Peptide aptamer-mediated modulation of prion protein α-cleavage as treatment strategy for prion and other neurodegenerative diseases

Despite intensive research,most neurodegenerative diseases cannot be cured and for some of them no treatment is available to increase survival or quality of life.Among the latter are prion diseases,fatal and transmissible neurodegenerative diseases of humans and other animals.

PI and RST Control Design and Comparison for Matrix Converters Using Venturini Modulation Strategy

This paper presents a thorough design and comparative study of two popular control techniques, i.e., classical Proportional Integral (PI) and RST, for Matrix Converters (MCs) in terms of tracking the reference and robustness. The output signal of MCs is directly affected by unbalanced grid voltage. Some research works have attempted to overcome this problem with PI control. However, this technique is known to offer lower performance when it is used in complex and nonlinear systems. On the other hand, RST control offers better performance, even in case of highly nonlinear systems. Therefore, the RST can achieve better performance to overcome the limitation of PI control of nonlinear systems. In this paper, a RST control method is proposed as output current controller to improve the performance of the MC powered by unbalanced grid voltage. The overall operating principle, Venturini modulation strategy of MC, PI control and characteristics of RST are presented.

A Dual Arm Complementary Hybrid Modulation Strategy Combining NL-SPWM for MMC Applications

In the medium voltage direct current(MVDC)transmission system,a small number of MMC sub modules will reduce the power quality.In this paper,based on the research background of Photovoltaic Medium VoltageDirect Current(PV-MVDC)system,aHybrid Modulation Strategy based on theDecoupledDouble SynchronousReference Frame(DDSRF)control strategy is proposed.The dual armcomplementary hybrid modulation combining nearest-level-SPWM(NL-SPWM)can keep the number of SMs in the ON state constant.Then,the corresponding voltage sharing control algorithm of sub module(SM)is introduced.Through theoretical calculation,the modulation strategy can be found to stabilize the DC voltage and reduce the harmonic content.A32-level MMC systemhas been developed to verity that the proposed hybrid modulation strategy and its SM voltage sharing algorithm have the advantages of restraining circulating current and maintaining capacitor voltage balance.

Research on Phase-Shifted Full-Bridge Circuit Based on Frequency and Phase-Shift Synthesis Modulation Strategy

The full-bridge converters usually use transformer leakage inductance and parallel resonant capacitors to achieve smooth current commutation and soft switching functions,which can easily cause problems such as energy leakage and significant duty cycle loss.This paper designs a novel full-bridge zero-current(FB-ZCS)converter with series resonant capacitors and proposes a frequency and phase-shift synthesis modulation(FPSSM)control strategy based on this topology.Compared with the traditional parallel resonant capacitor circuit,the passive components used are significantly reduced,the structure is simple,and there is only a slight energy loss.By controlling the charging time of the capacitor,it can be achieved without additional switches or auxiliary circuits.The automatic control of capacitor energy based on input current addresses the low efficiency of the traditional control strategies.This paper introduces its principle in detail and verifies it through simulation.Finally,an experimental prototype was built further to demonstrate the feasibility of the theory through experiments.The module can be applied to a photovoltaic DC collection system using input parallel output series(IPOS)cascade to provide a new topology for large-scale,long-distance DC transmission.

Research on Modulation Strategies Based on Multilevel Inverter Universal Hybrid Topology

Based on multi-module-cascaded inverter topology, this study presented a universal multilevel inverter hybrid topology and unified the researches on multilevel inverter topology. According to the freedom of this universal topology, several new hybrid topologies were constructed. Also, based on conventional modulation strategies- multi-carrier SPWM (Sinusoidal Pulse Width Modulation), hybrid modulation strategies were introduced corresponding to hybrid topologies, and a multilevel SVPWM (Space Vector Pulse Width Modulation) technique based on phase-shifted theory was naturally produced. Simulation and experiment results prove that hybrid topologies and corresponding modulation strategies are valid, which lay a foundation for practical application of hybrid multilevel inverter topologies.

