The Microwave Radiation Imager (MWRI) on board Chinese Fengyun-3 (FY-3) satellites provides measurements at 10.65, 18.7, 23.8, 36.5, and 89.0 GHz with both horizontal and vertical polarization channels. Brightness...The Microwave Radiation Imager (MWRI) on board Chinese Fengyun-3 (FY-3) satellites provides measurements at 10.65, 18.7, 23.8, 36.5, and 89.0 GHz with both horizontal and vertical polarization channels. Brightness temperature measurements of those channels with their central frequencies higher than 19 GHz from satellite-based microwave imager radiometers had traditionally been used to retrieve cloud liquid water path (LWP) over ocean. The results show that the lowest frequency channels are the most appropriate for retrieving LWP when its values are large. Therefore, a modified LWP retrieval algorithm is developed for retrieving LWP of different magnitudes involving not only the high frequency channels but also the lowest frequency channels of FY-3 MWRI. The theoretical estimates of the LWP retrieval errors are between 0.11 and 0.06 mm for 10.65- and 18.7-GHz channels and between 0.02 and 0.04 mm for 36.5- and 89.0-GHz channels. It is also shown that the brightness temperature observations at 10.65 GHz can be utilized to better retrieve the LWP greater than 3 mm in the eyewall region of Super Typhoon Neoguri (2014). The spiral structure of clouds within and around Typhoon Neoguri can be well captured by combining the LWP retrievals from different frequency channels.展开更多
Accurate measurements of soil moisture are beneficial to our understanding of hydrological processes in the earth system. A multivariable approach using the random forest(RF) machine learning technique is proposed to ...Accurate measurements of soil moisture are beneficial to our understanding of hydrological processes in the earth system. A multivariable approach using the random forest(RF) machine learning technique is proposed to estimate the soil moisture from Microwave Radiation Imager(MWRI) onboard Fengyun-3 C satellite. In this study, Soil Moisture Operational Products System(SMOPS) products disseminated from NOAA are used as a truth to train the algorithm with the input of MWRI brightness temperatures(TBs) at 10.65, 18.7, 23.8, 36.5, and 89.0 GHz, TB polarization ratios(PRs) at 10.65, 18.7, and 23.8 GHz, height in digital elevation model(DEM), and soil porosity. The retrieved soil moisture is also validated against the independent SMOPS data, and the correlation coefficient is about0.8 and mean bias is 0.002 m^3 m^-3 over the period from 1 August 2017 to 31 May 2019. Our retrieval of soil moisture also has a higher correlation with ECMWF ERA5 soil moisture data than the MWRI operational products. In the western part of China, the spatial distribution of MWRI soil moisture is much improved, compared to the MWRI operational products.展开更多
The production of true color images requires observational data in the red,green,and blue(RGB)bands.The Advanced Geostationary Radiation Imager(AGRI)onboard China’s Fengyun-4(FY-4)series of geostationary satellites o...The production of true color images requires observational data in the red,green,and blue(RGB)bands.The Advanced Geostationary Radiation Imager(AGRI)onboard China’s Fengyun-4(FY-4)series of geostationary satellites only has blue and red bands,and we therefore have to synthesize a green band to produce RGB true color images.We used random forest regression and conditional generative adversarial networks to train the green band model using Himawari-8 Advanced Himawari Imager data.The model was then used to simulate the green channel reflectance of the FY-4 AGRI.A single-scattering radiative transfer model was used to eliminate the contribution of Rayleigh scattering from the atmosphere and a logarithmic enhancement was applied to process the true color image.The conditional generative adversarial network model was better than random forest regression for the green band model in terms of statistical significance(e.g.,a higher determination coefficient,peak signal-to-noise ratio,and structural similarity index).The sharpness of the images was significantly improved after applying a correction for Rayleigh scattering,and the images were able to show natural phenomena more vividly.The AGRI true color images could be used to monitor dust storms,forest fires,typhoons,volcanic eruptions,and other natural events.展开更多
This study evaluates the in-orbit calibration uncertainty(CU)for the microwave radiation imager(MWRI)on board the Chinese polar-orbiting meteorological satellite Fengyun-3 C(FY-3 C).Uncertainty analysis of the MWRI pr...This study evaluates the in-orbit calibration uncertainty(CU)for the microwave radiation imager(MWRI)on board the Chinese polar-orbiting meteorological satellite Fengyun-3 C(FY-3 C).Uncertainty analysis of the MWRI provides a direct link to the calibration system of the sensor and quantifies the calibration confidence based on the prelaunch and postlaunch measurements.The unique design of the sensor makes the uncertainty in the calibration of the sensor highly correlate to the uncertainty in the brightness temperature(TB)measured at the hot view,while the cold view has negligible impacts on the calibration confidence.Lack of knowledge on the emission of the hot-load reflector hampers the MWRI calibration accuracy significantly in the descending passes of the orbits when the hotload reflector is heated nonuniformly by the solar illumination.Radiance contamination originating from the satellite and in-orbit environments could enter the primary reflector via the hot view and further impinge on the CU,especially at the 10.65-GHz channels where the main-beam width is much broader than that of higher-frequency channels.The monthly-mean CU is lower than 2 K at all channels,depending on the observed earth scenes and in-orbit environments,and the month-to-month variation of CU is also noticed for all channels.Due to the uncertainty in the emissive hot-load reflector,CU in the descending passes is generally larger than that in the ascending orbits.Moreover,up to 1-K CU difference between the ocean and land scenes is found for the 10.65-GHz channels,while this difference is less than 0.1 K at the 89-GHz channels.展开更多
