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New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties
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作者 Marwa Dhiabi Sirine Karoui +7 位作者 Mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar 《International Journal of Organic Chemistry》 2024年第3期107-122,共16页
The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was establishe... The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound. 展开更多
关键词 2-amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-amine Microwave Irradiation Tumoral Cell Line in Silico ADMET
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Synthesis, Crystal Structure and Antitumor Activity of (E)-4-tert-Butyl-N-(2,4-dichlorobenzylidene)-5-(1,2,4-triazol-1-yl)-thiazol-2-amine 被引量:5
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作者 胡艾希 覃智 +1 位作者 叶姣 夏曙 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第11期1680-1683,共4页
The title compound (E)-4-tert-butyl-N-(2,4-dichlorobenzylidene)-5-(1,2,4-triazol-1-yl)-thiazol-2-amine was synthesized by the reaction of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-thiazol-2-amine with 2,4-dichlorobe... The title compound (E)-4-tert-butyl-N-(2,4-dichlorobenzylidene)-5-(1,2,4-triazol-1-yl)-thiazol-2-amine was synthesized by the reaction of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-thiazol-2-amine with 2,4-dichlorobenzaldehyde, and its crystal structure was determined by singlecrystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 7.9748(4), b = 10.1803(5), c = 11.4603(6), α = 102.882(1), β = 100.253(1), γ = 104.457(1)°, V = 850.95(7)3, Z = 2, F(000) = 392, C16H15Cl2N5S, Mr = 380.29, Dc = 1.484 g/cm3, S = 1.095, μ = 0.512 mm-1, the final R = 0.0301 and wR = 0.0965 for 3334 observed reflections (I 〉 2σ(I)). The preliminary antitumor activity shows that for the title compound the IC50 of Hela is 0.175 μmol/mL and that of Bel7402 is 0.156 μmol/mL. 展开更多
关键词 (E)-4-tert-butyl-N-(2 4-dichorobenzylidene)-5-(1 2 4-triazl-1-yl)-thiazol-2-amine crystal structure synthesis antitumor activity
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Synthesis, Crystal Structure and Antitumor Activity of 4-tert-Butyl-N-(2-fluorophenyl)-5- (1H-1,2,4-triazol-1-yl)-thiazol-2-amine 被引量:1
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作者 李婉 叶姣 +2 位作者 沈芳 彭俊梅 胡艾希 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第12期1782-1786,共5页
The title compound has been synthesized by the reaction of 1-bromo-3,3-dime- thyl- 1 - (1 H- 1,2,4-triazol- 1 -yl)butan-2-one with 1 -(2-fluorophenyl)thiourea, and its crystal struc- ture was determined by single-... The title compound has been synthesized by the reaction of 1-bromo-3,3-dime- thyl- 1 - (1 H- 1,2,4-triazol- 1 -yl)butan-2-one with 1 -(2-fluorophenyl)thiourea, and its crystal struc- ture was determined by single-crystal X-ray diffraction. The crystal belongs to the orthorhombic system, space group Pbca with a = 15.2568(6), b = 12.1533(5), c = 16.7307(7) A, Z = 8, V = 3102.2(2) A3, Mr = 317.39, Dc = 1.359 g/cm3, S = 1.05, μ = 0.223 mm-1, F(000) = 1328, the final R = 0.034 and wR = 0.097 for 2590 observed reflections (I 〉 2σ(I)). X-ray crystal structure presents the intramolecular N-H…N hydrogen bond, which plays an important role in stabilizing the crystal structure. In addition, the preliminary biological test on the title compound shows good antitumor activity, with IC50 of 0.122 μmol/mL against the Hela cell line. 展开更多
关键词 4-tert-butyl-N-(2-fluorophenyl)-5-(1H-1 2 4-triazol-1-yl)thiazol-2-amine SYNTHESIS crystal structure antitumor activity
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Synthesis, Crystal Structure and Antitumor Activity of 4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)-N-(2-hydroxy-3,5-diiodinebenzyl)-thiazol-2-amine 被引量:1
