Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances.

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical treatment.Chemoradiotherapy,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of patients.However,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still uncertain.AIM To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for clinicians.METHODS A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to 2023.The Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple factors.RESULTS The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,respec-tively.The incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths occurred.In terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation metastasis.The 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,respectively.The 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,respectively.Multivariate analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for OS.CONCLUSION Postoperative intensity-modulated radiotherapy combined with chemotherapy for gastric cancer treatment is well tolerated and has acceptable adverse effects,which is beneficial for local tumor control and can improve the long-term survival of patients.The LNR was an independent prognostic factor for OS.For patients with a high risk of local recurrence,postoperative adjuvant chemoradiation should be considered.

Ex vivo liver resection followed by autotransplantation in radical resection of gastric cancer liver metastases:A case report

BACKGROUND Radical resection of gastric cancer liver metastases(GCLM)can increase the 5-year survival rate of GCLM patients.However,patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases.CASE SUMMARY A 29-year-old woman had a chief complaint of chronic abdominal pain for 1 year.Abdominal computed tomography and magnetic resonance imaging examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver.The anterior wall of the gastric antrum was unevenly thickened.The diagnosis of(gastric antrum)intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance.She underwent radical resection(excision of both gastric tumors and ex vivo liver resection followed by autotransplantation simultaneously)followed by XELOX adjuvant chemotherapy.Without serious postoperative complications,the patient was successfully discharged on the 20th day after the operation.Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved.The resected mass was confirmed to be poorly differentiated gastric carcinoma(hepatoid adenocarcinoma with neuroendocrine differentiation)with liver metastases in segments VIII.No recurrence or metastasis within the liver was found during a 7.5-year follow-up review that began 1 mo after surgery.CONCLUSION Application of ex vivo liver resection followed by autotransplantation in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.

Clinical importance and surgical decision-making regarding proximal resection margin for gastric cancer

Because of the intramural spread of gastric cancer,a sufficient length of a resection margin has to be attained to ensure complete excision of the tumor.There has been debate on an adequate length of proximal resection margin(PRM) and its related issues.Thus,the objective of this article is to review several studies on PRM and to summarize the current evidence on the subject.Although there is some discrepancy in the recommended values for PRM between authors,a PRM of more than 2-3 cm for early gastric cancer and 5-6 cm for advanced gastric cancer is thought to be acceptable.Once the margin is confirmed to be clear,however,the length of PRM measured in postoperative pathologic examination does not affect the patient's survival,even when it is shorter than the recommended values.Hence,the recommendations for PRM length should be applied only to intraoperative decision-making to prevent positive margins on the final pathology.Given that a negative resection margin is the ultimate goal of determining an adequate PRM,development and improvement of reliable methods to confirm a negative resection margin intraoperatively would minimize the extent of surgery and offer a better quality of life to more patients.In the same context,special attention has to be paid to patients who have advanced stage or diffuse-type gastric cancer,because they are more likely to have a positive margin.Therefore,a wider excision with intraoperative frozen section(IFS) examination of the resection margin is necessary.Despite all the attempts to avoid positive margins,there is still a certain rate of positive-margin cases.Since the negative impact of a positive margin on prognosis is mostly obvious in low N stage patients,aggressive further management,such as extensive re-operation,is required for these patients.In conclusion,every possible preoperative and intraoperative evaluation should be thoroughly carried out to identify in advance the patients with a high risk of having positive margins;these patients need careful management with a wider excision or an IFS examination to confirm a negative margin during surgery.

