Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To identify potential serum protein candidates involved in linking the traditional Chinese medicine(TCM)-defined qi deficiency constitution(QDC)to Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Using participants with the TCM-defined balanced constitution as a control population,labelfree quantitative proteomics was adopted to identify differentially expressed proteins(DEPs)in serum samples from two case populations:case population 1(participants with QDC)and case population 2(patients with PQDS of CSG).The DEPs discovered in both case populations were analyzed to identify common DEPs as potential candidates for proteins involved in the link between QDC and PQDS.Based on Kyoto Encyclopedia of Genes and Genomes pathway(KEGG)and Gene Ontology(GO)enrichment analysis and analysis of proteineprotein interaction networks,we evaluated the possible functions of these potential serum candidates.Results:We discovered 24 and 28 proteins that were differentially expressed in case populations 1 and 2,respectively,compared with the control population.Hierarchical clustering analysis showed that the expression profile of DEPs of individuals from the same population clustered well,while those from different populations were segregated.Furthermore,GO analysis revealed the 10 DEPs that were common to both case populations to be mainly associated with negative regulation of cellular metabolic and immune system processes while KEGG analysis indicated these proteins to be associated with complement and coagulation cascades and peroxisome proliferator-activated receptor signaling.Notably,serum levels of C4b-binding protein beta chain,glycosylphosphatidylinositol-specific phospholipase D1 and MS-F1 light chain variable region proteins were notably higher in the two case populations compared with the control,particularly in the case of CSG with PQDS.Conclusion:The results presented here provide new insights into the molecular mechanisms underlying development of PQDS of CSG from QDC,and suggest candidate serum biomarkers for future application in integrative medicine.

Screening for blood leukocyte microRNA biomarkers responsible for association between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To screen for blood leukocyte microRNA(miRNA)biomarkers responsible for the association between the traditional Chinese medicine(TCM)qi deficiency constitution(QDC)and the Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Peripheral blood leukocytes were separated from people of two TCM constitutions(balance and qi deficiency)and from CSG patients with PQDS.Total RNA was isolated from the leukocytes and subjected to subsequent high-throughput miRNA sequencing to identify the miRNAs that are specifically and highly expressed in persons of QDC and CSG patients with PQDS.In addition,the target genes of the associated miRNAs were predicted.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway-based enrichment analyses of these target genes were performed to further evaluate the associated miRNA candidates as potential biomarkers responsible for the association between QDC and PQDS of CSG.Results:Compared with the control group with a balance constitution(P<.05,fold change>1.5 or<0.5),31 and 38 differentially expressed miRNAs were found in persons of QDC and CSG patients with PQDS,respectively.In particular,hsa-miR-145-5p and hsa-miR-146a-3p were highly expressed in both the persons of QDC and CSG patients with PQDS.GO analysis of the target genes of the two common miRNAs showed that they were mainly associated with functions related to synthesis and metabolism,such as cellular nitrogen compound metabolic processes,biosynthetic processes,cellular protein modification processes,and cellular component assembly.KEGG analysis identified the common pathways enriched among the target genes,including the Hippo signaling pathway and the transcriptional misregulation pathway.The common target genes of the two miRNAs seemed to be associated with the spliceosome pathway and the RNA degradation pathway.Conclusion:Hsa-miR-145-5p and hsa-miR-146a-3p may serve as candidate biomarkers responsible for the association between QDC and PQDS of CSG.

A Study on the Law of Birth and Formation of Yang-Deficiency Constitution Based on the Theory of Five Movement and Six Qi

Objective:To explore the law of birth and yang deficiency constitution based on the theory of five movements and six qi,as well as to provide a new way to better realize the prevention of yang deficiency constitution.Methods:The data of TCM quality table and luck data were collected via questionnaires.According to the data of from the TCM quality table,the respondents were divided into yang deficiency constitution group and non-yang deficiency group.According to the luck data,the distributions of gestational age were compared between the two groups.Results:A total of 175 questionnaires were collected,of which 89 were non-yang deficiency constitution and 86 were yang deficiency constitution.The proportion of Ding year(15.1%)in the yang deficiency group was significantly higher than that in non-yang deficiency group(5.6%),in which the difference was statistically significant(P<0.05).Conclusion:The possibility of yang deficiency constitution is higher.

