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确定性筛选设计在Purcise Q膜纯化抗体的应用
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作者 胡晔 廖敏 《生物化工》 CAS 2024年第1期75-78,90,共5页
目的:通过确定性筛选设计(DSD)方法建立单抗的Purcise Q膜阴离子交换工艺,进一步降低残留宿主细胞蛋白(HCP)含量。方法:将亲和层析洗脱过滤液作为样品,进行Purcise Q膜层析,选取上样pH、上样电导、载量、流速、峰收集条件5个因子为输入... 目的:通过确定性筛选设计(DSD)方法建立单抗的Purcise Q膜阴离子交换工艺,进一步降低残留宿主细胞蛋白(HCP)含量。方法:将亲和层析洗脱过滤液作为样品,进行Purcise Q膜层析,选取上样pH、上样电导、载量、流速、峰收集条件5个因子为输入因子,以回收率、HCP去除率、多聚体含量为输出响应值,使用确定性筛选设计DOE模型进行实验。结果:在实验参数范围内,多聚体含量没有明显的变化,HCP含量显著降低。上样电导和载量显著影响HCP去除率,而载量、流速和峰收集条件则显著影响层析回收率。利用JMP的模拟实验功能获得了稳健工艺参数组合(上样电导3 ms/cm、载量300 g/L、流速25 MV/min、峰收集50 mAU/mm),进一步利用决策树机器学习方法自动获得设计空间(上样电导3.0~3.6 ms/cm、载量300~460 g/L、流速5~25 MV/min、峰收集50~180 mAU/mm)。结论:确定性筛选设计实验方法适用于膜层析的工艺开发,能够一段式快速获得稳健工艺参数组合和设计空间,对于工艺放大、工艺转移和降低生产风险极具指导意义。 展开更多
关键词 确定性筛选设计 Purcise q膜层析 宿主细胞蛋白 设计空间 稳健工艺参数
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Composition-integral Type Operators from F(p, q, s) Spaces to Bloch-type Spaces 被引量:2
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作者 LV Xiao-fen YING Shao-hong 《Chinese Quarterly Journal of Mathematics》 CSCD 2012年第3期352-356,共5页
This paper deals with the boundedness and compactness of the compositionintegral type operators T g, from F (p, q, s) spaces to(little) Bloch-type spaces in the unit ball of C n , where Tg,φf(z) =∫01fφ(tz)Rg(tz)(dt... This paper deals with the boundedness and compactness of the compositionintegral type operators T g, from F (p, q, s) spaces to(little) Bloch-type spaces in the unit ball of C n , where Tg,φf(z) =∫01fφ(tz)Rg(tz)(dt)/t , z ∈ B, g ∈ H(B) and φ∈H(B, B). 展开更多
关键词 F (p q s) space Bloch-type space BOUNDEDNESS COMPACTNESS
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THE EQUIVALENT CHARACTERIZATION OF F(p,q,s)SPACE ON BOUNDED SYMMETRIC DOMAINS OF Cn 被引量:4
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作者 黎深莲 张学军 徐思 《Acta Mathematica Scientia》 SCIE CSCD 2017年第6期1791-1802,共12页
LetΩ be a bounded symmetric domain in Cn. The purpose of this article is to define and characterize the general function space F(p, q, s) on Ω. Characterizing functions in the F(p, q, s) space is a work of consi... LetΩ be a bounded symmetric domain in Cn. The purpose of this article is to define and characterize the general function space F(p, q, s) on Ω. Characterizing functions in the F(p, q, s) space is a work of considerable interest nowadays. In this article, the authors give several equivalent descriptions of the functions in the F(p, q, s) space on Ω in terms of fractional differential operators. At the same time, the authors give the relationship between F(p, q, s) space and Bloch type space on Ω too. 展开更多
关键词 F(p q s) space equivalent description bounded symmetric domain
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AN INTEGRAL ESTIMATE AND THE EQUIVALENT NORMS ON F(p, q, s, k) SPACES IN THE UNIT BALL 被引量:8
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作者 张学军 黎深莲 +1 位作者 尚清丽 郭雨婷 《Acta Mathematica Scientia》 SCIE CSCD 2018年第6期1861-1880,共20页
In this article, the authors give a typical integral's bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F(p, q, s, k) space in theunit ball of Cn are given.
