A new curve fitting method with its mathematical models derived from the mass action law is presented which is applicable to several in vitro radioassays including RIA and RBA. Experiments revealed that the robustness...A new curve fitting method with its mathematical models derived from the mass action law is presented which is applicable to several in vitro radioassays including RIA and RBA. Experiments revealed that the robustness of this method is better than the conventional methods like Woolf plot in RBA and 4- parameter logistic plot in RIA. However, the robustness of this method is only relative: in some cases of RIA and RBA, the bias of the results may still be too large to be acceptable. Further improvement is expected to be studied.展开更多
文摘A new curve fitting method with its mathematical models derived from the mass action law is presented which is applicable to several in vitro radioassays including RIA and RBA. Experiments revealed that the robustness of this method is better than the conventional methods like Woolf plot in RBA and 4- parameter logistic plot in RIA. However, the robustness of this method is only relative: in some cases of RIA and RBA, the bias of the results may still be too large to be acceptable. Further improvement is expected to be studied.