China's FengYnn 3 (FY-3) polar orbiting satellites axe set to become an important sonrce of observational data for nu- merical weather prediction (NWP), atmospheric reanalyses, and climate monitoring studies over...China's FengYnn 3 (FY-3) polar orbiting satellites axe set to become an important sonrce of observational data for nu- merical weather prediction (NWP), atmospheric reanalyses, and climate monitoring studies over the next two decades. As part of the Climate Science for Service Partnership China (CSSP China) prograln, FY-3B Microwave Humidity Sounder 1 (MWHS-1) and FY-3C MWHS-2 observations have been thoroughly assessed and prepared for operational assimilation. This represents the first time observations from China's polar orbiting satellites have been used in the UK's global NWP model. Since 2016, continuous data quality monitoring has shown occasional bias changes found to be correlated to changes in the energy supply scheme regulating the platform heating system and other transient anomalies. Nonetheless, MWHS-1 and MWHS-2 significantly contribute to the 24-h forecast error reduction by 0.3% and 0.6%, respectively, and the combination of both instruments is shown to improve the fit to the model background of independent sounders by up to 1%. The observations from the Microwave Radiation Imager (MWRI) also are a potentially significant source of benefits for NWP models, but a solar-dependent bias observed in the instrument half-orbits has prevented their assimilation. This paper presents the bases of a correction scheme developed at the Met Office for the purpose of a future assimilation of MWRI data.展开更多
AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in...AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.展开更多
AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirr...AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirrhosis secondary to primary biliary cirrhosis were selected as the observation group, with the degree of patient liver cirrhosis graded by Child-Pugh (CP) score. Sixty healthy individuals were selected as the control group. The four indicators of hepatic fibrosis were detected in all research objects, including hyaluronic acid (HA), laminin (LN), type III collagen (PC III), and type IV collagen (IV-C). The liver parenchyma hardness value (LS) was then measured by ARFI technique. LS and the four indicators of liver fibrosis (HA, LN, PC III, and IV-C) were observed in different grade CP scores. The diagnostic value of LS and the four indicators of liver fibrosis in determining liver cirrhosis degree with PBC, whether used alone or in combination, were analyzed by receiver operating characteristic (ROC) curve. RESULTS: LS and the four indicators of liver fibrosis within the three classes (A, B, and C) of CP scores in the observation group were higher than in the control group, with C class > B class > A class; the differences were statistically significant (P < 0.01). Although AUC values of LS within the three classes of CP scores were higher than in the four indicators of liver fibrosis, sensitivity and specificity were unstable. The ROC curves of LS combined with the four indicators of liver fibrosis revealed that: AUC and sensitivity in all indicators combined in the A class of CP score were higher than in LS alone, albeit with slightly decreased specificity; AUC and specificity in all indicators combined in the B class of CP score were higher than in LS alone, with unchanged sensitivity; AUC values (0.967), sensitivity (97.4%), and specificity (90%) of all indicators combined in the C class of CP score were higher than in LS alone (0.936, 92.1%, 83.3%). CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value.展开更多
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tis...BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.展开更多
The solidification process of metals plays a critical role in their final microstructure and, correspondingly, in their performance. It is therefore important to probe the solidification behavior of metals using advan...The solidification process of metals plays a critical role in their final microstructure and, correspondingly, in their performance. It is therefore important to probe the solidification behavior of metals using advanced in situ techniques. Synchrotron radiation X-ray imaging is one of the most powerful techniques to observe the solidification process of metals directly. Here, we review the development of the solidification apparatus, including the directional solidification device, resistance furnace, multi-field coupling device, semisolid forming device, aerodynamic levitation apparatus, and laser additive manufacturing apparatus. We highlight the recent research progress on the use of synchrotron radiation X-ray imaging to reveal the solidification behavior of metals in the above circumstances. The future perspectives of synchrotron radiation X-ray imaging in metal research are discussed. Further development of this technique will contribute to improve the understanding of the solidification process of metals and other types of materials at different scales.展开更多
A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The t...A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).展开更多
Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation be...Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation between benign and malignant solid breast masses, meanwhile evaluate the influences of ARFI with breast imaging reporting and data system (BI-RADS) of suspicious masses. Methods: Seventy-five women with 86 breast lesions underwent conventional breast ultra- sound examination. Then B-mode BI-RADS features and assessments were recorded and standard breast US supplemented by ARFI elastographic examination were repeated. The data were recorded and analyzed as following: area ratio of breast lesion, the shear-wave velocity, the ratio of the shear-wave velocity between lesions and surrounding normal tissues, and according to the elastographic data reconsidered the BI-RADS category, all the results have been correlated with pathological results and make statistical evaluations of ARFI for differentiation between benign and malignant solid breast masses. Meantime our study has correlated the adjusted BI-RADS category of suspicious breast lesions with the pathological results and made assessment. Results: Thirty-eight patients were malignant breast carcinoma (31 invasive ductal carcinoma, 5 intraductal carcinoma in situ, 2 medullary carcinoma, 2 invasive Iobular carcinoma), 48 patients