Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grad...Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.展开更多
Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensio...Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensional and 3-dimensional echocardiography were performed in 52 subjects with suspected CHD.Longitudinal strain (LS) ,circumferential strain (CS) ,radial展开更多
In order to ensure the effective analysis and reconstruction of forests,it is key to ensure the quantitative description of their spatial structure.In this paper,a distance model for the optimal stand spatial structur...In order to ensure the effective analysis and reconstruction of forests,it is key to ensure the quantitative description of their spatial structure.In this paper,a distance model for the optimal stand spatial structure based on weighted Voronoi diagrams is proposed.In particular,we provide a novel methodological model for the comprehensive evaluation of the spatial structure of forest stands in natural mixed conifer-broadleaved forests and the formulation of management decision plans.The applicability of the rank evaluation and the optimal solution distance model are compared and assessed for different standard sample plots of natural mixed conifer-broadleaved forests.The effect of crown width on the spatial structure unit of the trees is observed to be higher than that of the diameter at breast height.Moreover,the influence of crown length is greater than that of tree height.There are nine possible spatial structure units determined by the weighted Voronoi diagram for the number of neighboring trees in the central tree,with an average intersection of neighboring crowns reaching 80%.The rank rating of natural forest sample plots is correlated with the optimal solution distance model,and their results are generally consistent for natural forests.However,the rank rating is not able to provide a quantitative assessment.The optimal solution distance model is observed to be more comprehensive than traditional methods for the evaluation of the spatial structure of forest stands.It can effectively reflect the trends in realistic stand spatial structure factors close to or far from the ideal structure point,and accurately assesses the forest spatial structure.The proposed optimal solution distance model improves the integrated evaluation of the spatial structure of forest stands and provides solid theoretical and technical support for sustainable forest management.展开更多
In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and ...In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and in modeling methods.Reliability assessment which provides a systematic approach for quantifying the risk of failure has been shown to be a promising tool for solving these challenging geotechnical engineering problems.The method provides a more consistent measure of the level of safety or“structural reliability”through the evaluation of a reliability index and the associated“failure”probability,and is a method that satisfies the need to clearly convey safety issues to the public and regulatory authorities.Various methods for calculating the reliability of geotechnical infrastructures with regard to the assessment of the ultimate and serviceability limit states have been proposed by many researchers and these approaches include:the direct Monte Carlo Simulation,Bayesian and other sampling techniques,the first-order reliability method and the second-order reliability method,the random field method,the response surface method and other surrogate models with the related probabilistic procedures.In this special issue of Geoscience Frontiers,we assemble eleven invited papers which provide insights on the latest developments and challenges in applying probabilistic and reliability methods to geotechnical infrastructure design.展开更多
Chinese has special quantifiers as a part of speech while English does not have independent quantifiers.To some degree,the difference comes from the different cultural backgrounds.
The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations ...The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations are caused by chromosomal aberrations,and they occur shortly before or after implantation.展开更多
As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,...As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,feasibility and model se-lection evaluation.Model selection evalution is the most complex stage.The consid-展开更多
Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of...Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell imaging.We have developed a general correlative FRET imaging method(CFIM)to quantify the subcellular coupling between an enzymatic activity and a phenotypic response in live cells,e.g.at focal adhesions(FAs).CFIM quantitatively evaluated the cause-effect relation-展开更多
Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and te...Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and techniques,e.g.,dynamic force spectroscopy(DFS),have been applied to probe the complex at single-bond level,the discrepancies in the loading rate dependence of bond rupture force were found in the assays,presumably due to the different pathways in energy landscape and binding kinetics of molecular complexes<sup>[2]</sup>.However,the underlying mechanisms remain unclear.Here an optical trap(OT)assay was used to quantify the bond rupture at r<sub>f</sub>≤20 pN/s展开更多
Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We...Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process.Four artificial models were designed to select suitable metrics among over 20 parameters.To validate the efficiency of image analysis,we analyzed rocks from badlands in Nanxiong Basin,Southeast China,under three different ranges of temperature differences(TD)during cyclic wetting and drying(WD).Our results show that TDs can accelerate the disintegration rate,and even if there is only a 20℃ difference in the range of TDs,an apparent difference in fragment size was observed.Moreover,the shape of fragments became more round as the increasing number of cyclic treatments,and for samples that went through the same number of treatments,the larger the temperature difference,the more round the shape became.All that serves as another evidence for landscape evolution response to climatic warming.展开更多
Objectives.Relationship between carotid atherosclerosis(CAS) and severity ofcoronary artery disease(CAD) and different risk factors were investigated,Theseverity of CAD was tried to predict using carotid duplex scanni...Objectives.Relationship between carotid atherosclerosis(CAS) and severity ofcoronary artery disease(CAD) and different risk factors were investigated,Theseverity of CAD was tried to predict using carotid duplex scanning and riskfactors investigation.Methods.Carotid duplex scanning were performed in 103 patients who had beenconsecutively examined by coronary angiography.Patients were divided into 3groups(normal,I-vassal disease and multi-vessel disease group) according tocoronary angiographic results.To quantify the extent of CAS,maximal unicknessmeasurements of all plaques were summed for an individual plaque score.Gensini’s CAD score was calculated to quantify the extent of coronary arteryatherosclerosis(CAAS),Relationship between carotid plaque score and extent ofCAAS was evaluated.Relationship between main risk factors and the degree ofatherosclerotic vascular involvement in carotid and coronary artery wasexamined using standard|sad partial correlation coefficients.Results.CAS plaques were more common in the bifurcation end in the left side.Intimal-medial thickness(IMT) of multi-vessel disease group was significantlylarger than that of the normal group(P【0.001).No significant differences werefound among these 3 groups with carotid Doppler parameters,A linearcorrelation between carotid duplex scanning parameters and carotid andcoronary atherosclerosis was found.Carotid plaque score was significantlyhigher in patients with l-vessel or multi-vessel CAD than that without significantCAD(P【0.001).There was e significant positive linear correlation betweencarotid plaque score and the extent of CAD(r=0.60,P【0.001).Age,male gender,smoking,hypertension,total cholesterol,LDL,plasma fibrinogen,and plateletaggregability were positively correlated with the extent of CAS and CAAS.HDLwas negatively correlated with CAS and CAAS.Formulas using carotid duplexscanning parameters and risk factors to predict the extent of CAD were provided.Contlusions.CAS was significantly correlated with the extent of CAAS.Age:male gender,smoking" hypertension,total cholesterol,LDL,plasma fibrinogen,and platelet aggregnbility were strong predictors for CAS and CAD.展开更多
Histomorphometric analysis of histologic sections of normal and diseased bone samples,such as healing allografts and fractures,is widely used in bone research.However,the utility of traditional semi-automated methods ...Histomorphometric analysis of histologic sections of normal and diseased bone samples,such as healing allografts and fractures,is widely used in bone research.However,the utility of traditional semi-automated methods is limited because they are labor-intensive and can have high interobserver variability depending upon the parameters being assessed,and primary data cannot be re-analyzed automatically.Automated histomorphometry has long been recognized as a solution for these issues,and recently has become more feasible with the development of digital whole slide imaging and computerized image analysis systems that can interact with digital slides.Here,we describe the development and validation of an automated application(algorithm)using Visiopharm's image analysis system to quantify newly formed bone,cartilage,and fibrous tissue in healing murine femoral allografts in high-quality digital images of H&E/alcian blue-stained decalcified histologic sections.To validate this algorithm,we compared the results obtained independently using OsteoMeasureTM and Visiopharm image analysis systems.The intraclass correlation coefficient between Visiopharm and OsteoMeasure was very close to one for all tissue elements tested,indicating nearly perfect reproducibility across methods.This new algorithm represents an accurate and labor-efficient method to quantify bone,cartilage,and fibrous tissue in healing mouse allografts.展开更多
