The cytosolic chaperonin T-complex protein 1-ring complex(TRiC)or chaperonin containing T-complex protein 1(CCT)is essential in de novo folding of approximately 10%of the eukaryotic,newly translated polypeptides as we...The cytosolic chaperonin T-complex protein 1-ring complex(TRiC)or chaperonin containing T-complex protein 1(CCT)is essential in de novo folding of approximately 10%of the eukaryotic,newly translated polypeptides as well as misfolded proteins.There is a close link between the TRiC/CCT cytosolic chaperonin and neurodegenerative diseases(Lopez et al.,2015).A lot of research suggests that CCT plays neuroprotective roles in neurodegenerative diseases including Huntington’s disease(Lopez et al.,2015).Either overexpression of a single or all eight subunits(CCT1-8)or treatment of the substrate-binding apical domain of yeast CCT1(ApiCCT1)prevented mutant Huntingtin aggregation and improved cellular and neuronal functions(Zhao et al.,2016).Importantly,our recent study has demonstrated that both CCT and ApiCCT could reduce mutant Huntingtin level and enhance both anterograde and retrograde axonal transport of brain-derived neurotrophic factor.These results led to restoration of the trophic status of striatal neurons from a bacterial artificial chromosome transgenic mouse model of Huntington’s disease(Zhao et al.,2016).Axonal transport is regulated by many factors including microtubule-associated protein tau,which promotes tubulin polymerization and stabilizes microtubules.Impaired interaction between tau and microtubules plays a vital role in the pathogenesis of multiple neurodegenerative diseases(Wang and Mandelkow,2016).Interestingly,tau phosphorylation is also observed in brains of several Huntington’s disease mouse models and Huntington’s disease patients(Gratuze et al.,2016).In a recent study,we explored if CCT subunit has any effect on axonal transport in a tau-dependent pathway(Chen et al.,2018b).We focused on the retrograde axonal transport of brain-derived neurotrophic factor,as neurotrophic factor-mediated signaling in the form of signaling endosome is essential in both the developing and the mature nervous system and dysregulation of trafficking of neurotrophic factors is tightly linked to disorders of the nervous system(Chen et al.,2018a).We found that the expression of a single CCT subunit(CCT5)significantly promoted retrograde axonal transport of brain-derived neurotrophic factor in primary cortical neurons.Mechanically,CCT regulated the level of cyclin-dependent kinase 5(CDK5)/p35/p25 and,subsequently contributed to CCT-induced tau phosphorylation,which induced detachment of tau from microtubules(Chen et al.,2018b)(Figure 1).展开更多
Let M be a 2-torsion free semiprime G-ring with involution satisfying the condition that ( and ). In this paper, we will prove that if a non-zero Jordan G<sup>*</sup>-derivation d on M satisfies for all an...Let M be a 2-torsion free semiprime G-ring with involution satisfying the condition that ( and ). In this paper, we will prove that if a non-zero Jordan G<sup>*</sup>-derivation d on M satisfies for all and , then .展开更多
In this paper, it is defined that left *-α-derivation, generalized left *-α-derivation and *-α-derivation, generalized *-α-derivation of a *-ring where α is a homomorphism. The results which proved for generalize...In this paper, it is defined that left *-α-derivation, generalized left *-α-derivation and *-α-derivation, generalized *-α-derivation of a *-ring where α is a homomorphism. The results which proved for generalized left *-derivation of R in [1] are extended by using generalized left *-α-derivation. The commutativity of a *-ring with generalized left *-α-derivation is investigated and some results are given for generalized *-α-derivation.展开更多
ObjectiveThe study aimed to explore the factors regulating carotenoid accumulation in flesh color. MethodA loquat mutation （red-or orange-fleshed plant emerged a bud mutation of white-flesh in trunk） was used as mat...ObjectiveThe study aimed to explore the factors regulating carotenoid accumulation in flesh color. MethodA loquat mutation （red-or orange-fleshed plant emerged a bud mutation of white-flesh in trunk） was used as material; HPLC analysis of β-carotene content was conducted. ResultThe β-carotene concentration in the flesh of wild and mutant types was 60.9 and 4.6 μg/g fresh weight, respectively. According to the conserved regions of genes from rose family genome, carotenogenic gene fragments in wild and mutant types were obtained. No nucleotide variation of the carotenogenic gene fragments was observed between wild and mutant genome. Real-time quantitative polymerase chain reaction （Q-PCR） was compared and one carotenogenic gene, β-ring hydroxylase （HYB） were considerably suppressed in mature mutant loquat fruits compared with that in wild. The other six carotenogenic genes were also expressed but the expression patterns appeared to be not correlated with the amount of β-carotene concentration in wild loquat flesh. ConclusionThe mutant whitish loquat lacks the ability to synthesize β-carotene because of the transcriptional down-regulation of carotenogenic gene HYB.展开更多
