A facile and convenient approach for the one-pot synthesis of 2,4(1H,3H)-quinazolinediones

A fast and efficient method is described for the one-pot synthesis of 2,4（1H,3H）-quinazolinediones by cyclization reaction of anthranilic acid derivatives with potassium cyanate and acetic acid in PEG.Good to high yields of the products obtain in short reaction times with simple work-up.

The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy

Quinazolinediones are particularly attractivc pharrnacophores because of theix wide range of bioactivities. A convenient synthetic pathway to three-substituted quinazolinc-2,4-dionc derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium mcthoxidc. Good to cxceUcnt yields have bccn achieved.