Objective: To evaluate the relationship between the genetic polymorphism of prostate stem cell antigen (PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia(IM) and dysplasi...Objective: To evaluate the relationship between the genetic polymorphism of prostate stem cell antigen (PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia(IM) and dysplasia(Dys), a population-based study was conducted in Linqu County, a high-risk area of gastric cancer (GC) in China. Methods: The prevalence of gastric lesions including superficial gastritis(SG), chronic atrophic gastritis(CAG), IM and Dys was determined by histopathologic examination. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The effects of PSCA genetic variant on the risks of IM and Dys were calculated by unconditional logistic regression. Results: Multivariate analysis revealed subjects carrying PSCA rs2294008 CT/TT genotype were associated with an increased risk of IM (OR=1.38, 95% CI=1.11-1.71) and Dys (OR=1.75, 95% CI=1.36-2.26), especially for subjects with H.pylori infection (IM: OR=1.34, 95% CI=1.05-1.71; Dys: OR=1.82, 95% CI=1.37-2.42). Furthermore, H. pylori infection and PSCA rs2294008 CT/TT genotype were observed to jointly elevate the risk of IM (OR=3.32, 95% CI=2.33-4.71) and Dys (OR=4.58, 95% CI=2.99-7.04). Conclusion: This study suggested that PSCA rs2294008 might have an impact on the risk of IM or Dys among the high risk population of GC.展开更多
目的系统评价前列腺干细胞抗原(PSCA)rs2294008位点多态性与胃癌癌前病变是否存在相关性。方法应用计算机检索电子数据库Pub Med、Sino Med、CNKI、万方、VIP,按纳入标准搜索含有研究PSCA rs2294008多态性与胃癌癌前病变相关性的文章,...目的系统评价前列腺干细胞抗原(PSCA)rs2294008位点多态性与胃癌癌前病变是否存在相关性。方法应用计算机检索电子数据库Pub Med、Sino Med、CNKI、万方、VIP,按纳入标准搜索含有研究PSCA rs2294008多态性与胃癌癌前病变相关性的文章,并对所纳入文献进行Meta分析。结果共5篇文章纳入研究,病例组2 310例,对照组3 240例,研究表明,PSCA ra2294008等位基因模型、加性模型、共显性模型、显性模型与胃癌癌前病变的易感性有关,差异有统计学意义(T vs C:OR=1.18,95%CI:1.09~1.28,P<0.0001;TT vs CC:OR=1.46,95%CI:1.08~1.97,P=0.01;CT vs CC:OR=1.25,95%CI:1.09~1.42,P=0.0009;CT+TT vs CC:OR=1.31,95%CI:1.16~1.49,P<0.0001),隐性模型与胃癌癌前病变的易感性有关,但差异无统计学意义(TT vs CT+CC:OR=1.24,95%CI:0.93~1.66,P=0.15)。PSCA突变等位基因T增加了萎缩性胃炎的易感性,差异有统计学意义(T vs C:OR=1.24,95%CI:1.12~1.38,I2=24,P<0.0001;TT vs CC:OR=1.60,95%CI:1.28~2.01,I2=3,P<0.0001;CT vs CC:OR=1.42,95%CI:1.17~1.72,I^2=0,P=0.0004;CT+TT vs CC:OR=1.47,95%CI:1.22~1.77,I^2=0,P<0.0001;TT vs CC:OR=1.24,95%CI:1.04~1.47,I2=47,P=0.02)。结论 PSCA rs2294008位点多态性与胃癌癌前病变有相关性。展开更多
目的评价前列腺干细胞抗原(prostate stem cell antigen,PSCA)基因rs2976392多态位点与中国人群胃癌易感性的关联。方法通过计算机检索中国知网、万方数据库、维普数据库、NCBI、Embase、Web of Science等数据库获取关于胃癌与PSCA基因r...目的评价前列腺干细胞抗原(prostate stem cell antigen,PSCA)基因rs2976392多态位点与中国人群胃癌易感性的关联。方法通过计算机检索中国知网、万方数据库、维普数据库、NCBI、Embase、Web of Science等数据库获取关于胃癌与PSCA基因rs2976392多态位点相关的文献,检索时间为自建库起至2020年3月22日。对纳入文献进行质量评价后,使用RevMan 5.3和Stata 12.0软件进行Meta分析。结果最终纳入13篇文献共14项病例对照研究,包含6618例胃癌患者和6952例对照者。Meta分析显示,等位基因模型(A vs G)、显性基因模型(AA+GA vs GG)和1个共显性基因模型(AA vs GG)均显示PSCA基因rs2976392多态位点与中国人群胃癌发病风险增加有关(OR=1.28,95%CI:1.08~1.52,P=0.004;OR=1.35,95%CI:1.27~1.45,P<0.001;OR=1.51,95%CI:1.03~2.20,P=0.030)。亚组分析结果显示,所有基因模型均与汉族人群胃癌发病风险增加有关(均P<0.001),但与藏族人群胃癌发病风险无关(均P>0.05)。结论PSCA基因rs2976392多态位点与中国人群胃癌发病风险升高有关,且以纯合AA基因型汉族人群的胃癌发病风险最高。展开更多