Clinical observation of Guipi Decoction Combined with non steroidal drugs on sleep in elderly patients with acute traumatic pain and Qi deficiency constitutionabortion

Objective:To explore the effect of Guipi Decoction Combined with non steroidal anti-inflammatory drugs on sleep time of elderly patients with traumatic pain and Qi deficiency constitution during hospitalization.Methods:A total of 52 elderly patients hospitalized in the orthopedic(trauma)ward of the Second Affiliated Hospital of Zhejiang Chinese Medical University from November 2020 to may 2021 were randomly divided into control group and treatment group.Patients in the control group were treated with loxoprofen sodium tablets immediately after admission,and placebo was added to loxoprofen sodium tablets from the second day of admission;The patients in the treatment group were treated with loxoprofen sodium tablets after admission.Guipi Decoction was added on the basis of loxoprofen sodium tablets from the second day of admission.Before and after admission,all patients used the TCM constitution classification judgment table to evaluate the score of qi deficiency and VAS;From the first day to the fourth day after admission,the bracelet was worn to monitor the sleep time(total sleep time,deep sleep time,light sleep time and awakening times)every night.The patients were scored by VAS after taking drugs every morning.Results:Finally 25 patients in the control group and 24 patients in the treatment group completed the experiment.There was no significant difference in gender,age,fracture location,chronic medical history VAS score and TCM Qi deficiency constitution score,between two groups at admission(P>0.05).At the time of discharge,the score of qi deficiency constitution in the treatment group was 33.724±12.634;The TCM Qi deficiency constitution score of the control group was 42.25±15.912,and there was significant difference between the two groups(P<0.05);and there was significant difference in VAS score between the two groups at discharge(P<0.05).There were significant differences in total sleep time,light sleep time,deep sleep time and night awakening times between the two groups on the second,third and fourth day of admission(P<0.05).Conclusion:1.Guipi Decoction can significantly improve the sleep time of patients with Qi deficiency acute traumatic pain.2.Guipi Decoction can not only improve the constitution of patients with Qi deficiency bias,but also improve the VAS score at discharge.

Analysis of Constitutional Factors in Patients with Gallstone Disease

Objective: To summarize the common constitutional types in patients with gallstone disease and analyze influencing factors. Research Hypothesis: Qi stagnation constitution may be a potential predisposing constitution for gallstone disease, whereas the Balanced Constitution and Yin deficiency constitution have a lower tendency towards the development of the disease;gallstone disease is more prevalent among young men engaged in mental labor. Methods: A retrospective study was conducted on 180 patients with gallstone disease who were hospitalized in the Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (TCM), from July 2017 to July 2023. Additionally, 180 healthy individuals undergoing physical examinations at the Health Examination Center of the same hospital were selected as the normal control group. Both groups underwent general condition surveys, TCM constitution scales, Eysenck Personality Questionnaires, Brief Coping Styles Questionnaires, and Social Support Rating Scales to determine risk factors and common types. Results: Independent variables such as gender, Qi stagnation constitution, Balanced Constitution, negative coping scores, positive coping scores, and stressful life events were included in the model. The OR values for Balanced Constitution, gender, positive coping style, and overall social support were all less than 1, and the maximum value of the 95% confidence interval was also less than 1. After selecting the intercept into the model and analyzing the standardized regression coefficients, it was found that negative coping scores had a significant impact on the model, while stressful life events showed extremely high relevance to the study. Compared with the normal group, the frequency of Qi stagnation constitution in the study group significantly increased, with a significant difference (P χ2 = 11.109, P = 0.0009, indicating a significant difference (P χ2 = 4.0890, P = 0.0432, indicating a significant difference (P 0.05). However, when comparing mental workers with physical workers within the patient group, the frequency of Qi stagnation constitution in mental workers was significantly higher, with χ2 = 6.8467, P = 0.012, indicating a significant difference (P Conclusion: Qi stagnation constitution is a potential predisposing constitution for gallstone disease, whereas the tendency to develop the disease is relatively low for Balanced Constitution and Yin deficiency constitution. Gallstone disease is more commonly found in young male mental workers.

