生素ad 锌剂 呼吸道合胞病毒 肺炎 疗效
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