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Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network 被引量:2
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作者 Valentina Castillo Gabriela Mercado Claudio Hetz 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第7期1053-1054,共2页
Parkinson’s disease(PD)is the second most common neurodegenerative disease affecting 1%of the population over 60 years of age.The progressive degeneration of dopaminergic neurons at the substantia nigra pars compa... Parkinson’s disease(PD)is the second most common neurodegenerative disease affecting 1%of the population over 60 years of age.The progressive degeneration of dopaminergic neurons at the substantia nigra pars compacta(SNpc)results in a severe and gradual depletion of dopamine content in the striatum,a phenomena that is responsible for the characteristic motor symptoms of this disease. 展开更多
关键词 gene Gene therapy in Parkinson’s disease targeting the endplasmic reticulum proteostasis network
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