Structure and function of the fecal-associated microbiome in qi stagnation constitution

Objective:To clarify the structural and functional characteristics of the gut microbiota in individuals with qi stagnation constitution(QSC)and identify the potential biomarkers related to QSC.Methods:This cross-sectional study involved individuals with QSC and balanced constitution(BC)confirmed by TCM clinicians.The clinical features were recorded,and fecal samples were collected for 16S rDNA sequencing.The structure of the fecal-associated microbiome(FAM)was described by the alpha-diversity indexes,beta-distances,and relative abundances of dominant taxa.The differences in FAM distribution were analyzed by the Wilcoxon rank-sum test,MetagenomeSeq,and LEfSe analysis.The 16S rDNA gene sequences were assigned to the KEGG dataset to predict the functional information of bacterial metabolic pathways by using PICRUSt.Differences in functional pathways between groups were assessed with the Wilcoxon rank-sum test.The ROC curve based on specific operational taxonomic units(OTUs)was constructed,and the AUC was calculated.Results:Twenty-two individuals with BC and 8 with QSC were recruited.Significant differences between the two groups were found in body mass index,health status,and low-density lipoprotein,etc.There was no significant difference in the alpha-diversity index.PCoA showed no evident clustering of bacterial communities according to constitutions.Bacteroidaceae,Lachnospiraceae,Ruminococcaceae,and Prevotellaceae were the four common bacteria with high abundances.Notably,MetagenomeSeq,LEfSe analysis,and the Wilcoxon rank-sum test identified significantly different distributions of 66,42,and 36 OTUs,respectively.Predictive function analysis showed that 13 metabolic pathways were significantly differentially distributed,including those related to fatty acid synthesis.Five specific OTUs were selected as potential biomarkers of a QSC,and the AUC was 0.94.Conclusion:Individuals with QSC have unique FAM structure and related functional characteristics.Five specific OTUs were identified to serve as potentially effective biomarkers related to QSC.

A Discussion on the Constitution Factors of Thin Endometrium Based on the Theory of Qi and Blood

Thin endometrium has been proven to be a key contributing factor leading to infertility and poor pregnancy outcomes.Increasing the thickness and capacity of thin endometrium seems to be one of the challenging issues in reproductive medicine.The states of qi and blood are closely related to uterine blood circulation.Constitution is regarded as an important basis for determining the incidence as well as distinguishing,preventing,and treating diseases in traditional Chinese medicine.Based on the theory of qi and blood,this paper discusses the constitution factors of thin endometrium and puts forward the prospect of using big data tools to investigate the correlation between qi-blood imbalance constitution and the incidence of thin endometrium,so as to explore new approaches for the prevention and treatment of thin endometrium by regulating qi and blood as well as improving the constitution condition.

从“阳化气,阴成形”探讨慢性咳嗽之因机证治

慢性咳嗽是以咳嗽为主症或唯一症状、病程持续8周以上的呼吸系统疾病。慢性咳嗽病因复杂,病程较长,病势缠绵,且极易复发。西医诊断该病过程繁琐,治疗手段有限,而中医药以整体观念和辨证论治思想为指导,在缓解临床症状、预防疾病复发方面具有独特优势。该文以“阳化气,阴成形”为抓手,分析阴阳在慢性咳嗽因机证治全周期的重要意义,认为慢性咳嗽之病机关键为“阳化气,阴成形”功能失衡,以肺之气血失和、阴阳虚损为本,阳化而气行不畅、周流有碍,阴变而凝结停滞、壅塞肺络为标。治疗上,需要补肺、脾、肾阴阳之不足,泄气滞、水湿、痰饮、瘀血、热毒之有余,以恢复“阳化气,阴成形”之平衡。具体用药方面,主张以偏纠偏,以药物气味之偏性纠正人体阴阳之偏颇。另附典型医案二例,加以验证说明,以期为中医药防治慢性咳嗽提供新的诊疗思路和方法。