In this paper,we give the equivalent characterizations of principally quasi-Baer modules,and show that any direct summand of a principally quasi-Baer module inherits the property and any finite direct sum of mutually ...In this paper,we give the equivalent characterizations of principally quasi-Baer modules,and show that any direct summand of a principally quasi-Baer module inherits the property and any finite direct sum of mutually subisomorphic principally quasi-Baer modules is also principally quasi-Baer.Moreover,we prove that left principally quasi-Baer rings have Morita invariant property.Connections between Richart modules and principally quasi-Baer modules are investigated.展开更多
Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent ...Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent they take care of the sheaf representation as obtained by Lambek. Klein 4-rings and their several generalizations and extensions are proved to be members of such class of rings. An extension obtained is a McCoy ring and its power series ring is also proved to be a McCoy ring.展开更多
Let R be a ring. We consider left （or right） principal quasi-Baerness of the left skew formal power series ring R[[x;α]] over R where a is a ring automorphism of R. We give a necessary and sufficient condition unde...Let R be a ring. We consider left （or right） principal quasi-Baerness of the left skew formal power series ring R[[x;α]] over R where a is a ring automorphism of R. We give a necessary and sufficient condition under which the ring R[[x; α]] is left （or right） principally quasi-Baer. As an application we show that R[[x]] is left principally quasi-Baer if and only if R is left principally quasi- Baer and the left annihilator of the left ideal generated by any countable family of idempotents in R is generated by an idempotent.展开更多
In this paper, the (quasi-)Baerness of skew group ring and fixed ring is investigated. The following two results are obtained: if R is a simple ring with identity and G an outer automorphism group, then R G is a Baer ...In this paper, the (quasi-)Baerness of skew group ring and fixed ring is investigated. The following two results are obtained: if R is a simple ring with identity and G an outer automorphism group, then R G is a Baer ring;if R is an Artinian simple ring with identity and G an outer automorphism group, then RG is a Baer ring. Moreover, by decomposing Morita Context ring and Morita Context Theory, we provided several conditions of Morita Context ring, which is formed of skew group ring and fixed ring, to be (quasi-)Baer ring.展开更多
This paper mainly studies some properties of skew polynomial ring related to Morita invariance, Armendariz and (quasi)-Baer. First, we show that skew polynomial ring has no Morita invariance by the counterexample. The...This paper mainly studies some properties of skew polynomial ring related to Morita invariance, Armendariz and (quasi)-Baer. First, we show that skew polynomial ring has no Morita invariance by the counterexample. Then we prove a necessary condition that skew polynomial ring constitutes Armendariz ring. We lastly investigate that condition of skew polynomial ring is a (quasi)-Baer ring, and verify that the conditions is necessary, but not sufficient by example and counterexample.展开更多
文摘The cytosolic chaperonin T-complex protein 1-ring complex(TRiC)or chaperonin containing T-complex protein 1(CCT)is essential in de novo folding of approximately 10%of the eukaryotic,newly translated polypeptides as well as misfolded proteins.There is a close link between the TRiC/CCT cytosolic chaperonin and neurodegenerative diseases(Lopez et al.,2015).A lot of research suggests that CCT plays neuroprotective roles in neurodegenerative diseases including Huntington’s disease(Lopez et al.,2015).Either overexpression of a single or all eight subunits(CCT1-8)or treatment of the substrate-binding apical domain of yeast CCT1(ApiCCT1)prevented mutant Huntingtin aggregation and improved cellular and neuronal functions(Zhao et al.,2016).Importantly,our recent study has demonstrated that both CCT and ApiCCT could reduce mutant Huntingtin level and enhance both anterograde and retrograde axonal transport of brain-derived neurotrophic factor.These results led to restoration of the trophic status of striatal neurons from a bacterial artificial chromosome transgenic mouse model of Huntington’s disease(Zhao et al.,2016).Axonal transport is regulated by many factors including microtubule-associated protein tau,which promotes tubulin polymerization and stabilizes microtubules.Impaired interaction between tau and microtubules plays a vital role in the pathogenesis of multiple neurodegenerative diseases(Wang and Mandelkow,2016).Interestingly,tau phosphorylation is also observed in brains of several Huntington’s disease mouse models and Huntington’s disease patients(Gratuze et al.,2016).In a recent study,we explored if CCT subunit has any effect on axonal transport in a tau-dependent pathway(Chen et al.,2018b).We focused on the retrograde axonal transport of brain-derived neurotrophic factor,as neurotrophic factor-mediated signaling in the form of signaling endosome is essential in both the developing and the mature nervous system and dysregulation of trafficking of neurotrophic factors is tightly linked to disorders of the nervous system(Chen et al.,2018a).We found that the expression of a single CCT subunit(CCT5)significantly promoted retrograde axonal transport of brain-derived neurotrophic factor in primary cortical neurons.Mechanically,CCT regulated the level of cyclin-dependent kinase 5(CDK5)/p35/p25 and,subsequently contributed to CCT-induced tau phosphorylation,which induced detachment of tau from microtubules(Chen et al.,2018b)(Figure 1).