Design and modulation principles of molybdenum carbide-based materials for green hydrogen evolution

The green production of hydrogen from electrocatalytic water splitting is an important base and promising direction for the future of the large-scale application of hydrogen energy.The key of green hydrogen evolution depends on the development of low-cost and highly active electrocatalysts.Molybdenum carbides(MoxC),as a typical of earth-abundant transition-metal material,have accumulated great attention due to their low cost,earth abundance,electrical conductivity,similar d-band state to Pt,and regulated morphology/electronic structures.In this paper,recent researches focusing on MoxC for efficient HER in a wide pH range are summarized from respects of modulation of unique morphology,electronic structure,and electrode interface step by step.Briefly,modulation of morphology influence the apparent activity of catalyst,modulation of electronic structure of active sites by heteroatom doping and designing heterointerface boost intrinsic HER kinetics,and modulation of electrode interface via hybridization of MoxC structures with carbon materials can ensure the fast electron transfer and boost the activity.Besides the above methods discussed,perspective and challenges of designing MoxC as the substitute of Pt-based electrocatalyst for practical hydrogen generation in a wide pH range are pointed out.

Research on marketing module and competitive strategy of E-Business Based on the VIP Website

E-Business now is developing fast in China and the development of E-Business strategy is crucial as the right strategy can make the E-Business select the correct direction and get a better development. In this paper, combined with SWOT parameters module, we will make a thorough research on the strategies used by Vip.eom from different angles. After this research, we will have a good understanding of strategies used by VIP website and learn to make better decisions in the e-business world.

Harnessing immunity:Immunomodulatory therapies in COVID-19

An overly exuberant immune response,characterized by a cytokine storm and uncontrolled inflammation,has been identified as a significant driver of severe coronavirus disease 2019(COVID-19)cases.Consequently,deciphering the intricacies of immune dysregulation in COVID-19 is imperative to identify specific targets for intervention and modulation.With these delicate dynamics in mind,immunomodulatory therapies have emerged as a promising avenue for miti-gating the challenges posed by COVID-19.Precision in manipulating immune pathways presents an opportunity to alter the host response,optimizing antiviral defenses while curbing deleterious inflammation.This review article compre-hensively analyzes immunomodulatory interventions in managing COVID-19.We explore diverse approaches to mitigating the hyperactive immune response and its impact,from corticosteroids and non-steroidal drugs to targeted biologics,including anti-viral drugs,cytokine inhibitors,JAK inhibitors,convalescent plasma,monoclonal antibodies(mAbs)to severe acute respiratory syndrome coronavirus 2,cell-based therapies(i.e.,CAR T,etc.).By summarizing the current evidence,we aim to provide a clear roadmap for clinicians and researchers navigating the complex landscape of immunomodulation in COVID-19 treatment.CS Glucocorticoids are among the most widely prescribed drugs with their immune-suppressive and anti-inflammatory effect[84].The current guidelines for the treatment of COVID-19 recommend against the use of dexamethasone or other systemic CS in non-hospitalized patients in the absence of another indication[70].The RECOVERY trial demonstrates the reduced 28-d mortality among hospitalized patients with COVID-19 using dexamethasone compared to the usual standard of care,along with other investigators,such as Ahmed and Hassan[85].The benefit of dexamethasone was seen only among participants receiving either oxygen alone or invasive mechanical ventilation at randomization but not among those receiving no respiratory support at enrollment[85].In a systematic review and meta-analysis,Albuquerque et al[86]showed that in comparison to tocilizumab,baricitinib,and sarilumab are associated with high probabilities of similar mortality reductions among hospitalized COVID-19 concurrently treated with CS.As a result of the absence of SARS-CoV-2-specific antiviral medications,the effectiveness of COVID-19 treatments is reduced.Several COVID-19 therapies are now under investigation.However,the majority of them lack specificity,efficacy,and safety[87].Immunotherapy is a ground-breaking medical treatment that manipulates the immune system to fight diseases.Translational research is rapidly progressing,recognized as a significant breakthrough in 2013[88].Among the immunotherapeutic options for treating COVID-19 are Immunoglobulin,CP,antibodies,mAbs(mAbs),NK cells,T cells,TLR,cytokine therapies and immune modulators.