Reinforced concrete(RC) buildings in Nepal are constructed with RC frames and masonry infill panels. These structures exhibit a highly non-linear inelastic behavior resulting from the interaction between the panels ...Reinforced concrete(RC) buildings in Nepal are constructed with RC frames and masonry infill panels. These structures exhibit a highly non-linear inelastic behavior resulting from the interaction between the panels and frames. This paper presents an extensive case study of existing RC buildings in Nepal. Non-linear analyses were performed on structural models of the buildings considered as a bare frame and with masonry infill, in order to evaluate the influence of infill walls on the failure mechanisms. Five three-storey buildings with different structural configurations and detailing were selected. The effect of masonry infill panels on structural response was delineated by comparing the bare-framed response with the infill response. Seismic performance is evaluated with regard to global strength, stiffness, energy dissipation, inter-storey drift, and total deflection of the structure. A parametric analysis of structures with masonry infill is also performed. For this, the influence of different material properties is studied, namely diagonal compressive stress, modulus of elasticity and tensile stress of masonry infill panels. Study results show that masonry infill increases the global strength and stiffness of the structures; it decreases the inter-storey drift and hence the total displacement of the structure. The results quantify the influence of the infill panels on structural response and, in particular, the effect of the diagonal compressive strength of the masonry wall.展开更多
930425 Clinical application of brain SPECTimaging and rCBF measurement on alzeimers dis-eases and multi--infarct dementia.LI Biao (李彪),et al.Ruijing Hosp,Shanghai 2nd Med U-niv,Shanghai,200025.Chin J Nucl Med 1993;1...930425 Clinical application of brain SPECTimaging and rCBF measurement on alzeimers dis-eases and multi--infarct dementia.LI Biao (李彪),et al.Ruijing Hosp,Shanghai 2nd Med U-niv,Shanghai,200025.Chin J Nucl Med 1993;13(2):78—80.Brain SPECT imaging and rCBF measurementwere performed in 10 normal controls and 25 pa-tients including 17 Alzeimers Diseases (AD) and8 multi-infarct dementia (MID).The resultsshowed that by SPECT imaging in all of the pa-tients local cerebral blood supply insufficiencywas revealed and so were the characteristicchanges of AD and MID.Therefore展开更多
The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to cont...The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.展开更多
文摘Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.
文摘Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensional and 3-dimensional echocardiography were performed in 52 subjects with suspected CHD.Longitudinal strain (LS) ,circumferential strain (CS) ,radial
基金funded by National Key Research and development project(2022YFD2201001)。
文摘In order to ensure the effective analysis and reconstruction of forests,it is key to ensure the quantitative description of their spatial structure.In this paper,a distance model for the optimal stand spatial structure based on weighted Voronoi diagrams is proposed.In particular,we provide a novel methodological model for the comprehensive evaluation of the spatial structure of forest stands in natural mixed conifer-broadleaved forests and the formulation of management decision plans.The applicability of the rank evaluation and the optimal solution distance model are compared and assessed for different standard sample plots of natural mixed conifer-broadleaved forests.The effect of crown width on the spatial structure unit of the trees is observed to be higher than that of the diameter at breast height.Moreover,the influence of crown length is greater than that of tree height.There are nine possible spatial structure units determined by the weighted Voronoi diagram for the number of neighboring trees in the central tree,with an average intersection of neighboring crowns reaching 80%.The rank rating of natural forest sample plots is correlated with the optimal solution distance model,and their results are generally consistent for natural forests.However,the rank rating is not able to provide a quantitative assessment.The optimal solution distance model is observed to be more comprehensive than traditional methods for the evaluation of the spatial structure of forest stands.It can effectively reflect the trends in realistic stand spatial structure factors close to or far from the ideal structure point,and accurately assesses the forest spatial structure.The proposed optimal solution distance model improves the integrated evaluation of the spatial structure of forest stands and provides solid theoretical and technical support for sustainable forest management.
文摘In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and in modeling methods.Reliability assessment which provides a systematic approach for quantifying the risk of failure has been shown to be a promising tool for solving these challenging geotechnical engineering problems.The method provides a more consistent measure of the level of safety or“structural reliability”through the evaluation of a reliability index and the associated“failure”probability,and is a method that satisfies the need to clearly convey safety issues to the public and regulatory authorities.Various methods for calculating the reliability of geotechnical infrastructures with regard to the assessment of the ultimate and serviceability limit states have been proposed by many researchers and these approaches include:the direct Monte Carlo Simulation,Bayesian and other sampling techniques,the first-order reliability method and the second-order reliability method,the random field method,the response surface method and other surrogate models with the related probabilistic procedures.In this special issue of Geoscience Frontiers,we assemble eleven invited papers which provide insights on the latest developments and challenges in applying probabilistic and reliability methods to geotechnical infrastructure design.