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作者 叶姣 谢选青 +3 位作者 李康明 刘永超 孙利 胡艾希 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2015年第3期344-348,共5页
The title compound, 4-(tert-butyl)-5-(1 H- 1,2,4-triazol- 1 -yl)-N-(2-hydroxy-3,5-diio- dinebenzyl)thiazol-2-amine, was synthesized via the reduction of 4-(tert-butyl)-5-(1H-l,2,4- triazol-l-yl)-N-benzyliden... The title compound, 4-(tert-butyl)-5-(1 H- 1,2,4-triazol- 1 -yl)-N-(2-hydroxy-3,5-diio- dinebenzyl)thiazol-2-amine, was synthesized via the reduction of 4-(tert-butyl)-5-(1H-l,2,4- triazol-l-yl)-N-benzylidene-thiazol-2-amine with NaBH4, and its crystal structure was determined by single-crystal X-ray diffraction. The compound crystallizes in monoclinic system, space group P21/c with a = 7.91944(19), b = 10.5250(3), c = 24.4985(6) A, Z = 4, V = 2041.66(9) A3, Mr = 599.22, Dc = 1,949 Mg/m3, S = 1.120, p = 3.203 mm-1, F(000) = 1152, the final R = 0.0283 and wR = 0.0592 for 3490 observed reflections (I 〉 2σ(I)). X-ray analysis displays that the crystal water takes part in three intermolecular hydrogen bonds of O(2)-H(2A)…O(1), O(2)-H(2B)…N(I) and N(5)-H(5)…O(2), and an octatomic ring R^(8) is formed via intramolecular hydrogen bond of O(I)-H(IA)…N(4). Furthermore, the I…I contacts are involved in stabilizing the overall three-dimensional network structure. The preliminary biological test shows the title compound has good antitumor activity with the IC50 value of 26 μM against the Hela cell line. 展开更多
关键词 4-(tert-butyl)-5-(1H-1 2 4-triazol-1-yl)-N-(2-hydroxy-3-5-diiodinebenzyl)-thiazol-2-amine synthesis crystal structure antitumor activity
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Synthesis, Crystal Structure and Antitumor Activities of N,N,1-Triphenyl-1H-benzo[d]imidazol-5-amine Derivatives
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作者 SHAO Jia-Xin GUO Zi-Yin +2 位作者 PENG Shi-Yong ZHU Zhong-Zhi CHEN Xiu-Wen 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第11期1895-1901,共7页
In order to discover the novel antitumor agents,a series of N,N,1-triphenyl-1Hbenzo[d]imidazol-5-amine derivatives were designed and synthesized,and the structures were characterized by IR,H-RMS,1H and 13C NMR.X-ray c... In order to discover the novel antitumor agents,a series of N,N,1-triphenyl-1Hbenzo[d]imidazol-5-amine derivatives were designed and synthesized,and the structures were characterized by IR,H-RMS,1H and 13C NMR.X-ray crystallography showed that 4c is in monoclinic system,space group P1 with a=9.209(2),b=9.533(3),c=14.097(3)?,β=102.069(3)°,V=1202.2(5)?3,Z=2,F(000)=528,μ=1.74 mm–1,S=1.024,the final R=0.0448 and wR=0.1109.The in vitro antitumor activities of target compounds were evaluated by MTT assay against human cancer cell lines K562,HL-60,HeLa and BGC-823.The target compounds demonstrated weak or moderate antitumor activities against these cell lines. 展开更多
关键词 N N 1-triphenyl-1H-benzo[d]imidazol-5-amine derivatives synthesis crystal structure antitumor activity
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4-(7-Methoxy-2,2-dimethyl-2,3-dihydrobenzo-furan-5-yl)-N-(pyridin-2-yl)thiazol-2-amine: Chiral Crystal from Achiral Molecule
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作者 彭俊梅 曹高 +3 位作者 罗先福 胡艾希 叶姣 欧晓明 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2013年第8期1194-1198,共5页
The title compound 4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)-N- (pyridin-2-yl) thiazol-2-amine was synthesized by reacting 2-bromo-1-(7-methoxy-2,2-dime- thyl-2,3-dihydrobenzofuran-5-yl)ethanone with... The title compound 4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)-N- (pyridin-2-yl) thiazol-2-amine was synthesized by reacting 2-bromo-1-(7-methoxy-2,2-dime- thyl-2,3-dihydrobenzofuran-5-yl)ethanone with 1-(pyridine-2-yl)thiourea, and its crystal was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, chiral space group C2 with a = 18.1328(14), b = 5.5969(5), c = 19.2195(15) A, β= 115.5420(10)°, V= 1759.9(2)A3, Z = 4, F(000) = 744, C19H19N3O2S, Mr= 353.43, Dc= 1.334 g/cm3, S = 1.15, μ = 0.201 mm-1, the final R = 0.035 and wR = 0.111 for 2307 observed reflections (I 〉 2σ(I)). The Flack parameter is -0.03(10). The preliminary bioassay result indicated that the title compound exhibits strong insecticidal activity (93.75% mortality) against Mythimna separate at the concentration of 1.000 g/L. 展开更多
