BACKGROUND Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiatio...BACKGROUND Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature.CASE SUMMARY In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Treatment included resection, re-resection with nodal dissection, and adjuvant chemoradiotherapy. This patient was also diagnosed with 4 other secondary malignancies, including stage IV diffuse large B cell lymphoma in the abdomen with subsequent brain metastases, low-grade neuroendocrine carcinoma of the lung, Hurthle cell adenoma, and small B cell lymphoma before the patient expired. This case provides important information regarding the pathology, clinical sequelae, and management of a patient diagnosed with radiation-associated EMC amidst four concurrent malignancies.CONCLUSION Further investigation is needed on the efficacy of adjuvant radiotherapy in EMC,especially atypical EMC.展开更多
Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-...Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-old woman with stage I B2 cervical cancer underwent radical hysterectomy and pelvic external beam radiation therapy.Seventeen months later,violaceous lesions began to appear,quickly covering her entire lower abdominal wall,perineum,and upper thighs.These lesions were accompanied by small nodules and ulceration.Immunohistochemistry revealed positive expression of CD31 and CD34.Genetic testing revealed MYC amplification.The patient was finally diagnosed with RAAS and treated with albumin-bound paclitaxel and bevacizumab.However,her condition deteriorated quickly and she died 7 months later.Conclusion This case illustrates the importance of extensive biopsy of skin lesions suspected of denoting RAAS as early as possible.Pathological examination for CD31,CD34,and MYC assists early establishment of the diagnosis.展开更多
基金Supported by the National Institutes of Health grant,No.5K12CA090625-18(to Austin N Kirschner)from the Vanderbilt Clinical Oncology Research Career Development ProgramNCI/NIH Cancer Center Support Grant,No.5P30 CA68485-19the Vanderbilt Mouse Metabolic Phenotyping Center Grant No.2U24 DK059637-16
文摘BACKGROUND Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature.CASE SUMMARY In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Treatment included resection, re-resection with nodal dissection, and adjuvant chemoradiotherapy. This patient was also diagnosed with 4 other secondary malignancies, including stage IV diffuse large B cell lymphoma in the abdomen with subsequent brain metastases, low-grade neuroendocrine carcinoma of the lung, Hurthle cell adenoma, and small B cell lymphoma before the patient expired. This case provides important information regarding the pathology, clinical sequelae, and management of a patient diagnosed with radiation-associated EMC amidst four concurrent malignancies.CONCLUSION Further investigation is needed on the efficacy of adjuvant radiotherapy in EMC,especially atypical EMC.
文摘Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-old woman with stage I B2 cervical cancer underwent radical hysterectomy and pelvic external beam radiation therapy.Seventeen months later,violaceous lesions began to appear,quickly covering her entire lower abdominal wall,perineum,and upper thighs.These lesions were accompanied by small nodules and ulceration.Immunohistochemistry revealed positive expression of CD31 and CD34.Genetic testing revealed MYC amplification.The patient was finally diagnosed with RAAS and treated with albumin-bound paclitaxel and bevacizumab.However,her condition deteriorated quickly and she died 7 months later.Conclusion This case illustrates the importance of extensive biopsy of skin lesions suspected of denoting RAAS as early as possible.Pathological examination for CD31,CD34,and MYC assists early establishment of the diagnosis.