Prognostic Factors for Patients after Curative Resection for Proximal Gastric Cancer

The factors influencing the long-term survival of patients with proximal gastric cancer (PGC) after curative resection were investigated. Data from 171 patients who underwent curative resection for PGC were retrospectively analyzed. The patients were grouped according to the clinicopathological factors and operative procedures. The tumor depth (T stage) and lymph node metastasis (pN stage) were graded according to the fifth edition of TNM Staging System published by UICC in 1997. The metastatic lymph node ratio (MLR) was divided into four levels: 0%, 30%. The data of survival rate were analyzed by Kaplan-Meier method (log-rank test) and Cox regression model. The 5-year overall survival rate of 171 patients was 37.32%. The univariate analysis demonstrated that the survival time of the postoperative patients with PGC was related to tumor size (χ2=4.57, P=0.0325), gross type (χ2=21.38, P30% (χ2=13.34, P=0.0003), TNM Ⅲ (χ2=14.05, P=0.0002) or TNM Ⅳ stage (χ2=4.37, P=0.0366); and combining splenectomy was beneficial to the cases of T3 (χ2=5.68, P=0.0171) or MLR >30% (χ2=6.11, P=0.0134). It was concluded that MLR, pN stage, TNM stage, T stage, and gross type had advantages in providing a precise prognostic evaluation for patients undergoing curative resection for PGC, in which MLR was the most valuable index. TG and combining splenectomy were useful to improve the prognosis to patients with PGC of TNM Ⅲ/Ⅲ stage, serosa invasion, or extensive regional lymph node metastasis.

No long-term survival benefit with sustained-release 5-fluorouracil implants in patients with stages Ⅱ and Ⅲ gastric cancer

BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer is still unelucidated.AIM To explore the long-term survival benefit of using sustained-release 5-FU implants in stage Ⅱ and stage Ⅲ gastric cancer patients.METHODS Patients with gastric cancer in a locally advanced stage and who underwent an R0 radical resection between Jan 2014, to Dec 2016, in this single institution were included. Patients with pathological diagnoses other than adenocarcinoma were excluded. All included patients were grouped according to whether intraoperative sustained-release(SR) chemotherapy with 5-FU was used or not(NSR). The primary end-point was 5-year overall survival. Kaplan–Meier method with logrank test was used to analyze the overall survival of patients and Cox analysis was used to analyze prognosis factors of these patients.RESULTS In total, there were 563 patients with gastric cancer with locally advanced stage, who underwent an R0 radical resection. 309 patients were included in the final analysis. 219(70.9%) were men, with an average age of 58.25 years. Furthermore, 56(18.1%) received neoadjuvant chemotherapy, and 191(61.8%) were in TNM stage Ⅲ. In addition, 158 patients received intraoperative sustainedrelease chemotherapy with 5-FU and were included in the SR group, while the other 161 patients were included in the NSR group. The overall complication rate was 12.94% in the whole group and 10.81%, 16.46% in SR and NSR groups, respectively. There were no significant differences between the two groups in overall survival and complication rate(P > 0.05). The multivariate cox analysis indicated that only N Stage and neoadjuvant therapy were independent influencing factors of survival.CONCLUSION Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer.

Subcutaneous fat thickness and abdominal depth are risk factors for surgical site infection after gastric cancer surgery

BACKGROUND Surgical site infection(SSI)is one of the most common complications after gastric cancer(GC)surgery.The occurrence of SSI can lead to a prolonged postoperative hospital stay and increased medical expenses,and it can also affect postoperative rehabilitation and the quality of life of patients.Subcutaneous fat thickness(SFT)and abdominal depth(AD)can be used as predictors of SSI in patients undergoing radical resection of GC.AIM To explore the potential relationship between SFT or AD and SSI in patients undergoing elective radical resection of GC.METHODS Demographic,clinical,and pre-and intraoperative information of 355 patients who had undergone elective radical resection of GC were retrospectively collected from hospital electronic medical records.Univariate analysis was performed to screen out the significant parameters,which were subsequently analyzed using binary logistic regression and receiver-operating characteristic curve analysis.RESULTS The prevalence of SSI was 11.27%(40/355).Multivariate analyses revealed that SFT[odds ratio(OR)=1.150;95%confidence interval(95%CI):1.090-1.214;P<0.001],AD(OR=1.024;95%CI:1.009-1.040;P=0.002),laparoscopic-assisted surgery(OR=0.286;95%CI:0.030-0.797;P=0.017),and operation time(OR=1.008;95%CI:1.001-1.015;P=0.030)were independently associated with the incidence of SSI after elective radical resection of GC.In addition,the product of SFT and AD was a better potential predictor of SSI in these patients than either SFT or AD alone.CONCLUSION SFT and AD are independent risk factors and can be used as predictors of SSI in patients undergoing radical resection of GC.