关键词 4-(7-methoxy-2 2.dimethyl-2 3-dihydrobenzofuran-5-yl)-N-(pyridin-2-yl)thiazol-2-amine chiral crystal structure synthesis insecticidal activity
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Synthesis,Crystal Structure and Antitumor Activity of(E)-N-(4-Fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine
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作者 LIN Wei-Yuan YANG Fang +2 位作者 DUAN An-Na YOU Wen-Wei ZHAO Pei-Liang 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2018年第10期1557-1562,共6页
The crystal structure of the title compound(E)-N-(4-fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4 H-1,2,4-triazol-4-amine(C_(19)H_(19)FN_4O_3S,Mr = 402.44) was synthesized,and its struct... The crystal structure of the title compound(E)-N-(4-fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4 H-1,2,4-triazol-4-amine(C_(19)H_(19)FN_4O_3S,Mr = 402.44) was synthesized,and its structure was characterized by 1 H-NMR,13 C-NMR,ESI-MS and single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P1 with a = 9.228(13),b = 10.364(14),c = 10.641(14) ?,α = 85.323(3),β = 75.172(2),γ = 80.903(3)°,μ = 0.20 mm^(-1),M_r = 402.44,V = 970.64(10) ?~3,Z = 2,D_c = 1.377 g/cm^3,F(000) = 420,R = 0.0484 and wR = 0.1474 for 3181 observed reflections with I 〉 2σ(I).In addition,the preliminary bioassay indicated that the title compound 5 exhibits better inhibitory activity against Hela than 5-fluorouracil. 展开更多
关键词 (E)-N-(4-fluorobenzylidene)-3-(methylthio)-5-(3 4 5-trimethoxyphenyl)-4H-1 2 4-triazol-4-amine SYNTHESIS crystal structure anfitumor activity
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Greener approach towards the facile synthesis of 1,4-dihydropyrano[2,3-c]pyrazol-5-y1 cyanide derivatives at room temperature 被引量:5
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作者 Ravi S.Balaskar Sandip N.Gavade +3 位作者 Madhav S.Mane Bapurao B.Shingate Murlidhar S.Shingare Dhananjay V.Mane 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第10期1175-1179,共5页
This report describes triethylammonium acetate (TEAA) ionic liquid catalyzed one pot synthesis of 6-amino-4-aryl-5-cyano-3- methyl-1-phenyl-1,4-dihydropyrano [2,3-c]pyrazoles by the reaction of aromatic aldehyde, ma... This report describes triethylammonium acetate (TEAA) ionic liquid catalyzed one pot synthesis of 6-amino-4-aryl-5-cyano-3- methyl-1-phenyl-1,4-dihydropyrano [2,3-c]pyrazoles by the reaction of aromatic aldehyde, malononitrile and 3-methyl-1-phenyl-2- pyrazolin-5-one at room temperature. TEAA plays dual role as reaction media and catalyst. It can also be easily recovered and reused in several runs. TEAA provides greener reaction protocol to present methodology which obviates the need of organic solvents, expensive and toxic catalyst. 展开更多
关键词 Triethylammonium acetate (TEAA) 1 4-Dihydropyrano[2 3-c]pyrazol-5-yl cyanides Room temperature
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Enamine Configuration of 5-Methyl-2-phenyl-4- [(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one
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作者 QIAO Yu-Qin Lü Xing-Qiang +1 位作者 BAO Feng KANG Bei-Sheng 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第8期957-961,共5页