were benign breast lesions (23 fibroadenoma, 12 benign nodular hyperplasia, 5 phyllodes tumor, 6 adenosis, 2 intraductal papilloma). Underwent conventional breast ultrasound exam, 42 cases were BI-RADS category 3, 23 cases were BI-RADS category 4. When adding elastographic data, 46 cases were BI-RADS category 3 and 20 cases were BI-RADS category 4. Compared with pathological results showed for both the specificity of BIRADS features and the area under ROC curve has risen. Virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) data showed the area ratio (AR) between elastographic lesions area and B-mode lesions area, SWV (maximal shear-wave velocity of lesions), R-SWV (shear-wave velocity ratio between lesions and surrounding normal tissues) in benign breast lesions were lower than those in malignant lesions which has statistical significance and the cut-off point were 1.1,4.65 m/s, 5.18 respectively. Conclusion: The ARFI elastography can provide the reliable qualitative and quantitative analysis about hardness of breast lesions, supply the new BI-RADS category features to suspicious breast masses and serve as an effective diagnostic tool for differentiation between benign and malignant solid masses.展开更多
Sea surface temperature(SST)is a crucial physical parameter in meteorology and oceanography.This study demonstrates that the influence of earth incidence angle(EIA)on the SST retrieved from the microwave radiation ima...Sea surface temperature(SST)is a crucial physical parameter in meteorology and oceanography.This study demonstrates that the influence of earth incidence angle(EIA)on the SST retrieved from the microwave radiation imager(MWRI)onboard FengYun-3(FY-3)meteorological satellites should not be ignored.Compared with algorithms that do not consider the influence of EIA in the regression,those that integrate the EIA into the regression can enhance the accuracy of SST retrievals.Subsequently,based on the recalibrated Level 1B data from the FY-3/MWRI,a long-term SST dataset was reprocessed by employing the algorithm that integrates the EIA into the regression.The reprocessed SST data,including FY-3B/MWRI SST during 2010-2019,FY-3C/MWRI SST during 2013-2019,and FY-3D/MWRI SST during 2018-2020,were compared with the in-situ SST and the SST dataset from the Operational Sea Surface Temperature and Ice Analysis(OSTIA).The results show that the FY-3/MWRI SST data were consistent with both the in-situ SST and the OSTIA SST dataset.Compared with the Copernicus Climate Change Service V2.0 SST,the absolute deviation of the reprocessed SST,with a quality flag of 50,was less than 1.5℃.The root mean square errors of the FY-3/MWRI orbital,daily,and monthly SSTs,with a quality flag of 50,were approximately 0.82℃,0.69℃,and 0.37℃,respectively.The primary discrepancies between the FY-3/MWRI SST and the OSTIA SST were found mainly in the regions of the western boundary current and the Antarctic Circumpolar Current.Overall,this reprocessed SST product is recommended for El Niño and La Niña events monitoring.展开更多
Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted signifi...Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy range.Good spatial and temporal resolutions are useful for neutron energy-resolved imaging.However,their practical applications still face many technical challenges.In this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron Source.The neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B doping.The factors that caused the reduction in the detection efficiency were simulated and discussed.The neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of keV.The response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become dominant.This is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.展开更多
Progressive hepatic fibrosis can lead to cirrhosis,so its early detection is fundamental.Staging fibrosis is also critical for prognosis and management.The gold standard for these aims is liver biopsy,but it has sever...Progressive hepatic fibrosis can lead to cirrhosis,so its early detection is fundamental.Staging fibrosis is also critical for prognosis and management.The gold standard for these aims is liver biopsy,but it has several drawbacks,as it is invasive,expensive,has poor acceptance,is prone to inter observer variability and sampling errors,has poor repeatability,and has a risk of complications and mortality.Therefore,non-invasive imaging tests have been developed.This review mainly focuses on the role of transient elastography,acoustic radiation force impulse imaging,and magnetic resonance-based methods for the noninvasive diagnosis of cirrhosis.展开更多
Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which wa...Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which was earlier thought to be irreversible.However,it is now known that cirrhosis can in fact be reversed by treatment with oral anti-nucleotide drugs.Thus,early and accurate diagnosis of cirrhosis is important to allow an appropriate treatment strategy to be chosen and to predict the prognosis of patients with CHB.Liver biopsy is the reference standard for assessment of liver fibrosis.However,the method is invasive,and is associated with pain and complications that can be fatal.In addition,intra-and inter-observer variability compromises the accuracy of liver biopsy data.Only small tissue samples are obtained and fibrosis is heterogeneous in such samples.This confounds the two types of observer variability mentioned above.Such limitations have encouraged development of non-invasive methods for assessment of fibrosis.These include measurements of serum biomarkers of fibrosis;and assessment of liver stiffness via transient elastography,acoustic radiation force impulse imaging,real-time elastography,or magnetic resonance elastography.Although significant advances have been made,most work to date has addressed the diagnostic utility of these techniques in the context of cirrhosis caused by chronic hepatitis C infection.In the present review,we examine the advantages afforded by use of non-invasive methods to diagnose cirrhosis in patients with CHB infections and the utility of such methods in clinical practice.展开更多
Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, ...Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses.展开更多