宫颈高危型人乳头瘤病毒感染患者中医体质类型分布研究

目的:分析宫颈高危型人乳头瘤病毒(high risk human papilloma virus,HR-HPV)感染患者中医体质类型分布特点,为中医药调理体质防治宫颈HR-HPV感染提供依据。方法:选择2019年1月至2020年12月就诊于河南中医药大学第一附属医院妇科门诊及体检中心的420例宫颈HR-HPV感染者作为观察组,选择420例同时段宫颈HR-HPV检测阴性者为对照组。分析两组中医体质类型分布情况、观察组不同年龄段中医体质类型分布情况、观察组不同HR-HPV基因型别中医体质类型。结果:观察组中医体质分布依次为:痰湿质(30.50%)>湿热质(19.00%)>平和质(15.50%)>阳虚质(14.80%)>气虚质(10.00%)>阴虚质(5.90%)>瘀血质(2.70%)>气郁质(1.70%);对照组中医体质分布依次为:平和质(73.30%)>湿热质(8.40%)>阴虚质(5.70%)>痰湿质(4.50%)>气虚质(4.30%)>阳虚质/瘀血质(1.80%)>气郁质(0.20%)。两组中医体质类型比较,差异具有统计学意义(P<0.05),其中,痰湿质、湿热质、阳虚质、气虚质,两组间比较,差异具有统计学意义(P<0.001)。观察组体质类型居前三位的是痰湿质、湿热质、阳虚质,占全部体质类型的64.30%。对照组平和质324例,占比73.50%,观察组平和质81例,占比15.50%,两组间比较,差异具有统计学意义(P<0.001)。观察组中,痰湿质、阳虚质、阴虚质主要见于46~55岁,湿热质、气虚质、气郁质主要见于36~45岁,组间比较差异具有统计学意义(P<0.05)。两组宫颈HR-HPV16、18型和非16、18型中医体质比较,差异无统计学意义(P>0.05)。结论:痰湿质、湿热质、阳虚质为宫颈HR-HPV感染人群的易感体质;痰湿质、湿热质、阳虚质与年龄具有相关性,痰湿质多见于36~45岁,湿热质、阳虚质多见于46~55岁,HR-HPV基因型别与中医体质类型之间无明显相关性。

岭南地区亚健康人群睡眠状况与中医体质类型的相关性研究

【目的】探究岭南地区亚健康人群睡眠状况与中医体质类型的相关性。【方法】选取2022年5月~2023年5月于深圳市宝安区中医院治未病中心就诊的688例在深圳市居住5年以上,无严重心血管疾病,经亚健康人群评定量表评定为亚健康的人群为研究对象,采用匹兹堡睡眠质量指数(PSQI)量表、中医体质评定量表对其进行问卷调查,并将其睡眠状况与中医体质类型进行多元线性回归分析。【结果】(1)调查问卷发放回收情况:共发放688份问卷,其中,失访19份,回收669份,剔除无效问卷29份,最终共纳入有效问卷640份。(2)不同睡眠状况人群的PSQI量表评分情况:根据PSQI量表得分情况将人群分为睡眠优组(PSQI总分<8分)350例和睡眠差组(PSQI总分≥8分)290例,组间比较,睡眠优组的入睡时间、睡眠时间、睡眠障碍得分以及总分均明显低于睡眠差组(P<0.05或P<0.01)。(3)不同睡眠状况人群的中医体质类别分布情况:睡眠优者多表现为平和质(86.86%),睡眠差者多表现为偏颇体质(79.64%)。睡眠差人群中,偏颇体质排前3位的分别是湿热质(15.52%)、痰湿质(13.79%)以及气郁质(13.10%)。(4)多元线性回归分析结果显示,入睡时间与痰湿质、气郁质呈正相关(P<0.01),与平和质呈负相关(P<0.05);睡眠效率与湿热质、特禀质呈正相关(P<0.05或P<0.01),与平和质呈负相关(P<0.05);睡眠障碍与气郁质、阴虚质呈正相关(P<0.01);催眠药物与阴虚质呈正相关(P<0.01);日间功能障碍与痰湿质呈正相关(P<0.05)。【结论】岭南地区亚健康人群睡眠状况与其中医体质类型具有一定相关性,湿热质、痰湿质、气郁质、阴虚质、平和质、特禀质是影响睡眠状况主要的6种中医体质类别;结合中医体质辨识指导亚健康人群通过改善其体质从而达到未病先防的目的是很有意义的。

吕晓东论治肺结节经验撷菁

总结吕晓东教授运用中医药治疗肺结节的临床经验和学术思想。吕晓东教授基于阳化气,阴成形的两个基本生理功能观,考察肺结节的发生、发展的病理环节,认为肺结节形成之机理复杂,病因纷繁,为阴分邪气积聚为肺,但病性基础变化总体以阳虚为关键,病理以气滞痰瘀胶着于肺络为核心。在肺络病的指导原则下,运用扶阳抑阴、通补肺络的手段,恢复阳主阴从,一气周流,肺络调和的生理状态,从而调复肺脏的异常功能状态、消弭肺结节的病理改变,恢复身心健康的目的,临床每获良效,具有推广应用的价值。