Spleen-preserving splenic lymph node dissection in radical total gastrectomy

Radical gastrectomy has been recognized as the standard surgical treatment for advanced gastric cancer, and essentially applied in a wide variety of clinical settings. The thoroughness of lymph node dissection is an important prognostic factor for patients with advanced gastric cancer. Splenic lymph node dissection is required during D2 radical gastrectomy for upper stomach cancer. This is often accompanied by removal of the spleen in the past few decades. A growing number of investigators believe, however, that the spleen plays an important role as an immune organ, and thus they encourage the application of a spleen- preserving method for splenic hilum lymph node dissection.

腹腔镜胃癌根治术中左侧入路法与托出式胰后入路法治疗进展期近端胃癌的疗效

目的研究腹腔镜胃癌根治术中左侧入路法与托出式胰后入路法在治疗进展期近端胃癌中的疗效。方法回顾性分析106例行腹腔镜胃癌根治术的进展期近端胃癌患者临床资料,根据患者手术入路方式,将其分为左侧入路组(n=46)与托出式胰后入路组(n=60),比较2组围术期相关指标,随访1年,绘制生存曲线,比较2组术后生存情况。结果托出式胰后入路组患者手术时间短于左侧入路组,术中出血量少于左侧入路组,淋巴结清扫个数多于左侧入路组,差异具有统计学意义(P<0.05);2组切口长度、引流管拔除时间、营养管时间、术后肛门首次排气时间、开始流质饮食时间、术后首次下床活动时间以及术后住院时间比较,差异均无统计学意义(P>0.05)。2组术后并发症发生率比较,差异无统计学意义(P>0.05)。托出胰后入路组与左侧入路组患者术后1年生存时间比较,差异无统计学意义(P>0.05)。结论与腹腔镜下左侧入路相比,托出式胰后入路手术操作更为简单,能有效缩短手术时间,控制术中出血量,但2种术式对进展期近端胃癌患者近期疗效及远期生存情况的影响相似。

腹腔镜近端胃切除术与腹腔镜根治性全胃切除术治疗近端胃癌的效果比较

目的对比腹腔镜近端胃切除术与腹腔镜根治性全胃切除术治疗近端胃癌的临床效果。方法70例近端胃癌患者随机分为两组,A组采用腹腔镜近端胃切除术治疗,B组采用腹腔镜根治性全胃切除术治疗,比较两组的手术相关指标、炎性因子水平及并发症。结果A组的手术相关指标均优于B组,术后7 d的hs-CRP、IL-6、TNF-α水平均低于B组(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论与腹腔镜根治性全胃切除术相比,腹腔镜近端胃切除术治疗近端胃癌患者的创伤较小,术后炎性反应较轻。

腹腔镜远端胃癌根治术后不同方式吻合对术后胃食管反流的影响对比研究

目的研究腹腔镜远端胃癌根治术后使用两种不同的方式进行吻合对术后胃食管反流的影响。方法回顾性分析2019年1月-2022年12月本院收治的68例胃癌患者,随机分为两组,对两组患者进行腹腔镜远端胃癌根治术,观察组(n=35)患者进行Uncut Roux-en-Y吻合,对照组(n=33)患者进行B-Ⅱ+Braun吻合。观察两组相关指标,比较两组术后胃食管反流情况、术后营养状态以及术后产生胆汁反流、吻合口瘘、创面感染、残胃炎的患者例数。结果观察组胃肠功能恢复时间比对照组短(P<0.05);观察组GerdQ总评分均低于对照组(P<0.05);观察组术后1个月血红蛋白、白蛋白水平均高于对照组(P<0.05);观察组术后并发症低于对照组(P<0.05)。结论腹腔镜远端胃癌根治术后Uncut Roux-en-Y吻合的疗效较好,可以改善患者术后胃食管反流、营养状态,且并发症也较少。