Identification of extrahepatic metastases(EHM) of hepatocellular carcinoma(HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle t...Identification of extrahepatic metastases(EHM) of hepatocellular carcinoma(HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle tissue is extremely rare. We describe a unique case of HCC metastasizing to the paravertebral muscle. A 55-year-old man with a history of hepatitis B cirrhosis underwent partial liver resection with complete removal of HCC. Three months later, a computed tomography(CT) scan showed intrahepatic recurrence. The tumors were treated with yttrium-90 microspheres, transcatheter arterial chemoembolization, and sorafenib. Six months later, a CT scan showed an enhancing lesion of the left paravertebral muscle that on biopsy were consistent with metastatic HCC. The tumor was treated with stereotactic hypo-fractionated imageguided radiation therapy(SHFRT). A follow-up scan 3 mo post-radiotherapy revealed a stable appearance of the paravertebral muscle metastasis. Because of the progression in the intrahepatic tumors, the patient was treated with capecitabine, which was changed to dasatinib 6 mo later. The patient passed away three years after the primary surgical resection. Management of EHM poses an extreme challenge. This is the first case of HCC with EHM to the paravertebral muscle in which stability of disease was achieved using SHFRT. This case highlights the importance of early detection of hepatitis B viral infection and initiation of anti-viral therapy to decrease recurrence of HCC and prevent EHM.展开更多
Propagating disturbances(PDs) were studied along an active region loop using simultaneous imaging and spectroscopy. An image sequence recorded in the Fe Ⅸ/Fe X 171 channel, from TRACE and spectral data in the Si ...Propagating disturbances(PDs) were studied along an active region loop using simultaneous imaging and spectroscopy. An image sequence recorded in the Fe Ⅸ/Fe X 171 channel, from TRACE and spectral data in the Si Ⅻ 520.6 line obtained from CDS/SOHO, are analyzed. A space-time map constructed from the TRACE image sequence shows the presence of PDs close to the loop foot point propagating with an apparent speed of 39 km s-1. The periodicity was found to be 5.4 min.The corresponding spectroscopic data from CDS, at a location away from the foot point, show oscillations in all three line parameters roughly at the same period. At locations farther from the foot point, the line width oscillation seems to disappear while the Doppler velocity oscillation becomes prominent. We attribute this to the signature of propagating slow waves that get affected by flows/other events close to the foot point. Spectral line profiles do not show much asymmetry, however, it is difficult to infer anything due to the broadened Gaussian shape of the CDS line profiles.展开更多
Objective To explore the possibility of infrared objective display of the heat-sensitive (HS) acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion (LIDP) patients, infrared thermograms of the lum...Objective To explore the possibility of infrared objective display of the heat-sensitive (HS) acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion (LIDP) patients, infrared thermograms of the lumbar and back region were taken with a thermal texture maps(TTM) method at a natural state, followed by a heat-sensitive detection with moxibustion method [moxibustion was given at Yaoyangguan (腰阳关GV 3) area for 10 min]. The cases with thermal diffusion and heat transfer on the Yaoyangguan (腰阳关GV 3) area were recorded after ceasing of the suspended moxibustion. Then the infrared thermograms were taken by TTM for the second time, and the changes of infrared thermograms of the waist-back region before and after moxibustion were recorded. Finally, the differences between moxibustion and infrared detection methods in the heat-sensitive state on Yaoyangguan (腰阳关GV 3) area were compared in the LIDP patients. Results Before moxibustion, the infrared radiation intensity most displayed high-temperature characteristics on the Yaoyangguan (腰阳关GV 3) area in the LIDP patients. Compared with the moxibustion method, the sensitivity(true positive rate) was 86.4%, the specificity (true negative rate) was 70.0%, and the accuracy was 82.3%; after moxibustion at the Yaoyangguan (腰阳关GV 3) area, the infrared radiation enhanced area obviously extended vertically along the medial waist-back (the Governor Vessel) or horizontally along the Belt Vessel. Compared with the moxibustion method, the sensitivity (true positive rate) was 79.7%, the specificity (true negative rate) was 75.0% and the accuracy was 78.5%. Conclusion The HS state of Yaoyangguan (腰阳关GV 3) area in the LIDP patients can be objectively displayed by the infrared imaging to a certain extent; moxibustion at the HS acupoint produces the thermal phenomena, such as thermal expansion and heat transfer, which can be objectively displayed to a certain extent by the infrared imaging apart from the subjective feeling of the subject.展开更多
基金Supported by the National Natural Science Foundation of China(91337218 and 41475103)China Meteorological Administration Special Public Welfare Research Fund(GYHY201406008)
文摘The Microwave Radiation Imager (MWRI) on board Chinese Fengyun-3 (FY-3) satellites provides measurements at 10.65, 18.7, 23.8, 36.5, and 89.0 GHz with both horizontal and vertical polarization channels. Brightness temperature measurements of those channels with their central frequencies higher than 19 GHz from satellite-based microwave imager radiometers had traditionally been used to retrieve cloud liquid water path (LWP) over ocean. The results show that the lowest frequency channels are the most appropriate for retrieving LWP when its values are large. Therefore, a modified LWP retrieval algorithm is developed for retrieving LWP of different magnitudes involving not only the high frequency channels but also the lowest frequency channels of FY-3 MWRI. The theoretical estimates of the LWP retrieval errors are between 0.11 and 0.06 mm for 10.65- and 18.7-GHz channels and between 0.02 and 0.04 mm for 36.5- and 89.0-GHz channels. It is also shown that the brightness temperature observations at 10.65 GHz can be utilized to better retrieve the LWP greater than 3 mm in the eyewall region of Super Typhoon Neoguri (2014). The spiral structure of clouds within and around Typhoon Neoguri can be well captured by combining the LWP retrievals from different frequency channels.