基于“阳化气,阴成形”从温阳法论治肺部结节

《素问·阴阳应象大论篇》中记载的“阳化气,阴成形”高度概括了人体脏腑组织的生命活动,阴阳失衡是导致疾病发生的关键。本文通过分析“阳化气,阴成形”理论,发现肺部结节发生和发展的核心机制是“阳化气不足,阴成形太过”。结节乃有形之体,是机体阳气亏虚,精血津液运行障碍,化为痰饮瘀毒,敛聚局部而生;结节本质乃阳虚阴结,本虚标实,本虚即脾肾阳虚,标实即痰饮、瘀血、浊毒。中医学强调治病求本,故基于“阳化气,阴成形”理论,以温阳化气为基本治则,探讨温阳法在肺部结节治疗中的应用,分别从温阳补肾、温阳健脾、温阳化痰、温阳活血、温阳解毒和温阳散结等角度辨证施治,以防“阴成形太过”,使“阳化气”之功能正常发挥,则机体阴阳平衡,百病不生。

宁心汤治疗气阴两虚型永久性心房颤动患者新型冠状病毒感染后的临床疗效观察

目的评价宁心汤治疗气阴两虚型永久性心房颤动(房颤)患者新型冠状病毒(新冠病毒)感染后的临床疗效.方法收集2023年2月至8月在中国中医科学院广安门医院南区门诊就诊的120例新冠病毒感染气阴两虚型永久性房颤患者作为研究对象.将患者按随机数字表法分为对照组和治疗组,每组60例,最后每组各有1例脱落,余59例.治疗组给予宁心汤(药物组成:桂枝15 g,酒萸肉15 g,生地黄15 g,红景天15 g,人参6g,桑寄生10 g,黄连3g,丹参12 g,川芎10 g,麦冬12 g,醋五味子6g)免煎颗粒水冲服,每日2次;对照组给予辅酶Q1010 mg,每日3次,两组均连续治疗4周.观察两组治疗前后胸痛、头晕、乏力、倦怠懒言、心悸、胸闷气短、失眠、多梦等中医证候的改善情况,以及心率变异性(HRV)和心率减速力指标的变化.结果治疗组在改善胸痛、乏力、心悸、胸闷气短方面均有明显疗效,在倦怠懒言、失眠、多梦方面有所改善,在改善头晕方面无明显疗效.对照组在改善心悸方面有明显疗效,胸痛、胸闷气短方面有所改善,其余方面均无明显疗效.治疗组在改善胸痛、乏力、倦怠懒言、胸闷气短、失眠、多梦方面的有效率均明显高于对照组[胸痛:95.45%(42/44)比78.57%(33/42),乏力:83.67%(41/49)比31.25%(15/48),倦怠懒言:73.91%(34/46)比12.77%(6/47),胸闷气短:88.89%(48/54)比63.64%(35/55),失眠:78.43%(40/51)比12.24%(6/49),多梦:76.09%(35/46)比43.75%(21/48),均P<0.05].两组治疗后RR间期的标准差(SDNN)、相邻RR间期差值的均方根(RMSSD)、RR间期平均值的标准差(SDANN)、相邻RR间期差值>50 ms占总RR间期数的百分比(PNN50)均较治疗前明显升高,且治疗组治疗后RMSSD、SDANN、PNN50均明显高于对照组[RMSSD(ms):28.96±3.59比24.34±2.66,SDANN(ms):108.55±11.80比100.44±13.58,PNN50:7%(6%,7%)比5%(5%,6%),均P<0.05],两组治疗前后心率减速力比较差异均无统计学意义.结论宁心汤对改善气阴两虚型永久性房颤患者新冠病毒感染后中医证候及心率变异性均有良好效果.

