BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant and aggressive tumor,and high Ki-67 expression indicates poor histological differentiation and prognosis.Therefore,one of the challenges in diagno...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant and aggressive tumor,and high Ki-67 expression indicates poor histological differentiation and prognosis.Therefore,one of the challenges in diagnosing preoperatively patients with PDAC is predicting the degree of malignancy.Dynamic contrast-enhanced ultrasonography(DCE-US)plays a crucial role in abdominal tumor diagnosis,and can adequately show the microvascular composition within the tumors.However,the relationship between DCE-US and the Ki-67 labelling index remains unclear at the present time.AIM To predict the correlation between Ki-67 expression and the parameters of DCEUS.METHODS Patients with PDAC who underwent DCE-US were retrospectively analyzed.Patients who had received any treatment(radiotherapy or chemotherapy)prior to DCE-US;had incomplete clinical,imaging,or pathologic information;and had poor-quality image analysis were excluded.Correlations between Ki-67 expression and the parameters of DCE-US in patients with PDAC were assessed using Spearman’s rank correlation analysis.The diagnostic performances of these parameters in high Ki-67 expression group were evaluated according to receiver operating characteristic curve.RESULTS Based on the Ki-67 labelling index,30 patients were divided into two groups,i.e.,the high expression group and the low expression group.Among the relative quantitative parameters between the two groups,relative half-decrease time(rHDT),relative peak enhancement,relative wash-in perfusion index and relative wash-in rate were significantly different between two groups(P=0.018,P=0.025,P=0.028,P=0.035,respectively).The DCE-US parameter rHDT was moderately correlated with Ki-67 expression,and rHDT≥1.07 was more helpful in accurately diagnosing high Ki-67 expression,exhibiting a sensitivity and specificity of 53.8%and 94.1%,respectively.CONCLUSION One parameter of DCE-US,rHDT,correlates with high Ki-67 expression.It demonstrates that parameters obtained noninvasively by DCE-US could better predict Ki-67 expression in PDAC preoperatively.展开更多
目的:把握国内外无花果的研究现状与发展趋势,为无花果的深入研究与信息交流提供文献依据。方法:以中国知识资源总库(CNKI)、中国知识产权网数据库(CNIPR)、Elsevier、Springer Link和ACS(American Chemical Society)数据库为文献源,采...目的:把握国内外无花果的研究现状与发展趋势,为无花果的深入研究与信息交流提供文献依据。方法:以中国知识资源总库(CNKI)、中国知识产权网数据库(CNIPR)、Elsevier、Springer Link和ACS(American Chemical Society)数据库为文献源,采用文献计量学方法,对无花果文献按年度分布、研究领域、基金来源、关键词、载文期刊等特征进行检索与计量分析。结果:查得中文载文1709篇(1956年1月~2018年4月)、外文载文4706篇(1851年1月~2018年4月)、专利813项(1991年1月~2017年12月)。结论:国内研究比国外起步晚,但发展快,目前无论文献数量和质量还是发展态势和步伐均与国外基本一致,载文数量总体呈逐年增长,但近年来同比呈负增长;国内偏重于无花果栽培技术、药理学、微生物和储藏保鲜技术等研究;国外则集中于无花果活性物质提取、药理、代谢与成分分析等方面;无花果储藏保鲜新技术、果实深加工技术、抗逆抗病害高产传优品新品种培育、微生物及其利用、药理构效关系与活性物质分离纯化和安全性等将成为未来主要研究方向。随着人才和资金的大量投入,我国无花果的研究正朝着现代化道路快步迈进。展开更多
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant and aggressive tumor,and high Ki-67 expression indicates poor histological differentiation and prognosis.Therefore,one of the challenges in diagnosing preoperatively patients with PDAC is predicting the degree of malignancy.Dynamic contrast-enhanced ultrasonography(DCE-US)plays a crucial role in abdominal tumor diagnosis,and can adequately show the microvascular composition within the tumors.However,the relationship between DCE-US and the Ki-67 labelling index remains unclear at the present time.AIM To predict the correlation between Ki-67 expression and the parameters of DCEUS.METHODS Patients with PDAC who underwent DCE-US were retrospectively analyzed.Patients who had received any treatment(radiotherapy or chemotherapy)prior to DCE-US;had incomplete clinical,imaging,or pathologic information;and had poor-quality image analysis were excluded.Correlations between Ki-67 expression and the parameters of DCE-US in patients with PDAC were assessed using Spearman’s rank correlation analysis.The diagnostic performances of these parameters in high Ki-67 expression group were evaluated according to receiver operating characteristic curve.RESULTS Based on the Ki-67 labelling index,30 patients were divided into two groups,i.e.,the high expression group and the low expression group.Among the relative quantitative parameters between the two groups,relative half-decrease time(rHDT),relative peak enhancement,relative wash-in perfusion index and relative wash-in rate were significantly different between two groups(P=0.018,P=0.025,P=0.028,P=0.035,respectively).The DCE-US parameter rHDT was moderately correlated with Ki-67 expression,and rHDT≥1.07 was more helpful in accurately diagnosing high Ki-67 expression,exhibiting a sensitivity and specificity of 53.8%and 94.1%,respectively.CONCLUSION One parameter of DCE-US,rHDT,correlates with high Ki-67 expression.It demonstrates that parameters obtained noninvasively by DCE-US could better predict Ki-67 expression in PDAC preoperatively.
文摘目的:把握国内外无花果的研究现状与发展趋势,为无花果的深入研究与信息交流提供文献依据。方法:以中国知识资源总库(CNKI)、中国知识产权网数据库(CNIPR)、Elsevier、Springer Link和ACS(American Chemical Society)数据库为文献源,采用文献计量学方法,对无花果文献按年度分布、研究领域、基金来源、关键词、载文期刊等特征进行检索与计量分析。结果:查得中文载文1709篇(1956年1月~2018年4月)、外文载文4706篇(1851年1月~2018年4月)、专利813项(1991年1月~2017年12月)。结论:国内研究比国外起步晚,但发展快,目前无论文献数量和质量还是发展态势和步伐均与国外基本一致,载文数量总体呈逐年增长,但近年来同比呈负增长;国内偏重于无花果栽培技术、药理学、微生物和储藏保鲜技术等研究;国外则集中于无花果活性物质提取、药理、代谢与成分分析等方面;无花果储藏保鲜新技术、果实深加工技术、抗逆抗病害高产传优品新品种培育、微生物及其利用、药理构效关系与活性物质分离纯化和安全性等将成为未来主要研究方向。随着人才和资金的大量投入,我国无花果的研究正朝着现代化道路快步迈进。