基金Supported by the National Key Research and Development Program of China(2018YFC1506501)China Academy of Space Technology“Spaceborne Observations Coping with the Crisis of Global Warming Responsibility of Major Powers in the Paris Agreement”and“Research on the Design of the Spaceborne Observation System of Global Climate Change”projects。
文摘Accurate measurements of soil moisture are beneficial to our understanding of hydrological processes in the earth system. A multivariable approach using the random forest(RF) machine learning technique is proposed to estimate the soil moisture from Microwave Radiation Imager(MWRI) onboard Fengyun-3 C satellite. In this study, Soil Moisture Operational Products System(SMOPS) products disseminated from NOAA are used as a truth to train the algorithm with the input of MWRI brightness temperatures(TBs) at 10.65, 18.7, 23.8, 36.5, and 89.0 GHz, TB polarization ratios(PRs) at 10.65, 18.7, and 23.8 GHz, height in digital elevation model(DEM), and soil porosity. The retrieved soil moisture is also validated against the independent SMOPS data, and the correlation coefficient is about0.8 and mean bias is 0.002 m^3 m^-3 over the period from 1 August 2017 to 31 May 2019. Our retrieval of soil moisture also has a higher correlation with ECMWF ERA5 soil moisture data than the MWRI operational products. In the western part of China, the spatial distribution of MWRI soil moisture is much improved, compared to the MWRI operational products.
基金Supported by the National Key Research and Development Program of China(2018YFC150650)National Satellite Meteorological Center Mountain Flood Geological Disaster Prevention Meteorological Guarantee Project 2020 Construction Project(IN_JS_202004)。
文摘The production of true color images requires observational data in the red,green,and blue(RGB)bands.The Advanced Geostationary Radiation Imager(AGRI)onboard China’s Fengyun-4(FY-4)series of geostationary satellites only has blue and red bands,and we therefore have to synthesize a green band to produce RGB true color images.We used random forest regression and conditional generative adversarial networks to train the green band model using Himawari-8 Advanced Himawari Imager data.The model was then used to simulate the green channel reflectance of the FY-4 AGRI.A single-scattering radiative transfer model was used to eliminate the contribution of Rayleigh scattering from the atmosphere and a logarithmic enhancement was applied to process the true color image.The conditional generative adversarial network model was better than random forest regression for the green band model in terms of statistical significance(e.g.,a higher determination coefficient,peak signal-to-noise ratio,and structural similarity index).The sharpness of the images was significantly improved after applying a correction for Rayleigh scattering,and the images were able to show natural phenomena more vividly.The AGRI true color images could be used to monitor dust storms,forest fires,typhoons,volcanic eruptions,and other natural events.
基金Supported by the National Key Research and Development Program of China(2018YFB0504900 and 2018YFB0504902)National Natural Science Foundation of China(41805024 and 42005105)Open Fund of the State Key Laboratory of Hydroscience and Engineering and Tsinghua University–Ningxia Yinchuan Joint Research Institute of Digital Water Governance with Internet of Waters(sklhse-2021-Iow08)。
文摘This study evaluates the in-orbit calibration uncertainty(CU)for the microwave radiation imager(MWRI)on board the Chinese polar-orbiting meteorological satellite Fengyun-3 C(FY-3 C).Uncertainty analysis of the MWRI provides a direct link to the calibration system of the sensor and quantifies the calibration confidence based on the prelaunch and postlaunch measurements.The unique design of the sensor makes the uncertainty in the calibration of the sensor highly correlate to the uncertainty in the brightness temperature(TB)measured at the hot view,while the cold view has negligible impacts on the calibration confidence.Lack of knowledge on the emission of the hot-load reflector hampers the MWRI calibration accuracy significantly in the descending passes of the orbits when the hotload reflector is heated nonuniformly by the solar illumination.Radiance contamination originating from the satellite and in-orbit environments could enter the primary reflector via the hot view and further impinge on the CU,especially at the 10.65-GHz channels where the main-beam width is much broader than that of higher-frequency channels.The monthly-mean CU is lower than 2 K at all channels,depending on the observed earth scenes and in-orbit environments,and the month-to-month variation of CU is also noticed for all channels.Due to the uncertainty in the emissive hot-load reflector,CU in the descending passes is generally larger than that in the ascending orbits.Moreover,up to 1-K CU difference between the ocean and land scenes is found for the 10.65-GHz channels,while this difference is less than 0.1 K at the 89-GHz channels.