关键词 F(p q s k) space integral estimate equivalent norm unit ball
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CARLESON MEASURES,RIEMANN-STIELTJES OPERATORS AND MULTIPLIERS ON F(p,q,s)SPACES IN THE UNIT BALL OF C^n 被引量:3
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作者 彭茹 吴悠 邓方文 《Acta Mathematica Scientia》 SCIE CSCD 2016年第3期635-654,共20页
This paper is devoted to characterizing the Riemann-Stieltjes operators and pointwise multipliers on F(p, q, s) spaces in the unit ball of C^n which contain many classical function spaces, such as the Bloch space, B... This paper is devoted to characterizing the Riemann-Stieltjes operators and pointwise multipliers on F(p, q, s) spaces in the unit ball of C^n which contain many classical function spaces, such as the Bloch space, BMOA and Q8 spaces. The boundedness and compactness of these operators on F(p, q, s) spaces are characterized by means of an embedding theorem, i.e., F(p,q, s) spaces boundedly embedded into the tent-type spaces Tp,s^∞(μ) 展开更多
关键词 Carleson measures F(p q s) spaces tent-type spaces Riemann-Stieltjes operators MULTIPLIERS
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Weighted composition operators from F(p,q,s) spaces to Bers-type spaces in the unit ball 被引量:2
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作者 LU Xiao-fen 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2009年第4期462-472,共11页
This paper deals with the boundedness and compactness of the weighted composition operators from the F(p, q, s) spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to ... This paper deals with the boundedness and compactness of the weighted composition operators from the F(p, q, s) spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to Bers-type spaces Hv^∞( or little Bers-type spaces Hv,o∞ ), where v is normal. 展开更多
关键词 F(p q s) space Bers-type space weighted composition operator unit ball
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CRITERIA FOR AN ANALYTIC FUNCTION BELONGING TO THE Q_K SPACES 被引量:2
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作者 乌兰哈斯 《Acta Mathematica Scientia》 SCIE CSCD 2009年第1期33-44,共12页
The author gives a mild integral condition in a nondecreasing function K : [0, ∞) → [0, ∞), which is sufficient and the best possible to ensure that f is a Bloch function if and only if f belongs to QK, a Mbius-inv... The author gives a mild integral condition in a nondecreasing function K : [0, ∞) → [0, ∞), which is sufficient and the best possible to ensure that f is a Bloch function if and only if f belongs to QK, a Mbius-invariant space of functions analytic in the unit disk. Their contributions are slight improvements of known results, and the proofs presented here are independently developed. The corresponding results for meromorphic case are also given. 展开更多
关键词 Areally mean q-valent circumferentially mean q-valent qK spaces
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Toeplitz and Translation Operators on the q-Fock Spaces 被引量:1
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作者 Fethi Soltani 《Advances in Pure Mathematics》 2011年第6期325-333,共9页