带约束的Markov-modulated风险模型最优分红和注资策略

在考虑Markov-modulated风险模型分红约束和交易费用的基础上,以股东的折现分红减去折现注资之差的期望值最大为目标,讨论了模型的最优分红和注资策略问题.由随机控制理论建立HJB方程,得到相应的最优策略为Threshold策略.

Regenerative Braking Strategy for Motor Hoist by Ultracapacitor

Rising concern in environmental issues on global scale has made energy saving in powered equipment a very important subject.In order to improve the energy efficiency and driving range of a motor hoist,a regenerative braking system is designed and discussed.The system takes a unique ultracapacitor-only approach to energy storage system.The bi-directional bride DC？DC converter which regulates current flow to and from the ultracapacitor operates in two modes：boost and buck,depending on the direction of the flow.In order to provide constant input and output current at the ultracapacitor,this system uses a double proportional-integral（PI） control strategy in regulating the duty cycle of PWM to the DC？DC converter.The permanent magnet synchronous motor（PWSM） drive system is also studied.The space vector pulse width modulation（SVPWM） technique,along with a two-closed-loop vector control model,is adopted after detailed analysis of PMSM characteristics.The overall model and control strategy for this regenerative braking system is ultimately built and simulated under the MATLAB and Simulink environment.A test platform is built to obtain experimental results.Analysis of the results reveals that more than half of the gravitational potential energy can be recovered by this system.Simulation and experimentation results testify the validity of the double PI control strategy for interface circuit of ultracapacitor and SVPWM strategy for PMSM.

Improved Voltage Control Strategy for Photovoltaic Grid-Connected System Based on DoubleLayer Coordination Control

An improved automatic voltage coordination control strategy （AVCCS） based on ;automatic voltage control （AVC） and battery energy storage control （BESC） is proposed for photovoltaic grid-connected system （PVGS） to mitigate the voltage fluctuations caused by environmental disturbances. Only AVC is used when small environ- mental disturbances happen, while BESC is incorporated with AVC to restrain the voltage fluctuations when large disturbances happen. An adjustable parameter determining the allowed amplitudes of voltage fluctuations is introduced to realize the above switching process. A benchmark low voltage distribution system including ]？VGS is established by using the commercial software Dig SILENT. Simulation results show that the voltage under AVCCS satisfies the IEEE Standard 1547, and the installed battery capacity is also reduced. Meanwhile, the battery＇s service life is ex- tended by avoiding frequent charges/discharges in the control process.

Electrocatalytic oxygen evolution activities of metal chalcogenides and phosphides:Fundamentals,origins,and future strategies

The development of inexpensive and efficient electrocatalysts is key to commercializing energy-related electrocatalytic techniques such as water electrolyzers and metal-air batteries.In particular,novel oxygen evolution reaction(OER)pre-catalysts,such as transition metal chalcogenides(TMCs)and phosphides(TMPs),have evolved in recent years from traditional stable OER electrocatalysts,which show superior OER electrocatalytic performance compared with transition metal oxides(TMOs)or(oxy)hydroxides(TMOHs).In this feature article,we summarize recent advances in the development of TMCand TMP-based OER electrocatalysts,as well as approaches to improve the OER performance in terms of morphology,structure,composition,surface engineering,lattice-strained and in-situ transformation in the electrolysis process.In particular,the electrochemical stability of TMCs and TMPs in alkaline electrolytes and the evolution of morphology,structure and composition under OER conditions are discussed.In the last section,we discuss the challenges that need to be addressed in this specific area of research and the implications for further research.

