Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from Taiyuan, China in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic s...Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from Taiyuan, China in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic sex. Meth-ods: High-resolution GTG-banding chromosome technique was used to analyze the karyotype patterns. Results:In these patients, 57.58% were male pseudohermaphrodites (46, XY), 18.18%, female pseudohermaphrodites (46,XX), 12.12%, true hemaphrodites, and 12.12%, other karyotypes, Although testes can be seen in 88.8% of kary-otypes with Y chromosome, 73.68% of the patients were of female social sex. In 42.82% of patients the social sex isin conformity with their karyotypes. There were 2 cases of male pseudohennaphrodites, where the sex chromosome wasnormal, but abnormalities were found in chromosomes 9, 13, or 14. Conclusion: Sex chromosomes determine thedirection of gonadal and sex differentiation, while the development of the normal gonad and extemal genitalia shouldhave the participation of many autosomal chromosomes as well.展开更多
文摘Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from Taiyuan, China in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic sex. Meth-ods: High-resolution GTG-banding chromosome technique was used to analyze the karyotype patterns. Results:In these patients, 57.58% were male pseudohermaphrodites (46, XY), 18.18%, female pseudohermaphrodites (46,XX), 12.12%, true hemaphrodites, and 12.12%, other karyotypes, Although testes can be seen in 88.8% of kary-otypes with Y chromosome, 73.68% of the patients were of female social sex. In 42.82% of patients the social sex isin conformity with their karyotypes. There were 2 cases of male pseudohennaphrodites, where the sex chromosome wasnormal, but abnormalities were found in chromosomes 9, 13, or 14. Conclusion: Sex chromosomes determine thedirection of gonadal and sex differentiation, while the development of the normal gonad and extemal genitalia shouldhave the participation of many autosomal chromosomes as well.
