The presence of shale gas has been confirmed in almost every marine shale distribution area in North America.Formation conditions of shale gas in China are the most favorable for marine,organic-rich shale as well.But ...The presence of shale gas has been confirmed in almost every marine shale distribution area in North America.Formation conditions of shale gas in China are the most favorable for marine,organic-rich shale as well.But there has been little research focusing on shale gas in Qiangtang Basin,Qinghai-Tibet Plateau,where a lot of Mesozoic marine shale formations developed.Based on the survey results of petroleum geology and comprehensive test analysis data for Qinghai-Tibet Plateau,for the first time,this paper discusses characteristics of sedimentary development,thickness distribution,geochemistry,reservoir and burial depth of organic-rich shale,and geological conditions for shale gas formation in Qiangtang Basin.There are four sets of marine shale strata in Qiangtang Basin including Upper Triassic Xiaochaka Formation (T3x),Middle Jurassic Buqu Formation (J2b),Xiali Formation (J2x) and Upper Jurassic Suowa Formation (J3s),the sedimentary types of which are mainly bathyal-basin facies,open platform-platform margin slope facies,lagoon and tidal-fiat facies,as well as delta facies.By comparing it with the indicators of gas shale in the main U.S.basins,it was found that the four marine shale formations in Qiangtang Basin constitute a multi-layer distribution of organic-rich shale,featuring a high degree of thickness and low abundance of organic matter,high thermal evolution maturity,many kinds of brittle minerals,an equivalent content of quartz and clay minerals,a high content of feldspar and low porosity,which provide basic conditions for an accumulation of shale gas resources.Xiaochaka Formation shale is widely distributed,with big thickness and the best gas generating indicators.It is the main gas source layer.Xiali Formation shale is of intermediate thickness and coverage area,with relatively good gas generating indicators and moderate gas formation potential.Buqu Formation shale and Suowa Formation shale are of relatively large thickness,and covering a small area,with poor gas generating indicators,and limited gas formation potential.The shale gas geological resources and technically recoverable resources were estimated by using geologic analogy method,and the prospective areas and potentially favorable areas for Mesozoic marine shale gas in Qiangtang Basin are forecast and analyzed.It is relatively favorable in a tectonic setting and indication of oil and gas,shale maturity,sedimentary thickness and gypsum-salt beds,and in terms of mineral association for shale gas accumulation.But the challenge lies in overcoming the harsh natural conditions which contributes to great difficulties in ground engineering and exploration,and high exploration costs.展开更多
Prosperous Satellite Communications China is the birthplace of therocket.In the twelfth century,China began creating and usingthe rocket,which was believedthe oldest vehicle in the world.Its invention and creation dem...Prosperous Satellite Communications China is the birthplace of therocket.In the twelfth century,China began creating and usingthe rocket,which was believedthe oldest vehicle in the world.Its invention and creation demon-strates the outstanding intelli-gence and ability of the ancientChinese people. The splendid ancient civiliza-tions of China and other countriesjointly carried within themselvesthe seeds of modern space tech-nology.Through unremitting ef-forts of several thousand years,people’s good wish to fly into andexplore sapce has at last cometrue.Space technology has be-come an area which uses the展开更多
The rise of scientific computing was one of the most important advances in the S&T progress during the second half of the 20th century. Parallel with theoretical exploration and scientific experiments,scientific c...The rise of scientific computing was one of the most important advances in the S&T progress during the second half of the 20th century. Parallel with theoretical exploration and scientific experiments,scientific computing has become the 'third means' for scientific activities in the world today. The article gives a panoramic review of the subject during the past 50 years in China and lists the contributions made by Chinese scientists in this field. In addition, it reveals some key contents of related projects in the national research plan and looks into the development vista for the subject in China at the dawning years of the new century.展开更多
Introduction I am honored to have this opportunity to address the distinguished experts of the Shanghai Institutes for International Studies,SIIS on the issue of Asia in the Era of Globalization and Prospect for Japan...Introduction I am honored to have this opportunity to address the distinguished experts of the Shanghai Institutes for International Studies,SIIS on the issue of Asia in the Era of Globalization and Prospect for Japan-China Relations.I wish to thank Dr.Yang Jiemian。展开更多
