Hydrazinolysis ofethylthiopyrimidine derivative 2 gave 2-hydrazinopyrimidine 3 which used as a convenient precursor for the synthesis of pyrazolylpyrimidines, hydrazones and pyrimidotriazines. Also, treatment of 2 wit...Hydrazinolysis ofethylthiopyrimidine derivative 2 gave 2-hydrazinopyrimidine 3 which used as a convenient precursor for the synthesis of pyrazolylpyrimidines, hydrazones and pyrimidotriazines. Also, treatment of 2 with ethyl chloroacetate yielded N^-carbethoxymethyl-2-ethylthio-pyrimidine 15, which on reaction with ethyl carbazate and hydrazine hydrate afforded pyrimidotriazine and imidazopyrimidine, respectively. Chlorination of 2 using phosphorous oxycbloride yielded 4-chloropyrimidine 18, which reacted with some heterocyclic compounds having vicinal amino cyano groups to give some new polynuclear heterocyclic system. Also, the effect of some active methylene compounds on 18 was also studied. Some of the newly synthesized compounds were tested as mollucicidal agents against Biomphlaria alexandrina snails that caused intestinal bilharzias, the national problem in Egypt.展开更多
文摘Hydrazinolysis ofethylthiopyrimidine derivative 2 gave 2-hydrazinopyrimidine 3 which used as a convenient precursor for the synthesis of pyrazolylpyrimidines, hydrazones and pyrimidotriazines. Also, treatment of 2 with ethyl chloroacetate yielded N^-carbethoxymethyl-2-ethylthio-pyrimidine 15, which on reaction with ethyl carbazate and hydrazine hydrate afforded pyrimidotriazine and imidazopyrimidine, respectively. Chlorination of 2 using phosphorous oxycbloride yielded 4-chloropyrimidine 18, which reacted with some heterocyclic compounds having vicinal amino cyano groups to give some new polynuclear heterocyclic system. Also, the effect of some active methylene compounds on 18 was also studied. Some of the newly synthesized compounds were tested as mollucicidal agents against Biomphlaria alexandrina snails that caused intestinal bilharzias, the national problem in Egypt.