Compound 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one (C24H21N3O) crystallizes in the triclinic system, space group P1, with a = 9.267(3), b = 9.904(4),c = 12.035(4) A°, α ... Compound 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one (C24H21N3O) crystallizes in the triclinic system, space group P1, with a = 9.267(3), b = 9.904(4),c = 12.035(4) A°, α = 97.896(6), β = 103.865(6), γ = 107.950(6)°, Mr= 367.44, Z = 2, V = 993.2(6)A°^3,Dc = 1.229 g/cm^3,μ(MoKa) = 0.077 mm^-1 and F(000) = 388. The structure was refined to R =0.0444 and wR = 0.1199 for 2903 observed reflections (I 〉 2σ(I)). The results of ^1H NMR and single-crystal X-ray diffraction studies showed the enamine character of the compound. The strong intramolecular hydrogen bonds in the large conjugate system, together with weak intermolecular C-H……π hydrogen bonding and π……π stacking, lead to the formation of a multi-dimensional supramolecular network. 展开更多
关键词 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one enamine weak interaction snpramolecnlar network
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Selenium-catalyzed oxidative carbonylation of 1,2,3-thiadiazol-5-amine with amines to 1,2,3-thiadiazol-5-ylureas
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作者 Xiaopeng Zhang Shuxiang Dong +2 位作者 Qianqian Ding Xuesen Fan Guisheng Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第2期375-378,共4页
A facile one-pot, economical approach to 1,2,3-thiadiazol-5-ylureas was developed via seleniumcatalyzed oxidative carbonylation of 1,2,3-thiadiazol-5-amine with a series of amines in one-pot manner in the presence of ... A facile one-pot, economical approach to 1,2,3-thiadiazol-5-ylureas was developed via seleniumcatalyzed oxidative carbonylation of 1,2,3-thiadiazol-5-amine with a series of amines in one-pot manner in the presence of CO and O_2. This approach is featured with cheap and easily available raw materials,cheap and reusable catalyst selenium, one-pot procedure, high atomic economy, simple operations and no emission of corrosive wastes. 展开更多
关键词 SELENIUM OXIDATIVE CARBONYLATION 1 2 3-Thiadiazol-5-amine 1 2 3-Thiadiazol-5-ylureas PHASE-TRANSFER catalysis
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Synthesis and Crystal Structural Characterization of a Thiosemicarbazone Derived from 4-Acylpyrazolone 被引量:3
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作者 LIU Guang-Fei LIU Lang +2 位作者 HU Xin JIA Dian-Zeng YU Kai-Bei 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第10期1233-1237,共5页
The reaction of 4-(p-fluobenzoyl)-2,5-dihydro-3-methyl-1-phenyl pyrazol-5-one with thiosemicarbazide in MeOH followed by recrystallization in EtOH gave rise to yellowish lamellar crystals of 4(p-fluo-a-aminothiocar... The reaction of 4-(p-fluobenzoyl)-2,5-dihydro-3-methyl-1-phenyl pyrazol-5-one with thiosemicarbazide in MeOH followed by recrystallization in EtOH gave rise to yellowish lamellar crystals of 4(p-fluo-a-aminothiocarbonyl hydrazonobenzal)-2,5-dihydro-3-methyl- 1-phenyl pyrazol-5-one 1. It crystallizes in orthorhombic, space group Pbca with a = 18.445(4), b = 11.987(2), c = 19.249(4) °A,, V= 4256.1(18)°A^3, Z = 8, Mr = 415.49, Dc= 1.297 g/cm^3, T = 296(2) K, F(000) = 1744,μ(MoKα) = 0.186 cm^-1, R = 0.0521 and wR = 0.1211 for 1661 observed reflections with I 〉 2σ(I). The compound was structurally characterized by elemental analyses, IR and ^1H NMR. The intermolecular hydrogen bonds are present and a two-dimensional framework is formed by two intermolecular hydrogen bonds in the (001) plane. 展开更多
关键词 pyrazol-5-one thiosemicarhazide crystal structure SYNTHESIS
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N-Methylimidazolium perchlorate as a new ionic liquid for the synthesis of bis(pyrazol-5-ol)s under solvent-free conditions
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作者 Nader Ghaffari Khaligh Sharifah Bee Abd Hamid Salam J.J.Titinchi 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第1期104-108,共5页