基金supported by the UK-China Research&Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)China as part of the Newton Fund
文摘China's FengYnn 3 (FY-3) polar orbiting satellites axe set to become an important sonrce of observational data for nu- merical weather prediction (NWP), atmospheric reanalyses, and climate monitoring studies over the next two decades. As part of the Climate Science for Service Partnership China (CSSP China) prograln, FY-3B Microwave Humidity Sounder 1 (MWHS-1) and FY-3C MWHS-2 observations have been thoroughly assessed and prepared for operational assimilation. This represents the first time observations from China's polar orbiting satellites have been used in the UK's global NWP model. Since 2016, continuous data quality monitoring has shown occasional bias changes found to be correlated to changes in the energy supply scheme regulating the platform heating system and other transient anomalies. Nonetheless, MWHS-1 and MWHS-2 significantly contribute to the 24-h forecast error reduction by 0.3% and 0.6%, respectively, and the combination of both instruments is shown to improve the fit to the model background of independent sounders by up to 1%. The observations from the Microwave Radiation Imager (MWRI) also are a potentially significant source of benefits for NWP models, but a solar-dependent bias observed in the instrument half-orbits has prevented their assimilation. This paper presents the bases of a correction scheme developed at the Met Office for the purpose of a future assimilation of MWRI data.
文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.
文摘AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirrhosis secondary to primary biliary cirrhosis were selected as the observation group, with the degree of patient liver cirrhosis graded by Child-Pugh (CP) score. Sixty healthy individuals were selected as the control group. The four indicators of hepatic fibrosis were detected in all research objects, including hyaluronic acid (HA), laminin (LN), type III collagen (PC III), and type IV collagen (IV-C). The liver parenchyma hardness value (LS) was then measured by ARFI technique. LS and the four indicators of liver fibrosis (HA, LN, PC III, and IV-C) were observed in different grade CP scores. The diagnostic value of LS and the four indicators of liver fibrosis in determining liver cirrhosis degree with PBC, whether used alone or in combination, were analyzed by receiver operating characteristic (ROC) curve. RESULTS: LS and the four indicators of liver fibrosis within the three classes (A, B, and C) of CP scores in the observation group were higher than in the control group, with C class > B class > A class; the differences were statistically significant (P < 0.01). Although AUC values of LS within the three classes of CP scores were higher than in the four indicators of liver fibrosis, sensitivity and specificity were unstable. The ROC curves of LS combined with the four indicators of liver fibrosis revealed that: AUC and sensitivity in all indicators combined in the A class of CP score were higher than in LS alone, albeit with slightly decreased specificity; AUC and specificity in all indicators combined in the B class of CP score were higher than in LS alone, with unchanged sensitivity; AUC values (0.967), sensitivity (97.4%), and specificity (90%) of all indicators combined in the C class of CP score were higher than in LS alone (0.936, 92.1%, 83.3%). CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value.
文摘BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.
基金supported by the National Natural Science Foundation of China for Excellent Young Scholars(No.51922068)the National Natural Science Foundation of China(Nos.51821001,51904186)the fund of the State Key Laboratory of Solidification Processing in NWPU,China(No.SKLSP202102)。
文摘The solidification process of metals plays a critical role in their final microstructure and, correspondingly, in their performance. It is therefore important to probe the solidification behavior of metals using advanced in situ techniques. Synchrotron radiation X-ray imaging is one of the most powerful techniques to observe the solidification process of metals directly. Here, we review the development of the solidification apparatus, including the directional solidification device, resistance furnace, multi-field coupling device, semisolid forming device, aerodynamic levitation apparatus, and laser additive manufacturing apparatus. We highlight the recent research progress on the use of synchrotron radiation X-ray imaging to reveal the solidification behavior of metals in the above circumstances. The future perspectives of synchrotron radiation X-ray imaging in metal research are discussed. Further development of this technique will contribute to improve the understanding of the solidification process of metals and other types of materials at different scales.
基金Supported by the National Key Scientific Instrument and Equipment Development Projects of China under Grant No 81127901the National Natural Science Foundation of China under Grant Nos 61372017 and 30970828
文摘A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).
