Osteoporosis is a disease that decreases bone mass and increases bone porosity, weakening bones. The Paleo diet is an eating plan that imitates the dietary patterns of the Stone Age. It excludes grains, dairy, and pro...Osteoporosis is a disease that decreases bone mass and increases bone porosity, weakening bones. The Paleo diet is an eating plan that imitates the dietary patterns of the Stone Age. It excludes grains, dairy, and processed foods and emphasizes feeding on lean meats, fruits, vegetables, and nuts. Consumption of the Paleo diet has many positive sides, such as high protein intake and weight loss. Still, excluding dairy products risks calcium and vitamin D deficiencies, which are crucial for bone health. Statistics and simulations that have explored the relationship between the Paleo diet and bone health (especially for people suffering from low bone density) show mixed outcomes on bone health.). While the consumer does get lots of benefits from fruit and vegetable intake in a large sum due to them containing nutrients like magnesium, potassium, and vitamin K (which are also necessary for bone health), the lack of dairy products (gives the maximum amount of calcium and vitamin D) raises concerns about maintaining adequate bone mineral density (BMD). More information on this topic shows the negative impact of this diet on people suffering from osteoporosis due to a lack of nutrient intake that nourishes the bone. Although the Paleo diet can enhance overall health through nutrient-dense foods and reduced processed intake, it can’t be said the same for people suffering from osteoporosis.展开更多
目的 观察能量限制后不同饮食模式重饲的营养变迁模型体脂的改变以及与骨密度(bone mineral density,BMD)的关系。方法 8周龄雄性 SD 大鼠分为正常饮食(normal chow for 4/12 weeks, NC4/NC12)组、限制饮食(calorie restriction for 4 w...目的 观察能量限制后不同饮食模式重饲的营养变迁模型体脂的改变以及与骨密度(bone mineral density,BMD)的关系。方法 8周龄雄性 SD 大鼠分为正常饮食(normal chow for 4/12 weeks, NC4/NC12)组、限制饮食(calorie restriction for 4 weeks,R4)组、限食后普通饮食重饲(RN)组、限食后高脂饮食重饲(high-fat diet after calorie restriction,RH)组、高脂饮食(high-fat diet,HF)组。实验 4周、12周检测大鼠四肢、躯干及全身的体脂含量及BMD。结果 (1)与同期NC组相比,大鼠各部位脂肪含量在热卡限制期变化不明显( P >0.05),但四肢/躯干脂肪比例显著下降(分别为0.418和0.327),差异有统计学意义( P <0.05)。重饲后,RN及RH组除上肢外,其他部位脂肪含量(大腿、躯干及全身脂肪含量RN组为22.80、15.77、16.17,RH组为23.80、18.55、20.90)均明显升高(NC12组3部位脂肪含量分别为20.32、10.93、12.47),同时躯干/全身脂肪比例显著增加( P <0.05),尤以RH组为著(NC12、RN及RH组分别为0.720、0.753及0.765, P <0.01),达到HF组(0.768)水平。大腿/全身脂肪比例在重饲后呈下降趋势,其中RH组(0.115)差异有统计学意义(NC12为0.150, P <0.05)。四肢/躯干脂肪比例在RN(0.237)、RH(0.205)及HF(0.210)组均明显降低(NC12为0.320),但3组间比较,差异无统计学意义。(2)热卡限制使全身(0.111 g/cm^2)、躯干(0.094 g/cm^2)及大腿(0.098 g/cm^2)BMD呈显著下降趋势(NC4分别为0.120、0.109及0.107 g/cm^2, P <0.05)。恢复饮食后,RN及RH组的BMD均有不同程度的提升,RN 组3个部位的BMD均恢复至正常水平( P >0.05),RH 组全身(0.145 g/cm^2)、躯干(0.127 g/cm^2)及大腿(0.121 g/cm^2)3个部位的BMD仍明显低于 NC12组(3个部位BMD分别为0.150、 0.136及0.130 g/cm^2)。HF 组躯干(0.141 g/cm^2)及全身BMD(0.153 g/cm^2)均明显高于NC12 组( P <0.01)。(3)多元逐步回归结果显示,体质量是影响全身、大腿及躯干BMD的最重要因素, r 值分别为0.894,0.754,0.914( P <0.001);除体质量外,大腿/全身脂肪比例是影响全身BMD( r =-0.583, P <0.001)、躯干脂肪含量是影响躯干BMD( r =-0.675, P < 0.001)的另一重要因素。结论 营养变迁可导致全身不同部位脂质含量增加,躯干部脂肪堆积明显,以限食后开放高脂饮食为著;各部位骨密度在营养变迁过程中,呈现先降低后升高的动态改变,高脂饮食重饲骨密度恢复程度较正常饮食重饲为差;体质量、大腿/全身脂肪比例及躯干脂肪含量是影响全身及局部骨密度的重要因素。展开更多