In this work, we introduce a class of Hilbert spaces Fq of entire functions on the disk , , with reproducing kernel given by the q-exponential function eq(z);and we prove some properties concerning Toeplitz operators ... In this work, we introduce a class of Hilbert spaces Fq of entire functions on the disk , , with reproducing kernel given by the q-exponential function eq(z);and we prove some properties concerning Toeplitz operators on this space. The definition and properties of the space extend naturally those of the well-known classical Fock space. Next, we study the multiplication operator Dq by and the q-Derivative operator on the Fock space Fq;and we prove that these operators are adjoint-operators and continuous from this space into itself. Lastly, we study a generalized translation operators and a Weyl commutation relations on Fq . 展开更多
关键词 q-Fock spaces q-Exponential Function q-DERIVATIVE Operator q-Translation OPERATORS q-Toeplitz OPERATORS q-Weyl Commutation Relations
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Fock Spaces for the q-Dunkl Kernel
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作者 Fethi Soltani 《Advances in Pure Mathematics》 2012年第3期169-176,共8页
In this work, we introduce a class of Hilbert spaces of entire functions on the disk , 0<q<1 , with reproducing kernel given by the q-Dunkl kernel . The definition and properties of the space extend naturally th... In this work, we introduce a class of Hilbert spaces of entire functions on the disk , 0<q<1 , with reproducing kernel given by the q-Dunkl kernel . The definition and properties of the space extend naturally those of the well-known classical Fock space. Next, we study the multiplication operator Q by z and the q-Dunkl operator on the Fock space;and we prove that these operators are adjoint-operators and continuous from this space into itself. 展开更多
关键词 Generalized q-Fock spaceS q-Dunkl KERNEL q-Dunkl Operator q-Translation OPERATORS
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iShim and Water Excitation Improves the Signal-to-Noise Ratio on q-Space Imaging: A Single-Center Clinical Study
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作者 Yoshifumi Sone Junichi Hata +9 位作者 Yasushi Sera Katsuya Maruyama Thomas Benkert Zhouchen Lu Jun Kasahara Hideyuki Okano Morio Matsumoto Masaya Nakamura Daisuke Nakashima Takeo Nagura 《Open Journal of Radiology》 2018年第4期244-259,共16页
Purpose: This study aimed to examine whether the signal-to-noise ratio (SNR) could be increased by combining integrated slice-by-slice shimming (iShim) with a fat suppression (FS) method other than short-tau inversion... Purpose: This study aimed to examine whether the signal-to-noise ratio (SNR) could be increased by combining integrated slice-by-slice shimming (iShim) with a fat suppression (FS) method other than short-tau inversion recovery (STIR) in diffusion-weighted imaging (DWI) and q-space imaging (qsi). Methods: We acquired DWI images (b-values: 0 and nine steps from 400 to 10,000 s/mm2 for six axes) using a prototypical single-shot echo planar imaging sequence by combining two types of shimming (3D Shim and iShim) and two types of FS (STIR and water excitation [WE]) in 10 volunteers. In the DWI study, the SNR for each b-value, FS effect in the b0 image, and distortion in the added image (b0 - b10,000) were evaluated for the above-mentioned four imaging methods. qsi involved original DWI images. In the qsi study, the SNR was evaluated. Results: With regard to both 3D Shim and iShim, the SNRs were significantly higher when using WE than when using STIR in b0 - b900 images (p Conclusion: The combination of iShim and WE has a high SNR on qsi. 展开更多
