Periodic markets are an important aspect of local economies,providing a platform for farmers(producers),wholesalers,retailers,and consumers to interact face-to-face and exchange goods and services.These markets have b...Periodic markets are an important aspect of local economies,providing a platform for farmers(producers),wholesalers,retailers,and consumers to interact face-to-face and exchange goods and services.These markets have been increasing in urban areas in Africa,Asia,and South America because of urbanization.The increase of periodic urban markets(PUMs)in urban areas is observed as an index of modernization,reflecting a response to transition process.However,there are limited studies on how social interactions in PUMs contribute to sustainable livelihoods.This study investigated the types of social interactions occurring in PUMs in Ghana,the benefits of social interactions for participants of PUMs,and how social interactions contribute to sustainable livelihoods.This research interviewed 162 participants,comprising 27 farmers(farmers were regarded as producers in this study),61 retailers,47 wholesalers from 9 selected PUMs across Ghana,and 27 officers from government institutions and non-governmental market associations to obtain their opinions.We analyzed the interview data using the NVivo software.The results showed that there are seven kinds of social interactions in PUMs,including(i)producer-wholesaler relationship,(ii)producer-consumer relationship,(iii)wholesaler-retailer relationship,(iv)retailer-consumer relationship,(v)trader-driver relationship,(vi)trader-institution relationship,and(vii)trader-international buyer relationship.We found that these social interactions in PUMs enhance sustainable livelihoods by supporting human,social,financial,natural,and physical assets of traders(traders refer to producers,wholesalers,and retailers in this study).Therefore,we concluded that the development of policies to improve PUMs could strengthen social interactions,enabling the achievement of sustainable livelihoods in developing countries.展开更多
通过子带Wiener滤波结合PUM(Probabilistic Union Model)模型,实现在噪声环境下连续字语音识别的方法。该方法先通过对语音信号进行子带Wiener滤波预处理消除已知噪声,为PUM模型提供只有局部被噪声污染的语音信号,再利用PUM模型进行抗...通过子带Wiener滤波结合PUM(Probabilistic Union Model)模型,实现在噪声环境下连续字语音识别的方法。该方法先通过对语音信号进行子带Wiener滤波预处理消除已知噪声,为PUM模型提供只有局部被噪声污染的语音信号,再利用PUM模型进行抗噪语音识别。试验表明在各种不同的噪声环境下,该新方法有更高的平均识别率。展开更多
Posttranscriptional regulation of cancer gene expression programs plays a vital role in carcinogenesis;identifying the critical regulators of tumorigenesis and their molecular targets may provide novel strategies for ...Posttranscriptional regulation of cancer gene expression programs plays a vital role in carcinogenesis;identifying the critical regulators of tumorigenesis and their molecular targets may provide novel strategies for cancer diagnosis and therapeutics.Highly conserved RNA-binding protein Pumilio-1(PUM1)regulates mouse growth and cell proliferation,propelling us to examine its role in cancer.We found human PUM1 is highly expressed in a diverse group of cancer,including prostate cancer;enhanced PUM1 expression is also correlated with reduced survival among prostate cancer patients.Detailed expression analysis in twenty prostate cancer tissues showed enhanced expression of PUM1 at mRNA and protein levels.Knockdown of PUM1 reduced prostate cancer cell proliferation and colony formation,and subcutaneous injection of PUM1 knockdown cells led to reduced tumor size.Downregulation of PUM1 in prostate cancer cells consistently elevated cyclin-dependent kinase inhibitor 1B(CDKN1B)protein expression through increased translation but did not impact its mRNA level,while overexpression of PUM1 reduced CDKN1B protein level.Our finding established a critical role of PUM1 mediated translational control,particularly the PUM1-CDKN1B axis,in prostate cancer cell growth and tumorigenesis.We proposed that PUM1-CDKN1B regulatory axis may represent a novel mechanism for the loss of CDKN1B protein expression in diverse cancers and potential targets for therapeutics development.展开更多
Starting with the meanings of the terms “risk” and “uncertainty,””he paper compares uncertainty management with risk management in project management. We bring some doubt to the use of “risk” and “uncertainty...Starting with the meanings of the terms “risk” and “uncertainty,””he paper compares uncertainty management with risk management in project management. We bring some doubt to the use of “risk” and “uncertainty” interchangeably in project management and deem their scope, methods, responses, monitoring and controlling should be different too. Illustrations are given covering terminology, description, and treatment from different perspectives of uncertainty management and risk management. Furthermore, the paper retains that project risk management (PRM) processes might be modified to facilitate an uncertainty management perspective, and we support that project uncertainty management (PUM) can enlarge its contribution to improving project management performance, which will result in a significant change in emphasis compared with most risk management.展开更多