文摘Let M be a 2-torsion free semiprime G-ring with involution satisfying the condition that ( and ). In this paper, we will prove that if a non-zero Jordan G<sup>*</sup>-derivation d on M satisfies for all and , then .
文摘In this paper, it is defined that left *-α-derivation, generalized left *-α-derivation and *-α-derivation, generalized *-α-derivation of a *-ring where α is a homomorphism. The results which proved for generalized left *-derivation of R in [1] are extended by using generalized left *-α-derivation. The commutativity of a *-ring with generalized left *-α-derivation is investigated and some results are given for generalized *-α-derivation.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest of China(201003073)Key Laboratory Program of Agriculture Ministry of China(2013JCYJ-004)+1 种基金Applied Basic Research Program of Chengdu City Science and Technology Bureau(11DXYB039NC)Youth Foundation of Sichuan Province(2011QNJJ-010)~~
文摘ObjectiveThe study aimed to explore the factors regulating carotenoid accumulation in flesh color. MethodA loquat mutation （red-or orange-fleshed plant emerged a bud mutation of white-flesh in trunk） was used as material; HPLC analysis of β-carotene content was conducted. ResultThe β-carotene concentration in the flesh of wild and mutant types was 60.9 and 4.6 μg/g fresh weight, respectively. According to the conserved regions of genes from rose family genome, carotenogenic gene fragments in wild and mutant types were obtained. No nucleotide variation of the carotenogenic gene fragments was observed between wild and mutant genome. Real-time quantitative polymerase chain reaction （Q-PCR） was compared and one carotenogenic gene, β-ring hydroxylase （HYB） were considerably suppressed in mature mutant loquat fruits compared with that in wild. The other six carotenogenic genes were also expressed but the expression patterns appeared to be not correlated with the amount of β-carotene concentration in wild loquat flesh. ConclusionThe mutant whitish loquat lacks the ability to synthesize β-carotene because of the transcriptional down-regulation of carotenogenic gene HYB.
基金Foundation item： the National Natural Science Foundation of China （No. 10671122）.
文摘In this paper,we give the equivalent characterizations of principally quasi-Baer modules,and show that any direct summand of a principally quasi-Baer module inherits the property and any finite direct sum of mutually subisomorphic principally quasi-Baer modules is also principally quasi-Baer.Moreover,we prove that left principally quasi-Baer rings have Morita invariant property.Connections between Richart modules and principally quasi-Baer modules are investigated.
文摘Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent they take care of the sheaf representation as obtained by Lambek. Klein 4-rings and their several generalizations and extensions are proved to be members of such class of rings. An extension obtained is a McCoy ring and its power series ring is also proved to be a McCoy ring.
基金Supported by National Natural Science Foundation of China (Grant No.10961021)the Cultivation Fund of the Key Scientific and Technical Innovation Project,Ministry of Education of China
文摘Let R be a ring. We consider left （or right） principal quasi-Baerness of the left skew formal power series ring R[[x;α]] over R where a is a ring automorphism of R. We give a necessary and sufficient condition under which the ring R[[x; α]] is left （or right） principally quasi-Baer. As an application we show that R[[x]] is left principally quasi-Baer if and only if R is left principally quasi- Baer and the left annihilator of the left ideal generated by any countable family of idempotents in R is generated by an idempotent.
文摘In this paper, the (quasi-)Baerness of skew group ring and fixed ring is investigated. The following two results are obtained: if R is a simple ring with identity and G an outer automorphism group, then R G is a Baer ring;if R is an Artinian simple ring with identity and G an outer automorphism group, then RG is a Baer ring. Moreover, by decomposing Morita Context ring and Morita Context Theory, we provided several conditions of Morita Context ring, which is formed of skew group ring and fixed ring, to be (quasi-)Baer ring.
文摘This paper mainly studies some properties of skew polynomial ring related to Morita invariance, Armendariz and (quasi)-Baer. First, we show that skew polynomial ring has no Morita invariance by the counterexample. Then we prove a necessary condition that skew polynomial ring constitutes Armendariz ring. We lastly investigate that condition of skew polynomial ring is a (quasi)-Baer ring, and verify that the conditions is necessary, but not sufficient by example and counterexample.
