Significance of trace element quantities in the prostatic secretion of patients with benign prostatic hyperplasia and prostate cancer

Aim:Benign prostatic hyperplasia and prostate cancer is an internationally important health problem of the man,particularly in developed countries.The aim of this exploratory study was to evaluate whether significant difference in the levels of Zn and some other trace elements of prostatic fluid exist between the inflamed and malignantly transformed prostate.Methods:Prostatic fluid levels of Br,Fe,Rb,Sr,and Zn were prospectively evaluated in 52 patients with benign prostatic hyperplasia and 24 patients with prostate cancer.Measurements were performed using 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis.Prostatic fluid samples were divided into two portions.One was used for cytological study to exclude prostatitis,while the other was intended for trace element analysis.Results:Mean values±standard error of means for concentration(mg/L)of trace element in the prostatic fluid of hyperplastic prostate were:Br 2.32±0.30,Fe 11.5±1.8,Rb 1.70±0.23,Sr 1.41±0.26,and Zn 488±42.The contents of Rb and Zn were significantly lower(approximately 3.2 and 7.7 times,respectively)in fluid of cancerous prostate compared with those in fluid of hyperplastic prostate.Conclusion:There are significant differences in trace element contents in the fluid of hyperplastic and malignantly transformed prostate.The great decrease in levels of Rb and Zn in the fluid of cancerous prostate might demonstrate ;an involvement of these trace elements in etiology and pathogenesis of malignant prostate tumors.It was supposed that the differences in Rb and Zn levels in prostatic fluid can be used as tumor markers.

Clinicaland Experimental Study on Chronic Prostatitis with Blood Stasis Syndrome Treated by Prostatitis Recipe

Objective: To test and verify the effects of prostatitis decoction and its capsule on the treatment of chronic prostatitis with blood stasis Syndrome, and its therapeutic mechanism. Methods: The total of 561 patients were treated for 2 months, decoction group 322 cases, and capsule group 239 cases. As control group, 95 patients were treated with Qianliekang (前列康) tablets. Expressed prostatic secretion (EPS) pH and Zn content were measured before and after treatment. Observation on hemorheology and microcirculation disturbance with animal experiments were conducted. Results: The cure rate of prostatitis decoction and capsule groups was 65.8%, and 54.4% respectively, that of the control group was only 17.9%. EPS pH and Zn were markedly improved after prostatitis decoction treatment. Experimental work revealed that prostatitis decoction and its capsule had lowered the whole blood viscosity, thrombocyte adhesiveness rate and dry weight of thrombus in blood stasis rabbit model; and on rats model of microcirculation disturbance caused by adrenalin, the prostatitis decoction and its capsules had obviously delayed the occurrence of reduction and stopping of blood flow in arterioles. Conclusion: Prostatitis decoction (capsule) was effective in treating chronic prostatitis.