文摘Periodic markets are an important aspect of local economies,providing a platform for farmers(producers),wholesalers,retailers,and consumers to interact face-to-face and exchange goods and services.These markets have been increasing in urban areas in Africa,Asia,and South America because of urbanization.The increase of periodic urban markets(PUMs)in urban areas is observed as an index of modernization,reflecting a response to transition process.However,there are limited studies on how social interactions in PUMs contribute to sustainable livelihoods.This study investigated the types of social interactions occurring in PUMs in Ghana,the benefits of social interactions for participants of PUMs,and how social interactions contribute to sustainable livelihoods.This research interviewed 162 participants,comprising 27 farmers(farmers were regarded as producers in this study),61 retailers,47 wholesalers from 9 selected PUMs across Ghana,and 27 officers from government institutions and non-governmental market associations to obtain their opinions.We analyzed the interview data using the NVivo software.The results showed that there are seven kinds of social interactions in PUMs,including(i)producer-wholesaler relationship,(ii)producer-consumer relationship,(iii)wholesaler-retailer relationship,(iv)retailer-consumer relationship,(v)trader-driver relationship,(vi)trader-institution relationship,and(vii)trader-international buyer relationship.We found that these social interactions in PUMs enhance sustainable livelihoods by supporting human,social,financial,natural,and physical assets of traders(traders refer to producers,wholesalers,and retailers in this study).Therefore,we concluded that the development of policies to improve PUMs could strengthen social interactions,enabling the achievement of sustainable livelihoods in developing countries.
文摘通过子带Wiener滤波结合PUM(Probabilistic Union Model)模型,实现在噪声环境下连续字语音识别的方法。该方法先通过对语音信号进行子带Wiener滤波预处理消除已知噪声,为PUM模型提供只有局部被噪声污染的语音信号,再利用PUM模型进行抗噪语音识别。试验表明在各种不同的噪声环境下,该新方法有更高的平均识别率。
基金supported by the National Natural Science Foundation of China(Grant No.31771652 and No.81270737).
文摘Posttranscriptional regulation of cancer gene expression programs plays a vital role in carcinogenesis;identifying the critical regulators of tumorigenesis and their molecular targets may provide novel strategies for cancer diagnosis and therapeutics.Highly conserved RNA-binding protein Pumilio-1(PUM1)regulates mouse growth and cell proliferation,propelling us to examine its role in cancer.We found human PUM1 is highly expressed in a diverse group of cancer,including prostate cancer;enhanced PUM1 expression is also correlated with reduced survival among prostate cancer patients.Detailed expression analysis in twenty prostate cancer tissues showed enhanced expression of PUM1 at mRNA and protein levels.Knockdown of PUM1 reduced prostate cancer cell proliferation and colony formation,and subcutaneous injection of PUM1 knockdown cells led to reduced tumor size.Downregulation of PUM1 in prostate cancer cells consistently elevated cyclin-dependent kinase inhibitor 1B(CDKN1B)protein expression through increased translation but did not impact its mRNA level,while overexpression of PUM1 reduced CDKN1B protein level.Our finding established a critical role of PUM1 mediated translational control,particularly the PUM1-CDKN1B axis,in prostate cancer cell growth and tumorigenesis.We proposed that PUM1-CDKN1B regulatory axis may represent a novel mechanism for the loss of CDKN1B protein expression in diverse cancers and potential targets for therapeutics development.
文摘Starting with the meanings of the terms “risk” and “uncertainty,””he paper compares uncertainty management with risk management in project management. We bring some doubt to the use of “risk” and “uncertainty” interchangeably in project management and deem their scope, methods, responses, monitoring and controlling should be different too. Illustrations are given covering terminology, description, and treatment from different perspectives of uncertainty management and risk management. Furthermore, the paper retains that project risk management (PRM) processes might be modified to facilitate an uncertainty management perspective, and we support that project uncertainty management (PUM) can enlarge its contribution to improving project management performance, which will result in a significant change in emphasis compared with most risk management.
