IQ67-domain(IQD)proteins function in plant defense and in organ development.The mechanisms by which they influence cotton fiber development are unknown.In the present study,GhIQD10 was expressed mainly in the transiti...IQ67-domain(IQD)proteins function in plant defense and in organ development.The mechanisms by which they influence cotton fiber development are unknown.In the present study,GhIQD10 was expressed mainly in the transition period of cotton fiber development,and GhIQD10-overexpression lines showed shorter fibers.GhIQD10 interacted with GhCaM7 and the interaction was inhibited by Ca^(2+).In in vitro ovule culture,Ca^(2+)rescued the shorter-fiber phenotype of GhIQD10-overexpression lines,which were insensitive to the Ca^(2+)channel inhibitor verapamil and the Ca^(2+)pool release channel blocker 2-aminoethoxydiphenyl borate.We conclude that GhIQD10 affects cotton fiber elongation via Ca^(2+)signaling by interacting with GhCaM7.Brassinosteroid(BR)biosynthesis and signaling genes were up-regulated in GhIQD10-overexpression lines.Fiber development in these lines was not affected by epibrassinolide or the BR biosynthesis inhibitor brassinozole,indicating that the influence of GhIQD10 on fiber elongation was not associated with BR.展开更多
目的 采用定量非对称回波的最小二乘估算法迭代水脂分离序列(iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence, IDEAL-IQ)联合计算机显微断层扫描(micro computed t...目的 采用定量非对称回波的最小二乘估算法迭代水脂分离序列(iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence, IDEAL-IQ)联合计算机显微断层扫描(micro computed tomography, Micro-CT)技术评估兔1型糖尿病腰椎骨髓脂肪含量和骨小梁微结构相关性。材料与方法 将16只雄性日本大耳白兔随机分为糖尿病组(n=8)和对照组(n=8),糖尿病组采用四氧嘧啶造模。在造模成功后第0、4、8、12、16周通过IDEAL-IQ定量评估兔腰椎骨髓脂肪含量。在第16周采用Micro-CT及组织病理学检查对兔腰椎骨小梁微结构进行定量评估。不同时间点腰椎IDEAL-IQ脂肪分数差异比较采用重复测量方差分析;同一时间点组间脂肪分数、Micro-CT骨小梁形态计量学参数、组织病理学参数差异比较采用独立样t检验或Mann-Whitney U检验;采用Pearson相关系数评估骨髓脂肪分数与骨小梁形态计量学参数、组织病理学参数相关性。结果 糖尿病组骨髓脂肪含量随时间变化呈上升趋势,且差异存在统计学意义(P<0.05),而对照组各时间点脂肪含量差异无统计学意义(P>0.05);糖尿病组与对照组腰椎骨髓脂肪分数在第16周差异有统计学意义(59.987±4.859 vs. 51.015±8.469,P<0.05);第16周糖尿病组骨体积、总表面积、骨表面积、骨表面积总体积比、骨小梁数量均低于对照组,而骨小梁分离度高于对照组,差异有统计学意义(P<0.05);组织病理学结果显示,与对照组相比,第16周糖尿病兔腰椎骨髓脂肪细胞数量(32.875±11.051 vs. 71.667±13.125, P<0.01)增加,而骨小梁数量(11.375±1.506vs.4.333±1.211, P<0.01)与骨小梁面积(0.927±0.071vs.0.312±0.100, P<0.01)明显减少;IDEAL-IQ脂肪分数与组织病理学脂肪细胞计数呈正相关关系(r=0.539 95%CI:0.012~0.832),与骨小梁模式因子、骨小梁结构模型指数、骨小梁分离度呈轻中度正相关关系,与骨矿物质密度、总体积、骨体积、骨体积分数、总表面积、骨表面积、骨表面积体积比、骨表面积总体积比、骨小梁数量呈轻至中度负相关关系。结论 1型糖尿病腰椎骨髓脂肪含量与骨小梁微结构变化存在相关性,IDEAL-IQ联合Micro-CT的多模态定量影像技术有望为1型糖尿病提供全面的骨髓微环境评估策略。展开更多
In this paper,we study the asymptotic behavior of a class of inverse quotient curvature flow in the anti-de Sitter-Schwarzschild manifold.We prove that under suitable convex conditions for the initial hypersurface,one...In this paper,we study the asymptotic behavior of a class of inverse quotient curvature flow in the anti-de Sitter-Schwarzschild manifold.We prove that under suitable convex conditions for the initial hypersurface,one can get the long-time existence for the inverse curvature flow.Moreover,we also get that the principal curvatures of the evolving hypersurface converge to 1 when t→+∞.展开更多
BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metaboli...BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metabolic profiles of children with DS and compare them to standard controls,using magnetic resonance spectroscopy(MRS)and correlating the results with IQ.METHODS This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as controls.MRS was used to evaluate ratios of choline/creatine(Cho/Cr),N-acetyl aspartic acid/creatine(NAA/Cr),and myoinositol/creatine(MI/Cr(in the frontal,temporal,and occipital lobes and basal ganglia and compared to controls and correlated with IQ.RESULTS Children with DS showed significant reductions in NAA/Cr and MI/Cr and a non-significant reduction in Cho/Cr in frontal lobes compared to controls.Additionally,we observed significant decreases in NAA/Cr,MI/Cr,and Cho/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to controls.Furthermore,there was a significant correlation between IQ and metabolic ratios in the brains of children with DS.CONCLUSION Brain metabolic profile could be a good predictor of IQ in children with DS.展开更多
Diophantine equations have always fascinated mathematicians about existence, finitude, and the calculation of possible solutions. Among these equations, one of them will be the object of our research. This is the Pyth...Diophantine equations have always fascinated mathematicians about existence, finitude, and the calculation of possible solutions. Among these equations, one of them will be the object of our research. This is the Pythagoras’- Fermat’s equation defined as follows. (1) when , it is well known that this equation has an infinity of solutions but has none (non-trivial) when . We also know that the last result, named Fermat-Wiles theorem (or FLT) was obtained at great expense and its understanding remains out of reach even for a good fringe of professional mathematicians. The aim of this research is to set up new simple but effective tools in the treatment of Diophantine equations and that of Pythagoras-Fermat. The tools put forward in this research are the properties of the quotients and the Diophantine remainders which we define as follows. Let a non-trivial triplet () solution of Equation (1) such that . and are called the Diophantine quotients and remainders of solution . We compute the remainder and the quotient of b and c by a using the division algorithm. Hence, we have: and et with . We prove the following important results. if and only if and if and only if . Also, we deduce that or for any hypothetical solution . We illustrate these results by effectively computing the Diophantine quotients and remainders in the case of Pythagorean triplets using a Python program. In the end, we apply the previous properties to directly prove a partial result of FLT. .展开更多
基金funded by the National Natural Science Foundation of China(31571722 and 31971984).
文摘IQ67-domain(IQD)proteins function in plant defense and in organ development.The mechanisms by which they influence cotton fiber development are unknown.In the present study,GhIQD10 was expressed mainly in the transition period of cotton fiber development,and GhIQD10-overexpression lines showed shorter fibers.GhIQD10 interacted with GhCaM7 and the interaction was inhibited by Ca^(2+).In in vitro ovule culture,Ca^(2+)rescued the shorter-fiber phenotype of GhIQD10-overexpression lines,which were insensitive to the Ca^(2+)channel inhibitor verapamil and the Ca^(2+)pool release channel blocker 2-aminoethoxydiphenyl borate.We conclude that GhIQD10 affects cotton fiber elongation via Ca^(2+)signaling by interacting with GhCaM7.Brassinosteroid(BR)biosynthesis and signaling genes were up-regulated in GhIQD10-overexpression lines.Fiber development in these lines was not affected by epibrassinolide or the BR biosynthesis inhibitor brassinozole,indicating that the influence of GhIQD10 on fiber elongation was not associated with BR.