文摘Chinese has special quantifiers as a part of speech while English does not have independent quantifiers.To some degree,the difference comes from the different cultural backgrounds.
文摘The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations are caused by chromosomal aberrations,and they occur shortly before or after implantation.
文摘As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,feasibility and model se-lection evaluation.Model selection evalution is the most complex stage.The consid-
文摘Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell imaging.We have developed a general correlative FRET imaging method(CFIM)to quantify the subcellular coupling between an enzymatic activity and a phenotypic response in live cells,e.g.at focal adhesions(FAs).CFIM quantitatively evaluated the cause-effect relation-
基金supported by National Natural Science Foundation of China grants 10902117, 31230027,30730032,and 10332060
文摘Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and techniques,e.g.,dynamic force spectroscopy(DFS),have been applied to probe the complex at single-bond level,the discrepancies in the loading rate dependence of bond rupture force were found in the assays,presumably due to the different pathways in energy landscape and binding kinetics of molecular complexes<sup>[2]</sup>.However,the underlying mechanisms remain unclear.Here an optical trap(OT)assay was used to quantify the bond rupture at r<sub>f</sub>≤20 pN/s
基金funded by the Natural Science Foundation of China(Grants 41901005)financial support from China Scholarship Council[grant number CSC201806995083]supported by the Ministry of Education,Science and Technological Development,Republic of Serbia(Grant No.451-039/2021-14/200026,451-03-9/2021-14/200168 and 451-03-9/2021-14/200358)。
文摘Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process.Four artificial models were designed to select suitable metrics among over 20 parameters.To validate the efficiency of image analysis,we analyzed rocks from badlands in Nanxiong Basin,Southeast China,under three different ranges of temperature differences(TD)during cyclic wetting and drying(WD).Our results show that TDs can accelerate the disintegration rate,and even if there is only a 20℃ difference in the range of TDs,an apparent difference in fragment size was observed.Moreover,the shape of fragments became more round as the increasing number of cyclic treatments,and for samples that went through the same number of treatments,the larger the temperature difference,the more round the shape became.All that serves as another evidence for landscape evolution response to climatic warming.
文摘Objectives.Relationship between carotid atherosclerosis(CAS) and severity ofcoronary artery disease(CAD) and different risk factors were investigated,Theseverity of CAD was tried to predict using carotid duplex scanning and riskfactors investigation.Methods.Carotid duplex scanning were performed in 103 patients who had beenconsecutively examined by coronary angiography.Patients were divided into 3groups(normal,I-vassal disease and multi-vessel disease group) according tocoronary angiographic results.To quantify the extent of CAS,maximal unicknessmeasurements of all plaques were summed for an individual plaque score.Gensini’s CAD score was calculated to quantify the extent of coronary arteryatherosclerosis(CAAS),Relationship between carotid plaque score and extent ofCAAS was evaluated.Relationship between main risk factors and the degree ofatherosclerotic vascular involvement in carotid and coronary artery wasexamined using standard|sad partial correlation coefficients.Results.CAS plaques were more common in the bifurcation end in the left side.Intimal-medial thickness(IMT) of multi-vessel disease group was significantlylarger than that of the normal group(P【0.001).No significant differences werefound among these 3 groups with carotid Doppler parameters,A linearcorrelation between carotid duplex scanning parameters and carotid andcoronary atherosclerosis was found.Carotid plaque score was significantlyhigher in patients with l-vessel or multi-vessel CAD than that without significantCAD(P【0.001).There was e significant positive linear correlation betweencarotid plaque score and the extent of CAD(r=0.60,P【0.001).Age,male gender,smoking,hypertension,total cholesterol,LDL,plasma fibrinogen,and plateletaggregability were positively correlated with the extent of CAS and CAAS.HDLwas negatively correlated with CAS and CAAS.Formulas using carotid duplexscanning parameters and risk factors to predict the extent of CAD were provided.Contlusions.CAS was significantly correlated with the extent of CAAS.Age:male gender,smoking" hypertension,total cholesterol,LDL,plasma fibrinogen,and platelet aggregnbility were strong predictors for CAS and CAD.