达芬奇机器人系统与腹腔镜远端胃癌根治术近期疗效比较

目的比较达芬奇机器人系统与腹腔镜远端胃癌根治术的近期疗效。方法回顾性选取2021年11月至2024年2月宁波大学附属第一医院收治的胃窦、胃角癌患者200例,均择期行远端胃癌根治术。其中98例患者行达芬奇机器人手术治疗,为机器人组;另102例患者行腹腔镜手术治疗,为腹腔镜手术组。比较两组患者围术期指标、术后并发症发生情况。结果两组患者手术时间、术后住院时间比较差异均无统计学意义(均P>0.05)。与腹腔镜组比较,机器人组患者术中出血量较少,术后首次排气时间较短,但手术费用较高,差异均有统计学意义(均P<0.05)。机器人组患者术后并发症发生率低于腹腔镜组(2.04%比8.82%,P<0.05)。结论针对胃癌患者实施远端胃癌根治术,相较于腹腔镜手术,采用达芬奇机器人系统手术的出血量少,术后患者恢复排气时间短,并发症少。

根治性近端胃切除联合双通道重建术对胃癌患者围术期指标及营养指标的影响

目的分析根治性近端胃切除联合双通道重建术对胃癌患者围术期指标及营养指标的影响。方法选取胃癌患者60例,随机分为对照组和观察组,各30例。对照组行根治性全胃切除术+Roux-en-Y消化道重建术,观察组行根治性近端胃切除联合双通道重建术。对比两组的围术期指标、术后恢复情况、营养指标、生活质量、并发症发生情况。结果观察组术中出血量(89.65±10.21)ml少于对照组的(105.31±17.45)ml,手术时间(116.27±13.34)min、消化道重建时间(32.25±3.71)min、住院时间(8.35±1.36)d、肠鸣音恢复时间(25.36±2.59)h、肛门排气时间(43.26±5.46)h、进流食时间(84.36±6.87)h、下床活动时间(52.43±5.24)h均短于对照组的(139.84±16.25)min、(39.87±5.31)min、(10.69±1.87)d、(31.48±3.37)h、(54.89±7.58)h、(98.57±8.33)h、(59.67±6.57)h(P<0.05)。术后,两组血红蛋白(Hb)、总蛋白(TP)、白蛋白(ALB)均较术前降低,但观察组Hb(116.57±11.69)g/L、TP(67.35±4.89)g/L、ALB(40.56±4.71)g/L均高于对照组的(101.35±9.75)、(61.26±3.67)、(33.48±3.69)g/L(P<0.05)。术后,两组躯体疼痛、生理职能、生理机能、一般健康状况、精力、社会功能、情感职能、精神健康评分均较术前升高,且观察组较对照组更高(P<0.05)。观察组并发症发生率为6.67%(2/30),低于对照组的26.67%(8/30)(P<0.05)。结论对胃癌患者行根治性近端胃切除联合双通道重建术具有创伤小、术后恢复快等优势,还可改善患者营养状态,提高生活质量,且无严重并发症,临床可推行应用。

胃癌患者腹腔镜手术治疗中根治术的应用对肿瘤标志物及并发症的影响

目的:针对胃癌患者的治疗,分析腹腔镜下根治术对于肿瘤标志物及并发症产生的影响作用。方法:将在麻城市人民医院行手术治疗胃癌患者,共计有64例,分组基于术式的差异分为腹腔镜组、开腹组,对两组患者的治疗结果进行比较。结果:与开腹组比较,腹腔镜组手术持续时间长,并且具有更少的术中出血量,缩短了患者的住院持续时间(P<0.05)。此外,实施腹腔手术,患者独自下床活动时间更短,患者术后拔除引流管时间以及手术治疗后首次肛门排气时间均更短(P<0.05);在术前,对比两组患者CEA、CA724水平,差异很少(P>0.05),分别于术后3个月、6个月测定两组CEA、CA724水平发生的变化,结果显示均下降(P<0.05),同时腹腔镜组上述指标发生更为明显的变化;此外,术后腹腔镜组具有更低的并发症发生率(P<0.05)。结论:针对胃癌患者的治疗,腹腔镜根治术术后恢复快,能够降低肿瘤标志物水平,减少并发症。