基于五运六气理论对深圳地区中年人先天禀赋与糖尿病罹患相关性研究

【目的】探究中年人糖尿病罹患的运气禀赋与高风险因素的相关性。【方法】分析深圳市广州中医药大学深圳医院(福田)中年糖尿病患者611例,根据出生日期推算患者所属运气情况以及运气相合情况,采用卡方检验和Logistic回归分析影响罹患因素。【结果】(1)岁运分布为火运太过(太火)最多,差异有统计学意义(χ^(2)=24.794,P=0.003)。(2)主运为金运分布最多,客运为水运不及(少水)分布最多,差异均有统计学意义(χ^(2)=10.678,P=0.030;χ^(2)=18.411,P=0.031)。(3)主气分布为太阴湿土最多,客气分布为少阴君火最多,差异均有统计学意义(χ^(2)=15.268,P=0.009;χ^(2)=11.282,P=0.046)。(4)运气相合情况最多为异化小逆年,差异有统计学意义(χ^(2)=236.28,P<0.001)。(5)男性患者中出生时间的主气为太阴湿土时段罹患糖尿病风险高于女性,差异有统计学意义(OR=0.554,95%置信区间为0.321~0.955,P=0.034)。【结论】患有糖尿病的中年人出生日期存在岁运为太火、主运为金运、客运为少水、主气为太阴湿土、客气为少阴君火、运气相合年份为小逆年的五运六气特征,提示中年人罹患糖尿病与先天运气禀赋相关,应重点注意火、寒、湿三种因素的影响。

基于体质可调论治糖尿病大血管病变

糖尿病大血管病变为糖尿病后期的严重并发症,具有较高的致残致死率,早期干预可达既病防变目的,对于改善患者生活质量、节约医疗资源意义深远。中医体质学说认为人的体质不仅禀赋于先天,亦可通过外在手段干预而改变。糖尿病大血管病变的好发体质类型主要集中在阴虚质、气虚质、痰湿质与血瘀质。以中医治未病思想为指导,从体质可调出发,列举验案2则,为糖尿病大血管病变的高危体质类型制定出中医药、饮食、运动等具体体质调节方案,及早纠正体质偏颇,以期为临床防治糖尿病大血管病变提供参考。

959例子宫内膜异位症患者中医体质分布特点

【目的】探讨959例子宫内膜异位症(EMs)患者的中医体质分布特点。【方法】选取2019年1月至2019年11月就诊于中国中医科学院广安门医院、首都医科大学附属北京妇产医院、北京医院、北京中医药大学东方医院、首都医科大学附属友谊医院、首都医科大学附属复兴医院的EMs患者959例,记录患者的一般情况,进行中医体质辨识,分析其中医体质分布情况、兼夹体质的关联关系以及与年龄、合并痛经的关系。【结果】(1)EMs患者的体质分布占比由多到少依次为阳虚质65.1%(624/959)、气郁质58.4%(560/959)、气虚质52.8%(506/959)、血瘀质44.2%(424/959)、痰湿质42.5%(408/959)、湿热质41.9%(402/959)、阴虚质39.6%(380/959)、平和质26.8%(257/959)、特禀质16.6%(159/959);患者中单一体质者较少,占比为20.2%(194/959),兼夹体质者居多,占比为79.8%(765/959)。(2)基于Apriori算法的关联规则挖掘结果发现相关规则33条,气虚质-阳虚质、血瘀质-阳虚质、血瘀质-气郁质是其中置信度较高的关联规则。(3)与35岁及以下患者相比,35岁以上患者中血瘀质所占比例较大(P<0.05);与无痛经患者相比,合并痛经患者各偏颇体质占比均增加、平和体质占比减少(P<0.05或P<0.01)。【结论】阳虚质、气郁质、气虚质、血瘀质是EMs患者的高发体质类型,EMs患者中医体质兼夹现象普遍存在,较单一偏颇体质更为常见;从温阳、解郁、益气、活血角度管理EMs,及时纠正偏颇体质,防止疾病进展,可有效发挥中医体质调理的“治未病”效果。

从“阳化气,阴成形”辨治癌性疼痛探析

以“阳化气,阴成形”理论阐述癌性疼痛的病机,并探析癌性疼痛的辨治,认为“阳化气”“阴成形”的太过与不及是癌性疼痛的发生机制,通过调节阴阳以指导癌性疼痛的辨治,补虚损、散阴形、抗肿瘤三法来补虚治痛,散消阴结,消瘤治痛,从而实现阴阳平衡。