An Experimental Module in the Teaching of Genetics,with a Special Reference to Reform and Innovation in Genetics Experiments

Genetics is a major course in Life Sciences,and also a basic course in other disciplines or specialties,such as Agricultural Sciences,Medical Sciences and etc.Genetic experiments are not only the important content of the undergraduate teaching in Life Science but also the most common and efficient teaching approach in Life Science.Based on an introduction to reform and innovation of genetics experiment instruction,this article aims at discussing how to classify experimental modules and teaching practices.In our experimental test,the whole experiments consist of three modules:general experiments,integrated experiments,and research-based experiments.The research-based experiment is given as an instance.We herein figure out the instruction of experiment contents and guidance of learning methods,corresponding to various requirements in different teaching stage.In our opinion,post-graduates can act as teaching-assistants,which will facilitate undergraduates to participate in genetic experiments,improve their ability to operate by hand,and foster their innovative consciousness and scientific-thinking ability.

Hybrid Control Strategy for Matrix Converter Fed Wind Energy Conversion System

In this paper, a hybrid control strategy for a matrix converter fed wind energy conversion system is presented. Since the wind speed may vary, output parameters like power, frequency and voltage may fluctuate. Hence it is necessary to design a system that regulates output parameters, such as voltage and frequency, and thereby provides a constant voltage and frequency output from the wind energy conversion system. Matrix converter is used in the proposed solution as the main power conditioner as a more efficient alternative when compared to traditional back-back converter structure. To control the output voltage, a vector modulation based refined control structure is used. A power tracker is included to maximize the mechanical output power of the turbine. Over current protection and clamp circuit input protection have been introduced to protect the system from over current. It reduces the spikes generated at the output of the converter. The designed system is capable of supplying an output voltage of constant frequency and amplitude within the expected ranges of input during the operation. The matrix converter control using direct modulation method, modified Venturini modulation method and vector modulation method was simulated, the results were compared and it was inferred that vector modulation method was superior to the other two methods. With the proposed technique, voltage transfer ratio and harmonic profile have been improved compared to the other two modulation techniques. The behaviour of the system is corroborated by MATLAB Simulink, and hardware is realized using an FPGA controller. Experimental results are found to be matching with the simulation results.

基于改进ResNet34网络的变电站设备巡检图像分类识别的方法

针对变电站设备巡检图像识别领域中存在的图像规模有限和识别准确率低等问题,提出了一种基于改进ResNet34网络的图像分类识别方法。采用Seam Carving算法对图像中的低能量区域进行压缩以保留关键特征;同时使用弹性变换、高斯噪声等6种图像增强技术来增强图像的多样性。将基础ResNet34网络与卷积注意力模块结合,增强模型对设备巡检图像关键特征的提取能力。使用在ImageNet数据集上的预训练模型作为迁移学习的特征提取器来解决样本数量不足的问题。在Adam优化器中引入余弦退火策略来动态调整学习率使改进的ResNet34网络更快收敛至最优解。试验结果表明所提方法比基础ResNet34网络的准确率提升了0.0733,损失率降低了0.2019,为变电站设备巡检图像识别领域提供了一种可靠的解决方案。

适用于中点箝位型三电平逆变器的多目标调制策略

为同时实现中点箝位型三电平逆变器的中点电压平衡和共模电压降低,分别分析了基于载波脉宽调制(CBPWM)和基于虚拟空间矢量脉宽调制(VSVPWM)的中点电压平衡和共模电压降低方法。基于CBPWM提出一种可以降低共模电压的载波脉宽调制(RCMV_CBPWM)策略,可将大多数工作区域的共模电压限制在直流侧电压的1/6以内。为了实现上述2个目标,同时不过分增加开关损耗,在RCMV_CBPWM基础上提出了一种多目标调制(MOPWM)策略,在全调制度和全负载功率因数范围内,共模电压可限制在直流侧电压的1/6以内并实现中点电压平衡,且其开关损耗低于VSVPWM。比较了MOPWM、RCMV_CBPWM和VSVPWM在中点电压控制、共模电压降低和开关损耗降低方面的性能。实验结果验证了MOPWM的可行性和优越性。

