RadA is highly conserved in bacteria and belongs to the RecA/RadA/Rad51 protein su-perfamily found in bacteria,archaea and eukarya. In Archaea,it plays a critical role in homologous re-combination process due to its R...RadA is highly conserved in bacteria and belongs to the RecA/RadA/Rad51 protein su-perfamily found in bacteria,archaea and eukarya. In Archaea,it plays a critical role in homologous re-combination process due to its RecA-like function. In Escherichia coli,it takes part in conjugational recom-bination and DNA repair but is not as important as that of archaea. Using PSI-BLAST searches,we found that Deinococcus radiodurans RadA had a higher similarity to that of bacteria than archaea and eukarya. Disruption of radA gene in D. radiodurans resulted in a modestly decreased resistance to gamma radiation and ultraviolet,but had no effect on the resistance to hydrogen peroxide. Complementa-tion of the radA disruptant by both E. coli radA and D. radiodurans radA could fully restore its resistance to gamma radiation and ultraviolet irradiation. Further domain function analyses of D. radiodurans RadA showed that the absence of the zinc finger domain resulted in a slightly more sensitive phenotype to gamma and UV radiation than that of the radA mutant,while the absence of the Lon protease domain exhib-ited a slightly increased resistance to gamma and UV radiation. These data suggest that D. radiodurans RadA does play an important role in the DNA damage repair processes and its three different domains have different functions.展开更多
The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the ang...The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the angle-dependent beampattern to an angle-time-range-dependent three-dimensional function by modulating the frequencies/time delays/phases across different transmit antenna elements.In this respect,extra Degrees-of-Freedom(DOFs)in the range domain are achieved,which opens up an innovative way to fulfil the tasks with enhanced system performance by jointly using the angle and range information.This paper summaries the developments of waveform diverse radars,including the Frequency Diverse Array(FDA),the Space-Time-CirculatingArray(STCA),and the Element-Pulse-Coding(EPC)frameworks,with emphasis on the analysis of the range-dependent beampattern from the basic properties upon how it is controlled.Moreover,the most recent advances of utilizing such a range-dependent beampattern in target detection,parameter estimation and identifiability,clutter suppression,jammer suppression and Synthetic Aperture Radar(SAR)imaging are discussed.展开更多
基金Acknowledgements The authors would like to thank Prof. Fu Junjie （Radiation Center of Zhejiang University） for his help in irradiation treatment. This work was supported by the National Basic Research Program of China （Grant No. 2004CB19604）, a grant for Distinguished Young Scientist of China （Grant No. 30425038） and the National Natural Science Foundation of China （Grant No. 30330020）.
文摘RadA is highly conserved in bacteria and belongs to the RecA/RadA/Rad51 protein su-perfamily found in bacteria,archaea and eukarya. In Archaea,it plays a critical role in homologous re-combination process due to its RecA-like function. In Escherichia coli,it takes part in conjugational recom-bination and DNA repair but is not as important as that of archaea. Using PSI-BLAST searches,we found that Deinococcus radiodurans RadA had a higher similarity to that of bacteria than archaea and eukarya. Disruption of radA gene in D. radiodurans resulted in a modestly decreased resistance to gamma radiation and ultraviolet,but had no effect on the resistance to hydrogen peroxide. Complementa-tion of the radA disruptant by both E. coli radA and D. radiodurans radA could fully restore its resistance to gamma radiation and ultraviolet irradiation. Further domain function analyses of D. radiodurans RadA showed that the absence of the zinc finger domain resulted in a slightly more sensitive phenotype to gamma and UV radiation than that of the radA mutant,while the absence of the Lon protease domain exhib-ited a slightly increased resistance to gamma and UV radiation. These data suggest that D. radiodurans RadA does play an important role in the DNA damage repair processes and its three different domains have different functions.
基金supported in part by the National Nature Science Foundation of China(Nos.62101402,61931016,62071344)China Postdoctoral Science Foundation(Nos.2021TQ0261,2021M702547)Young Elite Scientists Sponsorship Program by CAST(2021QNRC001).
文摘The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the angle-dependent beampattern to an angle-time-range-dependent three-dimensional function by modulating the frequencies/time delays/phases across different transmit antenna elements.In this respect,extra Degrees-of-Freedom(DOFs)in the range domain are achieved,which opens up an innovative way to fulfil the tasks with enhanced system performance by jointly using the angle and range information.This paper summaries the developments of waveform diverse radars,including the Frequency Diverse Array(FDA),the Space-Time-CirculatingArray(STCA),and the Element-Pulse-Coding(EPC)frameworks,with emphasis on the analysis of the range-dependent beampattern from the basic properties upon how it is controlled.Moreover,the most recent advances of utilizing such a range-dependent beampattern in target detection,parameter estimation and identifiability,clutter suppression,jammer suppression and Synthetic Aperture Radar(SAR)imaging are discussed.