N-Methylimidazolium perchlorate([MIm]ClO_4) was synthesized and some of its physico-chemical properties, such as density, surface tension were investigated. A thermo gravimetric analysis(TGA) and solvent performan... N-Methylimidazolium perchlorate([MIm]ClO_4) was synthesized and some of its physico-chemical properties, such as density, surface tension were investigated. A thermo gravimetric analysis(TGA) and solvent performance were also studied. The results show that this ionic liquid is an excellent catalyst for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives under solvent-free conditions.This method has the advantages of high yield, clean transformation, simple operation and short reaction time. The ionic liquid can be recycled without significant loss of activity. 展开更多
关键词 Ionic liquid N-Methylimidazolium perchlorate Bis(pyrazol-5-ol)s Recycle
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Syntheses of Some 3-[1′(1′H)-Substituent-pyrazol-5′-yl] benzo[5,6]coumarins
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作者 E-LDEEN Ibrahim Mohey +3 位作者 AL-WAKEEL El-Sayed Ismail El-MAWLA Ahmed Gad 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第7期670-675,共6页
3-[1′ (1′ H)-Substituent-pyrazol-5′-yl] benzo[5, 6] coumarins and3-(1′,2′-oxazol-5′-yl)benzo[5,6]coumarin were prepared via condensation of3-(2′-formyl-1′-chlorovinyl) benzo [5, 6] coumarin with hydrazine deri... 3-[1′ (1′ H)-Substituent-pyrazol-5′-yl] benzo[5, 6] coumarins and3-(1′,2′-oxazol-5′-yl)benzo[5,6]coumarin were prepared via condensation of3-(2′-formyl-1′-chlorovinyl) benzo [5, 6] coumarin with hydrazine derivatives or hydroxylamine.Reaction of 3-[1′(1′ H)-pyrazol-5′-yl] benzo[5, 6] coumarin with alkyl halidcs, olefiniccompounds or acid chlorides are described. 展开更多
关键词 heterocycle synthesis pyrazol-5′-ylbenzo [5 6] coumarin alkylation atpyrazole nitrogen
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Syntheses, Crystal Structures and Antibacterial Activities of Copper(Ⅱ) and Zinc(Ⅱ) Complexes Based on (E)-4-fluoro-2-((3-morpholinopropylimino)methyl)phenol
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作者 方瑞琴 肖竹平 +2 位作者 胡晓慧 焦庆才 朱海亮 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第7期981-986,共6页
Two Schiff base complexes [Cu(L)2] (1) and [Zn(L)2]·3H2O(2) of (E)-4-fluoro-2-((3-morpholino propylimino)methyl)phenol (HL) have been synthesized and characterized by elemental analysis and single... Two Schiff base complexes [Cu(L)2] (1) and [Zn(L)2]·3H2O(2) of (E)-4-fluoro-2-((3-morpholino propylimino)methyl)phenol (HL) have been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. Crystal data for 1: triclinic, space group Pī with a=4.8000(10), b=11.109(2), c=13.921(3),α=66.55(3),β=80.35(3),γ=81.09(3)°, V=668.2(2)3 , Z=1, Dc=1.477g/cm 3 , F(000)=311, and the final R=0.0744 and wR=0.1601 for 2301 observed reflections with I 〉 2σ(I). And those for 2: monoclinic, space group P21 /c with a=14.789(3), b=11.713(2), c=18.846(4),β=107.85(3)°, V=3107.4(11)3 , Z=4, D c=1.389 g/cm 3 , F(000)=1368, and the final R=0.0749 and wR=0.1348 for 5423 observed reflections with I 〉 2σ(I). Both 1 and 2 are four-coordinated complexes, with a square-planar geometry of copper(Ⅱ) in 1 and a slightly distorted tetrahedral geometry of zinc(Ⅱ) in 2. An asymmetric unit consists of only one half of a Cu ion and one L ligand in 1, while an asymmetric unit is composed of one Zn ion, two L ligands and three water molecules in 2. Non-classical C-H···O and C-H F hydrogen bonds play important roles in the formation of a 1D chain of 1, but O-H O and O-H N hydrogen bonds play dominant roles in the self-assembly of a 3D network of 2. The antibacterial activities of 1 and 2 against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. coli and E. cloacae have been evaluated by MTT method. 展开更多