文摘目的 采用定量非对称回波的最小二乘估算法迭代水脂分离序列(iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence, IDEAL-IQ)联合计算机显微断层扫描(micro computed tomography, Micro-CT)技术评估兔1型糖尿病腰椎骨髓脂肪含量和骨小梁微结构相关性。材料与方法 将16只雄性日本大耳白兔随机分为糖尿病组(n=8)和对照组(n=8),糖尿病组采用四氧嘧啶造模。在造模成功后第0、4、8、12、16周通过IDEAL-IQ定量评估兔腰椎骨髓脂肪含量。在第16周采用Micro-CT及组织病理学检查对兔腰椎骨小梁微结构进行定量评估。不同时间点腰椎IDEAL-IQ脂肪分数差异比较采用重复测量方差分析;同一时间点组间脂肪分数、Micro-CT骨小梁形态计量学参数、组织病理学参数差异比较采用独立样t检验或Mann-Whitney U检验;采用Pearson相关系数评估骨髓脂肪分数与骨小梁形态计量学参数、组织病理学参数相关性。结果 糖尿病组骨髓脂肪含量随时间变化呈上升趋势,且差异存在统计学意义(P<0.05),而对照组各时间点脂肪含量差异无统计学意义(P>0.05);糖尿病组与对照组腰椎骨髓脂肪分数在第16周差异有统计学意义(59.987±4.859 vs. 51.015±8.469,P<0.05);第16周糖尿病组骨体积、总表面积、骨表面积、骨表面积总体积比、骨小梁数量均低于对照组,而骨小梁分离度高于对照组,差异有统计学意义(P<0.05);组织病理学结果显示,与对照组相比,第16周糖尿病兔腰椎骨髓脂肪细胞数量(32.875±11.051 vs. 71.667±13.125, P<0.01)增加,而骨小梁数量(11.375±1.506vs.4.333±1.211, P<0.01)与骨小梁面积(0.927±0.071vs.0.312±0.100, P<0.01)明显减少;IDEAL-IQ脂肪分数与组织病理学脂肪细胞计数呈正相关关系(r=0.539 95%CI:0.012~0.832),与骨小梁模式因子、骨小梁结构模型指数、骨小梁分离度呈轻中度正相关关系,与骨矿物质密度、总体积、骨体积、骨体积分数、总表面积、骨表面积、骨表面积体积比、骨表面积总体积比、骨小梁数量呈轻至中度负相关关系。结论 1型糖尿病腰椎骨髓脂肪含量与骨小梁微结构变化存在相关性,IDEAL-IQ联合Micro-CT的多模态定量影像技术有望为1型糖尿病提供全面的骨髓微环境评估策略。
基金supported by the Postdoctoral Fund of Zhejiang Province,China (ZJ2022004).
文摘In this paper,we study the asymptotic behavior of a class of inverse quotient curvature flow in the anti-de Sitter-Schwarzschild manifold.We prove that under suitable convex conditions for the initial hypersurface,one can get the long-time existence for the inverse curvature flow.Moreover,we also get that the principal curvatures of the evolving hypersurface converge to 1 when t→+∞.
文摘BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metabolic profiles of children with DS and compare them to standard controls,using magnetic resonance spectroscopy(MRS)and correlating the results with IQ.METHODS This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as controls.MRS was used to evaluate ratios of choline/creatine(Cho/Cr),N-acetyl aspartic acid/creatine(NAA/Cr),and myoinositol/creatine(MI/Cr(in the frontal,temporal,and occipital lobes and basal ganglia and compared to controls and correlated with IQ.RESULTS Children with DS showed significant reductions in NAA/Cr and MI/Cr and a non-significant reduction in Cho/Cr in frontal lobes compared to controls.Additionally,we observed significant decreases in NAA/Cr,MI/Cr,and Cho/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to controls.Furthermore,there was a significant correlation between IQ and metabolic ratios in the brains of children with DS.CONCLUSION Brain metabolic profile could be a good predictor of IQ in children with DS.
文摘Diophantine equations have always fascinated mathematicians about existence, finitude, and the calculation of possible solutions. Among these equations, one of them will be the object of our research. This is the Pythagoras’- Fermat’s equation defined as follows. (1) when , it is well known that this equation has an infinity of solutions but has none (non-trivial) when . We also know that the last result, named Fermat-Wiles theorem (or FLT) was obtained at great expense and its understanding remains out of reach even for a good fringe of professional mathematicians. The aim of this research is to set up new simple but effective tools in the treatment of Diophantine equations and that of Pythagoras-Fermat. The tools put forward in this research are the properties of the quotients and the Diophantine remainders which we define as follows. Let a non-trivial triplet () solution of Equation (1) such that . and are called the Diophantine quotients and remainders of solution . We compute the remainder and the quotient of b and c by a using the division algorithm. Hence, we have: and et with . We prove the following important results. if and only if and if and only if . Also, we deduce that or for any hypothetical solution . We illustrate these results by effectively computing the Diophantine quotients and remainders in the case of Pythagorean triplets using a Python program. In the end, we apply the previous properties to directly prove a partial result of FLT. .
