Analysis of the Effect of Different Treatment Schemes on Helicobacter Pylori Infection on Improving the Quality of Life of Patients

Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infection were selected and randomly assigned Combined treatment with omeprazole,amoxicillin and clarithromycin was named group A;Group B was treated with omeprazole,amoxicillin,clarithromycin and colloidal bismuth pectin;Group C was given omeprazole,amoxicillin,clarithromycin and metronidazole.Results:The symptom score and gastroscope score of group B or C were lower than those of group A(P<0.05);The incidence of adverse reactions and HP eradication rate in group C were lower than those in group B,and those in group B were lower than those in group A(P<0.05);The quality of life score of group C was higher than that of group B,and that of group B was higher than that of group A,P<0.05.Conclusions:The sequential therapy of omeprazole,amoxicillin,clarithromycin and metronidazole in patients with Helicobacter pylori infection can improve the HP eradication rate,improve the quality of life of patients,which is safe and efficient.

Evaluation of morbidity in Schistosoma mansoni-positive primary and secondary school children after four years of mass drug administration of praziquantel in western Kenya

Background:World Health Organization guidelines recommend preventive chemotherapy with praziquantel to control morbidity due to schistosomiasis.The primary aim of this cross-sectional study was to determine if 4 years of annual mass drug administration(MDA)in primary and secondary schools lowered potential markers of morbidity in infected children 1 year after the final MDA compared to infected children prior to initial MDA intervention.Methods:Between 2012 and 2016 all students in two primary and three secondary schools within three kilometers of Lake Victoria in western Kenya received annual mass praziquantel administration.To evaluate potential changes in morbidity we measured height,weight,mid-upper arm circumference,hemoglobin levels,abdominal ultrasound,and quality of life in children in these schools.This study compared two cross-sectional samples of Schistosoma mansoni egg-positive children:one at baseline and one at year five,1 year after the fourth annual MDA.Data were analyzed for all ages(6–18 years old)and stratified by primary(6–12 years old)and secondary(12–18 years old)school groups.Results:The prevalence of multiple potential morbidity markers did not differ significantly between the egg-positive participants at baseline and those at 5 years by Mann Whitney nonparametric analysis and Fisher’s exact test for continuous and categorical data,respectively.There was a small but significantly higher score in school-related quality of life assessment by year five compared to baseline by Mann Whitney analysis(P=0.048)in 13–18 year olds where malaria-negative.However,anemia was not positively impacted by four annual rounds of MDA,but registered a significant negative outcome.Conclusions:We did not detect differences in morbidity markers measured in a population of those infected or re-infected after multiple MDA.This could have been due to their relative insensitivity or a failure of MDA to prevent morbidity among those who remain infected.High malaria transmission in this area and/or a lack of suitable methods to measure the more subtle functional morbidities caused by schistosomiasis could be a factor.Further research is needed to identify and develop well-defined,easily quantifiable S.mansoni morbidity markers for this age group.