文摘Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation between benign and malignant solid breast masses, meanwhile evaluate the influences of ARFI with breast imaging reporting and data system (BI-RADS) of suspicious masses. Methods: Seventy-five women with 86 breast lesions underwent conventional breast ultra- sound examination. Then B-mode BI-RADS features and assessments were recorded and standard breast US supplemented by ARFI elastographic examination were repeated. The data were recorded and analyzed as following: area ratio of breast lesion, the shear-wave velocity, the ratio of the shear-wave velocity between lesions and surrounding normal tissues, and according to the elastographic data reconsidered the BI-RADS category, all the results have been correlated with pathological results and make statistical evaluations of ARFI for differentiation between benign and malignant solid breast masses. Meantime our study has correlated the adjusted BI-RADS category of suspicious breast lesions with the pathological results and made assessment. Results: Thirty-eight patients were malignant breast carcinoma (31 invasive ductal carcinoma, 5 intraductal carcinoma in situ, 2 medullary carcinoma, 2 invasive Iobular carcinoma), 48 patients were benign breast lesions (23 fibroadenoma, 12 benign nodular hyperplasia, 5 phyllodes tumor, 6 adenosis, 2 intraductal papilloma). Underwent conventional breast ultrasound exam, 42 cases were BI-RADS category 3, 23 cases were BI-RADS category 4. When adding elastographic data, 46 cases were BI-RADS category 3 and 20 cases were BI-RADS category 4. Compared with pathological results showed for both the specificity of BIRADS features and the area under ROC curve has risen. Virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) data showed the area ratio (AR) between elastographic lesions area and B-mode lesions area, SWV (maximal shear-wave velocity of lesions), R-SWV (shear-wave velocity ratio between lesions and surrounding normal tissues) in benign breast lesions were lower than those in malignant lesions which has statistical significance and the cut-off point were 1.1,4.65 m/s, 5.18 respectively. Conclusion: The ARFI elastography can provide the reliable qualitative and quantitative analysis about hardness of breast lesions, supply the new BI-RADS category features to suspicious breast masses and serve as an effective diagnostic tool for differentiation between benign and malignant solid masses.
基金National Natural Science Foundation of China(42330602)Youth Innovation Team for“FengYun Satellite Remote Sensing Product Verification”(CMA2023QN12)。
文摘Sea surface temperature(SST)is a crucial physical parameter in meteorology and oceanography.This study demonstrates that the influence of earth incidence angle(EIA)on the SST retrieved from the microwave radiation imager(MWRI)onboard FengYun-3(FY-3)meteorological satellites should not be ignored.Compared with algorithms that do not consider the influence of EIA in the regression,those that integrate the EIA into the regression can enhance the accuracy of SST retrievals.Subsequently,based on the recalibrated Level 1B data from the FY-3/MWRI,a long-term SST dataset was reprocessed by employing the algorithm that integrates the EIA into the regression.The reprocessed SST data,including FY-3B/MWRI SST during 2010-2019,FY-3C/MWRI SST during 2013-2019,and FY-3D/MWRI SST during 2018-2020,were compared with the in-situ SST and the SST dataset from the Operational Sea Surface Temperature and Ice Analysis(OSTIA).The results show that the FY-3/MWRI SST data were consistent with both the in-situ SST and the OSTIA SST dataset.Compared with the Copernicus Climate Change Service V2.0 SST,the absolute deviation of the reprocessed SST,with a quality flag of 50,was less than 1.5℃.The root mean square errors of the FY-3/MWRI orbital,daily,and monthly SSTs,with a quality flag of 50,were approximately 0.82℃,0.69℃,and 0.37℃,respectively.The primary discrepancies between the FY-3/MWRI SST and the OSTIA SST were found mainly in the regions of the western boundary current and the Antarctic Circumpolar Current.Overall,this reprocessed SST product is recommended for El Niño and La Niña events monitoring.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515030074)the National Natural Science Foundation of China(No.12035017)。
文摘Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy range.Good spatial and temporal resolutions are useful for neutron energy-resolved imaging.However,their practical applications still face many technical challenges.In this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron Source.The neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B doping.The factors that caused the reduction in the detection efficiency were simulated and discussed.The neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of keV.The response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become dominant.This is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.
文摘Progressive hepatic fibrosis can lead to cirrhosis,so its early detection is fundamental.Staging fibrosis is also critical for prognosis and management.The gold standard for these aims is liver biopsy,but it has several drawbacks,as it is invasive,expensive,has poor acceptance,is prone to inter observer variability and sampling errors,has poor repeatability,and has a risk of complications and mortality.Therefore,non-invasive imaging tests have been developed.This review mainly focuses on the role of transient elastography,acoustic radiation force impulse imaging,and magnetic resonance-based methods for the noninvasive diagnosis of cirrhosis.