腹腔镜辅助胃癌根治术联合基于微信平台的延续性干预对患者自我护理能力的影响

目的:探讨腹腔镜辅助胃癌根治术联合基于微信平台的延续性干预对患者自我护理能力的影响。方法:本研究选取商丘市第一人民医院2021年1月至2023年1月110例行腹腔镜下胃癌根治术患者,进行回顾性分析,将所有患者按照干预方法的不同分为对照组55例和研究组55例。给予对照组患者传统院外护理措施,研究组患者则在对照组的基础上实施基于微信平台的延续性干预措施,均进行为期1年的干预。将两组患者术后康复相关指标进行对比,将两组患者干预前后自我护理能力测定量表(ESCA)评分和生活质量评分进行对比。结果:研究组患者首次肛门排气时间、住院时间均相较于对照组缩短(P<0.05);两组患者胃管拔除时间、下地活动时间、进食流质饮食时间经对比,均未见明显差异(P>0.05);干预后两组患者健康知识水平、自我概念、自我护理技能及总分均相较于干预前上升,且研究组患者上述评分均较对照组高(P<0.05),而两组患者干预前后组内、组间自我责任感评分对比,均未见明显差异(P>0.05);干预后两组患者躯体功能、情绪功能、社会功能、认知功能及总体健康状况评分与干预前比均上升,且研究组患者与对照组相比更高(P<0.05),而干预前后两组患者角色功能评分组内、组间经对比,未见明显差异(P>0.05)。结论:基于微信平台的延续性干预运用于腹腔镜胃癌根治术后患者中,可缩短患者住院时间,促进患者快速康复,同时可有助于自我护理能力、生活质量的提升。

保留左结肠动脉腹腔镜直肠癌根治术对患者胃功能、并发症的影响

目的探析保留左结肠动脉(leftcolicartery,LCA)腹腔镜直肠癌根治术对患者胃功能、并发症的影响。方法选取2020年12月至2023年11月敦化市医院收治的57例行腹腔镜直肠癌根治术患者,按随机数字分组法分为对照组(28例)与观察组(29例)。对照组患者术中不保留LCA,观察组术中保留LCA。对比两组并发症发生率、胃功能、排尿功能、肛肠动力学。结果与术前比,术后30d两组患者的胃泌素、胃动素、胃蛋白酶原Ⅰ、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)水平均升高,且观察组患者的胃泌素、胃动素、胃蛋白酶原Ⅰ、CGRP水平高于对照组;与术前相比,术后30d两组患者的肛管静息压、肛管最大收缩压均降低,且观察组患者的肛管静息压、肛管最大收缩压均高于对照组,差异均有显著性(P<0.05)。术后7d两组患者的膀胱过度活动症状评分(overactive bladder symptom scale,OABSS)各项评分较术前均降低,且术后7d观察组患者的OABSS各项评分低于对照组,差异均有显著性(P<0.05)。观察组患者术后并发症总发生率低于对照组,差异有显著性(P<0.05)。结论腹腔镜根治术中保留LCA可改善直肠癌患者的肛肠动力学指标,快速恢复其胃功能与排尿功能,并降低并发症发生风险。

益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证的效果研究

目的观察益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证的临床效果。方法选取2020年6月至2022年12月首都医科大学附属北京康复医院收治的110例早期胃癌根治术后气血亏虚证患者为研究对象,根据随机数字表法分为对照组和观察组,各55例。对照组给予胃癌根治术后西医常规治疗及早期康复功能锻炼,观察组在对照组基础上给予益气补血方治疗。分别对2组患者中医临床症状积分、胃肠功能恢复情况、营养状况、免疫功能及胃肠道不良反应进行对比分析。结果对照组脱落1例、观察组脱落2例,最终对照组54例、观察组53例患者完成本研究。术后30 d,2组临床症状积分均低于术前,且观察组低于对照组[(16±3)分比(18±4)分](均P<0.001)。观察组术后胃肠鸣音恢复时间、首次肛门排气时间、首次排便时间均短于对照组(均P<0.001)。术后30 d,2组血红蛋白、转铁蛋白、总蛋白、免疫球蛋白A(IgA)、IgG、IgM、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)比值均高于治疗前、且观察组均高于对照组,2组CD_(8)^(+)均低于术前、且观察组低于对照组(均P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证可有效促进胃肠功能恢复、营养状况改善和免疫功能恢复。