关键词 iShim FAT Suppression WATER EXCITATION DIFFUSION-WEIGHTED IMAGING q-space IMAGING (qsi)
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Multiplication and Translation Operators on the Fock Spaces for the q-Modified Bessel Function
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作者 Fethi Soltani 《Advances in Pure Mathematics》 2011年第4期221-227,共7页
We study the multiplication operator M by z2 and the q-Bessel operator Δq,αon a Hilbert spaces Fq,α of entire functions on the disk D( o, ) , 0qq,α into itself. Next, we study a generalized translation operators o... We study the multiplication operator M by z2 and the q-Bessel operator Δq,αon a Hilbert spaces Fq,α of entire functions on the disk D( o, ) , 0qq,α into itself. Next, we study a generalized translation operators on Fq,α . 展开更多
关键词 Generalized q-Fock spaces q-Iα Modified BESSEL Function q-Bessel OPERATOR MULTIPLICATION OPERATOR q-Translation Operators
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<i>Q<sub>K</sub></i>Type Spaces and Bloch Type Spaces on the Unit Ball
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作者 Rong Hu 《Advances in Pure Mathematics》 2019年第10期857-862,共6页
Different function spaces have certain inclusion or equivalence relations. In this paper, the author introduces a class of M&#246;bius-invariant Banach spaces QK,0 (p,q) of analytic function on the unit ball of Cn... Different function spaces have certain inclusion or equivalence relations. In this paper, the author introduces a class of M&#246;bius-invariant Banach spaces QK,0 (p,q) of analytic function on the unit ball of Cn, where K:(0,∞)→[0,∞) are non-decreasing functions and 0P∞, p/2-n-1q∞, studies the inclusion relations between QK,0 (p,q) and a class of B0α spaces which was known before, and concludes that QK,0 (p,q) is a subspace of B0(q+n+1)/p, and the sufficient and necessary condition on kernel function K(r) such that QK,0 (p,q)= B0(q+n+1)/p. 展开更多
关键词 Unit Ball qK 0(p q) B0(q+n+1)/p space Equivalence Relation
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CRITERIA FOR AN ANALYTIC FUNCTION BELONGING TO THE Q_K SPACES 被引量:1
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作者 乌兰哈斯 《软件工程师》 2009年第4期-,共12页
The author gives a mild integral condition in a nondecreasing function K : [0, ∞) → [0, ∞), which is sufficient and the best possible to ensure that f is a Bloch function if and only if f belongs to QK, a Mbius-i... The author gives a mild integral condition in a nondecreasing function K : [0, ∞) → [0, ∞), which is sufficient and the best possible to ensure that f is a Bloch function if and only if f belongs to QK, a Mbius-invariant space of functions analytic in the unit disk. Their contributions are slight improvements of known results, and the proofs presented here are independently developed. The corresponding results for meromorphic case are also given. 展开更多
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认知雷达中基于Q学习的自适应波形选择算法 被引量:7
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作者 王彬 汪晋宽 +1 位作者 宋昕 韩英华 《系统工程与电子技术》 EI CSCD 北大核心 2011年第5期1007-1012,共6页
自适应波形选择器是认知雷达中智能发射器的重要组成部分。有效的波形选择能够在不同的环境下选择发射最优的波形序列,从而以更高的精度追踪目标。针对雷达目标转移概率未知这一特点,把自适应波形选择问题建模为随机动态规划模型,提出应... 自适应波形选择器是认知雷达中智能发射器的重要组成部分。有效的波形选择能够在不同的环境下选择发射最优的波形序列,从而以更高的精度追踪目标。针对雷达目标转移概率未知这一特点,把自适应波形选择问题建模为随机动态规划模型,提出应用Q学习的方法来解决这个问题。仿真结果说明,该算法接近于最优波形选择方案,并且状态估计的不确定性低于固定波形。 展开更多
