BACKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical challenge.The therapeutic use o...BACKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical challenge.The therapeutic use of methylprednisolone sodium succinate(MPSS)via different administration routes,in combination with conventional medications,remains a topic of interest.AIM To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid-to high-frequency SSNHL.METHODS The medical records of 109 patients with mid-to high-frequency SSNHL were analyzed.The patients were divided into three groups based on the route of administration:Group A[intratympanic(IT)injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection],Group B(intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection),and Group C(single IT injection of MPSS).The intervention effects were compared and analyzed.RESULTS The posttreatment auditory thresholds in Group A(21.23±3.34)were significantly lower than those in Groups B(28.52±3.36)and C(30.23±4.21;P<0.05).Group A also exhibited a significantly greater speech recognition rate(92.23±5.34)than Groups B and C.The disappearance time of tinnitus,time to hearing recovery,and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and C(P<0.05).The total effective rate in Group A(97.56%)was significantly greater than that in Groups B and C(77.14%and 78.79%,χ^(2)=7.898,P=0.019).Moreover,the incidence of adverse reactions in Groups A and C was significantly lower than that in Group B(4.88%,3.03%vs 2.57%,χ^(2)=11.443,P=0.003),and the recurrence rate in Group A was significantly lower than that in Groups B and C(2.44%vs 20.00%vs 21.21%,χ^(2)=7.120,P=0.028).CONCLUSION IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administration via intravenous infusion and a single IT injection of MPSS.This approach effectively improves patients'hearing and reduces the risk of disease recurrence.展开更多
In order to understand the kinetic characteristics of coal gas desorption based on the pulsating injection （PI）, the research experimentally studied the kinetic process of methane desorption in terms of the PI and h...In order to understand the kinetic characteristics of coal gas desorption based on the pulsating injection （PI）, the research experimentally studied the kinetic process of methane desorption in terms of the PI and hydrostatic injection （HI）. The results show that the kinetic curves of methane desorption based on PI and HI are consistent with each other, and the diffusion model can best describe the characteristics of meth- ane desorption. Initial velocity, diffusion capacity and ultimate desorption amount of methane desorption after P! are greater than those after HI, and the ultimate desorption amount increases by 16.7-39.7%. Methane decay rate over the time is less than that of the HI. The PI influences the diffusion model param- eters, and it makes the mass transfer Biot number B＇_i decrease and the mass transfer Fourier series F＇_0 increase. As a result, PI makes the methane diffusion resistance in the coal smaller, methane diffusion rate greater, mass transfer velocity faster and the disturbance range of methane concentration wider than HI. Therefore, the effect of methane desorption based on PI is better than that of HI.展开更多
Cavitation commonly induces performance deterioration and system vibration in many engineering applications.This paper aims to investigate the effects of air injection on cavitation evolution,pressure pulsation and vi...Cavitation commonly induces performance deterioration and system vibration in many engineering applications.This paper aims to investigate the effects of air injection on cavitation evolution,pressure pulsation and vibration in a centrifugal pump with inducer.In this paper,the high-speed camera is used to capture the gas flow pattern and cavitation evolution process in the inducer.The impacts of air injection on the inlet pressure pulsation and vibration are also investigated.The results show that the cavitation development in the inducer undergoes four patterns:incipient cavitation,sheet cavitation,cloud cavitation and super cavitation.During the development of cavitation,the main frequency of the pressure pulsation shifts to lower frequencies,and the amplitude of the vibration increases.In addition,air injection promotes the incipient cavitation but delays the cavitation development.A small amount of air can effectively decrease amplitudes of pressure pulsation and vibration.But as the air content increases,the fluctuations and amplitudes of pressure pulsation and vibration increase.展开更多
文摘BACKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical challenge.The therapeutic use of methylprednisolone sodium succinate(MPSS)via different administration routes,in combination with conventional medications,remains a topic of interest.AIM To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid-to high-frequency SSNHL.METHODS The medical records of 109 patients with mid-to high-frequency SSNHL were analyzed.The patients were divided into three groups based on the route of administration:Group A[intratympanic(IT)injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection],Group B(intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection),and Group C(single IT injection of MPSS).The intervention effects were compared and analyzed.RESULTS The posttreatment auditory thresholds in Group A(21.23±3.34)were significantly lower than those in Groups B(28.52±3.36)and C(30.23±4.21;P<0.05).Group A also exhibited a significantly greater speech recognition rate(92.23±5.34)than Groups B and C.The disappearance time of tinnitus,time to hearing recovery,and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and C(P<0.05).The total effective rate in Group A(97.56%)was significantly greater than that in Groups B and C(77.14%and 78.79%,χ^(2)=7.898,P=0.019).Moreover,the incidence of adverse reactions in Groups A and C was significantly lower than that in Group B(4.88%,3.03%vs 2.57%,χ^(2)=11.443,P=0.003),and the recurrence rate in Group A was significantly lower than that in Groups B and C(2.44%vs 20.00%vs 21.21%,χ^(2)=7.120,P=0.028).CONCLUSION IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administration via intravenous infusion and a single IT injection of MPSS.This approach effectively improves patients'hearing and reduces the risk of disease recurrence.
基金financially supported by the National Basic Research Program of China (No. 2011CB201205)the National Natural Science Foundation of China (No. 51274195)+2 种基金the Natural Science Foundation of Jiangsu Province of China (No. BK2012571)the National Major Scientific Instrument and Equipment Development Project of China (No. 2013YQ17046309)the Education Department Science and Technology Key Project of Henan Province of China (14B440007)
文摘In order to understand the kinetic characteristics of coal gas desorption based on the pulsating injection （PI）, the research experimentally studied the kinetic process of methane desorption in terms of the PI and hydrostatic injection （HI）. The results show that the kinetic curves of methane desorption based on PI and HI are consistent with each other, and the diffusion model can best describe the characteristics of meth- ane desorption. Initial velocity, diffusion capacity and ultimate desorption amount of methane desorption after P! are greater than those after HI, and the ultimate desorption amount increases by 16.7-39.7%. Methane decay rate over the time is less than that of the HI. The PI influences the diffusion model param- eters, and it makes the mass transfer Biot number B＇_i decrease and the mass transfer Fourier series F＇_0 increase. As a result, PI makes the methane diffusion resistance in the coal smaller, methane diffusion rate greater, mass transfer velocity faster and the disturbance range of methane concentration wider than HI. Therefore, the effect of methane desorption based on PI is better than that of HI.
基金supported by the National Natural Science Foundation of China(Grant No.51979126).
文摘Cavitation commonly induces performance deterioration and system vibration in many engineering applications.This paper aims to investigate the effects of air injection on cavitation evolution,pressure pulsation and vibration in a centrifugal pump with inducer.In this paper,the high-speed camera is used to capture the gas flow pattern and cavitation evolution process in the inducer.The impacts of air injection on the inlet pressure pulsation and vibration are also investigated.The results show that the cavitation development in the inducer undergoes four patterns:incipient cavitation,sheet cavitation,cloud cavitation and super cavitation.During the development of cavitation,the main frequency of the pressure pulsation shifts to lower frequencies,and the amplitude of the vibration increases.In addition,air injection promotes the incipient cavitation but delays the cavitation development.A small amount of air can effectively decrease amplitudes of pressure pulsation and vibration.But as the air content increases,the fluctuations and amplitudes of pressure pulsation and vibration increase.