基金funded by grants(1S10RR027340-01 and AR43510) to BFB,and (R01 DE019902,P30 AR061307 and P50 AR054041) to EMS,from the National Institutes of Health
文摘Histomorphometric analysis of histologic sections of normal and diseased bone samples,such as healing allografts and fractures,is widely used in bone research.However,the utility of traditional semi-automated methods is limited because they are labor-intensive and can have high interobserver variability depending upon the parameters being assessed,and primary data cannot be re-analyzed automatically.Automated histomorphometry has long been recognized as a solution for these issues,and recently has become more feasible with the development of digital whole slide imaging and computerized image analysis systems that can interact with digital slides.Here,we describe the development and validation of an automated application(algorithm)using Visiopharm's image analysis system to quantify newly formed bone,cartilage,and fibrous tissue in healing murine femoral allografts in high-quality digital images of H&E/alcian blue-stained decalcified histologic sections.To validate this algorithm,we compared the results obtained independently using OsteoMeasureTM and Visiopharm image analysis systems.The intraclass correlation coefficient between Visiopharm and OsteoMeasure was very close to one for all tissue elements tested,indicating nearly perfect reproducibility across methods.This new algorithm represents an accurate and labor-efficient method to quantify bone,cartilage,and fibrous tissue in healing mouse allografts.
基金supported by the Eurasian University Network for International Cooperation in Earthquake(EU-NICE)
文摘Reinforced concrete(RC) buildings in Nepal are constructed with RC frames and masonry infill panels. These structures exhibit a highly non-linear inelastic behavior resulting from the interaction between the panels and frames. This paper presents an extensive case study of existing RC buildings in Nepal. Non-linear analyses were performed on structural models of the buildings considered as a bare frame and with masonry infill, in order to evaluate the influence of infill walls on the failure mechanisms. Five three-storey buildings with different structural configurations and detailing were selected. The effect of masonry infill panels on structural response was delineated by comparing the bare-framed response with the infill response. Seismic performance is evaluated with regard to global strength, stiffness, energy dissipation, inter-storey drift, and total deflection of the structure. A parametric analysis of structures with masonry infill is also performed. For this, the influence of different material properties is studied, namely diagonal compressive stress, modulus of elasticity and tensile stress of masonry infill panels. Study results show that masonry infill increases the global strength and stiffness of the structures; it decreases the inter-storey drift and hence the total displacement of the structure. The results quantify the influence of the infill panels on structural response and, in particular, the effect of the diagonal compressive strength of the masonry wall.
文摘930425 Clinical application of brain SPECTimaging and rCBF measurement on alzeimers dis-eases and multi--infarct dementia.LI Biao (李彪),et al.Ruijing Hosp,Shanghai 2nd Med U-niv,Shanghai,200025.Chin J Nucl Med 1993;13(2):78—80.Brain SPECT imaging and rCBF measurementwere performed in 10 normal controls and 25 pa-tients including 17 Alzeimers Diseases (AD) and8 multi-infarct dementia (MID).The resultsshowed that by SPECT imaging in all of the pa-tients local cerebral blood supply insufficiencywas revealed and so were the characteristicchanges of AD and MID.Therefore
文摘930012 Dipyridamole <sup>201</sup>T1 myocardial perfu-sion tomography and Bull’s-eye analysis forquantitative evaluation of CAD.JING Maosong(蒋茂松),TANG Xi(唐熙).Huadong Hosp,Shanghai.Chin J Nucl Med 1992;12(3):141—143.To assess the ability of quantitative analysisof dipyridamole <sup>201</sup>T1 tomography for
基金funded by Development Plan(973 Plan) of National Critical and Basic Research,No.2012CB518505,2010CB530500,2006CB504504
文摘The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.