高血压患者体质类型与认知障碍相关性研究

目的:探讨高血压伴认知障碍(CI)患者的体质分布情况及CI的影响因素。方法:纳入3799例高血压患者,分为CI组和无认知障碍(NCI)组,记录两组患者一般资料(年龄、性别、文化程度、婚姻状态、工作类型、烟酒史等)、实验室指标(空腹血糖、血脂、血肌酐等)水平、量表[简易智力状态检查量表(MMSE)、匹兹堡睡眠质量指数量表(PSQI)、中医体质类型量表]评分等信息。以体质类型为主要监测指标,分析高血压伴CI患者体质类型分布状况。结果:3799例高血压患者中有506例(13.32%)被纳入CI组。CI组患者年龄、年龄大于60岁人群比例、女性比例、文化程度在初中以下人群比例、工作类型以体力劳动为主人群比例、3级高血压人群比例、有睡眠障碍人群比例、高血压病程、血肌酐水平显著高于NCI组(P<0.05);汉族人群比例、吸烟人群比例、饮酒人群比例、体质量指数(BMI)及甘油三酯、胆固醇、低密度脂蛋白(LDL)水平低于NCI组(P<0.05)。CI组气虚质患者人数最多,NCI组平和质患者人数最多。偏颇质高血压患者的定向、记忆、计算、回忆、命名、阅读、执行、书写认知功能比平和质高血压患者更差(P<0.05)。Logistic回归分析显示,体质类型是CI发病的影响因素,气虚质、气郁质与CI发生相关。年龄大于60岁、文化程度低、汉族以外的其他民族、存在睡眠障碍、LDL水平低与CI发生有关。结论:不同中医体质的高血压患者CI发病倾向不同,气虚质、气郁质与CI发生相关,此类体质者应从“体病相关”理论出发,采取相应预防措施。

基于“阳化气,阴成形”理论浅谈中西医结合治疗肺癌机制

肺癌是临床上最常见的恶性肿瘤之一,其发病率逐年上升。自古代起,黄帝内经及历代医家就对肺癌提出了有效的治疗法则。他们认为“阳化气”不足,而“阴成形”太过,是导致肺癌发病的重要原因之一。文章旨在对“阳化气,阴成形”理论在中西医结合治疗肺癌方面的研究进行综述,以期为肺癌的治疗和研究提供新的思路。

儿童青少年近视与中医体质类型相关性研究的Meta分析

目的 通过Meta分析探讨儿童青少年近视与中医体质类型的相关性。方法 检索PubMed、Web of Science、Elsevier、中国知网、万方、维普、中国生物医学文献数据库中关于儿童青少年近视与中医体质类型相关性研究的文献,检索时间为建库至2023年7月1日。对文献按照纳入标准与排除标准进行筛选和数据提取,采用纽卡斯尔-渥太华量表(NOS)对文献质量进行评分,RevMan 5.4软件进行统计分析。结果 (1)一般情况:共纳入5项研究,包括20,829例受试者,其中近视患者9,050例,非近视者11,779例。近视儿童青少年的体质占比前4位的类型分别为平和质(33.50%)、阳虚质(22.02%)、气虚质(14.69%)、阴虚质(9.19%)。(2)平和质:病例组平和质体质类型人数占比低于对照组,差异有统计学意义[OR=0.480,95%CI(0.270,0.850),Z=2.530,P=0.010)]。(3)气虚质:病例组气虚质体质类型人数占比高于对照组,差异有统计学意义[OR=2.010,95%CI(1.140,3.560),Z=2.400,P=0.020)]。(4)阳虚质和阴虚质:2组阳虚质和阴虚质体质类型人数占比,差异无统计学意义(P>0.05)。(5)其他体质:其他5种体质在近视的儿童青少年中占比较少,从高到低依次为湿热质(6.80%)、气郁质(5.48%)、痰湿质(5.26%)、特禀质(2.11%)、血瘀质(1.51%)。病例组中,湿热质[OR=0.870,95%CI(0.790,0.970),Z=2.620,P=0.009)]、气郁质[OR=0.830,95%CI(0.740,0.930),Z=3.170,P=0.002)]、血瘀质[OR=0.770,95%CI(0.620,0.950),Z=2.390,P=0.020)]体质类型人数占比高于对照组,差异均有统计学意义;而2组特禀质、痰湿质体质类型人数占比,差异无统计学意义(P>0.05)。结论 气虚质、阴虚质、阳虚质是儿童青少年近视患者的主要偏颇体质类型,并且气虚质可能是其发生近视的主要体质危险因素。