An Ayurvedic medicine, Liv-52 has been studied as a prophylactic against beryllium induced toxicity in rats. Administration of beryllium per se caused severe degenerative and necrotic changes in liver, kidney, lungs a...An Ayurvedic medicine, Liv-52 has been studied as a prophylactic against beryllium induced toxicity in rats. Administration of beryllium per se caused severe degenerative and necrotic changes in liver, kidney, lungs and spleen. Its administration reduced glycogen content, activity of alkaline phosphatase and adenosine triphosphatase in these oreans. On the contrary, activities of acid phosphatase and glucose-6-phosphatase were increased singificantly. In Liv-52 primed rats significant recoupment was observed in all the parameters展开更多
Objective： To investigate the protective effects of ecdysterone（EDS） on the allograft heart transplant model of rats. Methods： Fifty healthy Sprayue-Dawley（SD） rats were divided into donors and recipients random...Objective： To investigate the protective effects of ecdysterone（EDS） on the allograft heart transplant model of rats. Methods： Fifty healthy Sprayue-Dawley（SD） rats were divided into donors and recipients randomly. Hearts were harvested and placed heterotopically into allogenic recipients. All animals were divided into three groups： sham-operation group（only opening and closing the abdomen, n=l 0）, EDS group（injected intraperitoneally with 20 mg/（kg · day） of EDS, n = 10）, and control group （injected intraperitoneally with normal saline, n = 10）. The pathological changes of myocardial tissue were analyzed by light microscopy and transmission electron microscopy and the levels of myocardial enzymes（GOT, LDH, CPK）, SOD, ET-1, NO, MDA in serum were measured. Tissue samples underwent the detection ofapoptotic cell death by in situ terminal deoxyribonucleotide transferase-mediated dUTP nick end labeling for apoptotic index（M） and also by immunohistochemistry method to study the expressions of Bcl-2 and Bax. Results： Pathological examination and transmission electron microscope observation showed greater myocardium damage in the control group. EDS group showed a decrease in the amount of myocardial enzymes, MDA, ET-1 and an increase in the levels of SOD, NO, compared to the control group. The A1 of EDS group became lower than that of control group, meanwhile the EDS group increased the expression of Bcl-2 and decreased the expression of Bax. Conclusion： EDS has protective effects on heteroptopic heart transplantation, which provides a new idea for myocardial protection in heart transplantation. However, the mechanism of its protective effect needs further research.展开更多
文摘An Ayurvedic medicine, Liv-52 has been studied as a prophylactic against beryllium induced toxicity in rats. Administration of beryllium per se caused severe degenerative and necrotic changes in liver, kidney, lungs and spleen. Its administration reduced glycogen content, activity of alkaline phosphatase and adenosine triphosphatase in these oreans. On the contrary, activities of acid phosphatase and glucose-6-phosphatase were increased singificantly. In Liv-52 primed rats significant recoupment was observed in all the parameters
文摘Objective： To investigate the protective effects of ecdysterone（EDS） on the allograft heart transplant model of rats. Methods： Fifty healthy Sprayue-Dawley（SD） rats were divided into donors and recipients randomly. Hearts were harvested and placed heterotopically into allogenic recipients. All animals were divided into three groups： sham-operation group（only opening and closing the abdomen, n=l 0）, EDS group（injected intraperitoneally with 20 mg/（kg · day） of EDS, n = 10）, and control group （injected intraperitoneally with normal saline, n = 10）. The pathological changes of myocardial tissue were analyzed by light microscopy and transmission electron microscopy and the levels of myocardial enzymes（GOT, LDH, CPK）, SOD, ET-1, NO, MDA in serum were measured. Tissue samples underwent the detection ofapoptotic cell death by in situ terminal deoxyribonucleotide transferase-mediated dUTP nick end labeling for apoptotic index（M） and also by immunohistochemistry method to study the expressions of Bcl-2 and Bax. Results： Pathological examination and transmission electron microscope observation showed greater myocardium damage in the control group. EDS group showed a decrease in the amount of myocardial enzymes, MDA, ET-1 and an increase in the levels of SOD, NO, compared to the control group. The A1 of EDS group became lower than that of control group, meanwhile the EDS group increased the expression of Bcl-2 and decreased the expression of Bax. Conclusion： EDS has protective effects on heteroptopic heart transplantation, which provides a new idea for myocardial protection in heart transplantation. However, the mechanism of its protective effect needs further research.