关键词 波形选择 q学习 空间划分 认知雷达
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Bergman空间和q-Bloch空间之间的复合算子 被引量:5
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作者 唐笑敏 胡璋剑 《数学年刊(A辑)》 CSCD 北大核心 2006年第1期109-118,共10页
本文讨论了Bergman空间和q-Bloch空间(小q-Bloch空间)之间的复合算子Cφ的有界性和紧性特征,得到了以下结论:(1)Cφ是q-Bloch空间(小q-Bloch空间)到Bergman空间的有界算子或紧算子之充要条件; (2)Cφ是Bergman空间到q-Bloch空间的有界... 本文讨论了Bergman空间和q-Bloch空间(小q-Bloch空间)之间的复合算子Cφ的有界性和紧性特征,得到了以下结论:(1)Cφ是q-Bloch空间(小q-Bloch空间)到Bergman空间的有界算子或紧算子之充要条件; (2)Cφ是Bergman空间到q-Bloch空间的有界算子或紧算子之充要条件; (3)Cφ是Bergman空间到小q-Bloch空间的有界算子或紧算子之充要条件,还给出了算子 Cφ0的范数估计,此处Cφ0(f)(z)=foφ(z)-f(φ(0)). 展开更多
关键词 BERGMAN空间 q-Bloch空间 q-Bloch空间 复合算子 范数
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双重d-q空间下五相电压源逆变器空间矢量脉宽调制死区效应分析与补偿 被引量:12
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作者 薛诚 宋文胜 冯晓云 《中国电机工程学报》 EI CSCD 北大核心 2017年第9期2667-2676,共10页
电压源逆变器(voltage source inverter,VSI)受到死区效应以及开关暂态过程等非线性因素的影响,导致负载电机定子相电流中含有低次谐波,畸变率较大。针对五相VSI系统,在分析其双重d-q子谐波空间及电压矢量空间状态分布的基础上,进行空... 电压源逆变器(voltage source inverter,VSI)受到死区效应以及开关暂态过程等非线性因素的影响,导致负载电机定子相电流中含有低次谐波,畸变率较大。针对五相VSI系统,在分析其双重d-q子谐波空间及电压矢量空间状态分布的基础上,进行空间矢量脉宽调制算法死区效应的研究。然后,以五相永磁同步电机矢量控制算法为例,根据仿真中设置不同的死区时间得到的电压谐波含量,验证理论分析的正确性,同时对其电流控制方案进行改进,实现双重d-q空间下的谐波电流闭环抑制,从而对VSI系统死区效应进行补偿,达到了消除电机电流中低次谐波的目的。计算机仿真和硬件在环半实物实验结果均验证了该方案的正确性和有效性。 展开更多
关键词 永磁同步电机 五相电压源逆变器 空间矢量脉宽调制 死区效应 双重谐波空间 谐波分析
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基于知识融合和深度强化学习的智能紧急切机决策 被引量:1
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作者 李舟平 曾令康 +4 位作者 姚伟 胡泽 帅航 汤涌 文劲宇 《中国电机工程学报》 EI CSCD 北大核心 2024年第5期1675-1687,I0001,共14页
紧急控制是在严重故障后维持电力系统暂态安全稳定的重要手段。目前常用的“人在环路”离线紧急控制决策制定方式存在效率不高、严重依赖专家经验等问题,该文提出一种基于知识融合和深度强化学习(deep reinforcement learning,DRL)的智... 紧急控制是在严重故障后维持电力系统暂态安全稳定的重要手段。目前常用的“人在环路”离线紧急控制决策制定方式存在效率不高、严重依赖专家经验等问题,该文提出一种基于知识融合和深度强化学习(deep reinforcement learning,DRL)的智能紧急切机决策制定方法。首先,构建基于DRL的紧急切机决策制定框架。然后,在智能体处理多个发电机决策时,由于产生的高维决策空间使得智能体训练困难,提出决策空间压缩和应用分支竞争Q(branching dueling Q,BDQ)网络的两种解决方法。接着,为了进一步提高智能体的探索效率和决策质量,在智能体训练中融合紧急切机控制相关知识经验。最后,在10机39节点系统中的仿真结果表明,所提方法可以在多发电机决策时快速给出有效的紧急切机决策,应用BDQ网络比决策空间压缩的决策性能更好,知识融合策略可引导智能体减少无效决策探索从而提升决策性能。 展开更多
关键词 紧急切机决策 深度强化学习 决策空间 分支竞争q网络 知识融合
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超球上F(p,q,s)空间上的几个问题 被引量:5
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作者 张学军 刘亚玲 胡朝辉 《湖南师范大学自然科学学报》 CAS 北大核心 2009年第4期3-6,共4页
探讨了Cn中超球上一般函数空间F(p,q,s)和一些函数空间的相互关系,并证明了当0≤s≤n时F(p,q,s)是Bloch型空间β(q+n+1)/p的真子空间.
关键词 F(P q S)空间 BLOCH型空间 单位球 包含关系
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从Bloch型空间到Q_K(p,q)空间上的复合算子 被引量:3
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作者 龙见仁 伍鹏程 《江西师范大学学报(自然科学版)》 CAS 北大核心 2011年第3期286-291,共6页
假设φ是单位圆D上一个解析自映射.Bloch型空间Bμ是单位圆D上一个Banach空间,定义Bμ上复合算子Cφ:Cφf=f°φ,对所有的f∈Bμ.利用K-Carleson测度刻画了Bμ(Bμ,.0)空间到QK(p,q)空间的复合算子的有界性,以及Bμ空间到QK,0(p,q)... 假设φ是单位圆D上一个解析自映射.Bloch型空间Bμ是单位圆D上一个Banach空间,定义Bμ上复合算子Cφ:Cφf=f°φ,对所有的f∈Bμ.利用K-Carleson测度刻画了Bμ(Bμ,.0)空间到QK(p,q)空间的复合算子的有界性,以及Bμ空间到QK,0(p,q)空间的复合算子的有界性和紧性. 展开更多
关键词 复合算子 BLOCH型空间 qK(p q)空间 K-Carleson测度 紧性 有界性
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Gleason问题在多复变F(p,q,s)空间上的可解性 被引量:4
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作者 张学军 刘亚玲 肖建斌 《数学年刊(A辑)》 CSCD 北大核心 2010年第2期221-228,共8页
在0<p<∞,0≤s<∞,max{-n-1,-s-1}<q<∞的条件下,证明了Gleason问题在C^n中以单位球为支撑集的一般函数空间F(p,q,s)上是可解的.
关键词 GLEASON问题 F(P q S)空间 单位球
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