Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing c...Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole.展开更多
An efficient synthesis of functionalized 6-decalone 16, starting from a dienolate anion 3a via a tandem Michael reaction, is described. 16 could be used as a potential intermediate for synthesis of drimane related ses...An efficient synthesis of functionalized 6-decalone 16, starting from a dienolate anion 3a via a tandem Michael reaction, is described. 16 could be used as a potential intermediate for synthesis of drimane related sesquiterpenes.展开更多
A C/D ring synthon of vitamin D is readily obtained from cholesteryl acetate via oxidation, elimination of acetoxy group and Norrish type II photochemical reaction.
The first diastereodivergent formal[4+1]cycloaddition reactions of azoalkenes with p-quinone methides(pQMs)have been accomplished.The reported reaction occurred via a domino oxa-1,4-addition/1,6-addition process,allow...The first diastereodivergent formal[4+1]cycloaddition reactions of azoalkenes with p-quinone methides(pQMs)have been accomplished.The reported reaction occurred via a domino oxa-1,4-addition/1,6-addition process,allowing the use of common azoalkenes as C1 synthons.A broad range of 2,3-dihydrobenzofurans was smoothly prepared in good yields and with reversible diastereoselectivities.The steric hindrance and hydrogenbonding interaction were proposed to account for the two different modes of diastereo-control.The projected reaction features the employment of azoalkene as carbene-like C1 synthon,mild conditions,broad substrate scope and tunable diastereoselectivity.展开更多
基金supported by the National Natural Science Foundation of China(21971073,22001075,22231002)the Natural Science Foundation of Guangdong Province(2019A1515011468)+2 种基金the Discipline Construction Project of Guangdong Medical University(4SG23231G,4SG23249G)the Ordinary University Characteristic Innovation Project of Guangdong Province(2022KTSCX047)the Key-Area Research and Development Program of Guangdong Province(2020B010188001)。
文摘Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole.
文摘An efficient synthesis of functionalized 6-decalone 16, starting from a dienolate anion 3a via a tandem Michael reaction, is described. 16 could be used as a potential intermediate for synthesis of drimane related sesquiterpenes.
文摘A C/D ring synthon of vitamin D is readily obtained from cholesteryl acetate via oxidation, elimination of acetoxy group and Norrish type II photochemical reaction.
基金support from the Natural Science Foundation of Henan Province(No.222300420084)the Application Research Plan of Key Scientific Research Projects in Colleges and Universities of Henan Province(No.22A150056)is gratefully acknowledged.
文摘The first diastereodivergent formal[4+1]cycloaddition reactions of azoalkenes with p-quinone methides(pQMs)have been accomplished.The reported reaction occurred via a domino oxa-1,4-addition/1,6-addition process,allowing the use of common azoalkenes as C1 synthons.A broad range of 2,3-dihydrobenzofurans was smoothly prepared in good yields and with reversible diastereoselectivities.The steric hindrance and hydrogenbonding interaction were proposed to account for the two different modes of diastereo-control.The projected reaction features the employment of azoalkene as carbene-like C1 synthon,mild conditions,broad substrate scope and tunable diastereoselectivity.