Three new pyridine type alkaloids,(-)-vinmajpyridines A–C(1–3),along with two known alkaloids,have been isolated from the aerial parts of Vinca major cultivated in Pakistan.Their structures have been elucidated by m...Three new pyridine type alkaloids,(-)-vinmajpyridines A–C(1–3),along with two known alkaloids,have been isolated from the aerial parts of Vinca major cultivated in Pakistan.Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data.The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines(GITC-3#and GITC-18#),glioblastoma cell lines(U-87MG and T98G),and lung cancer cell line A-549,but none of them was active at 20 lg/mL concentration.展开更多
基金The authors are grateful to the National Natural Science Foundation of China(81225024)for financial support.
文摘Three new pyridine type alkaloids,(-)-vinmajpyridines A–C(1–3),along with two known alkaloids,have been isolated from the aerial parts of Vinca major cultivated in Pakistan.Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data.The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines(GITC-3#and GITC-18#),glioblastoma cell lines(U-87MG and T98G),and lung cancer cell line A-549,but none of them was active at 20 lg/mL concentration.