基金supported by a grant from the Program of National Natural Science Foundation of China(No.30772515)the National"863"High-Tech Res & Dev Program of China(No.2006A A02A402)
文摘Objective: To evaluate the relationship between the genetic polymorphism of prostate stem cell antigen (PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia(IM) and dysplasia(Dys), a population-based study was conducted in Linqu County, a high-risk area of gastric cancer (GC) in China. Methods: The prevalence of gastric lesions including superficial gastritis(SG), chronic atrophic gastritis(CAG), IM and Dys was determined by histopathologic examination. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The effects of PSCA genetic variant on the risks of IM and Dys were calculated by unconditional logistic regression. Results: Multivariate analysis revealed subjects carrying PSCA rs2294008 CT/TT genotype were associated with an increased risk of IM (OR=1.38, 95% CI=1.11-1.71) and Dys (OR=1.75, 95% CI=1.36-2.26), especially for subjects with H.pylori infection (IM: OR=1.34, 95% CI=1.05-1.71; Dys: OR=1.82, 95% CI=1.37-2.42). Furthermore, H. pylori infection and PSCA rs2294008 CT/TT genotype were observed to jointly elevate the risk of IM (OR=3.32, 95% CI=2.33-4.71) and Dys (OR=4.58, 95% CI=2.99-7.04). Conclusion: This study suggested that PSCA rs2294008 might have an impact on the risk of IM or Dys among the high risk population of GC.
文摘目的系统评价前列腺干细胞抗原(PSCA)rs2294008位点多态性与胃癌癌前病变是否存在相关性。方法应用计算机检索电子数据库Pub Med、Sino Med、CNKI、万方、VIP,按纳入标准搜索含有研究PSCA rs2294008多态性与胃癌癌前病变相关性的文章,并对所纳入文献进行Meta分析。结果共5篇文章纳入研究,病例组2 310例,对照组3 240例,研究表明,PSCA ra2294008等位基因模型、加性模型、共显性模型、显性模型与胃癌癌前病变的易感性有关,差异有统计学意义(T vs C:OR=1.18,95%CI:1.09~1.28,P<0.0001;TT vs CC:OR=1.46,95%CI:1.08~1.97,P=0.01;CT vs CC:OR=1.25,95%CI:1.09~1.42,P=0.0009;CT+TT vs CC:OR=1.31,95%CI:1.16~1.49,P<0.0001),隐性模型与胃癌癌前病变的易感性有关,但差异无统计学意义(TT vs CT+CC:OR=1.24,95%CI:0.93~1.66,P=0.15)。PSCA突变等位基因T增加了萎缩性胃炎的易感性,差异有统计学意义(T vs C:OR=1.24,95%CI:1.12~1.38,I2=24,P<0.0001;TT vs CC:OR=1.60,95%CI:1.28~2.01,I2=3,P<0.0001;CT vs CC:OR=1.42,95%CI:1.17~1.72,I^2=0,P=0.0004;CT+TT vs CC:OR=1.47,95%CI:1.22~1.77,I^2=0,P<0.0001;TT vs CC:OR=1.24,95%CI:1.04~1.47,I2=47,P=0.02)。结论 PSCA rs2294008位点多态性与胃癌癌前病变有相关性。
文摘目的评价前列腺干细胞抗原(prostate stem cell antigen,PSCA)基因rs2976392多态位点与中国人群胃癌易感性的关联。方法通过计算机检索中国知网、万方数据库、维普数据库、NCBI、Embase、Web of Science等数据库获取关于胃癌与PSCA基因rs2976392多态位点相关的文献,检索时间为自建库起至2020年3月22日。对纳入文献进行质量评价后,使用RevMan 5.3和Stata 12.0软件进行Meta分析。结果最终纳入13篇文献共14项病例对照研究,包含6618例胃癌患者和6952例对照者。Meta分析显示,等位基因模型(A vs G)、显性基因模型(AA+GA vs GG)和1个共显性基因模型(AA vs GG)均显示PSCA基因rs2976392多态位点与中国人群胃癌发病风险增加有关(OR=1.28,95%CI:1.08~1.52,P=0.004;OR=1.35,95%CI:1.27~1.45,P<0.001;OR=1.51,95%CI:1.03~2.20,P=0.030)。亚组分析结果显示,所有基因模型均与汉族人群胃癌发病风险增加有关(均P<0.001),但与藏族人群胃癌发病风险无关(均P>0.05)。结论PSCA基因rs2976392多态位点与中国人群胃癌发病风险升高有关,且以纯合AA基因型汉族人群的胃癌发病风险最高。