文摘Osteoporosis is a disease that decreases bone mass and increases bone porosity, weakening bones. The Paleo diet is an eating plan that imitates the dietary patterns of the Stone Age. It excludes grains, dairy, and processed foods and emphasizes feeding on lean meats, fruits, vegetables, and nuts. Consumption of the Paleo diet has many positive sides, such as high protein intake and weight loss. Still, excluding dairy products risks calcium and vitamin D deficiencies, which are crucial for bone health. Statistics and simulations that have explored the relationship between the Paleo diet and bone health (especially for people suffering from low bone density) show mixed outcomes on bone health.). While the consumer does get lots of benefits from fruit and vegetable intake in a large sum due to them containing nutrients like magnesium, potassium, and vitamin K (which are also necessary for bone health), the lack of dairy products (gives the maximum amount of calcium and vitamin D) raises concerns about maintaining adequate bone mineral density (BMD). More information on this topic shows the negative impact of this diet on people suffering from osteoporosis due to a lack of nutrient intake that nourishes the bone. Although the Paleo diet can enhance overall health through nutrient-dense foods and reduced processed intake, it can’t be said the same for people suffering from osteoporosis.
文摘目的 观察能量限制后不同饮食模式重饲的营养变迁模型体脂的改变以及与骨密度(bone mineral density,BMD)的关系。方法 8周龄雄性 SD 大鼠分为正常饮食(normal chow for 4/12 weeks, NC4/NC12)组、限制饮食(calorie restriction for 4 weeks,R4)组、限食后普通饮食重饲(RN)组、限食后高脂饮食重饲(high-fat diet after calorie restriction,RH)组、高脂饮食(high-fat diet,HF)组。实验 4周、12周检测大鼠四肢、躯干及全身的体脂含量及BMD。结果 (1)与同期NC组相比,大鼠各部位脂肪含量在热卡限制期变化不明显( P >0.05),但四肢/躯干脂肪比例显著下降(分别为0.418和0.327),差异有统计学意义( P <0.05)。重饲后,RN及RH组除上肢外,其他部位脂肪含量(大腿、躯干及全身脂肪含量RN组为22.80、15.77、16.17,RH组为23.80、18.55、20.90)均明显升高(NC12组3部位脂肪含量分别为20.32、10.93、12.47),同时躯干/全身脂肪比例显著增加( P <0.05),尤以RH组为著(NC12、RN及RH组分别为0.720、0.753及0.765, P <0.01),达到HF组(0.768)水平。大腿/全身脂肪比例在重饲后呈下降趋势,其中RH组(0.115)差异有统计学意义(NC12为0.150, P <0.05)。四肢/躯干脂肪比例在RN(0.237)、RH(0.205)及HF(0.210)组均明显降低(NC12为0.320),但3组间比较,差异无统计学意义。(2)热卡限制使全身(0.111 g/cm^2)、躯干(0.094 g/cm^2)及大腿(0.098 g/cm^2)BMD呈显著下降趋势(NC4分别为0.120、0.109及0.107 g/cm^2, P <0.05)。恢复饮食后,RN及RH组的BMD均有不同程度的提升,RN 组3个部位的BMD均恢复至正常水平( P >0.05),RH 组全身(0.145 g/cm^2)、躯干(0.127 g/cm^2)及大腿(0.121 g/cm^2)3个部位的BMD仍明显低于 NC12组(3个部位BMD分别为0.150、 0.136及0.130 g/cm^2)。HF 组躯干(0.141 g/cm^2)及全身BMD(0.153 g/cm^2)均明显高于NC12 组( P <0.01)。(3)多元逐步回归结果显示,体质量是影响全身、大腿及躯干BMD的最重要因素, r 值分别为0.894,0.754,0.914( P <0.001);除体质量外,大腿/全身脂肪比例是影响全身BMD( r =-0.583, P <0.001)、躯干脂肪含量是影响躯干BMD( r =-0.675, P < 0.001)的另一重要因素。结论 营养变迁可导致全身不同部位脂质含量增加,躯干部脂肪堆积明显,以限食后开放高脂饮食为著;各部位骨密度在营养变迁过程中,呈现先降低后升高的动态改变,高脂饮食重饲骨密度恢复程度较正常饮食重饲为差;体质量、大腿/全身脂肪比例及躯干脂肪含量是影响全身及局部骨密度的重要因素。