半结构式访谈联合赋能教育对行晚期胃癌根治术患者自我效能及生命意义认知的影响

目的探究半结构式访谈联合赋能教育对行晚期胃癌根治术患者自我效能及生命意义认知的影响。方法将甘肃省武威肿瘤医院胃肠科于2022年1~12月收治的240例经胃癌根治术治疗的晚期胃癌患者纳为研究对象,根据简单随机分组法将所有患者分为赋能组与访谈组,每组120例。赋能组给予常规赋能教育,访谈组给予半结构式访谈联合赋能教育。对比2组心理压力等的变化。结果干预后,2组患者的焦虑和抑郁自评量表、疲乏量表评分均较干预前显著下降,自我效能感量表和生命意义认知量表评分均较干预前显著升高(P均<0.05),且访谈组均优于赋能组(P均<0.05)。结论半结构式访谈联合赋能教育可有效缓解经胃癌根治术治疗的晚期胃癌患者的负性情绪及疲乏情况,有效提高其自我效能与生命意义认知水平。

健脾补中化浊汤联合西药对胃癌根治术患者免疫功能、近期预后的影响

目的:探究健脾补中化浊汤对胃癌根治术患者免疫功能、近期预后的影响。方法:研究医院2020年1月~2023年1月收治的35例胃癌根治术后患者,按随机数表法将上述患者分为对照组(n=17,常规治疗联合西医治疗)和研究组(n=18,对照组基础上联合健脾补中化浊汤治疗),比较两组患者中医症状评分、疗效、胃肠功能、免疫功能、近期预后、不良反应。结果:(1)相较于治疗前,治疗后两组患者中医症状积分均有下降(P<0.05),且研究组相较于对照组均更低(P<0.05);(2)研究组总有效率相较于对照组更高(P<0.05);(3)相较于治疗前,治疗后两组患者胃泌素及胃动素水平均有升高,且研究组相较于对照组均更高(P<0.05);相较于治疗前,治疗后两组患者生长抑素水平均有降低,且研究组相较于对照组均更低(P<0.05);(4)相较于治疗前,治疗后两组患者CD4^(+)及自然杀伤细胞(NK)水平均有升高,且研究组相较于对照组均更高(P<0.05);(5)两组患者近期预后及不良反应比较无统计学意义(P>0.05)。结论:健脾补中化浊汤对于胃癌根治术后患者而言,更能改善中医症状和近期预后,更有利于提升治疗疗效、胃肠功能及免疫功能,且安全性较高,具有推广价值。

3D高清腹腔镜在腹腔镜胃癌根治术中的应用

目的探讨3D高清腹腔镜在腹腔镜胃癌根治术中的临床应用价值。方法选取我院2013年1月～2013年12月分别采用3D高清腹腔镜（3D组）和2D高清腹腔镜（2D组）行胃癌根治术各40例，对比两组在手术持续时间、术中失血量、学习曲线、住院花费等方面的差异。结果手术持续时间3D高清腹腔镜组2．8±0．6h，明显低于2D高清腹腔镜组3．2±0．8h（P=0．032），两组相比有明显差异（P〈0．05）。术中失血量3D高清腹腔镜组110±18ml，2D高清腹腔镜组120±21ml，两组相比无统计学上差异（P=0．543）。住院花费3D高清腹腔镜组7．5±1．6万元，2D高清腹腔镜组7．1±1.3万元，两组相比无统计学上差异（P=0．162）。结论3D高清腹腔镜能提供清晰的三维立体视觉，良好的深度感，可实现精确操作，缩短手术时间。并且，在3D高清视野下能更陕地提高外科医生的手术操作能力和手术技巧，明显缩短学习曲线。