The development of new polymerization routes to afford N-heterocyclic polymers is of vital importance and highly desired for various practical applications. Herein, a facile and efficient polyannulation reaction of du...The development of new polymerization routes to afford N-heterocyclic polymers is of vital importance and highly desired for various practical applications. Herein, a facile and efficient polyannulation reaction of dual-activated alkyne and pyridines was developed to construct novel N-heterocyclic poly(quinolizine)s. This polymerization can proceed smoothly under catalystfree conditions with 100% atom utilization to furnish poly(quinolizine)s with high molecular weights(up to 34,100) and welldefined structures in acceptable yields. The resulting polymers show good solubility, high thermal stability and strong red emission. Moreover, the prepared poly(quinolizine)s exhibit low cytotoxicity and can selectively label lysosomes in live cells.Considering the remarkable advantages of readily available raw materials, mild polymerization conditions, atom economy, and excellent product performance, this new and efficient polymerization tool will open up enormous opportunities for preparing functional N-heterocyclic polymers.展开更多
A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. M...A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mild condition. The structures of perfluoroalkylated quinolizine derivatives were char- acterized by means of IH NMR, 13C NMR, 19F NMR, IR, LRMS and HRMS. Furthermore, the reaction mechanism was proposed.展开更多
Two new indole alkaloids, 4-oxo-4,12-dihydroindolo[2,3-a]quinolizine-3-carbaldehyde (1) and 1,6,7-trihydro-indolo- [2,3-a]furan[3,4-g]quinolizine-3,4(13H)-dione (2), were isolated from Nauclea officinalis. Their struc...Two new indole alkaloids, 4-oxo-4,12-dihydroindolo[2,3-a]quinolizine-3-carbaldehyde (1) and 1,6,7-trihydro-indolo- [2,3-a]furan[3,4-g]quinolizine-3,4(13H)-dione (2), were isolated from Nauclea officinalis. Their structures were determined on the basis of 1D and 2D NMR spectral data.展开更多
The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic,...The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic, space group P21 with a = 10.257（3）, b = 8.954（3）, c = 11.541（4） A°, β= 109.772（6）°, V= 997.5（6）A°^3, Dc= 1.376 g/cm^3, μ = 0.107 mm^-1, Z= 2, F（000） = 432, S = 1.041, the final R = 0.0356 and wR = 0.0884. In the molecular structure, the ring of N（1）-C（5）-C（6）-C（7）-C（8）-C（13） is of twisting-boat conformation, and the ring of N（1 ）-C（1 ）- C（2）-C（3）-C（4）-C（5） is nearly a plane.展开更多
基金supported by the National Natural Science Foundation of China(22101028,21788102)the start-up funding from Beijing Normal University(310432102,310432103)+3 种基金the Innovation and Technology Commission(ITC-CNERC14SC01)the Science and Technology Plan of Shenzhen(JCYJ20160229205601482,JCYJ20180507183832744,JCYJ20170818113602462)the Natural Science Foundation of Guangdong Province(2019B121205002)the Research Grants Council of Hong Kong(16305618,16304819,16305320,NHKUST609/19,C6009-17G,C6014-20W/16)。
文摘The development of new polymerization routes to afford N-heterocyclic polymers is of vital importance and highly desired for various practical applications. Herein, a facile and efficient polyannulation reaction of dual-activated alkyne and pyridines was developed to construct novel N-heterocyclic poly(quinolizine)s. This polymerization can proceed smoothly under catalystfree conditions with 100% atom utilization to furnish poly(quinolizine)s with high molecular weights(up to 34,100) and welldefined structures in acceptable yields. The resulting polymers show good solubility, high thermal stability and strong red emission. Moreover, the prepared poly(quinolizine)s exhibit low cytotoxicity and can selectively label lysosomes in live cells.Considering the remarkable advantages of readily available raw materials, mild polymerization conditions, atom economy, and excellent product performance, this new and efficient polymerization tool will open up enormous opportunities for preparing functional N-heterocyclic polymers.
文摘A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mild condition. The structures of perfluoroalkylated quinolizine derivatives were char- acterized by means of IH NMR, 13C NMR, 19F NMR, IR, LRMS and HRMS. Furthermore, the reaction mechanism was proposed.
文摘Two new indole alkaloids, 4-oxo-4,12-dihydroindolo[2,3-a]quinolizine-3-carbaldehyde (1) and 1,6,7-trihydro-indolo- [2,3-a]furan[3,4-g]quinolizine-3,4(13H)-dione (2), were isolated from Nauclea officinalis. Their structures were determined on the basis of 1D and 2D NMR spectral data.
基金The project was supported by the Foundation of Science and Technology Department of Guangdong Province (2003C103006, 2004B30101007)
文摘The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic, space group P21 with a = 10.257（3）, b = 8.954（3）, c = 11.541（4） A°, β= 109.772（6）°, V= 997.5（6）A°^3, Dc= 1.376 g/cm^3, μ = 0.107 mm^-1, Z= 2, F（000） = 432, S = 1.041, the final R = 0.0356 and wR = 0.0884. In the molecular structure, the ring of N（1）-C（5）-C（6）-C（7）-C（8）-C（13） is of twisting-boat conformation, and the ring of N（1 ）-C（1 ）- C（2）-C（3）-C（4）-C（5） is nearly a plane.