基于调频信号自适应分解的电池储能辅助二次调频控制策略

以清洁能源发电为代表的零碳机组大规模并入电网,其间歇性和不确定性带来的频率波动愈发凸显。针对电池储能辅助火电机组调频灵活性不足、荷电状态维持效果不理想的问题,提出一种基于调频信号自适应分解的储能辅助二次调频控制策略。首先,综合灵敏度、储能荷电状态、频率偏差状态3个因素,给出区域调节需求信号和区域控制误差信号的切换时机判据;计及火电机组爬坡率限制和储能荷电状态限制,提出自适应调频信号分解策略,构建回报增益与荷电状态之间的规律并将其作为调节参考值,利用频率偏差对参考值进行修正,最后通过状态一致性检测模块判断回报增益的输出,以实现2种调频资源的优势互补。通过单区域系统频率响应模型仿真,验证了本文策略的有效性。结果表明:本文策略能够提高系统的灵活性,使各调频资源形成互补关系。

一种高性能低成本的中压异质器件混合型模块化多电平变换器及其控制策略

针对少子模块数的中压模块化多电平变换器(modular multilevel converter,MMC)装置损耗、成本等指标难以综合提升的问题,该文提出一种基于Si基绝缘栅双极型晶体管(insulated gate bipolar transistor,IGBT)和SiC基金属氧化物半导体场效应晶体管(metal oxide semiconductor field effect transistor,MOSFET)混合的模块化多电平变换器,简称异质器件混合型模块化多电平变换器(heterogeneous device hybrid MMC,HDHMMC)。HDHMMC由全Si IGBT的低频模块和Si IGBT与SiC MOSFET混合的高频模块组成。针对此拓扑提出一种特定的高低频混合调制策略,充分发挥Si IGBT通态损耗低、SiC MOSFET开关损耗低的优势。此外,详细分析了高低频模块的能量波动机理,并针对高低频模块直流侧电容电压不稳定问题提出一种特定的稳压策略。仿真和实验结果验证了HDHMMC拓扑及其调制、稳压策略的可行性。最后,将HDHMMC与现有MMC拓扑进行损耗与成本对比,证明所提拓扑可以更好地平衡成本、效率、功率密度等性能指标。

基于新型VLMZVM的ANPC型三电平并网逆变器环流抑制方法

为解决广泛应用在大功率分布式发电系统中的多机有源中点钳位(ANPC)型三电平并网逆变器间的低频零序环流问题,提出一种基于虚拟大矢量的新型十三矢量调制(VLMZVM)策略。通过建立多机ANPC型三电平并网逆变器零序环流模型,分析零序环流产生机理和影响因素,通过检测零序环流状态,实时选择虚拟大矢量或实际大矢量合成方法来抑制零序环流,并提出区分奇偶扇区的矢量分配方法快速选择合成矢量。实验结果验证了新型VLMZVM策略能在电流突变、参数不一致、全功率因数范围都具有很好的环流抑制效果。

一种两倍升压五电平开关电容逆变器

开关电容型逆变器具有使用单直流电源输入、电容电压自均衡、输出谐波含量低以及高电压增益的优势。本文提出一种新型五电平逆变器拓扑,该拓扑由1个直流电源、2个浮动电容、1个电感以及4对互补开关管构成;采用多载波层叠调制策略实现开关电容与输入电源的分时串并联运行;实现了2倍电压增益、五电平输出以及电容电压自均衡;通过增加电感抑制了开关电容充电时存在的脉冲电流,降低了开关管的电流应力。此外,逆变电路中没有单独二极管器件,使得该电路具有能量双向流动的能力,扩展了电路的应用范围。本文详细分析了电路的构成及工作过程,仿真及实验结果验证了所提出的逆变器具有可行性。