关键词 5)-fluoro-salicylaldehyde 3-morpholinopropan-1-amine Schiffbase complexes crystal structure antibacterial activities
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Effect of an Organic Inhibitor on the Electrical Properties of High Carbon Steel in Simulated Acid Environment
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作者 Osarolube Eziaku 《Journal of Materials Science and Chemical Engineering》 2014年第7期28-33,共6页
The effect of 1-Phenyl-3-Methyl Pyrazol-5-one (HPMP) on the electrical properties of high carbon steel in Hydrochloric acid (HCI), Trioxonitrate (v) acid (HNO3) and Perchloric acid (HCIO4) was studied by weight loss m... The effect of 1-Phenyl-3-Methyl Pyrazol-5-one (HPMP) on the electrical properties of high carbon steel in Hydrochloric acid (HCI), Trioxonitrate (v) acid (HNO3) and Perchloric acid (HCIO4) was studied by weight loss method. The acidic medium caused a complete degradation of the electrical properties of the coated and uncoated high carbon steel. However, the attack was more on the uncoated coupons, which showed that HPHP is an effective corrosion inhibitor. HNO3 had the most severe effect on the metal. The coupons coated with HPMP generally had higher values of resistance (0.0155 Ω) and conductivity (6.20 mho/m) in HCI environment than the uncoated coupons (0.0043 Ω) and (1.72 mho/m). Similar results were obtained for HNO3 and HCIO4 environments. These values are lower than the values obtained for as-received coupons: -0.0466 and 8.64 mho/m respectively. 展开更多
关键词 ELECTRICAL Properties Corrosion High Carbon Steel 1-Phenyl-3-Methyl pyrazol-5-One
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Heterocyclization of thiocarbonohydrazides:Facile synthesis of 5-unsubstituted-1,3,4-thiadiazoles
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作者 Alaa A.Hassan Fathy F.Abdel-Latif +3 位作者 Mohamed Abdel Aziz Sara M.Mostafa Stefan Brse Martin Nieger 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第9期1183-1186,共4页
2-(Hydrazinecarbothioyl)-N-substituted hydrazinecarbothioamides react with 2,3,5,6-tetrachloro-1,4-benzoquinone in high yields in a novel fast and facile method to give 5-unsubstituted-1,3,4-thiadiazole-2-amine deri... 2-(Hydrazinecarbothioyl)-N-substituted hydrazinecarbothioamides react with 2,3,5,6-tetrachloro-1,4-benzoquinone in high yields in a novel fast and facile method to give 5-unsubstituted-1,3,4-thiadiazole-2-amine derivatives.The synthesized compounds were characterized by spectroscopic methods and confirmed by using X-ray crystallography.A rationale for the formation of the products is presented. 展开更多
关键词 Thiocarbonohydrazides 5-Unsubstituted 1 3 4-thiadiazol-2-amines Tetrachloro-1 4-benzoquinone X-ray crystallography
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Catalyst free synthesis of fused pyrido[2,3-d]pyrimidines and pyrazolo[3,4-b]pyridines in water 被引量:2
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作者 Abbas Rahmati Zahra Khalesi 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第10期1149-1152,共4页
A one-pot, three-component condensation reaction of an aldehyde, benzoyl acetonitrile (3-oxo-3-phenylpropane nitrile) and 6- amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione or 3-methyl-l-phenyl-lH-pyrazol-5-amine in... A one-pot, three-component condensation reaction of an aldehyde, benzoyl acetonitrile (3-oxo-3-phenylpropane nitrile) and 6- amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione or 3-methyl-l-phenyl-lH-pyrazol-5-amine in water to give fused pyrido[2,3- d]pyrimidines and pyrazolo[3,4-b]pyridines in high yields without any catalyst, is described. 展开更多
关键词 AMINOPYRAZOLE Aqueous media 3-Methyl-l-phenyl-lH-pyrazol-5-amine Pyrazolo[3 4-b]pyridine
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