Most of the studies on characteristic towns have made policy interpretation and planning convergence as the research focus. There is still a lack of in-depth discussion on the connotation, essence and scientificalness...Most of the studies on characteristic towns have made policy interpretation and planning convergence as the research focus. There is still a lack of in-depth discussion on the connotation, essence and scientificalness of characteristic towns. Starting from planning rationality and the source of characteristic towns, this study summarizes the cultivation process and essence of characteristic towns, looks forward to its development prospects and expounds the connotation, innovation and scientificalness of characteristic towns in east China’s Zhejiang Province and other places. The study believes that the innovation of the characteristic town Zhejiang model is reflected in the three aspects of industrial choice, space carrier and system design, but there are rational logical faults from the existing cases to the promotion of the whole province, from Zhejiang experience to national promotion. From the perspective of planning rationality, the construction of characteristic towns in China is a development model under the leadership of political rationality. Planners should clearly understand and provide technical rational support to improve the practice of characteristic towns.展开更多
The onset of critical rare diseases(RDs)in children is rapid and dangerous,accompanied by a high mortality rate,which brings a heavy burden to both families and society.Multiple malformations,neuromuscular diseases,me...The onset of critical rare diseases(RDs)in children is rapid and dangerous,accompanied by a high mortality rate,which brings a heavy burden to both families and society.Multiple malformations,neuromuscular diseases,metabolic diseases,and heart diseases are the most common types of RDs in children of China,often manifesting with multiple organ dysfunction.At present,the diagnosis and treatment of critical RDs in children face challenges such as prolonged diagnosis time,a high misdiagnosis rate,limited treatment modalities,and a significant disease burden.However,with the progress in genetic testing technology,the establishment of multidisciplinary diagnosis and treatment platforms,and the implementation of relevant RD policies in China,children with critical RDs will received enhanced medical services,experience improved prognoses,and reintegrate into social life.展开更多
Microneedles(MNs)can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions,resulting in increased therapeutic efficacy while having minimum side effects....Microneedles(MNs)can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions,resulting in increased therapeutic efficacy while having minimum side effects.MNs are used to deliver different kinds of therapeutics(e.g.,small molecules,macromolecules,nanomedicines,living cells,bacteria,and exosomes)for treating various skin disorders,including superficial tumors,wounds,skin infections,inflammatory skin diseases,and abnormal skin appearance.The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy.Through careful designing,MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes.Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing,scar removal,and hair regeneration via a mechanical communication pathway.Although MNs have several advantages,the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation,making it difficult for clinical translation.In this study,we summarized the various applications,emerging challenges,and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation.展开更多
Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and respons...Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments.展开更多
Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the applica...Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the application of BIM technology in practice,and approaches from the integration of BIM design-construction.This paper also puts forward the integration of cross-stage information based on the BIM+Geographic Information System(GIS)construction information management system to realize the BIM whole life cycle management,and provides directional support for the continuous and efficient application of BIM technology in engineering practice.展开更多
BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation therapy.It is unclear whether catheter ablation(CA)has further benefits in the...BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation therapy.It is unclear whether catheter ablation(CA)has further benefits in these patients.METHODS AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the analysis.Patients were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity score.The primary outcome was a composite of all-cause death or ischemic stroke(IS)/SE.RESULTS During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,P<0.001].There was a significant decreasing risk of all-cause mortality(HR=0.43,95%CI:0.31–0.61,P<0.001),IS/SE(HR=0.73,95%CI:0.54–0.97,P=0.033),cardiovascular mortality(HR=0.32,95%CI:0.19–0.54,P<0.001)and AF recurrence(HR=0.33,95%CI:0.30–0.37,P<0.001)in the CA group compared to that in the MT group.Sensitivity analysis generated consistent results when adjusting for time-dependent usage of anticoagulants.CONCLUSIONS In AF patients with a prior stroke history,CA was associated with a lower combined risk of all-cause death or IS/SE.Further clinical trials are warranted to confirm the benefits of CA in these patients.展开更多
Cluster of differentiation 74(CD74),also called as major histocompatibility complex class Ⅱ(MHCⅡ)invariant chain,is involved in trafficking MHCⅡ cell surface molecules on antigen-presenting cells and has been impli...Cluster of differentiation 74(CD74),also called as major histocompatibility complex class Ⅱ(MHCⅡ)invariant chain,is involved in trafficking MHCⅡ cell surface molecules on antigen-presenting cells and has been implicated in many signaling pathways.For example,the interaction between CD74 and macrophage migration inhibitory factor cyto kine(MIF) leads to the activation of a plethora of pathways such as extracellular regulated protein kinases,phosphoinositide 3-kinase.展开更多
We have been pleased that our paper Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco) based on remote sensing and geographic information systems(GIS) was of interest to our colleagu...We have been pleased that our paper Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco) based on remote sensing and geographic information systems(GIS) was of interest to our colleagues who commented it in China Geology 5(2022) 1–4.展开更多
