To enlarge the detection range of traditional fiber-optic spectrometer,two rotating parabolic mirrors were first used in the design of fiber-optic collector for spectrometer,which can extend the detection range of spe...To enlarge the detection range of traditional fiber-optic spectrometer,two rotating parabolic mirrors were first used in the design of fiber-optic collector for spectrometer,which can extend the detection range of spectrometer from centimeter-scale to50m,as a super-low altitude remote sensing detector under passive lighting conditions.According to the performance requirements of fiber-spectrometer for optical collector,this study deduced the calculation formulae of design size of parabolic optical collector applied to different sensitivity spectrometers,different detection targets,different detection ranges and different weathers.Based on the calculation results,the model of fiber-optic collector with a diameter of16mm and a height of7.8mm was designed by ZEMAX.And then,TracePro,a light simulation software,was applied to ray tracing.The simulation results of optical radiation magnification agrees well with theoretical value,and the relative error is less than0.78%.This optical collector can effectively extend the detection range of spectrometer and expand its application fields and scopes.Compared with traditional refractive optical collector,it has several advantages of compact structure,low weight and low cost.展开更多
Objective:To investigate the effects of Heijiangdan Ointment(黑绛丹膏,HJD) on oxidative stress in (60)Co γ-ray radiation-induced dermatitis in mice.Methods:Female Wistar mice with grade 4 radiation dermatitis i...Objective:To investigate the effects of Heijiangdan Ointment(黑绛丹膏,HJD) on oxidative stress in (60)Co γ-ray radiation-induced dermatitis in mice.Methods:Female Wistar mice with grade 4 radiation dermatitis induced by ^(60)Co γ-rays were randomly divided into four groups(n=12 per group);the HJD-treated,recombinant human epidermal growth factor(rhEGF)-treated,Trolox-treated,and untreated groups,along with a negative control group.On the 11 th and 21 st days after treatment,6 mice in each group were chosen for evaluation.The levels of superoxide dismutase(SOD),malondialdehyde(MDA),and lactate dehydrogenase(LDH) were detected using spectrophotometric methods.The fibroblast mitochondria were observed by transmission electron microscopy(TEM).The expressions of fibroblast growth factor 2(FGF-2) and transforming growth factor β1(TGF-β1) were analyzed by western blot.Results:Compared with the untreated group,the levels of SOD,MDA and LDH,on the 11 th and 21 st days after treatment showed significant difference(P〈0.05).TEM analysis indicated that fibroblast mitochondria in the untreated group exhibited swelling and the cristae appeared fractured,while in the HJD group,the swelling of mitochondria was limited and the rough endoplasmic reticulum appeared more relaxed.The expressions of FGF-2 and TGF-β1 increased in the untreated group compared with the negative control group(P〈0.05).After treatment,the expression of FGF-2,rhEGF and Trolox in the HJD group were significantly increased compared with the untreated group(P〈0.05),or compared with the negative control group(P〈0.05).The expression of TGF-β1 showed significant difference between untreated and negative control groups(P〈0.05).HJD and Trolox increased the level of TGF-β1 and the difference was marked as compared with the untreated and negative control groups(P〈0.05).Conclusion:HJD relieves oxidative stress-induced injury,increases the antioxidant activity,mitigates the fibroblast mitochondrial damage,up-regulates the expression of growth factor,and promotes mitochondrial repair in mice.展开更多
基金National Natural Science Foundation of China(No.61376052)State Key Laboratory Program(No.SKT1507)
文摘To enlarge the detection range of traditional fiber-optic spectrometer,two rotating parabolic mirrors were first used in the design of fiber-optic collector for spectrometer,which can extend the detection range of spectrometer from centimeter-scale to50m,as a super-low altitude remote sensing detector under passive lighting conditions.According to the performance requirements of fiber-spectrometer for optical collector,this study deduced the calculation formulae of design size of parabolic optical collector applied to different sensitivity spectrometers,different detection targets,different detection ranges and different weathers.Based on the calculation results,the model of fiber-optic collector with a diameter of16mm and a height of7.8mm was designed by ZEMAX.And then,TracePro,a light simulation software,was applied to ray tracing.The simulation results of optical radiation magnification agrees well with theoretical value,and the relative error is less than0.78%.This optical collector can effectively extend the detection range of spectrometer and expand its application fields and scopes.Compared with traditional refractive optical collector,it has several advantages of compact structure,low weight and low cost.
基金Supported by the National Natural Science Foundation of China(No.30973745)
文摘Objective:To investigate the effects of Heijiangdan Ointment(黑绛丹膏,HJD) on oxidative stress in (60)Co γ-ray radiation-induced dermatitis in mice.Methods:Female Wistar mice with grade 4 radiation dermatitis induced by ^(60)Co γ-rays were randomly divided into four groups(n=12 per group);the HJD-treated,recombinant human epidermal growth factor(rhEGF)-treated,Trolox-treated,and untreated groups,along with a negative control group.On the 11 th and 21 st days after treatment,6 mice in each group were chosen for evaluation.The levels of superoxide dismutase(SOD),malondialdehyde(MDA),and lactate dehydrogenase(LDH) were detected using spectrophotometric methods.The fibroblast mitochondria were observed by transmission electron microscopy(TEM).The expressions of fibroblast growth factor 2(FGF-2) and transforming growth factor β1(TGF-β1) were analyzed by western blot.Results:Compared with the untreated group,the levels of SOD,MDA and LDH,on the 11 th and 21 st days after treatment showed significant difference(P〈0.05).TEM analysis indicated that fibroblast mitochondria in the untreated group exhibited swelling and the cristae appeared fractured,while in the HJD group,the swelling of mitochondria was limited and the rough endoplasmic reticulum appeared more relaxed.The expressions of FGF-2 and TGF-β1 increased in the untreated group compared with the negative control group(P〈0.05).After treatment,the expression of FGF-2,rhEGF and Trolox in the HJD group were significantly increased compared with the untreated group(P〈0.05),or compared with the negative control group(P〈0.05).The expression of TGF-β1 showed significant difference between untreated and negative control groups(P〈0.05).HJD and Trolox increased the level of TGF-β1 and the difference was marked as compared with the untreated and negative control groups(P〈0.05).Conclusion:HJD relieves oxidative stress-induced injury,increases the antioxidant activity,mitigates the fibroblast mitochondrial damage,up-regulates the expression of growth factor,and promotes mitochondrial repair in mice.