基金Supported by A grant of the South Korea Healthcare technology R and D projectMinistry of Health and Welfare+1 种基金South KoreaNo.HI10C2020
文摘Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which was earlier thought to be irreversible.However,it is now known that cirrhosis can in fact be reversed by treatment with oral anti-nucleotide drugs.Thus,early and accurate diagnosis of cirrhosis is important to allow an appropriate treatment strategy to be chosen and to predict the prognosis of patients with CHB.Liver biopsy is the reference standard for assessment of liver fibrosis.However,the method is invasive,and is associated with pain and complications that can be fatal.In addition,intra-and inter-observer variability compromises the accuracy of liver biopsy data.Only small tissue samples are obtained and fibrosis is heterogeneous in such samples.This confounds the two types of observer variability mentioned above.Such limitations have encouraged development of non-invasive methods for assessment of fibrosis.These include measurements of serum biomarkers of fibrosis;and assessment of liver stiffness via transient elastography,acoustic radiation force impulse imaging,real-time elastography,or magnetic resonance elastography.Although significant advances have been made,most work to date has addressed the diagnostic utility of these techniques in the context of cirrhosis caused by chronic hepatitis C infection.In the present review,we examine the advantages afforded by use of non-invasive methods to diagnose cirrhosis in patients with CHB infections and the utility of such methods in clinical practice.
文摘Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses.
文摘Identification of extrahepatic metastases(EHM) of hepatocellular carcinoma(HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle tissue is extremely rare. We describe a unique case of HCC metastasizing to the paravertebral muscle. A 55-year-old man with a history of hepatitis B cirrhosis underwent partial liver resection with complete removal of HCC. Three months later, a computed tomography(CT) scan showed intrahepatic recurrence. The tumors were treated with yttrium-90 microspheres, transcatheter arterial chemoembolization, and sorafenib. Six months later, a CT scan showed an enhancing lesion of the left paravertebral muscle that on biopsy were consistent with metastatic HCC. The tumor was treated with stereotactic hypo-fractionated imageguided radiation therapy(SHFRT). A follow-up scan 3 mo post-radiotherapy revealed a stable appearance of the paravertebral muscle metastasis. Because of the progression in the intrahepatic tumors, the patient was treated with capecitabine, which was changed to dasatinib 6 mo later. The patient passed away three years after the primary surgical resection. Management of EHM poses an extreme challenge. This is the first case of HCC with EHM to the paravertebral muscle in which stability of disease was achieved using SHFRT. This case highlights the importance of early detection of hepatitis B viral infection and initiation of anti-viral therapy to decrease recurrence of HCC and prevent EHM.
文摘Propagating disturbances(PDs) were studied along an active region loop using simultaneous imaging and spectroscopy. An image sequence recorded in the Fe Ⅸ/Fe X 171 channel, from TRACE and spectral data in the Si Ⅻ 520.6 line obtained from CDS/SOHO, are analyzed. A space-time map constructed from the TRACE image sequence shows the presence of PDs close to the loop foot point propagating with an apparent speed of 39 km s-1. The periodicity was found to be 5.4 min.The corresponding spectroscopic data from CDS, at a location away from the foot point, show oscillations in all three line parameters roughly at the same period. At locations farther from the foot point, the line width oscillation seems to disappear while the Doppler velocity oscillation becomes prominent. We attribute this to the signature of propagating slow waves that get affected by flows/other events close to the foot point. Spectral line profiles do not show much asymmetry, however, it is difficult to infer anything due to the broadened Gaussian shape of the CDS line profiles.
基金Supported by National Natural Science Fund:30760320National Key Basic Research Development Project("973" Project):2009 CB 522902Jiangxi Provincial 2007 Key Science and Technique Innovation Project
文摘Objective To explore the possibility of infrared objective display of the heat-sensitive (HS) acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion (LIDP) patients, infrared thermograms of the lumbar and back region were taken with a thermal texture maps(TTM) method at a natural state, followed by a heat-sensitive detection with moxibustion method [moxibustion was given at Yaoyangguan (腰阳关GV 3) area for 10 min]. The cases with thermal diffusion and heat transfer on the Yaoyangguan (腰阳关GV 3) area were recorded after ceasing of the suspended moxibustion. Then the infrared thermograms were taken by TTM for the second time, and the changes of infrared thermograms of the waist-back region before and after moxibustion were recorded. Finally, the differences between moxibustion and infrared detection methods in the heat-sensitive state on Yaoyangguan (腰阳关GV 3) area were compared in the LIDP patients. Results Before moxibustion, the infrared radiation intensity most displayed high-temperature characteristics on the Yaoyangguan (腰阳关GV 3) area in the LIDP patients. Compared with the moxibustion method, the sensitivity(true positive rate) was 86.4%, the specificity (true negative rate) was 70.0%, and the accuracy was 82.3%; after moxibustion at the Yaoyangguan (腰阳关GV 3) area, the infrared radiation enhanced area obviously extended vertically along the medial waist-back (the Governor Vessel) or horizontally along the Belt Vessel. Compared with the moxibustion method, the sensitivity (true positive rate) was 79.7%, the specificity (true negative rate) was 75.0% and the accuracy was 78.5%. Conclusion The HS state of Yaoyangguan (腰阳关GV 3) area in the LIDP patients can be objectively displayed by the infrared imaging to a certain extent; moxibustion at the HS acupoint produces the thermal phenomena, such as thermal expansion and heat transfer, which can be objectively displayed to a certain extent by the infrared imaging apart from the subjective feeling of the subject.