The publisher regrets to publish this article without“Declaration of Competing Interest”.The publisher would like to apologise for any inconvenience caused.The below“Declaration of interests”text should be added.D...The publisher regrets to publish this article without“Declaration of Competing Interest”.The publisher would like to apologise for any inconvenience caused.The below“Declaration of interests”text should be added.Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.展开更多
Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collec...Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collection and treatment facilities lag behind,so that a large number of wastewater enters urban water,making urban water become gradually black and smelly.In order to provide a good living environment for human beings,a large number of scholars actively explore the treatment technology of black and smelly water.In this paper,the evolution process of black and smelly water was introduced firstly,and then the treatment technology of black and smelly water was summarized.Finally,the prospects for the development of the treatment technology were put forward.展开更多
Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation...Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by subgroups.Results: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity analyses.Conclusions: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.展开更多
Understanding and modeling individuals’behaviors during epidemics is crucial for effective epidemic control.However,existing research ignores the impact of users’irrationality on decision-making in the epidemic.Mean...Understanding and modeling individuals’behaviors during epidemics is crucial for effective epidemic control.However,existing research ignores the impact of users’irrationality on decision-making in the epidemic.Meanwhile,existing disease control methods often assume users’full compliance with measures like mandatory isolation,which does not align with the actual situation.To address these issues,this paper proposes a prospect theorybased framework to model users’decision-making process in epidemics and analyzes how irrationality affects individuals’behaviors and epidemic dynamics.According to the analysis results,irrationality tends to prompt conservative behaviors when the infection risk is low but encourages risk-seeking behaviors when the risk is high.Then,this paper proposes a behavior inducement algorithm to guide individuals’behaviors and control the spread of disease.Simulations and real user tests validate our analysis,and simulation results show that the proposed behavior inducement algorithm can effectively guide individuals’behavior.展开更多
基金co-funded by National Science and Technology Major Special Project (Grant No.2011ZX05018-001 and 2011ZX05028-002)PetroChina Co. Ltd. Project (Grant No.2011D-5002-02, 2014E-050202)
文摘The presence of shale gas has been confirmed in almost every marine shale distribution area in North America.Formation conditions of shale gas in China are the most favorable for marine,organic-rich shale as well.But there has been little research focusing on shale gas in Qiangtang Basin,Qinghai-Tibet Plateau,where a lot of Mesozoic marine shale formations developed.Based on the survey results of petroleum geology and comprehensive test analysis data for Qinghai-Tibet Plateau,for the first time,this paper discusses characteristics of sedimentary development,thickness distribution,geochemistry,reservoir and burial depth of organic-rich shale,and geological conditions for shale gas formation in Qiangtang Basin.There are four sets of marine shale strata in Qiangtang Basin including Upper Triassic Xiaochaka Formation (T3x),Middle Jurassic Buqu Formation (J2b),Xiali Formation (J2x) and Upper Jurassic Suowa Formation (J3s),the sedimentary types of which are mainly bathyal-basin facies,open platform-platform margin slope facies,lagoon and tidal-fiat facies,as well as delta facies.By comparing it with the indicators of gas shale in the main U.S.basins,it was found that the four marine shale formations in Qiangtang Basin constitute a multi-layer distribution of organic-rich shale,featuring a high degree of thickness and low abundance of organic matter,high thermal evolution maturity,many kinds of brittle minerals,an equivalent content of quartz and clay minerals,a high content of feldspar and low porosity,which provide basic conditions for an accumulation of shale gas resources.Xiaochaka Formation shale is widely distributed,with big thickness and the best gas generating indicators.It is the main gas source layer.Xiali Formation shale is of intermediate thickness and coverage area,with relatively good gas generating indicators and moderate gas formation potential.Buqu Formation shale and Suowa Formation shale are of relatively large thickness,and covering a small area,with poor gas generating indicators,and limited gas formation potential.The shale gas geological resources and technically recoverable resources were estimated by using geologic analogy method,and the prospective areas and potentially favorable areas for Mesozoic marine shale gas in Qiangtang Basin are forecast and analyzed.It is relatively favorable in a tectonic setting and indication of oil and gas,shale maturity,sedimentary thickness and gypsum-salt beds,and in terms of mineral association for shale gas accumulation.But the challenge lies in overcoming the harsh natural conditions which contributes to great difficulties in ground engineering and exploration,and high exploration costs.
