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Study on syndrome differentiation based on pharmacology of syndrome management system-a case of Qi and Yin deficiency syndrome
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作者 Wen-Jun Wang Shao-Jie Huang +6 位作者 Juan-Li Zhang Yang Ma Fei Mu Yu-Cheng Liao Jing-Wen Wang Ai-Dong Wen Yi Ding 《History & Philosophy of Medicine》 2020年第4期119-128,共10页
Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to ... Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to reveal the essence of the corresponding syndrome by studying the drugs and targets of Qi and Yin deficiency.Fourteen Chinese herbs treating Qi and Yin deficiency were retrieved and used more than 30 times,and 9,317 related targets were predicted.The common targets of action were 85.Topological analysis was carried out by using degree centrality,closeness centrality and betweenness centrality to confirm that estrogen receptor(ESR1),tumor necrosis factor(TNF),D(2)dopamine receptor(DRD2),vitamin D3 receptor(VDR),glucocorticoid receptor(NR3C1),acetylcholinesterase(ACHE)and endothelin-1(EDN1)were highly correlated with Qi and Yin deficiency syndrome.Through the target to find Qi and Yin deficiency syndrome corresponding to 17 categories of diseases.A new idea was provided for studying the biological essence of TCM clinical syndrome differentiation. 展开更多
关键词 Pharmacology of syndrome management system Data mining qi and yin deficiency syndrome Drug law
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