pupillary constriction occurs with intravenous administration of opioids such as sufentanil.However, few studies have investigated the pupillary effects of intrathecal （IT） sufentanil. It has previously been demonst...pupillary constriction occurs with intravenous administration of opioids such as sufentanil.However, few studies have investigated the pupillary effects of intrathecal （IT） sufentanil. It has previously been demonstrated that the cephalad spread within the cerebrospinal fluid of IT sufentanil results in side effects. There are two principal findings of the present study： （1） spinal sufentanil combined with low-dose of bupivacaine in patients with lower abdominal or lower extremity procedures induces a dose-dependent pupillary constriction that is far more sensitive than other centrally-mediated side effects; （2） the pupillary effect of IT sufentanil correlates closely with the adequacy of spinal anesthesia.展开更多
文摘pupillary constriction occurs with intravenous administration of opioids such as sufentanil.However, few studies have investigated the pupillary effects of intrathecal （IT） sufentanil. It has previously been demonstrated that the cephalad spread within the cerebrospinal fluid of IT sufentanil results in side effects. There are two principal findings of the present study： （1） spinal sufentanil combined with low-dose of bupivacaine in patients with lower abdominal or lower extremity procedures induces a dose-dependent pupillary constriction that is far more sensitive than other centrally-mediated side effects; （2） the pupillary effect of IT sufentanil correlates closely with the adequacy of spinal anesthesia.