文摘Prosperous Satellite Communications China is the birthplace of therocket.In the twelfth century,China began creating and usingthe rocket,which was believedthe oldest vehicle in the world.Its invention and creation demon-strates the outstanding intelli-gence and ability of the ancientChinese people. The splendid ancient civiliza-tions of China and other countriesjointly carried within themselvesthe seeds of modern space tech-nology.Through unremitting ef-forts of several thousand years,people’s good wish to fly into andexplore sapce has at last cometrue.Space technology has be-come an area which uses the
文摘The rise of scientific computing was one of the most important advances in the S&T progress during the second half of the 20th century. Parallel with theoretical exploration and scientific experiments,scientific computing has become the 'third means' for scientific activities in the world today. The article gives a panoramic review of the subject during the past 50 years in China and lists the contributions made by Chinese scientists in this field. In addition, it reveals some key contents of related projects in the national research plan and looks into the development vista for the subject in China at the dawning years of the new century.
文摘Introduction I am honored to have this opportunity to address the distinguished experts of the Shanghai Institutes for International Studies,SIIS on the issue of Asia in the Era of Globalization and Prospect for Japan-China Relations.I wish to thank Dr.Yang Jiemian。
文摘Most of the studies on characteristic towns have made policy interpretation and planning convergence as the research focus. There is still a lack of in-depth discussion on the connotation, essence and scientificalness of characteristic towns. Starting from planning rationality and the source of characteristic towns, this study summarizes the cultivation process and essence of characteristic towns, looks forward to its development prospects and expounds the connotation, innovation and scientificalness of characteristic towns in east China’s Zhejiang Province and other places. The study believes that the innovation of the characteristic town Zhejiang model is reflected in the three aspects of industrial choice, space carrier and system design, but there are rational logical faults from the existing cases to the promotion of the whole province, from Zhejiang experience to national promotion. From the perspective of planning rationality, the construction of characteristic towns in China is a development model under the leadership of political rationality. Planners should clearly understand and provide technical rational support to improve the practice of characteristic towns.
基金National Key Clinical Specialty Construction Project:Grant/Award Number:2021-451Beijing Major Epidemic Prevention and Control Key Specialty Outstanding Project:Grant/Award Number:2021-135。
文摘The onset of critical rare diseases(RDs)in children is rapid and dangerous,accompanied by a high mortality rate,which brings a heavy burden to both families and society.Multiple malformations,neuromuscular diseases,metabolic diseases,and heart diseases are the most common types of RDs in children of China,often manifesting with multiple organ dysfunction.At present,the diagnosis and treatment of critical RDs in children face challenges such as prolonged diagnosis time,a high misdiagnosis rate,limited treatment modalities,and a significant disease burden.However,with the progress in genetic testing technology,the establishment of multidisciplinary diagnosis and treatment platforms,and the implementation of relevant RD policies in China,children with critical RDs will received enhanced medical services,experience improved prognoses,and reintegrate into social life.
基金financially supported by the National Natural Science Foundation of China(82104071)Natural Science Foundation of Guangdong Province(2022B1515020085)Leading Entrepreneurship Team Project of Zengcheng District(202001004)。
文摘Microneedles(MNs)can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions,resulting in increased therapeutic efficacy while having minimum side effects.MNs are used to deliver different kinds of therapeutics(e.g.,small molecules,macromolecules,nanomedicines,living cells,bacteria,and exosomes)for treating various skin disorders,including superficial tumors,wounds,skin infections,inflammatory skin diseases,and abnormal skin appearance.The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy.Through careful designing,MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes.Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing,scar removal,and hair regeneration via a mechanical communication pathway.Although MNs have several advantages,the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation,making it difficult for clinical translation.In this study,we summarized the various applications,emerging challenges,and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation.
基金National Natural Science Foundation of China under Grant No.52278503。
文摘Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments.
基金Chongqing Engineering Institute 2023 Intramural Research Fund Grant Project:Highway Engineering Construction Process Management and Technological Innovation Research Based on BIM Technology(Project number:2023xzky04)。
文摘Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the application of BIM technology in practice,and approaches from the integration of BIM design-construction.This paper also puts forward the integration of cross-stage information based on the BIM+Geographic Information System(GIS)construction information management system to realize the BIM whole life cycle management,and provides directional support for the continuous and efficient application of BIM technology in engineering practice.
文摘BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation therapy.It is unclear whether catheter ablation(CA)has further benefits in these patients.METHODS AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the analysis.Patients were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity score.The primary outcome was a composite of all-cause death or ischemic stroke(IS)/SE.RESULTS During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,P<0.001].There was a significant decreasing risk of all-cause mortality(HR=0.43,95%CI:0.31–0.61,P<0.001),IS/SE(HR=0.73,95%CI:0.54–0.97,P=0.033),cardiovascular mortality(HR=0.32,95%CI:0.19–0.54,P<0.001)and AF recurrence(HR=0.33,95%CI:0.30–0.37,P<0.001)in the CA group compared to that in the MT group.Sensitivity analysis generated consistent results when adjusting for time-dependent usage of anticoagulants.CONCLUSIONS In AF patients with a prior stroke history,CA was associated with a lower combined risk of all-cause death or IS/SE.Further clinical trials are warranted to confirm the benefits of CA in these patients.
文摘Cluster of differentiation 74(CD74),also called as major histocompatibility complex class Ⅱ(MHCⅡ)invariant chain,is involved in trafficking MHCⅡ cell surface molecules on antigen-presenting cells and has been implicated in many signaling pathways.For example,the interaction between CD74 and macrophage migration inhibitory factor cyto kine(MIF) leads to the activation of a plethora of pathways such as extracellular regulated protein kinases,phosphoinositide 3-kinase.
文摘We have been pleased that our paper Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco) based on remote sensing and geographic information systems(GIS) was of interest to our colleagues who commented it in China Geology 5(2022) 1–4.
文摘The publisher regrets to publish this article without“Declaration of Competing Interest”.The publisher would like to apologise for any inconvenience caused.The below“Declaration of interests”text should be added.Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
文摘Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collection and treatment facilities lag behind,so that a large number of wastewater enters urban water,making urban water become gradually black and smelly.In order to provide a good living environment for human beings,a large number of scholars actively explore the treatment technology of black and smelly water.In this paper,the evolution process of black and smelly water was introduced firstly,and then the treatment technology of black and smelly water was summarized.Finally,the prospects for the development of the treatment technology were put forward.
基金supported by grants from the Beijing Nova Program (No. Z201100006820069)CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021-I2M-1-023, 2021-I2M-1-010)Talent Incentive Program of Cancer Hospital Chinese Academy of Medical Sciences (Hope Star)。
文摘Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by subgroups.Results: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity analyses.Conclusions: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.
文摘Understanding and modeling individuals’behaviors during epidemics is crucial for effective epidemic control.However,existing research ignores the impact of users’irrationality on decision-making in the epidemic.Meanwhile,existing disease control methods often assume users’full compliance with measures like mandatory isolation,which does not align with the actual situation.To address these issues,this paper proposes a prospect theorybased framework to model users’decision-making process in epidemics and analyzes how irrationality affects individuals’behaviors and epidemic dynamics.According to the analysis results,irrationality tends to prompt conservative behaviors when the infection risk is low but encourages risk-seeking behaviors when the risk is high.Then,this paper proposes a behavior inducement algorithm to guide individuals’behaviors and control the spread of disease.Simulations and real user tests validate our analysis,and simulation results show that the proposed behavior inducement algorithm can effectively guide individuals’behavior.